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Preclinical Studies of Novel Agents for Lung Cancer

Institution: University of California, San Diego
Investigator(s): Michael Kelner, M.D., M.S.
Award Cycle: 1992 (Cycle 1) Grant #: 1KT-0001 Award: $225,000
Subject Area: Cancer
Award Type: New Investigator Awards
Abstracts
Publications

Preclinical evaluation of illudins as anti-cancer agents: Basis for selective cytotoxicity
Periodical: Journal of the National Cancer Institute Index Medicus:
Authors: Kelner MJ, McMorris TC, Taetle R ART
Yr: 1990 Vol: 82 Nbr: Abs: Pg: 1562-1565

Repair of illudin induced DNA damage requires involvement of ERCC-2 and ERCC-3 DNA repair proteins prior to ERCC-1 action
Periodical: Toxicologist Index Medicus:
Authors: McMorris TC, Kelner MJ ABS
Yr: 1992 Vol: 12 Nbr: Abs: Pg: 155

HPLC determination of a new anticancer agent (acylfulvene) in serum
Periodical: Neoplasma Index Medicus:
Authors: Brandsteterova E, Kelner MJ, McMorris TC, Estes L, Bagnell R, Montoya M ART
Yr: 1992 Vol: 39 Nbr: 6 Abs: Pg: 369-373

Structure activity-relationships of illudins: analogs with improved therapeutic index
Periodical: Index Medicus:
Authors: McMorris TC, Kelner MJ, Wang W, Estes LA, Montoya MM, Taetle R ART
Yr: 1992 Vol: 57 Nbr: 25 Abs: Pg: 6876-6883

HPLC analysis of novel anticancer agents - illudins and their analogs
Periodical: Journal of Liquid Chromatography Index Medicus:
Authors: Brandsteterova E, Kelner MJ, McMorris TC, Wang W, Bagnell R ART
Yr: 1993 Vol: 16 Nbr: 1 Abs: Pg: 115-125

Characterization of the energy-dependent illudin transport system in immortal and tumor cells
Periodical: Toxicologist Index Medicus:
Authors: Kelner MJ, McMorris TC ABS
Yr: 1993 Vol: 13 Nbr: Abs: 1214 Pg: 315

On the mechanism of toxicity of illudins
Periodical: Index Medicus:
Authors: McMorris TC, Kelner MJ, Wang W, Moon S, Taetle R ART
Yr: 1990 Vol: 3 Nbr: Abs: Pg: 574-579