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Tobacco Smoke, Benzene, & Mechanisms of Leukemogenesis

Institution:	University of California, Riverside
Investigator(s):	David Eastmond, Ph.D.
Award Cycle:	1992 (Cycle 1)	Grant #: 1KT-0036	Award: $224,492
Subject Area:	Cancer
Award Type:	New Investigator Awards

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Potential role of free radicals in benzene-induced myelotoxicity and leukemia
Periodical: Free Radical Biology and Medicine			Index Medicus:
Authors: Subrahmanyam VV, Ross D, Eastmond DA, Smith MT				ART
Yr: 1991	Vol: 11	Nbr: 5	Abs:	Pg: 495-515

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Aneuploidy detection in interphase human lymphocytes using chromosome-specific DNA probes following treatment with benzene metabolite, hydroquinone
Periodical: Toxicologist			Index Medicus:
Authors: Eastmond DA, Hasegawa L				ABS
Yr: 1991	Vol: 11	Nbr: 1	Abs: 949	Pg: 250

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Use of in situ hybridization with chromosome-specific DNA probes to detect aneuploidy in hydroquinone-treated interphase human lymphocytes
Periodical: Environmental and Molecular Mutagenesis			Index Medicus:
Authors: Eastmond DA, Hasegawa L				ABS
Yr: 1991	Vol: 17	Nbr: Suppl 19	Abs: A71	Pg:

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Use of a DNA probe and anti-kinetochore modified micronucleus assay to detect aneuploidy in the lymphocytes of tobacco smoking individuals
Periodical: Environmental Molecular Mutagenesis			Index Medicus:
Authors: Eastmond DA, Rupa DS, Hasegawa L, Thompson CL				ABS
Yr: 1992	Vol: 19	Nbr: Suppl 20	Abs:	Pg: 16

---

Induction of micronuclei and aneuploidy by the quinone-forming agents benzene and o-phenylphenol
Periodical:			Index Medicus:
Authors: Eastmond DA				ART
Yr: 1993	Vol: 67	Nbr: 1-3	Abs:	Pg: 105-118

---

Multicolor fluorescence in situ hybridization to detect aneuploidy and chromosomal breakage in interphase cells and micronuclei
Periodical:			Index Medicus:
Authors: Eastmond DA, Rupa DS, Chen H, Hasegawa L				ABS
Yr: 1992	Vol:	Nbr:	Abs:	Pg: 52

---

Multicolor fluorescence in situ hybridization to detect aneuploidy and chromosomal breakage in interphase cells and micronuclei
Periodical:			Index Medicus:
Authors: Eastmond DA, Rupa DS, Chen H, Hasegawa L				ABS
Yr: 1993	Vol:	Nbr:	Abs: 341	Pg: 64

---

Use of fluorescence in situ hybridization and an antikinetochore antibody to detect aneuploidy and chromosome breakage in mouse bone marrow and spleen following benzene exposure in vivo
Periodical: Toxicologist			Index Medicus:
Authors: Chen HW, Tomar R, Rupa DS, Eastmond DA				ABS
Yr: 1993	Vol: 13	Nbr:	Abs: 804	Pg: 218

---

The role of oxygen radicals in the formation of micronuclei induced by quinone-forming compounds
Periodical: Toxicologist			Index Medicus:
Authors: Dobo KL, Eastmond DA				ABS
Yr: 1993	Vol: 13	Nbr:	Abs: 806	Pg: 219

---

Detection of hyperdiploidy and chromosome breakage in interphase human lymphocytes following exposure to the benzene metabolite hydroquinone using multicolor fluorescence in istu hybridization with DNA probes
Periodical:			Index Medicus:
Authors: Eastmond DA, Rupa DS, Hasegawa LS				ART
Yr: 1994	Vol: 322	Nbr: 1	Abs:	Pg: 9-20

---

Chromosomal loss and breakage in mouse bone marrow and spleen cells exposed to benzene in vivo
Periodical: Cancer Research			Index Medicus:
Authors: Chen HW, Rupa DS, Tomar R, Eastmond DA				ART
Yr: 1949	Vol: 54	Nbr: 13	Abs:	Pg: 3533-3539

---

The role of oxygen radicals in the chromosomal loss and breakage induced by the quinone-forming compounds in hydroquinone and tert-butylhydroquinone
Periodical: Environmental and Molecular Mutagenesis			Index Medicus:
Authors: Dobo KE, Eastmond DA				ART
Yr: 1994	Vol:	Nbr:	Abs:	Pg:

---

Detection of hydroquinone-induced nonrandom breakage in the centromeric heterochromatin of mouse bone marrow cells using multicolor fluorescence in situ hybridization with the mouse major and minor satellite probes
Periodical:			Index Medicus:
Authors: Chen HW, Tomar R, Eastmond DA				ART
Yr: 1994	Vol:	Nbr:	Abs:	Pg:

---

Synergistic increases in chromosomal breakage within the euchromatin induced by an interaction of the benzene metabolites phenol and hydroquinone in mice
Periodical: Toxicologist			Index Medicus:
Authors: Chen HW, Eastmond DA				ABS
Yr: 1994	Vol: 14	Nbr:	Abs: 1274	Pg: 328

---

Chromosomal loss and the involvement of chromosomes X, Y, and 7 in spontaneous micronuclei (MN) formed in binucleated lymphocytes of non-smoking females and males
Periodical: Environmental Molecular Mutagenesis			Index Medicus:
Authors: Rupa DS, Hasegawa L, and Eastmond DA				ABS
Yr: 1994	Vol: 23	Nbr: S23	Abs:	Pg: 58

---

Nonrandom breakage in centromeric heterochromatin of mouse bone marrow cells following the administration of hydroquinone in vivo
Periodical: Environmental Molecular Mutagenesis			Index Medicus:
Authors: Chen HW, Eastmond DA				ABS
Yr: 1994	Vol: 23	Nbr: S23	Abs:	Pg: 9

---

Differential mutation rate reflected in occurrence and extent of loss of heterozygosity in TK-human lymphoblasts
Periodical: Environmental Molecular Mutagenesis			Index Medicus:
Authors: Dobo KL, Eastmond DA, Rumbos HS, Giver CR, Grosovsky AJ				ABS
Yr: 1994	Vol: 23	Nbr: S23	Abs:	Pg: 13

---

Detection of chromosomal aberrations in interphase cells following exposure to genotoxic agents in vitro and in vivo using fluorescence in situ hybridization with DNA probes
Periodical:			Index Medicus:
Authors: Eastmond DA, Rupa DS, Hasegawa L				ABS
Yr: 1994	Vol:	Nbr:	Abs: 181	Pg: 40

---

Potential role of free radicals in benzene-induced myelotoxicity and leukemia
Periodical: Free Radical Biology and Medicine			Index Medicus:
Authors: Subrahmanyam VV, Ross D, Eastmond DA, Smith MT				ART
Yr: 1991	Vol: 11	Nbr: 5	Abs:	Pg: 495-515

---

Aneuploidy detection in interphase human lymphocytes using chromosome-specific DNA probes following treatment with benzene metabolite, hydroquinone
Periodical: Toxicologist			Index Medicus:
Authors: Eastmond DA, Hasegawa L				ABS
Yr: 1991	Vol: 11	Nbr: 1	Abs: 949	Pg: 250

---

Use of in situ hybridization with chromosome-specific DNA probes to detect aneuploidy in hydroquinone-treated interphase human lymphocytes
Periodical: Environmental and Molecular Mutagenesis			Index Medicus:
Authors: Eastmond DA, Hasegawa L				ABS
Yr: 1991	Vol: 17	Nbr: Suppl 19	Abs: A71	Pg:

---

Use of a DNA probe and anti-kinetochore modified micronucleus assay to detect aneuploidy in the lymphocytes of tobacco smoking individuals
Periodical: Environmental Molecular Mutagenesis			Index Medicus:
Authors: Eastmond DA, Rupa DS, Hasegawa L, Thompson CL				ABS
Yr: 1992	Vol: 19	Nbr: Suppl 20	Abs:	Pg: 16

---

Induction of micronuclei and aneuploidy by the quinone-forming agents benzene and o-phenylphenol
Periodical:			Index Medicus:
Authors: Eastmond DA				ART
Yr: 1993	Vol: 67	Nbr: 1-3	Abs:	Pg: 105-118

---

Multicolor fluorescence in situ hybridization to detect aneuploidy and chromosomal breakage in interphase cells and micronuclei
Periodical:			Index Medicus:
Authors: Eastmond DA, Rupa DS, Chen H, Hasegawa L				ABS
Yr: 1992	Vol:	Nbr:	Abs:	Pg: 52

---

Multicolor fluorescence in situ hybridization to detect aneuploidy and chromosomal breakage in interphase cells and micronuclei
Periodical:			Index Medicus:
Authors: Eastmond DA, Rupa DS, Chen H, Hasegawa L				ABS
Yr: 1993	Vol:	Nbr:	Abs: 341	Pg: 64

---

Use of fluorescence in situ hybridization and an antikinetochore antibody to detect aneuploidy and chromosome breakage in mouse bone marrow and spleen following benzene exposure in vivo
Periodical: Toxicologist			Index Medicus:
Authors: Chen HW, Tomar R, Rupa DS, Eastmond DA				ABS
Yr: 1993	Vol: 13	Nbr:	Abs: 804	Pg: 218

---

The role of oxygen radicals in the formation of micronuclei induced by quinone-forming compounds
Periodical: Toxicologist			Index Medicus:
Authors: Dobo KL, Eastmond DA				ABS
Yr: 1993	Vol: 13	Nbr:	Abs: 806	Pg: 219

---

Detection of hyperdiploidy and chromosome breakage in interphase human lymphocytes following exposure to the benzene metabolite hydroquinone using multicolor fluorescence in istu hybridization with DNA probes
Periodical:			Index Medicus:
Authors: Eastmond DA, Rupa DS, Hasegawa LS				ART
Yr: 1994	Vol: 322	Nbr: 1	Abs:	Pg: 9-20

---

Chromosomal loss and breakage in mouse bone marrow and spleen cells exposed to benzene in vivo
Periodical: Cancer Research			Index Medicus:
Authors: Chen HW, Rupa DS, Tomar R, Eastmond DA				ART
Yr: 1949	Vol: 54	Nbr: 13	Abs:	Pg: 3533-3539

---

The role of oxygen radicals in the chromosomal loss and breakage induced by the quinone-forming compounds in hydroquinone and tert-butylhydroquinone
Periodical: Environmental and Molecular Mutagenesis			Index Medicus:
Authors: Dobo KE, Eastmond DA				ART
Yr: 1994	Vol:	Nbr:	Abs:	Pg:

---

Detection of hydroquinone-induced nonrandom breakage in the centromeric heterochromatin of mouse bone marrow cells using multicolor fluorescence in situ hybridization with the mouse major and minor satellite probes
Periodical:			Index Medicus:
Authors: Chen HW, Tomar R, Eastmond DA				ART
Yr: 1994	Vol:	Nbr:	Abs:	Pg:

---

Synergistic increases in chromosomal breakage within the euchromatin induced by an interaction of the benzene metabolites phenol and hydroquinone in mice
Periodical: Toxicologist			Index Medicus:
Authors: Chen HW, Eastmond DA				ABS
Yr: 1994	Vol: 14	Nbr:	Abs: 1274	Pg: 328

---

Chromosomal loss and the involvement of chromosomes X, Y, and 7 in spontaneous micronuclei (MN) formed in binucleated lymphocytes of non-smoking females and males
Periodical: Environmental Molecular Mutagenesis			Index Medicus:
Authors: Rupa DS, Hasegawa L, and Eastmond DA				ABS
Yr: 1994	Vol: 23	Nbr: S23	Abs:	Pg: 58

---

Nonrandom breakage in centromeric heterochromatin of mouse bone marrow cells following the administration of hydroquinone in vivo
Periodical: Environmental Molecular Mutagenesis			Index Medicus:
Authors: Chen HW, Eastmond DA				ABS
Yr: 1994	Vol: 23	Nbr: S23	Abs:	Pg: 9

---

Differential mutation rate reflected in occurrence and extent of loss of heterozygosity in TK-human lymphoblasts
Periodical: Environmental Molecular Mutagenesis			Index Medicus:
Authors: Dobo KL, Eastmond DA, Rumbos HS, Giver CR, Grosovsky AJ				ABS
Yr: 1994	Vol: 23	Nbr: S23	Abs:	Pg: 13

---

Detection of chromosomal aberrations in interphase cells following exposure to genotoxic agents in vitro and in vivo using fluorescence in situ hybridization with DNA probes
Periodical:			Index Medicus:
Authors: Eastmond DA, Rupa DS, Hasegawa L				ABS
Yr: 1994	Vol:	Nbr:	Abs: 181	Pg: 40

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