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Cigarette Smoke, Nicotine & Acid-induced Duodenal Injury

Institution: University of California, Los Angeles
Investigator(s): Felix Leung, M.D.
Award Cycle: 1992 (Cycle 1) Grant #: 1RT-0080 Award: $311,797
Subject Area: General Biomedical Science
Award Type: Research Project Awards
Abstracts
Publications

Endoscopic assessment of mucosal hemodynamic changes in a canine model of gastric ulcer
Periodical: Gastrointestinal Endoscopy Index Medicus:
Authors: Chung SCS, Sung JY, Suen M, Leung JW, Leung FW ART
Yr: 1991 Vol: 37 Nbr: 3 Abs: Pg: 310-314

Role of blood flow and alkaline secretion in acid-induced deep duodenal villous injury in the rat
Periodical: Index Medicus:
Authors: Leung FW ART
Yr: 1991 Vol: 260 Nbr: 3 Pt 1 Abs: Pg: G399-G404

Mucosal vascular stasis precedes loss of viablity of endothelial cells in rat acetic acid colitis
Periodical: Digestive Diseases and Sciences Index Medicus:
Authors: Leung FW, Koo A ART
Yr: 1991 Vol: 36 Nbr: 6 Abs: Pg: 727-732

Reproducible demonstration of blood flow at duodenal ulcer margins by endoscopic reflectance spectrophotometry
Periodical: Gastrointestinal Endoscopy Index Medicus:
Authors: Wong NW, Bondoc EM, Banez VP, et al. ART
Yr: 1991 Vol: 37 Nbr: 4 Abs: Pg: 455-459

Modulation of autoregulatory escape by capsaicin-sensitive afferent nerves in rat stomach
Periodical: Index Medicus:
Authors: Leung FW ART
Yr: 1992 Vol: 262 Nbr: 2 Pt 2 Abs: Pg: H562-H567

Role of capsaicin-sensitive afferent nerves in mucosal injury and injury-induced hyperemia in rat colon
Periodical: Index Medicus:
Authors: Leung FW ART
Yr: 1992 Vol: 262 Nbr: 2 Pt 1 Abs: Pg: G332-G337

Intragastric nicotine protects against 40% ethanol-induced gastric mucosal injury despite pretreatment with propranolol or N-ethylmaleimide in rats
Periodical: Digestive Diseases and Sciences Index Medicus:
Authors: Endoh K, Ro G, Leung FW ART
Yr: 1992 Vol: 37 Nbr: 3 Abs: Pg: 391-396

Mechanism of intragastric nicotine protection against ethanol-induced gastric injury
Periodical: Digestive Diseases and Sciences Index Medicus:
Authors: Endoh K, Baker M, Leung FW ART
Yr: 1991 Vol: 36 Nbr: 1 Abs: Pg: 39-46

Specific alpha-2-antagonist reduces intragastric nicotine-mediated protection against 40% ethanol-induced gastric mucosal injury in rats
Periodical: Clinical Research Index Medicus:
Authors: Endoh K, Baker M, Leung FW ABS
Yr: 1991 Vol: 39 Nbr: 1 Abs: Pg: 94A

Nicotine in a dose that blocks injury-induced hyperemia, aggravates hypertonic saline-induced gastric mucosal damage in rats
Periodical: Clinical Research Index Medicus:
Authors: Endoh K, Baker M, Leung FW ABS
Yr: 1991 Vol: 39 Nbr: 1 Abs: Pg: 94A

Intragastric (i.g.) nicotine protects the corpus but not the antral mucosa against 40% ethanol-induced injury in rats: Result of regional differences in nicotine concentration
Periodical: Clinical Research Index Medicus:
Authors: Leung FW, Scremin OU, Endoh K ABS
Yr: 1991 Vol: 39 Nbr: 1 Abs: Pg: 5A

Nicotine in a dose that blocks injury-induced hyperemia, aggravates hypertonic saline-induced gastric mucosal damage in rats
Periodical: Gastroenterology Index Medicus:
Authors: Endoh K, Leung FW ABS
Yr: 1991 Vol: 100 Nbr: 5 Pt 2 Abs: Pg: A59

alpha2-adrenoceptor mediates intragastric nicotine protection against ethanol-injury by a mucus-dependent mechanism in rats
Periodical: Index Medicus:
Authors: Endoh K, Leung FW ABS
Yr: 1991 Vol: 100 Nbr: 5 Pt 2 Abs: Pg: A59

Role of ganglionic stimulation and blockade in the mechanism of instragastric nicotine protection against ethanol-induced gastric mucosal injury in rats
Periodical: Gastroenterology Index Medicus:
Authors: Endoh K, Leung FW ABS
Yr: 1991 Vol: 100 Nbr: 5 Pt 2 Abs: Pg: A60

Intragastric (i.g.) nicotine protects the corpus but not the antral mucosa against 40% enthanol-induced injury in rats: result of regional differences in nicotine concentration
Periodical: Gastroenterology Index Medicus:
Authors: Leung FW, Scremin OU, Endoh K ABS
Yr: 1991 Vol: 100 Nbr: 5 Pt 2 Abs: Pg: A109

Mechanism of aggravation of mucosal injury by intravenous nicotine in rat stomach
Periodical: American Journal of Physiology Index Medicus:
Authors: Endoh K, Kauffman GL Jr, Leung FW ART
Yr: 1991 Vol: 261 Nbr: 6 Pt 1 Abs: Pg: G1037-G1042

Involvement of alpha2-adrenoceptors in the mechanism of intragastric nicotine protection against ethanol injury in rat stomach
Periodical: Digestive Diseases and Sciences Index Medicus:
Authors: Endoh K, Kao J, Baker M, Leung FW ABS
Yr: 1992 Vol: Nbr: Abs: Pg:

Mechanism of intragastric tetramethylammonium protection against 40% ethanol-induced gastric injury in rat stomach
Periodical: Digestive Diseases and Sciences Index Medicus:
Authors: Endoh K, Kao J, Baker M, Scremin OU, Leung FW ART
Yr: 1992 Vol: Nbr: Abs: Pg:

Superior is more important than inferior mesentric artery in maintaining mucosal perfusion and integrity in rat colon
Periodical: Digestive Diseases and Sciences Index Medicus:
Authors: Leung FW, Su KC, Pique JM, Thiefin G, Passaro E Jr, Guth PH ART
Yr: 0 Vol: Nbr: Abs: Pg:

Mechanism of protection by intragastric tetramethylammonium (TMA) against 40% ethanol (EtOH) injury in rat stomach
Periodical: Clinical Research Index Medicus:
Authors: Endoh K, Kao J, Baker M, Scremin OU, Leung FW ABS
Yr: 1992 Vol: 40 Nbr: 1 Abs: Pg: 97A

Intestinal hyperemia induced by intraduodenal hydrochloric acid in rats is partially mediated by capsaicin-sensitive afferent nerves
Periodical: Clinical Research Index Medicus:
Authors: Leung FW ABS
Yr: 1992 Vol: 40 Nbr: Abs: Pg: 97A

Intravenous (IV) nicotine potentiates the damaging effect of a non-injurious dose of intraduodenal (ID) HCl in rats
Periodical: Clinical Research Index Medicus:
Authors: Leung FW, Ro G, Baker M ABS
Yr: 1992 Vol: 40 Nbr: Abs: Pg: 126A

Intravenous (IV) nicotine impairs intestinal hyperemia induced by intraduodenal (ID) hydrochloric acid in rats
Periodical: Clinical Research Index Medicus:
Authors: Leung FW ABS
Yr: 1992 Vol: 40 Nbr: Abs: Pg: 122A

Mechanism of protection by intragastric tetramethylammonium (TMA) against 40% ethanol injury in rat stomach
Periodical: Gastroenterology Index Medicus:
Authors: Endoh K, Kao J, Baker M, Scremin OU, Leung FW ABS
Yr: 1992 Vol: Nbr: Abs: Pg:

Superior mesenteric artery is more important that inferior mesenteric artery in maintaining colonic mucosal perfusion and integrity in rats
Periodical: Digestive Diseases and Sciences Index Medicus:
Authors: Leung FW, Su KC, Pique JM, Thiefin G, Passaro E Jr, Guth PH ART
Yr: 1992 Vol: 37 Nbr: 9 Abs: Pg: 1329-1335

Regional differences in gut blood flow and mucosal damage in response to ischemia and reperfusion
Periodical: American Journal of Physiology Index Medicus:
Authors: Leung FW, Su KC, Passaro E Jr, Guth PH ART
Yr: 1992 Vol: 263 Nbr: 3 Pt 1 Abs: Pg: G301-G305

Mechanism of gastric hyperemia induced by intragastric hypertonic saline in rats
Periodical: Gastroenterology Index Medicus:
Authors: Endoh K, Kao J, Domek MJ, Leung FW ART
Yr: 1993 Vol: 104 Nbr: 1 Abs: Pg: 114-121

Instragastric nicotine protection against 40% ethanol injury in rat stomach - - role of ganglionic stimulation or blockade
Periodical: Digestive Diseases and Sciences Index Medicus:
Authors: Endoh K, Kao J, Baker M, Leung FW ART
Yr: 1192 Vol: 37 Nbr: 12 Abs: Pg: 1840-1846

Inhibition of spinal afferent nerve-mediated gastric hyperemia by nicotine -- role of ganglionic blockade
Periodical: American Journal of Physiology Index Medicus:
Authors: Leung FW ART
Yr: 1993 Vol: Nbr: Abs: Pg:

Involvement of alpha2-adrenoceptors in the mechanism of intragastric nicotine protection against ethanol injury in rat stomach
Periodical: Digestive Diseases and Sciences Index Medicus:
Authors: Endoh K, Kao J, Baker M, Leung FW ART
Yr: 1993 Vol: Nbr: Abs: Pg:

Mechanism of instragastric tetramethylammonium protection against 40% ethanol-induced gastric injury in rats
Periodical: Digestive Diseases and Sciences Index Medicus:
Authors: Endoh K, Kao J, Baker M, Scremin OU, Leung FW ART
Yr: 1993 Vol: Nbr: Abs: Pg:

Regional differences in mucosal hemodynamics in experimental colitis in the rat
Periodical: Digestive Diseases and Sciences Index Medicus:
Authors: Leung FW, Su KC, Yonei Y, Passaro E Jr, Guth PH ART
Yr: 1993 Vol: Nbr: Abs: Pg:

Instragastric nicotine protects against 40% ethanol-induced gastric injury despite pretreatment with NG-nitro-L-arginine methyl ester, guanithidine or adrenal medullectomy in rats
Periodical: Digestive Diseases and Sciences Index Medicus:
Authors: Iwata F, Endoh K, Leung FW ART
Yr: 1993 Vol: Nbr: Abs: Pg:

Intravenous nicotine potentiates the damaging effect of instraduodenal acid by reducing acid-induced hyperemia
Periodical: Gastroenterology Index Medicus:
Authors: Leung FW, Ro G, Baker M ABS
Yr: 1992 Vol: 102 Nbr: Abs: Pg: A220

Capsacian-sensitive afferent nerves mediate hyperemia and protection against injury induced by acid in rat duodenum
Periodical: Gastroenterology Index Medicus:
Authors: Leung FW ABS
Yr: 1992 Vol: 102 Nbr: Abs: Pg: A220

Mechanism and protective role of gastric hyperemia associated with injury induced by intragastric hypertonic saline in rats
Periodical: Gastroenterology Index Medicus:
Authors: Endoh K, Kao J, Leung FW ABS
Yr: 1992 Vol: 102 Nbr: Abs: Pg: A64

Mechanism of protection by intraperitoneal hexamethonium or mecamylamine against 40% ethanol injury in rat stomach
Periodical: Gastroenterology Index Medicus:
Authors: Endoh K, Kao J, Leung FW ABS
Yr: 1992 Vol: 102 Nbr: Abs: Pg: A64

16, 16 dimethylprostaglandin E2 (dmPGE2) protects against acid-induced deep duodenal villous damage despite simulataneous infusion of an ucler promoting dose of nicotine in rats
Periodical: Clinical Research Index Medicus:
Authors: Zhang XY, Kao J, Domek MJ, Leung FW ABS
Yr: 1993 Vol: 41 Nbr: Abs: Pg: 86A

Effect of tobacco (nicotine) smoke on gastric hyperemia induced by 2 M NaCl in rats
Periodical: Clinical Research Index Medicus:
Authors: Iwata F, Leung FW ABS
Yr: 1993 Vol: 41 Nbr: Abs: Pg: 16A

Nicotine inhibits gastric reactive hyperemia in rats
Periodical: Clinical Research Index Medicus:
Authors: Zhang XY, Kwok G, Endoh K, Leung FW ABS
Yr: 1993 Vol: 41 Nbr: Abs: Pg: 15A

Tobacco (nicotine) smoke blocks injury-induced gastric hyperemia and aggravates mucosal damage in rat stomach
Periodical: Gastroenterology Index Medicus:
Authors: Iwata F, Leung FW ABS
Yr: 1993 Vol: 104 Nbr: Abs: A110 Pg:

Aging impairs afferent nerve function in rat gut
Periodical: Gastroenterology Index Medicus:
Authors: Leung FW ABS
Yr: 1993 Vol: 104 Nbr: Abs: A631 Pg:

16, 16 dimethylprostaglandin E2 (dmPGE2) protects against acid-induced deep villous damage in rat duodenum despite simultaneous infusion of an ulcer promoting dose of dicotine
Periodical: Gastroenterology Index Medicus:
Authors: Zhang XY, Kao J, Domek MJ, Iwata F, Leung FW ABS
Yr: 1993 Vol: 104 Nbr: Abs: A230 Pg:

Capsaicin-sensitive nerves mediate hyperemia & protection against deep villous injury induced by acid in rat duodenum
Periodical: Gastroenterology Index Medicus:
Authors: Leung FW ABS
Yr: 1993 Vol: 104 Nbr: Abs: A132 Pg:

Intravenous nicotine modulates afferent nerve function by inhibiting reactive hyperemia in rat stomach
Periodical: Gastroenterology Index Medicus:
Authors: Zhang XY, Kwok G, Endoh K, Leung FW ABS
Yr: 1993 Vol: 104 Nbr: Abs: A230 Pg:

Reduction in acid-induced intestinal hyperemia aggravates superficial villous damage in rat duodenum
Periodical: Gastroenterology Index Medicus:
Authors: Zhang XY, Baker M, Iwata F, Leung FW ABS
Yr: 1993 Vol: 104 Nbr: Abs: A230 Pg:

Tobacco (nicotine) smoke and intravenous nicotine aggravate gastric mucosal damage induced induced by intragastric acidified aspirin in rats
Periodical: Gastroenterology Index Medicus:
Authors: Iwata F, Zhang XY, Leung FW ABS
Yr: 1993 Vol: 104 Nbr: Abs: A110 Pg:

Cigarette smoking aggravates acid-induced duodenal mucosal damage in rat - role of mesenteric vasoconstriction
Periodical: Gastroenterology Digest Index Medicus:
Authors: Zhang XY, Leung FW ART
Yr: 1994 Vol: Nbr: Abs: Pg:

beta-adrenergic mechanism mediates acute intragastric (ig) nicotine protection against ethanol-induced injury in rats
Periodical: Clinical Research Index Medicus:
Authors: Endoh K, Baker M, Leung FW ABS
Yr: 1990 Vol: 38 Nbr: Abs: 101A Pg:

Capsaicin-sensitive afferent sensory fibers mediate capsicin-induced and injury-induced colonic hyperemia
Periodical: Clinical Research Index Medicus:
Authors: Leung FW ABS
Yr: 1990 Vol: 38 Nbr: Abs: 104A Pg:

Reproducible demonstration of hemodynamic status of duodenal ulcer margins
Periodical: Gastrointestinal Endoscopy Index Medicus:
Authors: Wong NW, Leung JWC, Leung FW ABS
Yr: 1990 Vol: 36 Nbr: Abs: Pg: 218-219

High dose intravenous nicotine impairs injury-induced gastric hyerpermia
Periodical: Gastroenterology Index Medicus:
Authors: Endoh K, Leung FW ABS
Yr: 1990 Vol: 98 Nbr: Abs: A41 Pg:

Regional differences in capsaisin protection of acetic acid-induced colonic injury
Periodical: Gastroenterology Index Medicus:
Authors: Endoh K, Leung FW ABS
Yr: 1990 Vol: 98 Nbr: Abs: A446 Pg:

Mechanism of nicotine protection of ethanol-induced gastric injury
Periodical: Gastroenterology Index Medicus:
Authors: Endoh K, Leung FW ABS
Yr: 1990 Vol: 98 Nbr: Abs: A41 Pg:

Capsaicin-sensitive afferent sensory fibers mediate capsaicin-induced and injury-induced colonic hyperemia
Periodical: Gastroenterology Index Medicus:
Authors: Leung FW ABS
Yr: 1990 Vol: 98 Nbr: Abs: A187 Pg:

Capsaicin-sensitive afferent sensory fibers mediate autoregulatory escape from adrenergic (epinephrin) vasoconstriction in the rat stomach
Periodical: Gastroenterology Index Medicus:
Authors: Leung FW ABS
Yr: 1990 Vol: 98 Nbr: Abs: A187 Pg:

Nicotine in a dose that blocks injury-induced hyeremia aggravates hypertonic saline-induced gastric mucosal damage in rats
Periodical: Clinical Research Index Medicus:
Authors: Endoh K, Baker M, Leung FW ABS
Yr: 1991 Vol: 39 Nbr: Abs: 94A Pg:

Ten % dextrose (D10) induced gastric mucosal hyperemia in an in vivo everted rat stomach model - demonstration of endoscopic reflectance spectrophotometry
Periodical: Gastrointestinal Endoscopy Index Medicus:
Authors: Phan QQ, Leung FW ABS
Yr: 1991 Vol: 37 Nbr: Abs: Pg: 268

Reduction in index of oxygen saturation at the margin of active duodenal ulcers predicts slow healing
Periodical: Gastrointestinal Endoscopy Index Medicus:
Authors: Wong NW, Hsu R, Leung JWC, Leung FW ABS
Yr: 1991 Vol: 37 Nbr: Abs: Pg: 268-269

Effect of 10% acetic acid (AA) on colonic mucosal hemodynamics by reflectance spectrophotometry (RS) in rats
Periodical: Gastroenterology Index Medicus:
Authors: Leung FW ABS
Yr: 1991 Vol: 100 Nbr: Abs: A225 Pg:

Intraduodenal HCl-induced intestinal vascular changes
Periodical: Gastroenterology Index Medicus:
Authors: Leung FW ABS
Yr: 1991 Vol: 100 Nbr: Abs: A225 Pg:

Octreotide and vasopressin effects on canince gastric mucosal blood flow: comparison by endoscopic reflectance spectrophotometry
Periodical: Gastrointestinal Endoscopy Index Medicus:
Authors: Tarnasky PR, Kovacs TOG, Hirabayashi K, Leung FW, Jensen D ABS
Yr: 1992 Vol: 38 Nbr: Abs: Pg: 280

Changes in biliary mucosal blood flow in rat: effect of thermocoagulation
Periodical: American Journal of Gastroenterology Index Medicus:
Authors: Lee JG, Leung Fw, Leung JW ABS
Yr: 1993 Vol: 88 Nbr: Abs: Pg: 1535

Mechanism of aggravation of acetic acid-induced gastric ulcer in rats by nicotine cigarette smoke
Periodical: Clinical Research Index Medicus:
Authors: Iwata F, Leung FW ABS
Yr: 1994 Vol: 42 Nbr: Abs: 76A Pg:

Mechanism of aggravation of acetic acid-induced gastric ulcer in rats by nicotine cigarette smoke: inhibition of ulcer margin hyperemia
Periodical: Gastroenterology Index Medicus:
Authors: Iwata F, Leung FW ABS
Yr: 1994 Vol: 106 Nbr: Abs: A99 Pg:

Mesenteric hyperemia after intraduodenal acidification is modulated by endogenous nitric acid oxide but not histamine1- or adnosine-receptors
Periodical: Gastroenterology Index Medicus:
Authors: Leung FW, Kao J, Shang XY, Iwata F, Baker M ABS
Yr: 1994 Vol: 106 Nbr: Abs: A247 Pg: