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Determinants of Maximum Oxygen Transport.

Institution:	University of California, San Diego
Investigator(s):	Peter Wagner, M.D.
Award Cycle:	1992 (Cycle 1)	Grant #: 1RT-0227	Award: $282,699
Subject Area:	Pulmonary Disease
Award Type:	Research Project Awards

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Effect of Hb concentration on maximal O2 uptake in canine gastrocnemius muscle in situ
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Hogan MC, Bebout DE, Wagner PD				ART
Yr: 1991	Vol:	Nbr:	Abs:	Pg:

---

Contribution of exercising limbs to the slow component of oxygen uptake kinetics in man
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Poole DC, Schaffartzik W, Knight DR, et al.				ART
Yr: 1991	Vol:	Nbr:	Abs:	Pg:

---

Leg V02 during supramaximal cycling
Periodical: FASEB Journal			Index Medicus:
Authors: Knight DR, Poole DC, Schaffartzik W, et al.				ABS
Yr: 1991	Vol: 5	Nbr: 4	Abs: A661	Pg: 1691

---

Effect of hemoglobin concentraion on maximal O2 uptake in canine gastrocnemius muscle in situ
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Hogan MC, Bebout DE, Wagner PD				ART
Yr: 1991	Vol: 70	Nbr: 3	Abs:	Pg: 1105-1112

---

Contribution of exercising legs to the slow component of oxygen uptake kinetics in man
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Poole DC, Schaffartzik W, Knight DR, et al				ART
Yr: 1991	Vol: 71	Nbr: 4	Abs:	Pg: 1245-1253

---

Effect of increased Hb-O2 affinity in VO2max at constant O2 delivery in dog muscle in situ
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Hogan MC, Bebout DE, Wagner PD				ART
Yr: 1991	Vol: 70	Nbr: 6	Abs:	Pg: 2656-2662

---

Gas exchange and peripheral diffusion limitation
Periodical: Medicine and Science in Sports and Exercise			Index Medicus:
Authors: Wagner PD				ART
Yr: 1992	Vol: 24	Nbr: 1	Abs:	Pg: 54-58

---

Pulmonary and leg VO2 during submaximal exercise: implications for muscular efficiency
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Poole DC, Gaesser GA, Hogan MC, Knight DR, Wagner PD				ART
Yr: 1992	Vol: 72	Nbr: 2	Abs:	Pg: 805-810

---

The role of O2 in regulating tissue respiration in dog muscle working in situ
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Hogan MC, Arthur PG, Bebout DE, Hochachka PW, Wagner PD				ART
Yr: 1992	Vol:	Nbr:	Abs:	Pg:

---

Modeling the effects of hypoxia on ATP turnover in exercising muscle
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Arthur PG, Hogan MC, Bebout DE, Wagner PD, Hochachka PW				ART
Yr: 1992	Vol:	Nbr:	Abs:	Pg:

---

Central and peripheral aspects of oxygen transport and adaptations with exercise
Periodical: Sports Medicine			Index Medicus:
Authors: Wagner PD				ART
Yr: 1991	Vol: 11	Nbr: 3	Abs:	Pg: 133-142

---

Effects of exercise training and immobilization on muscle lactate and H+ concentrations, lactate efflux and maximal tension in canine gastrocnemius in situ
Periodical:			Index Medicus:
Authors: Bebout DE, Hogan MC, FACSM, Wagner PD				ABS
Yr: 1991	Vol: 12	Nbr:	Abs:	Pg: 339

---

Slow component of oxygen uptake kinetics is lactated principally in exercising limbs
Periodical:			Index Medicus:
Authors: Poole DC, Schaffartzik W, Knight DR, et al				ABS
Yr: 1991	Vol: 23	Nbr:	Abs: S132	Pg:

---

Effect of blood flow reduction on maximal O2 uptake in canine gastrocnemius muscle in situ
Periodical: FASEB Journal			Index Medicus:
Authors: Hogan MC, Bebout DE, Wagner PD				ABS
Yr: 1992	Vol: 6	Nbr: 4	Abs: A960	Pg:

---

Hyperoxia improves leg VO2max
Periodical: FASEB Journal			Index Medicus:
Authors: Knight DR, Schaffartik W, Poole DC, Hogan MC, Bebout DE, Wagner PD				ABS
Yr: 1992	Vol: 6	Nbr: 4	Abs: A1466	Pg:

---

Mechanisms which control VO2max
Periodical:			Index Medicus:
Authors: Barclay JK, Brechue WF, Cain SM, et al				ABS
Yr: 1992	Vol: 24	Nbr: 5	Abs: S40	Pg: 238

---

Agreement between pulmonary and leg VO2-power relationships during submaximal exercise
Periodical:			Index Medicus:
Authors: Poole DC, Gaesser GA, Knight DR, Wagner PD				ABS
Yr: 1992	Vol: 24	Nbr: 5	Abs: S69	Pg: 412

---

Maximal oxygen consumption
Periodical:			Index Medicus:
Authors: Wagner PD				ART
Yr: 1992	Vol: 10	Nbr: 1-2	Abs:	Pg: 15-19

---

Role of O2 in regulating tissue respiration in dog muscle working in situ
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Hogan MC, Arthur PG, Bebout DE, Hochachka PW, Wagner PD				ART
Yr: 1992	Vol: 73	Nbr: 2	Abs:	Pg: 728-736

---

Effects of training on muscle O2 transport at VO2max
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Roca J, Agusti A GN, Alonso A, et al				ART
Yr: 1992	Vol: 73	Nbr: 3	Abs:	Pg: 1067-1076

---

Relationship between body and leg VO2 during maximal cycle ergometry
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Knight DR, Poole DC, Schaffartzik W, et al				ART
Yr: 1992	Vol: 3	Nbr: 3	Abs:	Pg: 1114-1121

---

Modeling the effects of hypoxia on ATP turnover in exercising muscle
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Arthur PG, Hogan MC, Bebout DE, Wagner PD, Hochachka PW				ART
Yr: 1992	Vol: 73	Nbr: 2	Abs:	Pg: 737-742

---

Effects of training and immobilization on VO2 and DO2 in dog gastrocnemius muscle in situ
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Bebout DE, Hogan MC, Hempleman SC, Wagner PD				ART
Yr: 1993	Vol: 74	Nbr: 4	Abs:	Pg: 1697-1703

---

Effect of blood flow reduction on maximal O2 uptake in canine gastrocnemius muscle in situ
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Hogan MC, Bebout DE, Wagner PD				ART
Yr: 1993	Vol: 74	Nbr: 4	Abs:	Pg: 1742-1747

---

Muscle O2 transport and O2 dependent control of metabolism
Periodical: Medicine and Science in Sports and Exercise			Index Medicus:
Authors: Wagner PD				ART
Yr: 1993	Vol:	Nbr:	Abs:	Pg:

---

Effect of reduced hemoglobin concentration on maximal leg oxygen uptake during maximal exercise in humans
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Schaffartzik W, Barton ED, Poole DC, et al				ART
Yr: 1993	Vol: 75	Nbr: 2	Abs:	Pg: 491-498

---

Algebraic analysis of the determinants of VO2max
Periodical: Respiration Physiology			Index Medicus:
Authors: Wagner PD				ART
Yr: 1993	Vol: 93	Nbr: 2	Abs:	Pg: 221-237

---

Determinants of maximum oxygen uptake in rats acclimated to simulated altitude
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Gonzalez NC, Clancy RL, Wagner PD				ART
Yr: 1993	Vol: 75	Nbr: 4	Abs:	Pg: 1608-1614

---

Effect of FIO2 on acid release from the exercising leg at VO2max
Periodical: Physiologist			Index Medicus:
Authors: Knight DR, Poole DC, Hogan MC, Bebout DE, Wagner PD				ABS
Yr: 1992	Vol: 35	Nbr: 4	Abs:	Pg: 211

---

Close regulation of perfusion to metabolism between forelegs and hindlegs in the exercising horse
Periodical: Physiologist			Index Medicus:
Authors: Wagner PD, Nyman G, Biork M, et al				ABS
Yr: 1992	Vol: 35	Nbr: 4	Abs:	Pg: 226

---

Interaction between convective and diffusive oxygen transport
Periodical: Proceedings of the International Conference on Prevention and Early Diagnosis of Lung Cancer			Index Medicus:
Authors: Wagner PD				ABS
Yr: 1992	Vol:	Nbr:	Abs:	Pg: 110-111

---

Pulmonary gas exchange during normoxic helium-oxygen breathing in the horse
Periodical: FASEB Journal			Index Medicus:
Authors: Erickson K, Seaman J, Kubo K, et al				ABS
Yr: 1993	Vol: 7	Nbr: 3 Pt 1	Abs: 121	Pg: A22

---

Arterial PO2 during hypoxic helium-oxygen (He) breathing in the exercising horse
Periodical: FASEB Journal			Index Medicus:
Authors: Wagner PD, Seaman J, Kubo K, et al				ABS
Yr: 1993	Vol: 7	Nbr: 3 Pt 1	Abs: 121	Pg: A22

---

Ventilation-perfusion (VA/Q) mismatching during exercise in the thoroughbred (TB) horse
Periodical: FASEB Journal			Index Medicus:
Authors: Seaman J, Erickson K, Kubo K, et al				ABS
Yr: 1993	Vol: 7	Nbr: 3 Pt 1	Abs: 122	Pg: A22

---

Increased plasma O2 solubility improves O2 uptake in canine gastrocnemius muscle in situ
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Hogan MC, Willford DC, Keipert PE, Faithfull NS, Wagner PD				ART
Yr: 1992	Vol: 73	Nbr: 6	Abs:	Pg: 2470-2475

---

Effect of Hb concentration on maximal O2 uptake in canine gastrocnemius muscle in situ
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Hogan MC, Bebout DE, Wagner PD				ART
Yr: 1991	Vol:	Nbr:	Abs:	Pg:

---

Contribution of exercising limbs to the slow component of oxygen uptake kinetics in man
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Poole DC, Schaffartzik W, Knight DR, et al.				ART
Yr: 1991	Vol:	Nbr:	Abs:	Pg:

---

Leg V02 during supramaximal cycling
Periodical: FASEB Journal			Index Medicus:
Authors: Knight DR, Poole DC, Schaffartzik W, et al.				ABS
Yr: 1991	Vol: 5	Nbr: 4	Abs: A661	Pg: 1691

---

Effect of hemoglobin concentraion on maximal O2 uptake in canine gastrocnemius muscle in situ
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Hogan MC, Bebout DE, Wagner PD				ART
Yr: 1991	Vol: 70	Nbr: 3	Abs:	Pg: 1105-1112

---

Contribution of exercising legs to the slow component of oxygen uptake kinetics in man
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Poole DC, Schaffartzik W, Knight DR, et al				ART
Yr: 1991	Vol: 71	Nbr: 4	Abs:	Pg: 1245-1253

---

Effect of increased Hb-O2 affinity in VO2max at constant O2 delivery in dog muscle in situ
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Hogan MC, Bebout DE, Wagner PD				ART
Yr: 1991	Vol: 70	Nbr: 6	Abs:	Pg: 2656-2662

---

Gas exchange and peripheral diffusion limitation
Periodical: Medicine and Science in Sports and Exercise			Index Medicus:
Authors: Wagner PD				ART
Yr: 1992	Vol: 24	Nbr: 1	Abs:	Pg: 54-58

---

Pulmonary and leg VO2 during submaximal exercise: implications for muscular efficiency
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Poole DC, Gaesser GA, Hogan MC, Knight DR, Wagner PD				ART
Yr: 1992	Vol: 72	Nbr: 2	Abs:	Pg: 805-810

---

The role of O2 in regulating tissue respiration in dog muscle working in situ
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Hogan MC, Arthur PG, Bebout DE, Hochachka PW, Wagner PD				ART
Yr: 1992	Vol:	Nbr:	Abs:	Pg:

---

Modeling the effects of hypoxia on ATP turnover in exercising muscle
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Arthur PG, Hogan MC, Bebout DE, Wagner PD, Hochachka PW				ART
Yr: 1992	Vol:	Nbr:	Abs:	Pg:

---

Central and peripheral aspects of oxygen transport and adaptations with exercise
Periodical: Sports Medicine			Index Medicus:
Authors: Wagner PD				ART
Yr: 1991	Vol: 11	Nbr: 3	Abs:	Pg: 133-142

---

Effects of exercise training and immobilization on muscle lactate and H+ concentrations, lactate efflux and maximal tension in canine gastrocnemius in situ
Periodical:			Index Medicus:
Authors: Bebout DE, Hogan MC, FACSM, Wagner PD				ABS
Yr: 1991	Vol: 12	Nbr:	Abs:	Pg: 339

---

Slow component of oxygen uptake kinetics is lactated principally in exercising limbs
Periodical:			Index Medicus:
Authors: Poole DC, Schaffartzik W, Knight DR, et al				ABS
Yr: 1991	Vol: 23	Nbr:	Abs: S132	Pg:

---

Effect of blood flow reduction on maximal O2 uptake in canine gastrocnemius muscle in situ
Periodical: FASEB Journal			Index Medicus:
Authors: Hogan MC, Bebout DE, Wagner PD				ABS
Yr: 1992	Vol: 6	Nbr: 4	Abs: A960	Pg:

---

Hyperoxia improves leg VO2max
Periodical: FASEB Journal			Index Medicus:
Authors: Knight DR, Schaffartik W, Poole DC, Hogan MC, Bebout DE, Wagner PD				ABS
Yr: 1992	Vol: 6	Nbr: 4	Abs: A1466	Pg:

---

Mechanisms which control VO2max
Periodical:			Index Medicus:
Authors: Barclay JK, Brechue WF, Cain SM, et al				ABS
Yr: 1992	Vol: 24	Nbr: 5	Abs: S40	Pg: 238

---

Agreement between pulmonary and leg VO2-power relationships during submaximal exercise
Periodical:			Index Medicus:
Authors: Poole DC, Gaesser GA, Knight DR, Wagner PD				ABS
Yr: 1992	Vol: 24	Nbr: 5	Abs: S69	Pg: 412

---

Maximal oxygen consumption
Periodical:			Index Medicus:
Authors: Wagner PD				ART
Yr: 1992	Vol: 10	Nbr: 1-2	Abs:	Pg: 15-19

---

Role of O2 in regulating tissue respiration in dog muscle working in situ
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Hogan MC, Arthur PG, Bebout DE, Hochachka PW, Wagner PD				ART
Yr: 1992	Vol: 73	Nbr: 2	Abs:	Pg: 728-736

---

Effects of training on muscle O2 transport at VO2max
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Roca J, Agusti A GN, Alonso A, et al				ART
Yr: 1992	Vol: 73	Nbr: 3	Abs:	Pg: 1067-1076

---

Relationship between body and leg VO2 during maximal cycle ergometry
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Knight DR, Poole DC, Schaffartzik W, et al				ART
Yr: 1992	Vol: 3	Nbr: 3	Abs:	Pg: 1114-1121

---

Modeling the effects of hypoxia on ATP turnover in exercising muscle
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Arthur PG, Hogan MC, Bebout DE, Wagner PD, Hochachka PW				ART
Yr: 1992	Vol: 73	Nbr: 2	Abs:	Pg: 737-742

---

Effects of training and immobilization on VO2 and DO2 in dog gastrocnemius muscle in situ
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Bebout DE, Hogan MC, Hempleman SC, Wagner PD				ART
Yr: 1993	Vol: 74	Nbr: 4	Abs:	Pg: 1697-1703

---

Effect of blood flow reduction on maximal O2 uptake in canine gastrocnemius muscle in situ
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Hogan MC, Bebout DE, Wagner PD				ART
Yr: 1993	Vol: 74	Nbr: 4	Abs:	Pg: 1742-1747

---

Muscle O2 transport and O2 dependent control of metabolism
Periodical: Medicine and Science in Sports and Exercise			Index Medicus:
Authors: Wagner PD				ART
Yr: 1993	Vol:	Nbr:	Abs:	Pg:

---

Effect of reduced hemoglobin concentration on maximal leg oxygen uptake during maximal exercise in humans
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Schaffartzik W, Barton ED, Poole DC, et al				ART
Yr: 1993	Vol: 75	Nbr: 2	Abs:	Pg: 491-498

---

Algebraic analysis of the determinants of VO2max
Periodical: Respiration Physiology			Index Medicus:
Authors: Wagner PD				ART
Yr: 1993	Vol: 93	Nbr: 2	Abs:	Pg: 221-237

---

Determinants of maximum oxygen uptake in rats acclimated to simulated altitude
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Gonzalez NC, Clancy RL, Wagner PD				ART
Yr: 1993	Vol: 75	Nbr: 4	Abs:	Pg: 1608-1614

---

Effect of FIO2 on acid release from the exercising leg at VO2max
Periodical: Physiologist			Index Medicus:
Authors: Knight DR, Poole DC, Hogan MC, Bebout DE, Wagner PD				ABS
Yr: 1992	Vol: 35	Nbr: 4	Abs:	Pg: 211

---

Close regulation of perfusion to metabolism between forelegs and hindlegs in the exercising horse
Periodical: Physiologist			Index Medicus:
Authors: Wagner PD, Nyman G, Biork M, et al				ABS
Yr: 1992	Vol: 35	Nbr: 4	Abs:	Pg: 226

---

Interaction between convective and diffusive oxygen transport
Periodical: Proceedings of the International Conference on Prevention and Early Diagnosis of Lung Cancer			Index Medicus:
Authors: Wagner PD				ABS
Yr: 1992	Vol:	Nbr:	Abs:	Pg: 110-111

---

Pulmonary gas exchange during normoxic helium-oxygen breathing in the horse
Periodical: FASEB Journal			Index Medicus:
Authors: Erickson K, Seaman J, Kubo K, et al				ABS
Yr: 1993	Vol: 7	Nbr: 3 Pt 1	Abs: 121	Pg: A22

---

Arterial PO2 during hypoxic helium-oxygen (He) breathing in the exercising horse
Periodical: FASEB Journal			Index Medicus:
Authors: Wagner PD, Seaman J, Kubo K, et al				ABS
Yr: 1993	Vol: 7	Nbr: 3 Pt 1	Abs: 121	Pg: A22

---

Ventilation-perfusion (VA/Q) mismatching during exercise in the thoroughbred (TB) horse
Periodical: FASEB Journal			Index Medicus:
Authors: Seaman J, Erickson K, Kubo K, et al				ABS
Yr: 1993	Vol: 7	Nbr: 3 Pt 1	Abs: 122	Pg: A22

---

Increased plasma O2 solubility improves O2 uptake in canine gastrocnemius muscle in situ
Periodical: Journal of Applied Physiology			Index Medicus:
Authors: Hogan MC, Willford DC, Keipert PE, Faithfull NS, Wagner PD				ART
Yr: 1992	Vol: 73	Nbr: 6	Abs:	Pg: 2470-2475

---