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The Mechanism of Nicotine-Induced Gastric Mucosal Injury

Institution:	University of California, Los Angeles
Investigator(s):	Paul Guth, M.D.
Award Cycle:	1992 (Cycle 1)	Grant #: 1RT-0282	Award: $221,032
Subject Area:	General Biomedical Science
Award Type:	Research Project Awards

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Gastric surface cell intraccellualr pH (pH1) and mucous gel thickness during hydrocholoric acid back diffusion and ethanol (EtOH) exposure
Periodical: Gastroenterology			Index Medicus:
Authors: Kaneko K, Guth PH, Kaunitz JD				ABS
Yr: 1991	Vol: 100	Nbr: 5 Pt 2	Abs:	Pg: A94

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Opposite effects of acute and chronic nicotine on rat gastric mucous gel thickness
Periodical: Gastroenterology			Index Medicus:
Authors: Kaneko K, Guth PH, Kaunitz JD				ABS
Yr: 1991	Vol: 100	Nbr: 5 Pt 2	Abs:	Pg: A93

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Gastric surface cell intracellular pH (pHi) during luminal acidification in vivo
Periodical: Gastroenterology			Index Medicus:
Authors: Kaneko K, Guth PH, Kaunitz JD				ABS
Yr: 1991	Vol: 100	Nbr: 5 Pt 2	Abs:	Pg: A692

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In vivo measurement of rat gastric surgace cell intracellular pH
Periodical: American Journal of Physiology			Index Medicus:
Authors: Kaneko K, Guth PH, Kaunitz JD				ART
Yr: 1991	Vol: 261	Nbr: 3 Pt 1	Abs:	Pg: G548-G552

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Opposite effects of acute and chronic nicotine on rat gastric mucous gel thickness and intracellular pH
Periodical: Gastroenterology			Index Medicus:
Authors: Nishizaki Y, Kaunitz JD, Kaneko K, Guth PH				ABS
Yr: 1992	Vol: 102	Nbr: 4 Pt 2	Abs:	Pg: A136

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Mechanism of isoproterenol protection against ethanol-acid gastric mucosal injury
Periodical: Gastroenterology			Index Medicus:
Authors: Nishizaki Y, Kaunitz JD, Guth Ph				ABS
Yr: 1992	Vol: 102	Nbr: 4 Pt 2	Abs:	Pg: A136

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Mucous gel: an essential component of the gastric mucosal barrier
Periodical: Gastroenterology			Index Medicus:
Authors: Kaunitz JD, Nishizaki Y, Quintero E, Engel E, Guth PH				ABS
Yr: 1992	Vol: 102	Nbr: 4 Pt 2	Abs:	Pg: A95

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Na+/H+ exchange regulates intracellular pH of rat gastric surface cells in vivo
Periodical: Pflugers Archiv. European Journal of Physiology			Index Medicus:
Authors: Kaneko K, Guth PH, Kaunitz JD				ART
Yr: 1992	Vol: 421	Nbr: 4	Abs:	Pg: 322-328

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Uremia increases gastric mucosal permeability and acid back-diffusion injury in the rat
Periodical: Gastroenterology			Index Medicus:
Authors: Quintero E, Kaunitz J, Nishizaki Y, DeGiorgio R, Sternini C, Guth PH				ART
Yr: 1992	Vol: 103	Nbr: 6	Abs:	Pg: 1762-1768

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Effect of orogastric nicotine on rat gastric mucosal gel thickness, surface cell viability and intracellular pH
Periodical: Journal of Pharmacology and Experimental Therapeutics			Index Medicus:
Authors: Kaunitz JD, Nishizaki Y, Kaneko K, Guth PH				ART
Yr: 1993	Vol: 265	Nbr: 2	Abs:	Pg: 948-954

---

Isoproterenol enhances rat gastric mucosal barrier function in vivo
Periodical: Gastroenterology			Index Medicus:
Authors: Nishizaki Y, Guth PH, Kaunitz JD				ART
Yr: 1993	Vol: 105	Nbr: 2	Abs:	Pg: 340-346

---

Gastric surface cell intraccellualr pH (pH1) and mucous gel thickness during hydrocholoric acid back diffusion and ethanol (EtOH) exposure
Periodical: Gastroenterology			Index Medicus:
Authors: Kaneko K, Guth PH, Kaunitz JD				ABS
Yr: 1991	Vol: 100	Nbr: 5 Pt 2	Abs:	Pg: A94

---

Opposite effects of acute and chronic nicotine on rat gastric mucous gel thickness
Periodical: Gastroenterology			Index Medicus:
Authors: Kaneko K, Guth PH, Kaunitz JD				ABS
Yr: 1991	Vol: 100	Nbr: 5 Pt 2	Abs:	Pg: A93

---

Gastric surface cell intracellular pH (pHi) during luminal acidification in vivo
Periodical: Gastroenterology			Index Medicus:
Authors: Kaneko K, Guth PH, Kaunitz JD				ABS
Yr: 1991	Vol: 100	Nbr: 5 Pt 2	Abs:	Pg: A692

---

In vivo measurement of rat gastric surgace cell intracellular pH
Periodical: American Journal of Physiology			Index Medicus:
Authors: Kaneko K, Guth PH, Kaunitz JD				ART
Yr: 1991	Vol: 261	Nbr: 3 Pt 1	Abs:	Pg: G548-G552

---

Opposite effects of acute and chronic nicotine on rat gastric mucous gel thickness and intracellular pH
Periodical: Gastroenterology			Index Medicus:
Authors: Nishizaki Y, Kaunitz JD, Kaneko K, Guth PH				ABS
Yr: 1992	Vol: 102	Nbr: 4 Pt 2	Abs:	Pg: A136

---

Mechanism of isoproterenol protection against ethanol-acid gastric mucosal injury
Periodical: Gastroenterology			Index Medicus:
Authors: Nishizaki Y, Kaunitz JD, Guth Ph				ABS
Yr: 1992	Vol: 102	Nbr: 4 Pt 2	Abs:	Pg: A136

---

Mucous gel: an essential component of the gastric mucosal barrier
Periodical: Gastroenterology			Index Medicus:
Authors: Kaunitz JD, Nishizaki Y, Quintero E, Engel E, Guth PH				ABS
Yr: 1992	Vol: 102	Nbr: 4 Pt 2	Abs:	Pg: A95

---

Na+/H+ exchange regulates intracellular pH of rat gastric surface cells in vivo
Periodical: Pflugers Archiv. European Journal of Physiology			Index Medicus:
Authors: Kaneko K, Guth PH, Kaunitz JD				ART
Yr: 1992	Vol: 421	Nbr: 4	Abs:	Pg: 322-328

---

Uremia increases gastric mucosal permeability and acid back-diffusion injury in the rat
Periodical: Gastroenterology			Index Medicus:
Authors: Quintero E, Kaunitz J, Nishizaki Y, DeGiorgio R, Sternini C, Guth PH				ART
Yr: 1992	Vol: 103	Nbr: 6	Abs:	Pg: 1762-1768

---

Effect of orogastric nicotine on rat gastric mucosal gel thickness, surface cell viability and intracellular pH
Periodical: Journal of Pharmacology and Experimental Therapeutics			Index Medicus:
Authors: Kaunitz JD, Nishizaki Y, Kaneko K, Guth PH				ART
Yr: 1993	Vol: 265	Nbr: 2	Abs:	Pg: 948-954

---

Isoproterenol enhances rat gastric mucosal barrier function in vivo
Periodical: Gastroenterology			Index Medicus:
Authors: Nishizaki Y, Guth PH, Kaunitz JD				ART
Yr: 1993	Vol: 105	Nbr: 2	Abs:	Pg: 340-346

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