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The Mechanism of Nicotine-Induced Gastric Mucosal Injury

Institution: University of California, Los Angeles
Investigator(s): Paul Guth, M.D.
Award Cycle: 1992 (Cycle 1) Grant #: 1RT-0282 Award: $221,032
Subject Area: General Biomedical Science
Award Type: Research Project Awards
Abstracts
Publications

Gastric surface cell intraccellualr pH (pH1) and mucous gel thickness during hydrocholoric acid back diffusion and ethanol (EtOH) exposure
Periodical: Gastroenterology Index Medicus:
Authors: Kaneko K, Guth PH, Kaunitz JD ABS
Yr: 1991 Vol: 100 Nbr: 5 Pt 2 Abs: Pg: A94

Opposite effects of acute and chronic nicotine on rat gastric mucous gel thickness
Periodical: Gastroenterology Index Medicus:
Authors: Kaneko K, Guth PH, Kaunitz JD ABS
Yr: 1991 Vol: 100 Nbr: 5 Pt 2 Abs: Pg: A93

Gastric surface cell intracellular pH (pHi) during luminal acidification in vivo
Periodical: Gastroenterology Index Medicus:
Authors: Kaneko K, Guth PH, Kaunitz JD ABS
Yr: 1991 Vol: 100 Nbr: 5 Pt 2 Abs: Pg: A692

In vivo measurement of rat gastric surgace cell intracellular pH
Periodical: American Journal of Physiology Index Medicus:
Authors: Kaneko K, Guth PH, Kaunitz JD ART
Yr: 1991 Vol: 261 Nbr: 3 Pt 1 Abs: Pg: G548-G552

Opposite effects of acute and chronic nicotine on rat gastric mucous gel thickness and intracellular pH
Periodical: Gastroenterology Index Medicus:
Authors: Nishizaki Y, Kaunitz JD, Kaneko K, Guth PH ABS
Yr: 1992 Vol: 102 Nbr: 4 Pt 2 Abs: Pg: A136

Mechanism of isoproterenol protection against ethanol-acid gastric mucosal injury
Periodical: Gastroenterology Index Medicus:
Authors: Nishizaki Y, Kaunitz JD, Guth Ph ABS
Yr: 1992 Vol: 102 Nbr: 4 Pt 2 Abs: Pg: A136

Mucous gel: an essential component of the gastric mucosal barrier
Periodical: Gastroenterology Index Medicus:
Authors: Kaunitz JD, Nishizaki Y, Quintero E, Engel E, Guth PH ABS
Yr: 1992 Vol: 102 Nbr: 4 Pt 2 Abs: Pg: A95

Na+/H+ exchange regulates intracellular pH of rat gastric surface cells in vivo
Periodical: Pflugers Archiv. European Journal of Physiology Index Medicus:
Authors: Kaneko K, Guth PH, Kaunitz JD ART
Yr: 1992 Vol: 421 Nbr: 4 Abs: Pg: 322-328

Uremia increases gastric mucosal permeability and acid back-diffusion injury in the rat
Periodical: Gastroenterology Index Medicus:
Authors: Quintero E, Kaunitz J, Nishizaki Y, DeGiorgio R, Sternini C, Guth PH ART
Yr: 1992 Vol: 103 Nbr: 6 Abs: Pg: 1762-1768

Effect of orogastric nicotine on rat gastric mucosal gel thickness, surface cell viability and intracellular pH
Periodical: Journal of Pharmacology and Experimental Therapeutics Index Medicus:
Authors: Kaunitz JD, Nishizaki Y, Kaneko K, Guth PH ART
Yr: 1993 Vol: 265 Nbr: 2 Abs: Pg: 948-954

Isoproterenol enhances rat gastric mucosal barrier function in vivo
Periodical: Gastroenterology Index Medicus:
Authors: Nishizaki Y, Guth PH, Kaunitz JD ART
Yr: 1993 Vol: 105 Nbr: 2 Abs: Pg: 340-346