Research Portfolio

Search by: Title Institution Investigator Cycle Award Type Research Priority

Funding Opportunities

Call for Applications

Join our Mailing List

Join our mailing list to be notified of new funding opportunities. Your Email To receive information about funding opportunities, events, and program updates.

Interaction of Complement C4b-Binding Protein with Protein B

Institution:	Scripps Research Institute
Investigator(s):	John Griffin, Ph.D.
Award Cycle:	1992 (Cycle 1)	Grant #: 1RT-0304	Award: $616,016
Subject Area:	General Biomedical Science
Award Type:	Research Project Awards

---

Direct detection of activated protein C in blood from human subjects
Periodical: Blood			Index Medicus:
Authors: Gruber A, Griffin JH				ART
Yr: 1992	Vol: 79	Nbr: 9	Abs:	Pg: 2340-2348

---

Reevaluation of total, free and bound protein S and C4b-binding protein levels in plasma anticoagulated with citrate or hirudin
Periodical: Blood			Index Medicus:
Authors: Griffin JH, Gruber A, Fernandez JA				ART
Yr: 1992	Vol: 79	Nbr: 12	Abs:	Pg: 3203-3211

---

Normalization of markers of coagulation activation with a purified protein C concentrate in adults with homozygous protein C deficiency
Periodical: Blood			Index Medicus:
Authors: Conard J, Bauer KA, Gruber A, et al				ART
Yr: 1993	Vol: 82	Nbr: 4	Abs:	Pg: 1159-1164

---

Antithrombotic effects of thrombin-induced activation of endogenous protein C in primates
Periodical: Journal of Clinical Investigation			Index Medicus:
Authors: Hanson SR, Griffin JH, Kelly AB, Harker LA, Esmon CT, Gruber A				ART
Yr: 1993	Vol: 92	Nbr: 4	Abs:	Pg: 2003-2012

---

Identification of residues 413-433 of plasma protein S as essential for binding to C4b-binding protein
Periodical: Journal of Biological Chemistry			Index Medicus:
Authors: Fernandez JA, Heeb JA, Griffin JH				ART
Yr: 1993	Vol: 268	Nbr: 22	Abs:	Pg: 16788-16794

---

Inhibition of thrombosis by induced in vivo activation of the protein C (PC) pathway
Periodical: Blood			Index Medicus:
Authors: Gruber A, Harker LA, Griffin JH, Hanson SR				ABS
Yr: 1991	Vol: 78	Nbr:	Abs:	Pg: 184a

---

Cranial-specific hemostasis findings in acute ischemic stroke
Periodical: Annals of Neurology			Index Medicus:
Authors: Ameriso S, Wong VL, Gruber A, Ishii H, Fisher M				ABS
Yr: 1992	Vol: 32	Nbr:	Abs:	Pg: 240a

---

Induced anticoagulant therapy by endogenous activated protein C (APC)
Periodical: Thrombosis Research			Index Medicus:
Authors: Gruber A, Harker LA, Griffin JH, Esmon CT, Hanson SR				ABS
Yr: 1992	Vol: 65	Nbr:	Abs:	Pg: S126a

---

Decrease in circulating activated protein C (APC) in health cigarette smokers
Periodical: Blood			Index Medicus:
Authors: Gruber A, Fernandez JA, Heeb MJ, Griffin JH				ABS
Yr: 1992	Vol: 80	Nbr:	Abs:	Pg: 315a

---

Protein S, an antithrombotic factor, is synthesized and released by neural tumor cells
Periodical: Journal of Neurochemistry			Index Medicus:
Authors: Phillips DJ, Greengard JS, Fernandez JA, et al				ART
Yr: 1993	Vol: 61	Nbr: 1	Abs:	Pg: 344-347

---

Generation of activated protein C during thrombolysis
Periodical: Lancet			Index Medicus:
Authors: Gruber A, Pal A, Kiss RG, Sas G, Griffin JH				ART
Yr: 1993	Vol: 342	Nbr: 8882	Abs:	Pg: 1275-1276

---

Alteration of fibrin network by activated protein C
Periodical: Blood			Index Medicus:
Authors: Gruber A, Mori E, del Zoppo G, Waxman L, Griffin JH				ART
Yr: 1994	Vol: 83	Nbr: 9	Abs:	Pg: 2541-2548

---

A protein S binding site on C4b-binding protein involves beta chain residues 31-45
Periodical: Journal of Biological Chemistry			Index Medicus:
Authors: Fernandez JA, Griffin JH				ART
Yr: 1994	Vol: 269	Nbr: 4	Abs:	Pg: 2535-2540

---

Analysis of protein S C4b-binding protein interactions by homology modeling and inhibitory antibodies
Periodical: Biochemistry			Index Medicus:
Authors: Fernandez JA, Villoutreix BO, Hackeng TM, Griffin JH, Bouma BN				ART
Yr: 1994	Vol: 33	Nbr: 37	Abs:	Pg: 11073-11078

---

Identification of candidate residues for interaction of protein S with C4b binding protein and activated protein C
Periodical: Biochemical Journal			Index Medicus:
Authors: Greengard JS, Fernandez JA, Radtke K-P, Griffin JH				ART
Yr: 1994	Vol:	Nbr:	Abs:	Pg:

---

Direct detection of activated protein C in blood from human subjects
Periodical: Blood			Index Medicus:
Authors: Gruber A, Griffin JH				ART
Yr: 1992	Vol: 79	Nbr: 9	Abs:	Pg: 2340-2348

---

Reevaluation of total, free and bound protein S and C4b-binding protein levels in plasma anticoagulated with citrate or hirudin
Periodical: Blood			Index Medicus:
Authors: Griffin JH, Gruber A, Fernandez JA				ART
Yr: 1992	Vol: 79	Nbr: 12	Abs:	Pg: 3203-3211

---

Normalization of markers of coagulation activation with a purified protein C concentrate in adults with homozygous protein C deficiency
Periodical: Blood			Index Medicus:
Authors: Conard J, Bauer KA, Gruber A, et al				ART
Yr: 1993	Vol: 82	Nbr: 4	Abs:	Pg: 1159-1164

---

Antithrombotic effects of thrombin-induced activation of endogenous protein C in primates
Periodical: Journal of Clinical Investigation			Index Medicus:
Authors: Hanson SR, Griffin JH, Kelly AB, Harker LA, Esmon CT, Gruber A				ART
Yr: 1993	Vol: 92	Nbr: 4	Abs:	Pg: 2003-2012

---

Identification of residues 413-433 of plasma protein S as essential for binding to C4b-binding protein
Periodical: Journal of Biological Chemistry			Index Medicus:
Authors: Fernandez JA, Heeb JA, Griffin JH				ART
Yr: 1993	Vol: 268	Nbr: 22	Abs:	Pg: 16788-16794

---

Inhibition of thrombosis by induced in vivo activation of the protein C (PC) pathway
Periodical: Blood			Index Medicus:
Authors: Gruber A, Harker LA, Griffin JH, Hanson SR				ABS
Yr: 1991	Vol: 78	Nbr:	Abs:	Pg: 184a

---

Cranial-specific hemostasis findings in acute ischemic stroke
Periodical: Annals of Neurology			Index Medicus:
Authors: Ameriso S, Wong VL, Gruber A, Ishii H, Fisher M				ABS
Yr: 1992	Vol: 32	Nbr:	Abs:	Pg: 240a

---

Induced anticoagulant therapy by endogenous activated protein C (APC)
Periodical: Thrombosis Research			Index Medicus:
Authors: Gruber A, Harker LA, Griffin JH, Esmon CT, Hanson SR				ABS
Yr: 1992	Vol: 65	Nbr:	Abs:	Pg: S126a

---

Decrease in circulating activated protein C (APC) in health cigarette smokers
Periodical: Blood			Index Medicus:
Authors: Gruber A, Fernandez JA, Heeb MJ, Griffin JH				ABS
Yr: 1992	Vol: 80	Nbr:	Abs:	Pg: 315a

---

Protein S, an antithrombotic factor, is synthesized and released by neural tumor cells
Periodical: Journal of Neurochemistry			Index Medicus:
Authors: Phillips DJ, Greengard JS, Fernandez JA, et al				ART
Yr: 1993	Vol: 61	Nbr: 1	Abs:	Pg: 344-347

---

Generation of activated protein C during thrombolysis
Periodical: Lancet			Index Medicus:
Authors: Gruber A, Pal A, Kiss RG, Sas G, Griffin JH				ART
Yr: 1993	Vol: 342	Nbr: 8882	Abs:	Pg: 1275-1276

---

Alteration of fibrin network by activated protein C
Periodical: Blood			Index Medicus:
Authors: Gruber A, Mori E, del Zoppo G, Waxman L, Griffin JH				ART
Yr: 1994	Vol: 83	Nbr: 9	Abs:	Pg: 2541-2548

---

A protein S binding site on C4b-binding protein involves beta chain residues 31-45
Periodical: Journal of Biological Chemistry			Index Medicus:
Authors: Fernandez JA, Griffin JH				ART
Yr: 1994	Vol: 269	Nbr: 4	Abs:	Pg: 2535-2540

---

Analysis of protein S C4b-binding protein interactions by homology modeling and inhibitory antibodies
Periodical: Biochemistry			Index Medicus:
Authors: Fernandez JA, Villoutreix BO, Hackeng TM, Griffin JH, Bouma BN				ART
Yr: 1994	Vol: 33	Nbr: 37	Abs:	Pg: 11073-11078

---

Identification of candidate residues for interaction of protein S with C4b binding protein and activated protein C
Periodical: Biochemical Journal			Index Medicus:
Authors: Greengard JS, Fernandez JA, Radtke K-P, Griffin JH				ART
Yr: 1994	Vol:	Nbr:	Abs:	Pg:

---