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Interaction of Complement C4b-Binding Protein with Protein B

Institution: Scripps Research Institute
Investigator(s): John Griffin, Ph.D.
Award Cycle: 1992 (Cycle 1) Grant #: 1RT-0304 Award: $616,016
Subject Area: General Biomedical Science
Award Type: Research Project Awards
Abstracts
Publications

Direct detection of activated protein C in blood from human subjects
Periodical: Blood Index Medicus:
Authors: Gruber A, Griffin JH ART
Yr: 1992 Vol: 79 Nbr: 9 Abs: Pg: 2340-2348

Reevaluation of total, free and bound protein S and C4b-binding protein levels in plasma anticoagulated with citrate or hirudin
Periodical: Blood Index Medicus:
Authors: Griffin JH, Gruber A, Fernandez JA ART
Yr: 1992 Vol: 79 Nbr: 12 Abs: Pg: 3203-3211

Normalization of markers of coagulation activation with a purified protein C concentrate in adults with homozygous protein C deficiency
Periodical: Blood Index Medicus:
Authors: Conard J, Bauer KA, Gruber A, et al ART
Yr: 1993 Vol: 82 Nbr: 4 Abs: Pg: 1159-1164

Antithrombotic effects of thrombin-induced activation of endogenous protein C in primates
Periodical: Journal of Clinical Investigation Index Medicus:
Authors: Hanson SR, Griffin JH, Kelly AB, Harker LA, Esmon CT, Gruber A ART
Yr: 1993 Vol: 92 Nbr: 4 Abs: Pg: 2003-2012

Identification of residues 413-433 of plasma protein S as essential for binding to C4b-binding protein
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Fernandez JA, Heeb JA, Griffin JH ART
Yr: 1993 Vol: 268 Nbr: 22 Abs: Pg: 16788-16794

Inhibition of thrombosis by induced in vivo activation of the protein C (PC) pathway
Periodical: Blood Index Medicus:
Authors: Gruber A, Harker LA, Griffin JH, Hanson SR ABS
Yr: 1991 Vol: 78 Nbr: Abs: Pg: 184a

Cranial-specific hemostasis findings in acute ischemic stroke
Periodical: Annals of Neurology Index Medicus:
Authors: Ameriso S, Wong VL, Gruber A, Ishii H, Fisher M ABS
Yr: 1992 Vol: 32 Nbr: Abs: Pg: 240a

Induced anticoagulant therapy by endogenous activated protein C (APC)
Periodical: Thrombosis Research Index Medicus:
Authors: Gruber A, Harker LA, Griffin JH, Esmon CT, Hanson SR ABS
Yr: 1992 Vol: 65 Nbr: Abs: Pg: S126a

Decrease in circulating activated protein C (APC) in health cigarette smokers
Periodical: Blood Index Medicus:
Authors: Gruber A, Fernandez JA, Heeb MJ, Griffin JH ABS
Yr: 1992 Vol: 80 Nbr: Abs: Pg: 315a

Protein S, an antithrombotic factor, is synthesized and released by neural tumor cells
Periodical: Journal of Neurochemistry Index Medicus:
Authors: Phillips DJ, Greengard JS, Fernandez JA, et al ART
Yr: 1993 Vol: 61 Nbr: 1 Abs: Pg: 344-347

Generation of activated protein C during thrombolysis
Periodical: Lancet Index Medicus:
Authors: Gruber A, Pal A, Kiss RG, Sas G, Griffin JH ART
Yr: 1993 Vol: 342 Nbr: 8882 Abs: Pg: 1275-1276

Alteration of fibrin network by activated protein C
Periodical: Blood Index Medicus:
Authors: Gruber A, Mori E, del Zoppo G, Waxman L, Griffin JH ART
Yr: 1994 Vol: 83 Nbr: 9 Abs: Pg: 2541-2548

A protein S binding site on C4b-binding protein involves beta chain residues 31-45
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Fernandez JA, Griffin JH ART
Yr: 1994 Vol: 269 Nbr: 4 Abs: Pg: 2535-2540

Analysis of protein S C4b-binding protein interactions by homology modeling and inhibitory antibodies
Periodical: Biochemistry Index Medicus:
Authors: Fernandez JA, Villoutreix BO, Hackeng TM, Griffin JH, Bouma BN ART
Yr: 1994 Vol: 33 Nbr: 37 Abs: Pg: 11073-11078

Identification of candidate residues for interaction of protein S with C4b binding protein and activated protein C
Periodical: Biochemical Journal Index Medicus:
Authors: Greengard JS, Fernandez JA, Radtke K-P, Griffin JH ART
Yr: 1994 Vol: Nbr: Abs: Pg: