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Mechanism of Endothelin-Stimulated ANF Secretion

Institution: San Diego State University Research Foundation
Investigator(s): Christopher Glembotski, Ph.D.
Award Cycle: 1992 (Cycle 1) Grant #: 1RT-0317 Award: $447,480
Subject Area: Cardiovascular Disease
Award Type: Research Project Awards
Abstracts
Publications

Studies of the hormonal regulation of cellular location of ANF processing and the mechanisms of phenylephrine-, endothelin-, and potassium chloride-stimulated ANF secretion using a primary cardiocyte culture model
Periodical: Canadian Journal of Physiology and Pharmacology Index Medicus:
Authors: Glembotski CC, Irons CE, Sprenkle AB, et al. ART
Yr: 0 Vol: Nbr: Abs: Pg:

The alpha-adrenergic stimulation of ANF expression in cardiac myocytes requires calcium influx, protein kinase C, and calmodulin-regulated pathways
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Sei CA, Irons CE, Sprenkle AB, et al. ART
Yr: 0 Vol: Nbr: Abs: Pg:

Regulation of ANF gene expression in cardiac myocytes
Periodical: Circulation Index Medicus:
Authors: Sprenkle AB, Glembotski CC ART
Yr: 1991 Vol: Nbr: Abs: Pg:

Gene expression and ANF processing and secretion in cultured AT-1 cardiac myocytes
Periodical: Circulation Index Medicus:
Authors: Lanson NA, Glembotski CC, Steinhelper ME, Field LJ, Claycomb WC ART
Yr: 1992 Vol: 85 Nbr: 5 Abs: Pg: 1835-1841

Induction of atrial natriuretic factor and myosin light chain-2 gene expression in cultured ventricular myocytes by electrical stimulation of contraction
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: McDonough PM, Glembotski CC ART
Yr: 1992 Vol: 267 Nbr: Abs: Pg:

The cosecretional maturation by atrial natriuretic factor by primary atrial myocytes
Periodical: Molecular Endocrinology Index Medicus:
Authors: Sei CA, Hand GL, Murray SF, Glembotski CC ART
Yr: 1992 Vol: 6 Nbr: 3 Abs: Pg: 309-319

Protein kinase C and calmodulin kinase are required for endothelin-stimulated atrial natriuretic factor secretion from primary atrial myocytes
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Irons CE, Sei CA, Hidaka H, Glembotski CC ART
Yr: 1992 Vol: 267 Nbr: 8 Abs: Pg: 5211-5216

The alpha-adrenergic stimulation of atrial natriuretic factor expression in cardiac myocytes regulates calcium influx, protein kinase C and clamodulin-regulated pathways
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Sei CA, Irons CE, Sprenkle AB, McDonough PM, Brown JH, Glembotski CC ART
Yr: 1991 Vol: 266 Nbr: 24 Abs: Pg: 15910-15916

Studies of ANF processing and secretion using a primary cardiocyte culture model
Periodical: Canadian Journal of Physiology and Pharmacology Index Medicus:
Authors: Glembotski CC, Irons CE, Sprenkle SB, Sei CA ART
Yr: 1991 Vol: 69 Nbr: 10 Abs: Pg: 1525-1536

Regulated secretion of ANF from cultured ventricular myocytes
Periodical: American Journal of Physiology Index Medicus:
Authors: Irons CE, Sei CA, Glembotski CC ART
Yr: 1993 Vol: 264 Nbr: 1 Pt 2 Abs: Pg: H282-H285

Phenylephrine and endothelin differentially stimulate cardiac phosphoinositide hydrolysis and ANF expression
Periodical: American Journal of Physiology Index Medicus:
Authors: McDonough PM, Brown JH, Glembotski CC ART
Yr: 1993 Vol: 264 Nbr: 2 Pt 2 Abs: Pg: H625-H630

Induction of atrial natriuretic factor and myosin light chain-2 gene expression in cultured ventricular myocytes by electrical stimulation of contraction
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: McDonough PM, Glembotski CC ART
Yr: 1992 Vol: 267 Nbr: 17 Abs: Pg: 11665-11668

Identification of the receptor subtype responsible for endothelin-mediated protein kinase C activation and atrial natriuretic factor secretion from atrial myocytes
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Irons CE, Murray SF, Glembotski CC ART
Yr: 1993 Vol: 268 Nbr: 31 Abs: Pg: 23417-23421

Myocardial alpha-thrombin receptor activation induces hypertrophy and increases atrial natriuretic factor gene expression
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Glembotski CC, Irons CE, Krown KA, Murray SF, Sprenkle AB, Sei CA ART
Yr: 1993 Vol: 268 Nbr: 27 Abs: Pg: 20646-20652

Involvement of cytoplasmic calcium and protein kinases in the regulation of atrial natriuretic factor secretion by contraction rate and endothelin
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: McDonough PM, Stella SL, Glembotski CC ART
Yr: 1994 Vol: 269 Nbr: 13 Abs: Pg: 9466-9472