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Heterologous Expression of Brain Nicotinic Receptors

Institution: California Institute of Technology
Investigator(s): Henry Lester, Ph.D.
Award Cycle: 1992 (Cycle 1) Grant #: 1RT-0365 Award: $586,840
Subject Area: Nicotine Dependence
Award Type: Research Project Awards
Abstracts
Publications

TRIS+ NA+ permeability ratios of nicotinic acetylcholine receptors are reduced by mutations near the intracellular end of the M2 region
Periodical: Journal of General Physiology Index Medicus:
Authors: Cohen BN, Labarca C, Czyzyk L, Davidson N, Lester HA ART
Yr: 1992 Vol: 99 Nbr: Abs: Pg: 545-572

Pharmacological and kinetic properties of alpha4beta2 neuronal nicotinic acetylcholine receports expressed in Xenopus oocytes
Periodical: Index Medicus:
Authors: Charnet P, Labarca C, Cohen BC, Davidson N, Lester HA, Pilar G ART
Yr: 1992 Vol: 450 Nbr: Abs: Pg: 375-394

Ion-selectivity of mutated and wild-type nicotinic ACh channels
Periodical: Biophysics Journal Index Medicus:
Authors: Cohen BN, Labarca C, Davidson N, Lester H ABS
Yr: 1991 Vol: 59 Nbr: Abs: 33a Pg:

Structure of the gamma-less nicotinic acetylcholine receptor: learning from omission
Periodical: Molecular Pharmacology Index Medicus:
Authors: Charnet P, Labarca C, Lester HA ART
Yr: 1992 Vol: 41 Nbr: 4 Abs: Pg: 708-717

Mutations in M2 alter the selectivity of the mouse nicotinic acetylcholine receptor for organic and for alkali metal cations
Periodical: Journal of General Physiology Index Medicus:
Authors: Cohen BN, Labarca C, Davidson N, Lester HA ART
Yr: 1992 Vol: 100 Nbr: 3 Abs: Pg: 373-400

Regions of beta4.beta2 subunit chimeras that contribute to the agonist selectivity of neuronal nicotinic receptors
Periodical: FEBS Journal Index Medicus:
Authors: Figl A, Cohen BN, Quick MW, Davidson N, Lester HA ART
Yr: 1992 Vol: 308 Nbr: 3 Abs: Pg: 245-248

The permeation pathway of neurotransmitter-gated ion channels
Periodical: Annual Review of Biophysics and Biomolecular Structure Index Medicus:
Authors: Lester HA ART
Yr: 1992 Vol: 21 Nbr: Abs: Pg: 267-292

Regions of the beta subunit of the neuronal nicotinic receptor affecting agonist selectivity
Periodical: Society for Neuroscience Abstracts Index Medicus:
Authors: Figl A, Cohen BN, Quick MW, Yang X-C, Lester HA ABS
Yr: 1992 Vol: 18 Nbr: Abs: Pg: 1508

Subtypes of the beta subunit confer different antagonist sensitivities on neuronal nicotinic receptors
Periodical: Society for Neuroscience Abstracts Index Medicus:
Authors: Cohen BN, Figl A, Quick MW, Ishida AT, Lester HA ABS
Yr: 1992 Vol: 18 Nbr: Abs: Pg: 1508

Novel functional domains of the rat neuronal nicotinic beta subunit
Periodical: Society for Neuroscience Abstracts Index Medicus:
Authors: Figl A, Cohen BN, Gollub J, Davidson N, Lester HA ABS
Yr: 1993 Vol: 19 Nbr: Abs: Pg: 8