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Tobacco Carcinogens/C-Kinase Oxidative Activation/Metastasis

Institution: University of Southern California
Investigator(s): Rayudu Gopalakrishna, Ph.D.
Award Cycle: 1992 (Cycle 1) Grant #: 1RT-0388 Award: $363,557
Subject Area: Cancer
Award Type: Research Project Awards
Abstracts
Publications

Reversible oxidative activation and inactivation of protein kinase C by the mitogen/tumor promoter periodate
Periodical: Archives of Biochemistry and Biophysics Index Medicus:
Authors: Gopalakrishna R, Anderson WB ART
Yr: 1991 Vol: 285 Nbr: Abs: Pg: 382-387

Retinoids protect protein kinase C from oxidative modification induced by oxidant tumor promoters
Periodical: FASEB Journal Index Medicus:
Authors: Gundimeda U, Hara SK, Anderson WB, Gopalakrishna R ABS
Yr: 1992 Vol: 6 Nbr: Abs: 3820 Pg: A1596

Rapid filtration assays for protein kinase C activity and phorbol ester binding using multiwell plates with fitted filtration discs
Periodical: FASEB Journal Index Medicus:
Authors: Gopalakrishna R, Chen ZH, Gundimeda U, Wilson JC, Anderson WB ABS
Yr: 1992 Vol: 6 Nbr: Abs: 5308 Pg: A1853

Rapid filtration assays for protein kinase C activity and phorbol ester binding using multiwell plates with fitted filtration discs
Periodical: Analytical Biochemistry Index Medicus:
Authors: Gopalakrishna R, Chen ZH, Gundimeda U, Wilson JC, Anderson WB ART
Yr: 1992 Vol: 206 Nbr: 1 Abs: Pg: 24-35

Irreversible inactivation of protein kinase C by photosensitive inhibitor calphostin C
Periodical: Index Medicus:
Authors: Gopalakrishna R, Chen ZH, Gundimeda U ART
Yr: 1992 Vol: 314 Nbr: 2 Abs: Pg: 148-154

Nonphorbol tumor promoters okadaic acid and calyculin-A induce membrane translocation of protein kinase C
Periodical: Biochemistry and Biophysics Research Communications Index Medicus:
Authors: Gopalakrishna R, Chen ZH, Gundimeda U ART
Yr: 1992 Vol: 189 Nbr: 2 Abs: Pg: 950-957

Retinoids inhibit the oxidative modification of protein kinase C induced by oxidant tumor promoters
Periodical: Archives of Biochemistry and Biophysics Index Medicus:
Authors: Gundimeda U, Hara SK, Anderson WB, Gopalkrishna R ART
Yr: 1993 Vol: 300 Nbr: 1 Abs: Pg: 526-530

Catechol present in tobacco smoke induces membrane translocation and oxidative activation of protein kinase C in bronchial epithelial cells
Periodical: FASEB Journal Index Medicus:
Authors: Gundimeda U, Chen ZH, Gopalakrishna R ABS
Yr: 1993 Vol: 7 Nbr: 4 Abs: Pg: 4132

Acrolein and other aldehydes present in tobacco smoke induce activation/inactivation of protein kinase C--protection by thiols
Periodical: FASEB Journal Index Medicus:
Authors: Janzen D, Gundimeda U, Chen ZH, Gopalakrishna R ABS
Yr: 1993 Vol: 7 Nbr: 3 Abs: Pg: 2360

The antitumor promoter vitamin E decreases the rate of down-regulation of protein kinase C induced by phorbol esters and oxidants
Periodical: FASEB Journal Index Medicus:
Authors: Gopalakrishna R, Gundimeda U, Chen ZH, Anderson WB ABS
Yr: 1993 Vol: 7 Nbr: 4 Abs: Pg: 4996

Catechol, a tobacco smoke tumor promoter, influences oxidative regulation of kinase C and metastasis
Periodical: Proceedings of the American Association for Cancer Research Index Medicus:
Authors: Gundimeda U, Chen ZH, Gopalakrishna R ABS
Yr: 1993 Vol: 34 Nbr: Abs: Pg: 410

Nonphorbol tumor promoters okadaic and calyculin-A induce membrane translocation of protein kinase C
Periodical: Proceedings of the American Association for Cancer Research Index Medicus:
Authors: Chen ZH, Gundimeda U, Gopalakrishna R ABS
Yr: 1993 Vol: 34 Nbr: Abs: Pg: 1053

Antitumor promoters, retinoids induce a decrease in protein kinase C activity in lung carcinoma cells and suppress hematogenous metastasis
Periodical: FASEB Journal Index Medicus:
Authors: Jantzen D, Gundimeda U, Chen ZH, Gopalakrishna R ABS
Yr: 1993 Vol: 7 Nbr: 7 Abs: Pg: 397

Complete carcinogen benz(a)pyrene induces down-regulation of protein kinase C in nucleus and plasma membrane in lung carcinoma
Periodical: FASEB Journal Index Medicus:
Authors: Chen ZH, Gundimeda U, Gopalakrishna R ABS
Yr: 1993 Vol: 7 Nbr: 7 Abs: Pg: 396

Nitric oxide and nitric oxide-generating agents induce irreversible oxidative inactivation of protein kinase C by S-nitrosylation
Periodical: FASEB Journal Index Medicus:
Authors: Gundimeda U, Chen ZH, Gopalakrishna R ABS
Yr: 1993 Vol: 7 Nbr: 7 Abs: Pg: 395

Multiwell filtration assay for rapid determination of protein phosphatase activity: application to type type 1, 2A, 2C enzymes
Periodical: FASEB Journal Index Medicus:
Authors: Gopalakrishna R, Gundimeda U, Wilson JC, Chen ZH ABS
Yr: 1993 Vol: 7 Nbr: 7 Abs: Pg: 599