Research Portfolio

Search by: Title Institution Investigator Cycle Award Type Research Priority

Funding Opportunities

Call for Applications

Join our Mailing List

Join our mailing list to be notified of new funding opportunities. Your Email To receive information about funding opportunities, events, and program updates.

Tobacco Carcinogens/C-Kinase Oxidative Activation/Metastasis

Institution:	University of Southern California
Investigator(s):	Rayudu Gopalakrishna, Ph.D.
Award Cycle:	1992 (Cycle 1)	Grant #: 1RT-0388	Award: $363,557
Subject Area:	Cancer
Award Type:	Research Project Awards

---

Reversible oxidative activation and inactivation of protein kinase C by the mitogen/tumor promoter periodate
Periodical: Archives of Biochemistry and Biophysics			Index Medicus:
Authors: Gopalakrishna R, Anderson WB				ART
Yr: 1991	Vol: 285	Nbr:	Abs:	Pg: 382-387

---

Retinoids protect protein kinase C from oxidative modification induced by oxidant tumor promoters
Periodical: FASEB Journal			Index Medicus:
Authors: Gundimeda U, Hara SK, Anderson WB, Gopalakrishna R				ABS
Yr: 1992	Vol: 6	Nbr:	Abs: 3820	Pg: A1596

---

Rapid filtration assays for protein kinase C activity and phorbol ester binding using multiwell plates with fitted filtration discs
Periodical: FASEB Journal			Index Medicus:
Authors: Gopalakrishna R, Chen ZH, Gundimeda U, Wilson JC, Anderson WB				ABS
Yr: 1992	Vol: 6	Nbr:	Abs: 5308	Pg: A1853

---

Rapid filtration assays for protein kinase C activity and phorbol ester binding using multiwell plates with fitted filtration discs
Periodical: Analytical Biochemistry			Index Medicus:
Authors: Gopalakrishna R, Chen ZH, Gundimeda U, Wilson JC, Anderson WB				ART
Yr: 1992	Vol: 206	Nbr: 1	Abs:	Pg: 24-35

---

Irreversible inactivation of protein kinase C by photosensitive inhibitor calphostin C
Periodical:			Index Medicus:
Authors: Gopalakrishna R, Chen ZH, Gundimeda U				ART
Yr: 1992	Vol: 314	Nbr: 2	Abs:	Pg: 148-154

---

Nonphorbol tumor promoters okadaic acid and calyculin-A induce membrane translocation of protein kinase C
Periodical: Biochemistry and Biophysics Research Communications			Index Medicus:
Authors: Gopalakrishna R, Chen ZH, Gundimeda U				ART
Yr: 1992	Vol: 189	Nbr: 2	Abs:	Pg: 950-957

---

Retinoids inhibit the oxidative modification of protein kinase C induced by oxidant tumor promoters
Periodical: Archives of Biochemistry and Biophysics			Index Medicus:
Authors: Gundimeda U, Hara SK, Anderson WB, Gopalkrishna R				ART
Yr: 1993	Vol: 300	Nbr: 1	Abs:	Pg: 526-530

---

Catechol present in tobacco smoke induces membrane translocation and oxidative activation of protein kinase C in bronchial epithelial cells
Periodical: FASEB Journal			Index Medicus:
Authors: Gundimeda U, Chen ZH, Gopalakrishna R				ABS
Yr: 1993	Vol: 7	Nbr: 4	Abs:	Pg: 4132

---

Acrolein and other aldehydes present in tobacco smoke induce activation/inactivation of protein kinase C--protection by thiols
Periodical: FASEB Journal			Index Medicus:
Authors: Janzen D, Gundimeda U, Chen ZH, Gopalakrishna R				ABS
Yr: 1993	Vol: 7	Nbr: 3	Abs:	Pg: 2360

---

The antitumor promoter vitamin E decreases the rate of down-regulation of protein kinase C induced by phorbol esters and oxidants
Periodical: FASEB Journal			Index Medicus:
Authors: Gopalakrishna R, Gundimeda U, Chen ZH, Anderson WB				ABS
Yr: 1993	Vol: 7	Nbr: 4	Abs:	Pg: 4996

---

Catechol, a tobacco smoke tumor promoter, influences oxidative regulation of kinase C and metastasis
Periodical: Proceedings of the American Association for Cancer Research			Index Medicus:
Authors: Gundimeda U, Chen ZH, Gopalakrishna R				ABS
Yr: 1993	Vol: 34	Nbr:	Abs:	Pg: 410

---

Nonphorbol tumor promoters okadaic and calyculin-A induce membrane translocation of protein kinase C
Periodical: Proceedings of the American Association for Cancer Research			Index Medicus:
Authors: Chen ZH, Gundimeda U, Gopalakrishna R				ABS
Yr: 1993	Vol: 34	Nbr:	Abs:	Pg: 1053

---

Antitumor promoters, retinoids induce a decrease in protein kinase C activity in lung carcinoma cells and suppress hematogenous metastasis
Periodical: FASEB Journal			Index Medicus:
Authors: Jantzen D, Gundimeda U, Chen ZH, Gopalakrishna R				ABS
Yr: 1993	Vol: 7	Nbr: 7	Abs:	Pg: 397

---

Complete carcinogen benz(a)pyrene induces down-regulation of protein kinase C in nucleus and plasma membrane in lung carcinoma
Periodical: FASEB Journal			Index Medicus:
Authors: Chen ZH, Gundimeda U, Gopalakrishna R				ABS
Yr: 1993	Vol: 7	Nbr: 7	Abs:	Pg: 396

---

Nitric oxide and nitric oxide-generating agents induce irreversible oxidative inactivation of protein kinase C by S-nitrosylation
Periodical: FASEB Journal			Index Medicus:
Authors: Gundimeda U, Chen ZH, Gopalakrishna R				ABS
Yr: 1993	Vol: 7	Nbr: 7	Abs:	Pg: 395

---

Multiwell filtration assay for rapid determination of protein phosphatase activity: application to type type 1, 2A, 2C enzymes
Periodical: FASEB Journal			Index Medicus:
Authors: Gopalakrishna R, Gundimeda U, Wilson JC, Chen ZH				ABS
Yr: 1993	Vol: 7	Nbr: 7	Abs:	Pg: 599

---

Reversible oxidative activation and inactivation of protein kinase C by the mitogen/tumor promoter periodate
Periodical: Archives of Biochemistry and Biophysics			Index Medicus:
Authors: Gopalakrishna R, Anderson WB				ART
Yr: 1991	Vol: 285	Nbr:	Abs:	Pg: 382-387

---

Retinoids protect protein kinase C from oxidative modification induced by oxidant tumor promoters
Periodical: FASEB Journal			Index Medicus:
Authors: Gundimeda U, Hara SK, Anderson WB, Gopalakrishna R				ABS
Yr: 1992	Vol: 6	Nbr:	Abs: 3820	Pg: A1596

---

Rapid filtration assays for protein kinase C activity and phorbol ester binding using multiwell plates with fitted filtration discs
Periodical: FASEB Journal			Index Medicus:
Authors: Gopalakrishna R, Chen ZH, Gundimeda U, Wilson JC, Anderson WB				ABS
Yr: 1992	Vol: 6	Nbr:	Abs: 5308	Pg: A1853

---

Rapid filtration assays for protein kinase C activity and phorbol ester binding using multiwell plates with fitted filtration discs
Periodical: Analytical Biochemistry			Index Medicus:
Authors: Gopalakrishna R, Chen ZH, Gundimeda U, Wilson JC, Anderson WB				ART
Yr: 1992	Vol: 206	Nbr: 1	Abs:	Pg: 24-35

---

Irreversible inactivation of protein kinase C by photosensitive inhibitor calphostin C
Periodical:			Index Medicus:
Authors: Gopalakrishna R, Chen ZH, Gundimeda U				ART
Yr: 1992	Vol: 314	Nbr: 2	Abs:	Pg: 148-154

---

Nonphorbol tumor promoters okadaic acid and calyculin-A induce membrane translocation of protein kinase C
Periodical: Biochemistry and Biophysics Research Communications			Index Medicus:
Authors: Gopalakrishna R, Chen ZH, Gundimeda U				ART
Yr: 1992	Vol: 189	Nbr: 2	Abs:	Pg: 950-957

---

Retinoids inhibit the oxidative modification of protein kinase C induced by oxidant tumor promoters
Periodical: Archives of Biochemistry and Biophysics			Index Medicus:
Authors: Gundimeda U, Hara SK, Anderson WB, Gopalkrishna R				ART
Yr: 1993	Vol: 300	Nbr: 1	Abs:	Pg: 526-530

---

Catechol present in tobacco smoke induces membrane translocation and oxidative activation of protein kinase C in bronchial epithelial cells
Periodical: FASEB Journal			Index Medicus:
Authors: Gundimeda U, Chen ZH, Gopalakrishna R				ABS
Yr: 1993	Vol: 7	Nbr: 4	Abs:	Pg: 4132

---

Acrolein and other aldehydes present in tobacco smoke induce activation/inactivation of protein kinase C--protection by thiols
Periodical: FASEB Journal			Index Medicus:
Authors: Janzen D, Gundimeda U, Chen ZH, Gopalakrishna R				ABS
Yr: 1993	Vol: 7	Nbr: 3	Abs:	Pg: 2360

---

The antitumor promoter vitamin E decreases the rate of down-regulation of protein kinase C induced by phorbol esters and oxidants
Periodical: FASEB Journal			Index Medicus:
Authors: Gopalakrishna R, Gundimeda U, Chen ZH, Anderson WB				ABS
Yr: 1993	Vol: 7	Nbr: 4	Abs:	Pg: 4996

---

Catechol, a tobacco smoke tumor promoter, influences oxidative regulation of kinase C and metastasis
Periodical: Proceedings of the American Association for Cancer Research			Index Medicus:
Authors: Gundimeda U, Chen ZH, Gopalakrishna R				ABS
Yr: 1993	Vol: 34	Nbr:	Abs:	Pg: 410

---

Nonphorbol tumor promoters okadaic and calyculin-A induce membrane translocation of protein kinase C
Periodical: Proceedings of the American Association for Cancer Research			Index Medicus:
Authors: Chen ZH, Gundimeda U, Gopalakrishna R				ABS
Yr: 1993	Vol: 34	Nbr:	Abs:	Pg: 1053

---

Antitumor promoters, retinoids induce a decrease in protein kinase C activity in lung carcinoma cells and suppress hematogenous metastasis
Periodical: FASEB Journal			Index Medicus:
Authors: Jantzen D, Gundimeda U, Chen ZH, Gopalakrishna R				ABS
Yr: 1993	Vol: 7	Nbr: 7	Abs:	Pg: 397

---

Complete carcinogen benz(a)pyrene induces down-regulation of protein kinase C in nucleus and plasma membrane in lung carcinoma
Periodical: FASEB Journal			Index Medicus:
Authors: Chen ZH, Gundimeda U, Gopalakrishna R				ABS
Yr: 1993	Vol: 7	Nbr: 7	Abs:	Pg: 396

---

Nitric oxide and nitric oxide-generating agents induce irreversible oxidative inactivation of protein kinase C by S-nitrosylation
Periodical: FASEB Journal			Index Medicus:
Authors: Gundimeda U, Chen ZH, Gopalakrishna R				ABS
Yr: 1993	Vol: 7	Nbr: 7	Abs:	Pg: 395

---

Multiwell filtration assay for rapid determination of protein phosphatase activity: application to type type 1, 2A, 2C enzymes
Periodical: FASEB Journal			Index Medicus:
Authors: Gopalakrishna R, Gundimeda U, Wilson JC, Chen ZH				ABS
Yr: 1993	Vol: 7	Nbr: 7	Abs:	Pg: 599

---