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Molecular Mechanisms of Leukocyte Traffic to the Lungs

Institution: Stanford University
Investigator(s): Eugene Butcher, M.D.
Award Cycle: 1992 (Cycle 1) Grant #: 1RT-0454 Award: $345,676
Subject Area: Pulmonary Disease
Award Type: Research Project Awards
Abstracts
Publications

A two step model of leukocyte-endothelial cell interaction in inflammation: Distinct roles for LECAM-1 and the leukocyte 2 integrins in vivo
Periodical: Proceedings of the National Academy of Sciences of the United States of America Index Medicus:
Authors: von Andrian UH, Chambers JD, McEvoy L, et al ART
Yr: 0 Vol: Nbr: Abs: Pg:

Two step model of leukocyte-endothelial cell interaction in inflammation: Distince roles for LECAM-1 and leukocyte beta2 integrins in vivo
Periodical: Proceedings of the National Academy of Sciences of the United States of America Index Medicus:
Authors: von Andrian, Chambers JD, McEvoy L, Bargatze RF, Arfors KE, Butcher EC ART
Yr: 1991 Vol: 88 Nbr: 17 Abs: Pg: 7538-7542

The neutrophil selection LECAM-1 presents carbohydrate ligands to the vascular selections ELAM-1 and GMP-140
Periodical: Cell Index Medicus:
Authors: Picker LJ, Warnock RA, Burns AR, Doerschuk CM, Berg EL, Butcher EC ART
Yr: 1991 Vol: 66 Nbr: 5 Abs: Pg: 921-933

Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity
Periodical: Cell Index Medicus:
Authors: Butcher EC ART
Yr: 1991 Vol: 67 Nbr: 6 Abs: Pg: 1033-1036

Role of integrin alpha4beta7/alpha4betaP in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering
Periodical: Journal of Cell Biology Index Medicus:
Authors: Ruegg C, Postigo AA, Sikorski EE, Butcher EC, Pytela R, Erle DJ ART
Yr: 1992 Vol: 117 Nbr: 1 Abs: Pg: 179-189

L-selectin function is required for beta2 integrin-mediated neutrophil adhesion at phsyiological shear rates in vivo
Periodical: American Journal of Physiology Index Medicus:
Authors: von Andrian UH, Hansell P, Chambers JD, et al ART
Yr: 1992 Vol: 263 Nbr: 4 Pt 2 Abs: Pg: H1034-H1044

Neutrophil aggregation is beta2-integrin and L-selectin dependent in blood and isolated cells
Periodical: Journal of Immunology Index Medicus:
Authors: Simon SI, Chambers JD, Butcher EC, Sklar LA ART
Yr: 1992 Vol: 149 Nbr: 8 Abs: Pg: 2765-2771

Rapid G protein-regulated activation event involved in lymphocyte binding to high endothelial venules
Periodical: Journal of Experimental Medicine Index Medicus:
Authors: Bargatze RF, Butcher ED ART
Yr: 1993 Vol: 178 Nbr: 1 Abs: Pg: 367-372

L-selectin mediates neutrophil rolling in inflamed venules through sialyl Lewisx-dependent and -independent recognition pathways
Periodical: Blood Index Medicus:
Authors: von Andrian UH, Chambers JD, Berg EL, et al ART
Yr: 1993 Vol: 82 Nbr: 1 Abs: Pg: 182-191