SMART: Sequential Motion Adaptation to Improve Lung Cancer RT

Institution:	University of California, Los Angeles
Investigator(s):	Dan Ruan, Ph.D
Award Cycle:	2011 (Cycle 20)	Grant #: 20XT-0142	Award: $250,000
Subject Area:	Cancer
Award Type:	Exploratory/Developmental Award

Abstracts

Initial Award Abstract

Tobacco smoking, regardless of active or secondhand, is the major contributor and accounts for 87% of lung cancer. Radiation therapy is often for lung cancer treatment, either as a stand-alon modality or in combination with chemotherapy. Stereotactic Body Radiotherapy (SBRT) is an emerging technique utilizing high precision targeted delivery mechanism to ablate tumors, with demonstrated tumor local control for lung cancer treatment. Unfortunately, the highly focused dose in SBRT is also responsible for high local failure, morbidity and mortality when normal tissue is mistakenly irradiated - a particular concern as lung tumors exhibit significant motion (~5cm) under breathing. With treatment plans devised according to pre-treatment CT scans, such motion during treatment can introduce large discrepancy between delivered dose distribution and the plan, significantly compromising the efficacy of SBRT. To account for lung tumor motion during treatment, we propose a Sequential Motion Adaptive Radiotherapy (SMART) scheme, consisting of (1) real time motion monitoring via noninvasive online imaging and highly efficient image registration; (2) adaptive delivery based on estimated motion, with a sequential feedback control mechanism and online optimization. This study is expected to synergistically integrate with the fast developing image-guided-radiotherapy (IGRT) systems, and achieve significantly better agreement between delivery result and plan - guaranteeing desired coverage for lung tumors and maximal radiation sparing for normal tissue and critical organs such as heart, esophogas and spinal cord.

Publications

Dose shaping using targeted sparse optimization
Periodical: Medical Physics			Index Medicus:
Authors: G. Sayre, D Ruan				ART
Yr: 2013	Vol:	Nbr:	Abs:	Pg:

Estimating nonrigid motion from inconsistent inlensity wilh robust shape_x000D_ features
Periodical: Medical Physics			Index Medicus:
Authors: W. Liu, D. Ruan				ART
Yr: 2013	Vol:	Nbr:	Abs:	Pg:

Dose shaping using targeted sparse optimization
Periodical: Medical Physics			Index Medicus:
Authors: G. Sayre, D Ruan				ART
Yr: 2013	Vol:	Nbr:	Abs:	Pg:

Estimating nonrigid motion from inconsistent inlensity wilh robust shape_x000D_ features
Periodical: Medical Physics			Index Medicus:
Authors: W. Liu, D. Ruan				ART
Yr: 2013	Vol:	Nbr:	Abs:	Pg: