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Dietary effects on tobacco-related lung cancer

Institution: University of California, Berkeley
Investigator(s): Danica Chen, PhD
Award Cycle: 2011 (Cycle 20) Grant #: 20KT-0054 Award: $270,000
Subject Area: Cancer
Award Type: New Investigator Awards
Abstracts

Initial Award Abstract
The effects of smoking on human health are serious or even deadly. Among many tobacco-related diseases is lung cancer. A low calorie diet, termed calorie restriction, is known to prevent a wide spectrum of diseases, including cancer. Understanding the interaction between diet and genetic factors will provide opportunities to explore therapeutic targets to enjoy the benefits of a low calorie diet. Recent studies from my lab and many others have set a paradigm for identifying genetic factors regulated by a low calorie diet and exploring therapeutic opportunities by targeting these factors. We propose to greatly expand our initial findings to include a network of genetic factors that are subject to the regulation by a low calorie diet and examine the effects of these genetic factors on preventing tobacco smoke-induced lung cancer. We will also explore clinical evidence to support our hypothesis. Our studies provide a unique entry point to tackle tobacco use-related problems and hold promise for identifying therapeutic targets for treating tobacco-related diseases.