Research Portfolio

Funding Opportunities

Join our Mailing List
Join our mailing list to be notified of new funding opportunities.

Your Email

To receive information about funding opportunities, events, and program updates.

Dietary effects on tobacco-related lung cancer

Institution: University of California, Berkeley
Investigator(s): Danica Chen, PhD
Award Cycle: 2011 (Cycle 20) Grant #: 20KT-0054 Award: $270,000
Subject Area: Cancer
Award Type: New Investigator Awards

Initial Award Abstract
The effects of smoking on human health are serious or even deadly. Among many tobacco-related diseases is lung cancer. A low calorie diet, termed calorie restriction, is known to prevent a wide spectrum of diseases, including cancer. Understanding the interaction between diet and genetic factors will provide opportunities to explore therapeutic targets to enjoy the benefits of a low calorie diet. Recent studies from my lab and many others have set a paradigm for identifying genetic factors regulated by a low calorie diet and exploring therapeutic opportunities by targeting these factors. We propose to greatly expand our initial findings to include a network of genetic factors that are subject to the regulation by a low calorie diet and examine the effects of these genetic factors on preventing tobacco smoke-induced lung cancer. We will also explore clinical evidence to support our hypothesis. Our studies provide a unique entry point to tackle tobacco use-related problems and hold promise for identifying therapeutic targets for treating tobacco-related diseases.