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Determinants of Thrombin Interaction With Its Receptor

Institution: University of California, San Francisco
Investigator(s): Shaun Coughlin, M.D., Ph.D.
Award Cycle: 1993 (Cycle 2) Grant #: 2RT-0019 Award: $264,243
Subject Area: Cardiovascular Disease
Award Type: Research Project Awards
Abstracts
Publications

Domains specifying thrombin-receptor interaction
Periodical: Nature Index Medicus:
Authors: Vu TKH, Wheaton VI, Hung DT, Coughlin SR ART
Yr: 1991 Vol: 353 Nbr: 6345 Abs: Pg: 674-677

"Mirror image" antagonists of thrombin-induced platelet activation based on thrombin receptor structure
Periodical: Journal of Clinical Investigation Index Medicus:
Authors: Hung DT, Vu TKH, Wheaton VI, et al ART
Yr: 1992 Vol: 89 Nbr: 2 Abs: Pg: 444-450

Thrombin-induced events in non-platelet cells are mediated by the novel proteolytic mechanism defined by the cloned platelet thrombin receptor
Periodical: Journal of Cell Biology Index Medicus:
Authors: Hung DT, Vu TKH, Nelken NA, Coughlin SR ART
Yr: 1992 Vol: 116 Nbr: 3 Abs: Pg: 827-832

The cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation. Blocking antiserum to the thrombin receptor's hirudin-like domain
Periodical: Journal of Clinical Investigation Index Medicus:
Authors: Hung DT, Vu TKH, Wheaton VI, Ishii K, Coughlin SR ART
Yr: 1992 Vol: 89 Nbr: 4 Abs: Pg: 1350-1353

Perspectives: characterization of the cloned platelet thrombin receptor: issues and opportunities
Periodical: Journal of Clinical Investigation Index Medicus:
Authors: Coughlin SR, Vu TKH, Hung DT, Wheaton VI ART
Yr: 1992 Vol: 89 Nbr: 2 Abs: Pg: 351-355

Tethered ligan agonist peptides: structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Scarborough RM, Naughton M, Teng W, et al ART
Yr: 1992 Vol: 267 Nbr: 19 Abs: Pg: 13146-13149

The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate both phosphoinositide hyrdolysis and inhibit adenylyl cyclase
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Hung DT, Wong YH, Vu T-KH, Coughlin SR ART
Yr: 1992 Vol: 267 Nbr: 29 Abs: Pg: 20831-20834

Thrombin receptor expression in normal and atherosclerotic human arteries
Periodical: Journal of Clinical Investigation Index Medicus:
Authors: Nelken NA, Soifer SJ, O'Keefe J, Vu T-KH, Charo IF, Coughlin SR ART
Yr: 1992 Vol: 90 Nbr: 4 Abs: Pg: 1614-1621

Thrombin stimulates smooth muscle cell of cultured rat aortic proliferation by a proteolytically activated receptor
Periodical: Journal of Clinical Investigation Index Medicus:
Authors: McNamara CA, Sarembok IJ, Gimple LW, Fenton JW, Couglin SR, Owens GK ART
Yr: 1993 Vol: 91 Nbr: 1 Abs: Pg: 94-98

Kinetics of thrombin receptor cleavage on intact cells: relation to signalling
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Ishii K, Hein L, Kobilka BK, Coughlin SR ART
Yr: 1993 Vol: 268 Nbr: 13 Abs: Pg: 9780-9786

Expression cloning and characterization of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
Periodical: Seminars in Thrombosis and Hemostasis Index Medicus:
Authors: Coughlin SR, Vu T-KH, Hung DT, Wheaton VI ART
Yr: 1992 Vol: 18 Nbr: 2 Abs: Pg: 161-166

Thrombin receptor structure and function
Periodical: Cold Spring Harbor Symposium on Quantitative Biology Index Medicus:
Authors: Coughlin SR, Scarborough RM, Vu T-KH, Hung DT ART
Yr: 1993 Vol: 57 Nbr: Abs: Pg: 149-154

Disparate temporal expression of the prothrombin and thrombin receptor genes during mouse development
Periodical: American Journal of Pathology Index Medicus:
Authors: Soifer SJ, Peters KG, O'Keefe J, Coughlin SR ART
Yr: 1994 Vol: 144 Nbr: 1 Abs: Pg: 60-69

Inhibition of thrombin receptor signaling by a G protein-coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Ishii K, Chen J, Ishii M, et al ART
Yr: 1994 Vol: 269 Nbr: 2 Abs: Pg: 1125-1130

Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes
Periodical: Biochemistry Index Medicus:
Authors: Mathews II, Padmandabhan KP, Ganesh V, et al ART
Yr: 1994 Vol: 33 Nbr: 11 Abs: Pg: 3266-3279

Instracellular targeting and trafficking of thrombin receptors: a novel mechanism for resensitization of a G protein-coupled receptor
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Hein L, Ishii K, Coughlin SR, Kobilka BK ART
Yr: 1994 Vol: 269 Nbr: 44 Abs: Pg: 27719-27726

Thrombin receptor structure and function
Periodical: Thrombosis and Haemostasis Index Medicus:
Authors: Coughlin SR ART
Yr: 1993 Vol: 70 Nbr: 1 Abs: Pg: 184-187

Molecular mechanisms of thrombin signaling
Periodical: Seminars in Hematology Index Medicus:
Authors: Coughlin SR ART
Yr: 1994 Vol: 31 Nbr: 4 Abs: Pg: 270-277

Expanding horizons for receptors to G protein: diversity and disease
Periodical: Current Opinions in Cell Biology Index Medicus:
Authors: Coughlin SR ART
Yr: 1994 Vol: 6 Nbr: 2 Abs: Pg: 191-197

Thrombin receptor and cardiovascular disease
Periodical: Trends in Cardiovascular Medicine Index Medicus:
Authors: Coughlin SR ART
Yr: 1994 Vol: 4 Nbr: 2 Abs: Pg: 77-83