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Activated Protein C in Smokers Thrombosis

Institution: Scripps Research Institute
Investigator(s): Andras Gruber, M.D.
Award Cycle: 1993 (Cycle 2) Grant #: 2RT-0342 Award: $347,737
Subject Area: Cardiovascular Disease
Award Type: Research Project Awards
Abstracts
Publications

Direct detection of activated protein C in blood from human subjects
Periodical: Blood Index Medicus:
Authors: Gruber A, Griffin JH ART
Yr: 1992 Vol: 79 Nbr: 9 Abs: Pg: 2340-2348

Reevaluation of total, free and bound protein S and C4b-binding protein levels in plasma anticoagulated with citrate or hirudin
Periodical: Blood Index Medicus:
Authors: Griffin JH, Gruder A, Fernandez JA ART
Yr: 1992 Vol: 79 Nbr: 12 Abs: Pg: 3203-3211

Normalization of markers of coagulation activation with a purified protein C concentrate in adults with homozygous protein C deficiency
Periodical: Blood Index Medicus:
Authors: Conard J, Bauer KA, Gruber A, et al ART
Yr: 1993 Vol: 82 Nbr: 4 Abs: Pg: 1159-1164

Antithrombotic effects of thrombin-induced activation of endogenous protein C in primates
Periodical: Journal of Clinical Investigation Index Medicus:
Authors: Hanson SR, Griffin JH, Kelly AB, Harker LA, Esmon CT, Gruber A ART
Yr: 1993 Vol: 92 Nbr: 4 Abs: Pg: 2003-2012

Inhibition of thrombosis by induced in vivo activation of the protein C (PC) pathway
Periodical: Blood Index Medicus:
Authors: Gruber A, Harker LA, Griffin JH, Hanson SR ABS
Yr: 1991 Vol: 78 Nbr: Abs: Pg: 184a

Cranial-specific hemostasis findings in acute ischemic stroke
Periodical: Annals of Neurology Index Medicus:
Authors: Ameriso S, Wong VL, Gruber A, Ishii H, Fisher M ABS
Yr: 1992 Vol: 32 Nbr: Abs: Pg: 240a

Induced anticoagulant therapy by endogenous activated protein C (APC)
Periodical: Thrombosis Research Index Medicus:
Authors: Gruber A, Harker LA, Griffin JH, Esmon CT, Hanson SR ABS
Yr: 1992 Vol: 65 Nbr: Abs: Pg: S126a

Decrease in circulating activated protein C (APC) in healthy cigarette smokers
Periodical: Blood Index Medicus:
Authors: Gruber A, Fernandez JA, Heeb MJ, Griffin JH ABS
Yr: 1992 Vol: 80 Nbr: Abs: Pg: 315a

Modification of fibrin structure by activated protein C (APC) or tick anticoagulant peptide (TAP) aids fibrinolysis
Periodical: Blood Index Medicus:
Authors: Gruber A, Mori E, Change CM, del Zoppo GJ, Griffin JH ABS
Yr: 1992 Vol: 80 Nbr: Abs: Pg: 267a

Critical reevaluation of free protein S (PS) and C4B-binding protein (C4BP) levels and implications for thromotic risk
Periodical: Thrombosis and Haemostasis Index Medicus:
Authors: Griffin JH, Fernandez JA, Gruber A ABS
Yr: 1992 Vol: 65 Nbr: Abs: Pg: 195a

Generation of activated protein C during coronary thrombolysis in patients with myocardial infarction
Periodical: Thrombosis and Haemostasis Index Medicus:
Authors: Griffin JH, Fernandez JA, Pal A, Kiss RG, Sas G, Gruber A ABS
Yr: 1993 Vol: 69 Nbr: Abs: Pg: 1005a

Low circulating activated protein C levels in ischemic stroke
Periodical: Thrombosis and Haemostasis Index Medicus:
Authors: Macko RG, Gruber A, Griffin JH, et al ABS
Yr: 1993 Vol: 69 Nbr: Abs: Pg: 626a

Generation of activated protein C during thrombolysis
Periodical: Lancet Index Medicus:
Authors: Gruber A, Pal A, Kiss RG, Sas G, Griffin JH ART
Yr: 1993 Vol: 342 Nbr: 8882 Abs: Pg: 1275-1276

Facilitation of clot lysis with altered fibrin network due to activated protein C
Periodical: Blood Index Medicus:
Authors: Gruber A, Mori E, Heeb MJ, Zoppo GD, Chang CM, Griffin JH ART
Yr: 1993 Vol: Nbr: Abs: Pg:

Quantitation of circulating activated protein C (APC) in humans
Periodical: Thrombosis and Haemostasis Index Medicus:
Authors: Gruber A, Griffin JH ABS
Yr: 1991 Vol: 65 Nbr: Abs: Pg: 1119

Identification of alpha2-macroglobulin (alpha2M) and alpha2-antiplasmin (alpha2AP) as Ca++-dependent physiologic inhibitors of activated protein C (APC)
Periodical: Thrombosis and Haemostasis Index Medicus:
Authors: Heeb MJ, Gruber A, Griffin JH ABS
Yr: 1991 Vol: 65 Nbr: Abs: Pg: 781

Generation of both plasmin and activated protein C during thrombolytic therapy with streptokinase
Periodical: Blood Index Medicus:
Authors: Gruber A, Pal A, Kiss RG, Adtke KP, Sas G, Griffin JH ABS
Yr: 1993 Vol: 82 Nbr: Abs: Pg: 212a

Inhibition of plasminogen activator-dependent clot lysis by thrombomodulin
Periodical: Blood Index Medicus:
Authors: Gruber A, Griffin JH ABS
Yr: 1993 Vol: 82 Nbr: Abs: Pg: 280a