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Defensins and à2-macroglobulin in Lung Inflammation

Institution: University of California, Los Angeles
Investigator(s): Tomas Ganz, M.D., Ph.D.
Award Cycle: 1994 (Cycle 3) Grant #: 3RT-0015 Award: $316,269
Subject Area: Pulmonary Disease
Award Type: Research Project Awards
Abstracts
Publications

Alpha-2-macroglobulin binds defensins released by activated neutrophils
Periodical: American Review of Respiratory Disease Index Medicus:
Authors: Panyutich A, Ganz T ABS
Yr: 1993 Vol: 147 Nbr: Abs: Pg: A208

Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis
Periodical: Index Medicus:
Authors: Panyutich AV, Panyutich EA, Krapivin VA, Baturevich EA, Ganz T ART
Yr: 1993 Vol: 122 Nbr: 2 Abs: Pg: 202-207

C1-complement binds defensin in human blood
Periodical: Clinical Research Index Medicus:
Authors: Panyutich A, Szold O, Ganz T ART
Yr: 1994 Vol: Nbr: Abs: Pg:

Defensins reduce the barrier integrity of a cultured epithelial monolayer without cytotoxicity
Periodical: American Journal of Respiratory Cell and Molecular Biology Index Medicus:
Authors: Nygaard SD, Ganz T, Peterson MW ART
Yr: 1993 Vol: 8 Nbr: 2 Abs: Pg: 193-200

Identification of defensin binding to C1-complement
Periodical: FEBS Journal Index Medicus:
Authors: Panyutich AV, Szold O, Poon PH, Tseng Y, Ganz T ART
Yr: 1994 Vol: 356 Nbr: 2-3 Abs: Pg: 169-173

Human neutrophil defensin and serpins form complexes and inactive each other
Periodical: American Journal of Respiratory Cell and Molecular Biology Index Medicus:
Authors: Panyutich AV, Hiemstra PS, van Wetering S, Ganz T ART
Yr: 1995 Vol: 12 Nbr: 3 Abs: Pg: 351-357