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Role of aV Integrins in Malignancy of Tobacco/Induced Tumors

Institution: Scripps Research Institute
Investigator(s): David Cheresh, Ph.D.
Award Cycle: 1994 (Cycle 3) Grant #: 3RT-0061 Award: $485,909
Subject Area: Cancer
Award Type: Research Project Awards
Abstracts
Publications

A beta turn in the cytoplasmic tail of the integrin av subunit influences conformation and ligand binding of alphavbeta3
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Filardo EJ, Cheresh DA ART
Yr: 1994 Vol: 269 Nbr: 6 Abs: Pg: 4641-4647

Requirement of vascular integrin alphavbeta3 for angiogenesis
Periodical: Index Medicus:
Authors: Brooks PC, Clark RAF, Cheresh DA ART
Yr: 1994 Vol: 264 Nbr: 5158 Abs: Pg: 569-571

Integrin alphavbeta3 rescues melanoma cells from apoptosis in a three-dimensional collagen matrix
Periodical: Cell Index Medicus:
Authors: Montgomery AMP, Reisfield RA, Cheresh DA ART
Yr: 1994 Vol: Nbr: Abs: Pg:

Integrin alpha-v-beta-3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen
Periodical: Proceedings of the National Academy of Sciences of the United States of America Index Medicus:
Authors: Montgomery AMP, Reisfeld RA, Cheresh DA ART
Yr: 1994 Vol: 91 Nbr: 19 Abs: Pg: 8856-8860

Receptor tyrosine kinase signaling required for integrin alpha-v-beta-5-directed cell motility but not adhesion on vitronectin
Periodical: Journal of Cell Biology Index Medicus:
Authors: Klemke RL, Yebra M, Bayna EM, Cheresh DA ART
Yr: 1994 Vol: 127 Nbr: 3 Abs: Pg: 859-866

Integrin alpha-v-beta-3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
Periodical: Cell Index Medicus:
Authors: Brooks PC, Montgomery AMP, Rosenfeld M, et al ART
Yr: 1994 Vol: 79 Nbr: 7 Abs: Pg: 1157-1164

Inductin of carcinoma cell migration on vitronecti by NF-kappaB-dependent gene expression
Periodical: Molecular Biology of the Cell Index Medicus:
Authors: Yebra M, Filardo EJ, Bayna EM, Kawahara EM, Becker JC, Cheresh DA ART
Yr: 1995 Vol: 6 Nbr: 7 Abs: Pg: 841-850

Requirement of the NPXY Motif in the integrin beta-3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo
Periodical: Journal of Cell Biology Index Medicus:
Authors: Filardo EJ, Brooks PC, Deming SL, Damsky C, Cheresh DA ART
Yr: 1995 Vol: 130 Nbr: 2 Abs: Pg: 441-450