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Effects of Tobacco Smoke on Proto-Oncogene Activity

Institution: University of California, San Diego
Investigator(s): Michael Karin, Ph.D.
Award Cycle: 1994 (Cycle 3) Grant #: 3RT-0138 Award: $382,758
Subject Area: Cancer
Award Type: Research Project Awards

Identification of an oncoprotein- and UV- responsive protein kinase that binds and potentiates the c-Jun activation domain
Periodical: Genes and Development Index Medicus:
Authors: Hibi M, Lin A, Smeal T, Minden A, Karin M ART
Yr: 1993 Vol: 7 Nbr: 11 Abs: Pg: 2135-2148

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c_jun activation domain
Periodical: Cell Index Medicus:
Authors: Derijard B, Hibi M, Wu I-H, et al ART
Yr: 1994 Vol: 76 Nbr: 6 Abs: Pg: 1025-1037

JNK is involved in signal integration during costimulation of T lymphocytes
Periodical: Cell Index Medicus:
Authors: Su B, Jacinto E, Hibi M, Kallunki T, Karin M, Ben-Neriah Y ART
Yr: 1994 Vol: 77 Nbr: 5 Abs: Pg: 727-736

JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation
Periodical: Genes and Development Index Medicus:
Authors: Kallunki T, Su B, Tsigelny I, Sluss HK, et al ART
Yr: 1994 Vol: 8 Nbr: 24 Abs: Pg: 2996-3007

Induction of c-fos expression through JNK mediated TCF/Elk-1 phosphorylation
Periodical: Embo Journal Index Medicus:
Authors: Cavigelli M, Fabrizio D, Claret F-X, Karin M ART
Yr: 1995 Vol: Nbr: Abs: Pg:

c-fos transcriptional activity stimulated by Ha-Ras-activated protein kinase distinct from JNK and ERK
Periodical: Nature Index Medicus:
Authors: Deng T, Karin M ART
Yr: 1994 Vol: 371 Nbr: 6493 Abs: Pg: 171-175

Identification of a dual specificity kinase that activates the Jun kinases and p38-MpK2
Periodical: Science Index Medicus:
Authors: Lin A, Minden A, Martinetto H, et al ART
Yr: 1995 Vol: 268 Nbr: 5208 Abs: Pg: 286-290

Anti-tumor promotion by phenolic antioxidants: inhibition of AP-1 activity through induction of Fra expression
Periodical: Proceedings of the National Academy of Sciences of the United States of America Index Medicus:
Authors: Yoshioka K, Deng T, Cavigelli M, Karin M ART
Yr: 1995 Vol: 92 Nbr: 11 Abs: Pg: 4972-4976