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Supplement to tobacco disease in twins

Institution: University of Southern California
Investigator(s): Thomas Mack, M.D., M.P.H.
Award Cycle: 1999 (Cycle 8) Grant #: 8RT-0107H Award: $432,989
Subject Area: Epidemiology
Award Type: Research Project Awards
Abstracts

Initial Award Abstract
Observations on twin subjects can often provide the most exacting and conclusive measures of the health impact of personal choice as opposed to constitution or societal influence. Insufficient twin research in America has been brought to bear on the subject of tobacco use, because there are no convenient means of identifying representative twin subjects in quantity. We propose to complete the establishment of a roster of potential subjects who are simultaneously native Californians, twins, and current residents of California, and to characterize such individuals and pairs with respect to family history, medical history, and lifestyle, including the history of tobacco use for purposes of concurrent and subsequent study.

To date, about 20,000 individuals have been so characterized. We expect a complete registry to be comprised of well in excess of 65,000 well-documented individuals. When complete, this large and representative resource will be able to provide rosters of specifically chosen unique and compliant subjects for the study of all aspects of tobacco-related and other disease. Within the period of this grant we expect to begin a large comparison of the morbidity and mortality of twin smokers to their non-smoking twins. Other uses of the registry, separately proposed for support, address the personal reasons for initiating and quitting tobacco use, the genetic determinants of differences in phenotypic nicotine metabolism, the search for molecular and immunochemical measures of the residue of cumulative smoking, and the degree to which persons who take up smoking, in the presence of a family history of asthma or chronic obstructive pulmonary disease (both important tobacco-related diseases) place themselves by doing so at particularly high risk. Once established, researchers of various disciplines will be able to recruit subjects for many other analytic studies, including a wide variety of studies of tobacco-related conditions.

In addition, we will link the roster of known twins with the California Twin Registry and the California mortality files. This will allow us to identify pairs in which one death or one cancer case has occurred in order to quantify the strength of the relation between ever smoking and death/cancer when inheritance and early environment are held constant.
Publications

Representativeness of a roster of volunteer North American twins with chronic disease.
Periodical: Twin Research Index Medicus:
Authors: Mack TM, Deapen D, Hamilton AS ART
Yr: 2000 Vol: 3 Nbr: 1 Abs: Pg: 33-42

The occurrence of chronic disease and relevant exposure in a large population-based cohort of native Californian twins.
Periodical: Twin Research Index Medicus:
Authors: Cockburn M, Hamilton A, Zadnick J, Cozen W, Mack T ART
Yr: 2002 Vol: 5 Nbr: 5 Abs: Pg: 460-467

Further evidence for a strong genetic influence on the development of autoimmune thyroid disease: the California twin study.
Periodical: Twin Research Index Medicus:
Authors: Ringold DA, Nicoloff JT, Kessler M, Davis H, Hamilton A, Mack T ART
Yr: 2002 Vol: 12 Nbr: 8 Abs: Pg: 647-653

Prevalence of smoking and risk factors affecting smoking initiation and persistence in California twins.
Periodical: American Journal of Epidemiology Index Medicus:
Authors: Hamilton A, Cockburn M ART
Yr: 0 Vol: Nbr: Abs: Pg:

The simultaneous assessment of constitutional behavioral and environmental factors in the development of large nevi.
Periodical: American Journal of Epidemiology Index Medicus:
Authors: Cockburn M, Hamilton A, Mack T ART
Yr: 0 Vol: Nbr: Abs: Pg:

An estimate of physical activity prevalence in a large population-based cohort.
Periodical: Medicine and Science in Sports and Exercise Index Medicus:
Authors: Hawkins S, Cocburn M, Hamilton A, Mack T ART
Yr: 0 Vol: Nbr: Abs: Pg:

Development and representativeness of a large population-based cohort of native Californian twins.
Periodical: Twin Research Index Medicus:
Authors: Cockburn M, Hamilton A, Zadnick J, Cozen W, Mack T ABS
Yr: 2001 Vol: 4 Nbr: 4 Abs: Pg: 1-9

Effect of tobacco smoke on cytokines in twins.
Periodical: Twin Research Index Medicus:
Authors: Cozen W, Cockburn M, Gauderman J, Danley K, Stroud N, Mack T ABS
Yr: 2001 Vol: 4 Nbr: 3 Abs: Pg: 176

Susceptible HD cytokine phenotypes in twins.
Periodical: Twin Research Index Medicus:
Authors: Cozen W, Masood R, Gill P, Cockburn M, Gauderman J, Danley K, Stroud N, Mack T ABS
Yr: 2001 Vol: 4 Nbr: 3 Abs: Pg: 177

Factors related to smoking behavior and exposure in California twins.
Periodical: Twin Research Index Medicus:
Authors: Hamilton A, Cockburn M, Cozen W, Mack T ABS
Yr: 2001 Vol: 4 Nbr: 3 Abs: Pg: 185