Nicotine self-administration in an animal model
Abstracts
Initial Award Abstract |
|
Introduction and Objective: Tobacco addiction is a major health problem in the United States and the world with estimates of over 47 million current American smokers. Tobacco smoking is the leading, avoidable cause of disease and premature death in the U.S. It is estimated that more than 430,000 smoking-related deaths occur annually in the United States, and the economic costs are substantial, totaling over $138 billion in 1995. A critical question in the neurobiology of dependence on nicotine is what conveys the vulnerability to use tobacco products and the vulnerability to the transition from tobacco use to dependence. However this question is difficult to approach given that there are few animal models available to explore the transition from tobacco use to tobacco dependence from a motivational perspective.
Progress: Work from the first funding period characterized our model of unlimited access nicotine self-administration using 23-hour access to the drug and the transition to a dependent state. Dose-dependent alterations in the pattern nicotine self-administration, extinction of nicotine-seeking behavior, dependence measures, and changes in the pattern of responding for food and water are being characterized. Subsequent studies demonstrating that rats challenged with the nicotinic antagonist mecamylamine exhibit changes in nicotine intake have begun to validate our model.
Impact: Work from this funding period has provided us with a reliable dependence model and new avenues of research that will serve as exciting resources for exploring in future studies the neurobiological changes that convey vulnerability to the development of dependence in certain individuals. |
Publications
| Neurobiological mechanisms in the transition from drug use to drug dependence. |
| Periodical: Neuroscience Biobehavior |
Index Medicus: |
| Authors: Koob GF, Ahmed SH, Boutrel B, Chen SA, Kenny PJ, Markou A, O'Dell LE, et al. |
ART |
| Yr: 2004 |
Vol: 27 |
Nbr: |
Abs: |
Pg: 739-749 |
| Nicotine withdrawal in adolescent and adult rats. |
| Periodical: Annals of the New York Academy of Sciences |
Index Medicus: |
| Authors: O'Dell LE, Bruijnzeel AW, Ghozland S, Markou A, Koob GF |
ART |
| Yr: 0 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Characterization of nicotine intake, extinction, and precipitated withdrawal using 23-hr access to nicotine self-administration in rats. |
| Periodical: TRDRP Annual Report to the State of California Legislature |
Index Medicus: |
| Authors: O'Dell LE, Chen SA, Paterson NE, Markou A, Balster RL, Koob GF |
ABS |
| Yr: 2003 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Adolescent rats are less susceptible to nicotine withdrawal signs relative to their adult counterparts. |
| Periodical: College on Problems of Drug Dependence |
Index Medicus: |
| Authors: O'Dell LE, Bruijnzeel AW, Markou A, Koob GF |
ABS |
| Yr: 2004 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Metabotropic Glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self -administration but not nicotine and cocaine-induced facilitation of brain reward function in rats |
| Periodical: Annals of the New York Academy of Sciences |
Index Medicus: |
| Authors: Kenny, P.J., Paterson N.E., Boutrel B, Semenova S., Harrison A.A., Gasparini, F. , Koob G. |
ART |
| Yr: 2003 |
Vol: |
Nbr: |
Abs: |
Pg: 415-418 |
| Nicotine withdrawal in adolescent and adult rats |
| Periodical: Annals of the New York Academy of Sciences |
Index Medicus: |
| Authors: O'dell, L.E. Bruijnzee;, AW., Ghozland ,S. Markou, A and Koob, G.F. |
ART |
| Yr: 2004 |
Vol: |
Nbr: |
Abs: |
Pg: 167-174 |
| Investigations using immunization to attenuate the psychoactive effects of nicotine |
| Periodical: Bioorganic Medical Chemistry |
Index Medicus: |
| Authors: Carrera, M.R.A. , Ashley, J. A., Hoffman , T. Z., Isomura S., Wirsching, P. Koob, G.F. |
ART |
| Yr: 2004 |
Vol: |
Nbr: |
Abs: |
Pg: 563-570 |
| Monoamine Oxidase inhibition dramatically increases the motivation to self-administer nicotine in rats |
| Periodical: Journal of Neuroscience |
Index Medicus: |
| Authors: Guillem K, Vouillac C., Azar, MR., Parsons., L.H., Koob, G.F. Cador , M. and Stinus |
ART |
| Yr: 2005 |
Vol: |
Nbr: |
Abs: |
Pg: 8593-8600 |
| Diminished nicotine withdrawal in adolescent rats implications for vulnerability to addicition |
| Periodical: Psychopharmacology |
Index Medicus: |
| Authors: O'Dell, L.E., Bruijnzeel, A.W., Smith R.T., Parsons, L.H. Merves, M.L., Koob G.F. |
ART |
| Yr: 2006 |
Vol: 186 |
Nbr: |
Abs: |
Pg: 612-619 |
| MAO-A and MAO-B inhibition on nicotine self -administration in rats |
| Periodical: European Journal of Neuroscience |
Index Medicus: |
| Authors: Guillem, K., Vouillac, C., Azar, M.R. , Parsons , L.H., Koob, G.F., |
ART |
| Yr: 0 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Neurobiological mechanisms in the transition from drug use to drug dependence. |
| Periodical: Neuroscience Biobehavior |
Index Medicus: |
| Authors: Koob GF, Ahmed SH, Boutrel B, Chen SA, Kenny PJ, Markou A, O'Dell LE, et al. |
ART |
| Yr: 2004 |
Vol: 27 |
Nbr: |
Abs: |
Pg: 739-749 |
| Nicotine withdrawal in adolescent and adult rats. |
| Periodical: Annals of the New York Academy of Sciences |
Index Medicus: |
| Authors: O'Dell LE, Bruijnzeel AW, Ghozland S, Markou A, Koob GF |
ART |
| Yr: 0 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Characterization of nicotine intake, extinction, and precipitated withdrawal using 23-hr access to nicotine self-administration in rats. |
| Periodical: TRDRP Annual Report to the State of California Legislature |
Index Medicus: |
| Authors: O'Dell LE, Chen SA, Paterson NE, Markou A, Balster RL, Koob GF |
ABS |
| Yr: 2003 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Adolescent rats are less susceptible to nicotine withdrawal signs relative to their adult counterparts. |
| Periodical: College on Problems of Drug Dependence |
Index Medicus: |
| Authors: O'Dell LE, Bruijnzeel AW, Markou A, Koob GF |
ABS |
| Yr: 2004 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Metabotropic Glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self -administration but not nicotine and cocaine-induced facilitation of brain reward function in rats |
| Periodical: Annals of the New York Academy of Sciences |
Index Medicus: |
| Authors: Kenny, P.J., Paterson N.E., Boutrel B, Semenova S., Harrison A.A., Gasparini, F. , Koob G. |
ART |
| Yr: 2003 |
Vol: |
Nbr: |
Abs: |
Pg: 415-418 |
| Nicotine withdrawal in adolescent and adult rats |
| Periodical: Annals of the New York Academy of Sciences |
Index Medicus: |
| Authors: O'dell, L.E. Bruijnzee;, AW., Ghozland ,S. Markou, A and Koob, G.F. |
ART |
| Yr: 2004 |
Vol: |
Nbr: |
Abs: |
Pg: 167-174 |
| Investigations using immunization to attenuate the psychoactive effects of nicotine |
| Periodical: Bioorganic Medical Chemistry |
Index Medicus: |
| Authors: Carrera, M.R.A. , Ashley, J. A., Hoffman , T. Z., Isomura S., Wirsching, P. Koob, G.F. |
ART |
| Yr: 2004 |
Vol: |
Nbr: |
Abs: |
Pg: 563-570 |
| Monoamine Oxidase inhibition dramatically increases the motivation to self-administer nicotine in rats |
| Periodical: Journal of Neuroscience |
Index Medicus: |
| Authors: Guillem K, Vouillac C., Azar, MR., Parsons., L.H., Koob, G.F. Cador , M. and Stinus |
ART |
| Yr: 2005 |
Vol: |
Nbr: |
Abs: |
Pg: 8593-8600 |
| Diminished nicotine withdrawal in adolescent rats implications for vulnerability to addicition |
| Periodical: Psychopharmacology |
Index Medicus: |
| Authors: O'Dell, L.E., Bruijnzeel, A.W., Smith R.T., Parsons, L.H. Merves, M.L., Koob G.F. |
ART |
| Yr: 2006 |
Vol: 186 |
Nbr: |
Abs: |
Pg: 612-619 |
| MAO-A and MAO-B inhibition on nicotine self -administration in rats |
| Periodical: European Journal of Neuroscience |
Index Medicus: |
| Authors: Guillem, K., Vouillac, C., Azar, M.R. , Parsons , L.H., Koob, G.F., |
ART |
| Yr: 0 |
Vol: |
Nbr: |
Abs: |
Pg: |
