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Impacts of Thirdhand Smoke on Public Health

Institution: University of California, San Francisco
Investigator(s): Neal Benowitz, M.D.
Award Cycle: 2014 (Cycle 23) Grant #: 23PT-0013 Award: $2,458,143
Subject Area: Environmental Exposure/Toxicology
Award Type: Integrated Research Project
Abstracts

Initial Award Abstract

Thirdhand tobacco smoke (THS) refers to tobacco smoke residues in indoor environments that remain, react and/or re-emit from materials and/or re-suspend from surfaces (dust). THS is a new concept in the field of tobacco control and an advance in the field of toxicology. The concept of THS as a distinct entity that poses health risks for children and adults has emerged over the last decade. The long-term goals of the California Consortium on Thirdhand Smoke are to identify the health effects of exposure to THS, to develop environmental indicators and biomarkers of exposure to THS, and to devise and disseminate evidence-based policies to prevent and remediate such exposures. The California Consortium on Thirdhand Smoke includes researchers at Lawrence Berkeley National Laboratory, the University of California’s campuses in San Francisco and Riverside, San Diego State University and the University of Southern California, all of whom have developed strong collaborative links since working together from the first phase of the Consortium in 2010.

The specific aims and objectives of the proposed research are to:

1. Chemically characterize THS in order to identify potentially hazardous or toxic constituents that may be present in THS.

2. Characterize relevant and specific biomarkers that could serve as diagnostic indicators of exposure and demonstrate quantitation of human exposure levels to THS.

3. Provide scientific evidence either for or against clear and significant health risks to humans as a result of exposure to THS.

4. Design an evidence-based approach to THS exposure risk policies, policy implications and issues.

5. Disseminate any evidence related to the health risks of THS to the California tobacco control stakeholders as well as to the general public, including any recommendations on potential approaches to risk elimination.

Publications

A health threat to bystanders living in the homes of smokers: How smoke toxins deposited on surfaces can cause insulin resistance
Periodical: PLOS One Index Medicus:
Authors: Adhami, Neema, Shelley R. Starck, Cristina Flores, Manuela Martins Green ART
Yr: 2016 Vol: Nbr: DOI10.1371 Abs: Pg: 0149510

Thirdhand smoke: Chemical dynamics, cytotoxicity, and genotoxicity in outdoor and indoor environments
Periodical: Toxicology In Vitro Index Medicus:
Authors: Bahl V, Shim HJ, Jacob P 3rd, Dias K, Schick SF, Talbot P. ART
Yr: 2016 Vol: 32 Nbr: Abs: Pg: 220-31

Cytotoxicity of thirdhand smoke and Identification of acrolein as a volatile thirdhand smoke chemical that inhibits cell roliferation
Periodical: Toxicological Sciences Index Medicus:
Authors: Bahl, V., Weng, N., Schick, S., Sleiman, M., Whitehead, J. Ibarra, A., and P. Talbot ART
Yr: 2016 Vol: 150 Nbr: Abs: Pg: 234-246

Thirdhand smoke causes stress-induced hyperfusion and alters transcriptional profile of stem cells
Periodical: Toxicological Sciences Index Medicus:
Authors: Bahl V, Johnson K, Phandthong R, Zahedi A, Schick SF, Talbot T ART
Yr: 2016 Vol: 153 Nbr: 1 Abs: Pg: 55-69

THS Toxins Induce Hepatic Steatosis by Altering Oxidative Stress and SIRT1 Levels
Periodical: Journal of Clinical Toxicology Index Medicus:
Authors: Flores C, Adhami N, Martins-Green M ART
Yr: 2016 Vol: 6 Nbr: Abs: Pg: 318

Early exposure to thirdhand cigarette smoke affects body mass and the_x000D_ development of immunity in mice
Periodical: Scientific Reports Index Medicus:
Authors: Hang B, A. M. Snijders, Huang Y, Schick SF, Wang P, Xia Y, Havel C, Jacob III P, Benowitz ART
Yr: Vol: Nbr: Abs: Pg:

Thirdhand Smoke: New Evidence, Challenges, and Future Directions
Periodical: Chemical Research in Toxicology Index Medicus:
Authors: Jacob III PD, Benowitz NL, Destaillats H, Gundel LA, Hang B, Martins-Green M, Matt GE, Qui ART
Yr: Vol: Nbr: Abs: Pg:

Thirdhand smoke contamination in hospital settings: assessing exposure risk for vulnerable paediatric patients
Periodical: Tobacco Control Index Medicus:
Authors: Northrup TF, M Khan AM, Peyton Jacob III P, Benowitz NL, Hoh E, Hovell MF, Matt GE, AL Sto ART
Yr: 2015 Vol: Nbr: Abs: Pg: 052506

Thirdhand Smoke: State of the Science and a Call for Policy Expansion
Periodical: Public Health Reports Index Medicus:
Authors: Northrup TF, Jacob P 3rd, Benowitz NL, Hoh E, Quintana PJ, Hovell MF, Matt GE, Stotts AL ART
Yr: 2016 Vol: 131 Nbr: Abs: Pg: 233-8

Evaluating cell processes, quality, and biomarkers in pluripotent stem cells using video bioinformatics
Periodical: PLOS One Index Medicus:
Authors: Zahedi, A., On, V., Lin, S., Bays, B., Omaiye, E., Bhanu, B., and P. Talbot ART
Yr: 2016 Vol: 10.1371 Nbr: Abs: Pg: 0148642

A health threat to bystanders living in the homes of smokers: How smoke toxins deposited on surfaces can cause insulin resistance
Periodical: PLOS One Index Medicus:
Authors: Adhami, Neema, Shelley R. Starck, Cristina Flores, Manuela Martins Green ART
Yr: 2016 Vol: Nbr: DOI10.1371 Abs: Pg: 0149510

Thirdhand smoke: Chemical dynamics, cytotoxicity, and genotoxicity in outdoor and indoor environments
Periodical: Toxicology In Vitro Index Medicus:
Authors: Bahl V, Shim HJ, Jacob P 3rd, Dias K, Schick SF, Talbot P. ART
Yr: 2016 Vol: 32 Nbr: Abs: Pg: 220-31

Cytotoxicity of thirdhand smoke and Identification of acrolein as a volatile thirdhand smoke chemical that inhibits cell roliferation
Periodical: Toxicological Sciences Index Medicus:
Authors: Bahl, V., Weng, N., Schick, S., Sleiman, M., Whitehead, J. Ibarra, A., and P. Talbot ART
Yr: 2016 Vol: 150 Nbr: Abs: Pg: 234-246

Thirdhand smoke causes stress-induced hyperfusion and alters transcriptional profile of stem cells
Periodical: Toxicological Sciences Index Medicus:
Authors: Bahl V, Johnson K, Phandthong R, Zahedi A, Schick SF, Talbot T ART
Yr: 2016 Vol: 153 Nbr: 1 Abs: Pg: 55-69

THS Toxins Induce Hepatic Steatosis by Altering Oxidative Stress and SIRT1 Levels
Periodical: Journal of Clinical Toxicology Index Medicus:
Authors: Flores C, Adhami N, Martins-Green M ART
Yr: 2016 Vol: 6 Nbr: Abs: Pg: 318

Early exposure to thirdhand cigarette smoke affects body mass and the_x000D_ development of immunity in mice
Periodical: Scientific Reports Index Medicus:
Authors: Hang B, A. M. Snijders, Huang Y, Schick SF, Wang P, Xia Y, Havel C, Jacob III P, Benowitz ART
Yr: Vol: Nbr: Abs: Pg:

Thirdhand Smoke: New Evidence, Challenges, and Future Directions
Periodical: Chemical Research in Toxicology Index Medicus:
Authors: Jacob III PD, Benowitz NL, Destaillats H, Gundel LA, Hang B, Martins-Green M, Matt GE, Qui ART
Yr: Vol: Nbr: Abs: Pg:

Thirdhand smoke contamination in hospital settings: assessing exposure risk for vulnerable paediatric patients
Periodical: Tobacco Control Index Medicus:
Authors: Northrup TF, M Khan AM, Peyton Jacob III P, Benowitz NL, Hoh E, Hovell MF, Matt GE, AL Sto ART
Yr: 2015 Vol: Nbr: Abs: Pg: 052506

Thirdhand Smoke: State of the Science and a Call for Policy Expansion
Periodical: Public Health Reports Index Medicus:
Authors: Northrup TF, Jacob P 3rd, Benowitz NL, Hoh E, Quintana PJ, Hovell MF, Matt GE, Stotts AL ART
Yr: 2016 Vol: 131 Nbr: Abs: Pg: 233-8

Evaluating cell processes, quality, and biomarkers in pluripotent stem cells using video bioinformatics
Periodical: PLOS One Index Medicus:
Authors: Zahedi, A., On, V., Lin, S., Bays, B., Omaiye, E., Bhanu, B., and P. Talbot ART
Yr: 2016 Vol: 10.1371 Nbr: Abs: Pg: 0148642