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Structure-Function Correlations for Ras p21 and its Mutants

Institution: University of Southern California
Investigator(s): Arieh Warshel, Ph.D.
Award Cycle: 1995 (Cycle 4) Grant #: 4RT-0002 Award: $322,049
Subject Area: Cancer
Award Type: Research Project Awards
Abstracts
Publications

Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins
Periodical: Nature Structural Biology Index Medicus:
Authors: Schweins T, Geyer M, Scheffzek K, et al ART
Yr: 1995 Vol: 2 Nbr: 1 Abs: Pg: 36-44

Electrostatic control of GTP and GDP binding in the oncoprotein p21 ras
Periodical: Structure Index Medicus:
Authors: Muegge I, Schweins T, Langen R, Warshel A ART
Yr: 1996 Vol: 4 Nbr: Abs: Pg: 475-489

Mechanistic analysis of the observed linear free energy relationships in p21ras and related system
Periodical: Biochemistry Index Medicus:
Authors: Schweins T, Warshel A ART
Yr: 1996 Vol: 35 Nbr: Abs: Pg: 14232

Linear free energy relationships in the intrinsic and GTPase activating protein-stimulated guanosine 5'-triphosphate hydrolysis of p21ras
Periodical: Biochemistry Index Medicus:
Authors: Schweins T, Geyer M, Kalbitzer HR, et al ART
Yr: 1996 Vol: 35 Nbr: Abs: Pg: 14225

A fundamental assumption about OH- attack in phosphate hydrolysis is not fully justified
Periodical: Journal of the American Chemistry Society Index Medicus:
Authors: Florian J, Warshel A ART
Yr: 1997 Vol: 119 Nbr: Abs: Pg: 5473

The role of the metal ion in the p21 ras catalyzedGTP-hydrolysis: Mn2+ versus Mg2+
Periodical: Journal of Molecular Biology Index Medicus:
Authors: Schweins T, Scheffzek K, Assheuer R, Wittinghofer A ART
Yr: 1997 Vol: 266 Nbr: Abs: Pg: 847

Electrostatic contributions to protein-protein binding affinities: application to Rap/Raf interaction
Periodical: Proteins : Structure, Function, and Genetics Index Medicus:
Authors: Muegge I, Schweins T, Warshel A ART
Yr: 1998 Vol: 30 Nbr: Abs: Pg: 407

Phosphate ester hydrolysis in aqueous solution: associative versus dissociative mechanisms
Periodical: Journal of Chemical Physics Index Medicus:
Authors: Florian J, Warshel A ART
Yr: 1998 Vol: 102 Nbr: Abs: Pg: 719-734