Research Portfolio

Search by: Title Institution Investigator Cycle Award Type Research Priority

Funding Opportunities

Call for Applications

Join our Mailing List

Join our mailing list to be notified of new funding opportunities. Your Email To receive information about funding opportunities, events, and program updates.

Benzo[a]pyrene: Biogenetic Effects on Hepatocytes in Vitro

Institution:	University of California, San Diego
Investigator(s):	Hyam Leffert, M.D.
Award Cycle:	1995 (Cycle 4)	Grant #: 4RT-0076	Award: $321,199
Subject Area:	Cancer
Award Type:	Research Project Awards

---

Inactivation of plasmid reporter gene expression by one benzo(a)pyrene diol-epoxide DNA adduct in adult rat hepatocytes
Periodical: Cancer Research			Index Medicus:
Authors: Koch KS, Fletcher RG, Grond MP, et al				ART
Yr: 1993	Vol: 53	Nbr: 10	Abs:	Pg: 2279-2286

---

Chemical hepatocarcinogenesis: inactivation of plasmid gene expression by one benzo[a]pyrene diol epoxide DNA adduct in primary adult rat hepatocyte cultures and novel gene targeting approaches
Periodical: Cold Spring Harbor Symposium on Quantitative Biology			Index Medicus:
Authors: Koch KS, Grond M, Fletcher RG, Gleiberman AS, Leffert HL				ABS
Yr: 1993	Vol:	Nbr:	Abs:	Pg: 93

---

Retroviral vector transduction, DNA mediated transfection and cellular transplantation studies with primary cultures of adult and fetal rat hepatocytes
Periodical: Cold Spring Harbor Symposium on Quantitative Biology			Index Medicus:
Authors: Koch KS, Leffert HL				ABS
Yr: 1993	Vol:	Nbr:	Abs:	Pg: 136

---

A 43 base-pair complementary DNA sequence homology and triplet motif among putative polymeric immunoglobulin receptor messenger RNAs in regenerating liver
Periodical: Hepatology			Index Medicus:
Authors: Koch KS, Fletcher RG, Grond MP, Leffert HL				ART
Yr: 1993	Vol: 18	Nbr: 1	Abs:	Pg: 226-228

---

Mitogen function, cyclin mRNA cascades and p32/p33 cdk2 and p33/p34 cdc2 kinase expression during rat liver regeneration
Periodical: Cold Spring Harbor Symposium on Quantitative Biology			Index Medicus:
Authors: Koch KS, Fletcher RG, Grond MP, Leffert HL				ABS
Yr: 1993	Vol:	Nbr:	Abs:	Pg: 135

---

Hepatic regeneration and gene expression. A tribute to Hidematsu Hirai
Periodical: Journal of Tumor Marker Oncology			Index Medicus:
Authors: Koch KS, Leffert HL				ART
Yr: 1994	Vol: 9	Nbr: 1	Abs:	Pg: 35-36

---

Primary rat hepatocytes express cyclin D1 messenger RNA during their growth cycle and during mitogenic transitions induced by transforming growth factor-alpha
Periodical: Biochemistry and Biophysics Research Communications			Index Medicus:
Authors: Koch KS, Lu XP, Leffert HL				ART
Yr: 1994	Vol: 204	Nbr: 1	Abs:	Pg: 91-97

---

Activation of Jun kinase is an early event in hepatic regeneration
Periodical: Journal of Clinical Investigation			Index Medicus:
Authors: Westwick J, Weitzel C, Leffert HL, Brenner DA				ART
Yr: 1995	Vol: 95	Nbr: 2	Abs:	Pg: 803-810

---

Discordant expression and variable numbers of neighboring GGA- and GAA-rich triplet repeats in the 3' untranslated regions of two groups of messenger RNAs encoded by the rat polymeric immunoglobulin receptor gene
Periodical: Nucleic Acids Research			Index Medicus:
Authors: Koch KS, Gleiberman AG, Aoki T, et al				ART
Yr: 1995	Vol: 23	Nbr: 7	Abs:	Pg: 1098-1112

---

Construction of a fusion protein between protein A and green fluorescent protein and its application to Western blotting
Periodical: FEBS Journal			Index Medicus:
Authors: Aoki T, Takahashi Y, Koch KS, Leffert HL, Watabe H				ART
Yr: 1996	Vol: 384	Nbr: 2	Abs:	Pg: 193-197

---

Attenuation of gene expression by a trinucleotide repeat-rich tract from the terminal exon of the rat hepatic polymeric immunoglobulin receptor gene
Periodical: Journal of Molecular Biology			Index Medicus:
Authors: Aoki T, Koch KS, Leffert HL				ART
Yr: 1997	Vol: 267	Nbr:	Abs:	Pg: 229-236

---

Inactivation of plasmid reporter gene expression by one benzo(a)pyrene diol-epoxide DNA adduct in adult rat hepatocytes
Periodical: Cancer Research			Index Medicus:
Authors: Koch KS, Fletcher RG, Grond MP, et al				ART
Yr: 1993	Vol: 53	Nbr: 10	Abs:	Pg: 2279-2286

---

Chemical hepatocarcinogenesis: inactivation of plasmid gene expression by one benzo[a]pyrene diol epoxide DNA adduct in primary adult rat hepatocyte cultures and novel gene targeting approaches
Periodical: Cold Spring Harbor Symposium on Quantitative Biology			Index Medicus:
Authors: Koch KS, Grond M, Fletcher RG, Gleiberman AS, Leffert HL				ABS
Yr: 1993	Vol:	Nbr:	Abs:	Pg: 93

---

Retroviral vector transduction, DNA mediated transfection and cellular transplantation studies with primary cultures of adult and fetal rat hepatocytes
Periodical: Cold Spring Harbor Symposium on Quantitative Biology			Index Medicus:
Authors: Koch KS, Leffert HL				ABS
Yr: 1993	Vol:	Nbr:	Abs:	Pg: 136

---

A 43 base-pair complementary DNA sequence homology and triplet motif among putative polymeric immunoglobulin receptor messenger RNAs in regenerating liver
Periodical: Hepatology			Index Medicus:
Authors: Koch KS, Fletcher RG, Grond MP, Leffert HL				ART
Yr: 1993	Vol: 18	Nbr: 1	Abs:	Pg: 226-228

---

Mitogen function, cyclin mRNA cascades and p32/p33 cdk2 and p33/p34 cdc2 kinase expression during rat liver regeneration
Periodical: Cold Spring Harbor Symposium on Quantitative Biology			Index Medicus:
Authors: Koch KS, Fletcher RG, Grond MP, Leffert HL				ABS
Yr: 1993	Vol:	Nbr:	Abs:	Pg: 135

---

Hepatic regeneration and gene expression. A tribute to Hidematsu Hirai
Periodical: Journal of Tumor Marker Oncology			Index Medicus:
Authors: Koch KS, Leffert HL				ART
Yr: 1994	Vol: 9	Nbr: 1	Abs:	Pg: 35-36

---

Primary rat hepatocytes express cyclin D1 messenger RNA during their growth cycle and during mitogenic transitions induced by transforming growth factor-alpha
Periodical: Biochemistry and Biophysics Research Communications			Index Medicus:
Authors: Koch KS, Lu XP, Leffert HL				ART
Yr: 1994	Vol: 204	Nbr: 1	Abs:	Pg: 91-97

---

Activation of Jun kinase is an early event in hepatic regeneration
Periodical: Journal of Clinical Investigation			Index Medicus:
Authors: Westwick J, Weitzel C, Leffert HL, Brenner DA				ART
Yr: 1995	Vol: 95	Nbr: 2	Abs:	Pg: 803-810

---

Discordant expression and variable numbers of neighboring GGA- and GAA-rich triplet repeats in the 3' untranslated regions of two groups of messenger RNAs encoded by the rat polymeric immunoglobulin receptor gene
Periodical: Nucleic Acids Research			Index Medicus:
Authors: Koch KS, Gleiberman AG, Aoki T, et al				ART
Yr: 1995	Vol: 23	Nbr: 7	Abs:	Pg: 1098-1112

---

Construction of a fusion protein between protein A and green fluorescent protein and its application to Western blotting
Periodical: FEBS Journal			Index Medicus:
Authors: Aoki T, Takahashi Y, Koch KS, Leffert HL, Watabe H				ART
Yr: 1996	Vol: 384	Nbr: 2	Abs:	Pg: 193-197

---

Attenuation of gene expression by a trinucleotide repeat-rich tract from the terminal exon of the rat hepatic polymeric immunoglobulin receptor gene
Periodical: Journal of Molecular Biology			Index Medicus:
Authors: Aoki T, Koch KS, Leffert HL				ART
Yr: 1997	Vol: 267	Nbr:	Abs:	Pg: 229-236

---