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Benzo[a]pyrene: Biogenetic Effects on Hepatocytes in Vitro

Institution: University of California, San Diego
Investigator(s): Hyam Leffert, M.D.
Award Cycle: 1995 (Cycle 4) Grant #: 4RT-0076 Award: $321,199
Subject Area: Cancer
Award Type: Research Project Awards
Abstracts
Publications

Inactivation of plasmid reporter gene expression by one benzo(a)pyrene diol-epoxide DNA adduct in adult rat hepatocytes
Periodical: Cancer Research Index Medicus:
Authors: Koch KS, Fletcher RG, Grond MP, et al ART
Yr: 1993 Vol: 53 Nbr: 10 Abs: Pg: 2279-2286

Chemical hepatocarcinogenesis: inactivation of plasmid gene expression by one benzo[a]pyrene diol epoxide DNA adduct in primary adult rat hepatocyte cultures and novel gene targeting approaches
Periodical: Cold Spring Harbor Symposium on Quantitative Biology Index Medicus:
Authors: Koch KS, Grond M, Fletcher RG, Gleiberman AS, Leffert HL ABS
Yr: 1993 Vol: Nbr: Abs: Pg: 93

Retroviral vector transduction, DNA mediated transfection and cellular transplantation studies with primary cultures of adult and fetal rat hepatocytes
Periodical: Cold Spring Harbor Symposium on Quantitative Biology Index Medicus:
Authors: Koch KS, Leffert HL ABS
Yr: 1993 Vol: Nbr: Abs: Pg: 136

A 43 base-pair complementary DNA sequence homology and triplet motif among putative polymeric immunoglobulin receptor messenger RNAs in regenerating liver
Periodical: Hepatology Index Medicus:
Authors: Koch KS, Fletcher RG, Grond MP, Leffert HL ART
Yr: 1993 Vol: 18 Nbr: 1 Abs: Pg: 226-228

Mitogen function, cyclin mRNA cascades and p32/p33 cdk2 and p33/p34 cdc2 kinase expression during rat liver regeneration
Periodical: Cold Spring Harbor Symposium on Quantitative Biology Index Medicus:
Authors: Koch KS, Fletcher RG, Grond MP, Leffert HL ABS
Yr: 1993 Vol: Nbr: Abs: Pg: 135

Hepatic regeneration and gene expression. A tribute to Hidematsu Hirai
Periodical: Journal of Tumor Marker Oncology Index Medicus:
Authors: Koch KS, Leffert HL ART
Yr: 1994 Vol: 9 Nbr: 1 Abs: Pg: 35-36

Primary rat hepatocytes express cyclin D1 messenger RNA during their growth cycle and during mitogenic transitions induced by transforming growth factor-alpha
Periodical: Biochemistry and Biophysics Research Communications Index Medicus:
Authors: Koch KS, Lu XP, Leffert HL ART
Yr: 1994 Vol: 204 Nbr: 1 Abs: Pg: 91-97

Activation of Jun kinase is an early event in hepatic regeneration
Periodical: Journal of Clinical Investigation Index Medicus:
Authors: Westwick J, Weitzel C, Leffert HL, Brenner DA ART
Yr: 1995 Vol: 95 Nbr: 2 Abs: Pg: 803-810

Discordant expression and variable numbers of neighboring GGA- and GAA-rich triplet repeats in the 3' untranslated regions of two groups of messenger RNAs encoded by the rat polymeric immunoglobulin receptor gene
Periodical: Nucleic Acids Research Index Medicus:
Authors: Koch KS, Gleiberman AG, Aoki T, et al ART
Yr: 1995 Vol: 23 Nbr: 7 Abs: Pg: 1098-1112

Construction of a fusion protein between protein A and green fluorescent protein and its application to Western blotting
Periodical: FEBS Journal Index Medicus:
Authors: Aoki T, Takahashi Y, Koch KS, Leffert HL, Watabe H ART
Yr: 1996 Vol: 384 Nbr: 2 Abs: Pg: 193-197

Attenuation of gene expression by a trinucleotide repeat-rich tract from the terminal exon of the rat hepatic polymeric immunoglobulin receptor gene
Periodical: Journal of Molecular Biology Index Medicus:
Authors: Aoki T, Koch KS, Leffert HL ART
Yr: 1997 Vol: 267 Nbr: Abs: Pg: 229-236