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The Dopamine D2 Receptor in Nicotine Addiction

Institution:	City of Hope National Medical Center
Investigator(s):	David Comings, M.D.
Award Cycle:	1995 (Cycle 4)	Grant #: 4RT-0110	Award: $304,790
Subject Area:	General Biomedical Science
Award Type:	Research Project Awards

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Dopamine D2 receptor gene variants: association and linkage studies in impulsive-addictive-compulsive behaviors
Periodical: Pharmacogenetics			Index Medicus:
Authors: Blum K, Sheridan PJ, Wood RC, Braverman ER, Chen TJH, Comings DE				ART
Yr: 1995	Vol: 5	Nbr: 3	Abs:	Pg: 121-141

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The Dopamine D2 receptor (DRD2) gene: a genetic risk factor in smoking
Periodical: Pharmacogenetics			Index Medicus:
Authors: Comings DE, Ferry L, Bradshaw-Robinson S, et al				ART
Yr: 1996	Vol: 6	Nbr: 1	Abs:	Pg: 73-79

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Reward deficiency syndrome
Periodical: American Scientist			Index Medicus:
Authors: Blum K, Cull JG, Braverman ER, Commings DE				ART
Yr: 1996	Vol: 84	Nbr: 2	Abs:	Pg: 132-145

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Sequence of human tryptophan 2,3-dioxygenase (TDO2): presence of a glucocorticoid response-like element composed of a GTT repeat and an intronic CCCCT repeat
Periodical: Genomics			Index Medicus:
Authors: Comings DE, Muhleman D, Dieta G, Sherman M, Forest GL				ART
Yr: 1995	Vol: 29	Nbr: 2	Abs:	Pg: 390-396

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Tourette syndrome: a hereditary neuropsyhciatric spectrum disorder
Periodical: Annals of Clinical Psychiatry			Index Medicus:
Authors: Comings DE				ART
Yr: 1994	Vol: 6	Nbr: 4	Abs:	Pg: 235-245

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A study of the dopamine D2 receptor gene in pathological gambling
Periodical: Pharmacogenetics			Index Medicus:
Authors: Comings DE, Rosenthal RJ, Lesieur HR, et al				ART
Yr: 1996	Vol: 6	Nbr:	Abs:	Pg: 223-234

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Polygenic inheritance of Tourette syndrome, stuttering, attention deficit hyperactivity, conduct, and oppositional defiant disorder
Periodical: American Journal of Medical Genetics			Index Medicus:
Authors: Comings DE, Wu S, Chiu C, et al				ART
Yr: 1996	Vol: 67	Nbr: 3	Abs:	Pg: 264-288

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Exon and intron variants in the human trypophan 2,2-dioxygenase gene: potential association with Tourette syndrome, substance abuse and other disorders
Periodical: Pharmacogenetics			Index Medicus:
Authors: Comings DE				ART
Yr: 1996	Vol:	Nbr: 6	Abs:	Pg:

---

The molecular genetics of pathological gambing
Periodical: CNS Spectrums			Index Medicus:
Authors: Coming, DE				ART
Yr: 1998	Vol:	Nbr:	Abs:	Pg:

---

Exon & intron variants in the human tryptophan 2.3-dioxygenase gene: potential association with Tourette Syndrome, substance abuse & other disorders
Periodical: Pharmacogenetics			Index Medicus:
Authors: Comings DE, et al				ART
Yr: 1996	Vol:	Nbr:	Abs:	Pg: 6,307-6318

---

Correlation of length of VNTR alleles at the X-linked MAOA gene & phenotypic effect in Tourette Syndrome & drug abuse
Periodical: Molecular Psychiatry			Index Medicus:
Authors: Gade R, Muhleman D, Blake H, MacMurray J, et al				ART
Yr: 1997	Vol:	Nbr:	Abs:	Pg:

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Studies of the potential role of the dopamine D1 receptor gene in addictive behaviors
Periodical: Molecular Psychiatry			Index Medicus:
Authors: Comings DE, et al				ART
Yr: 1997	Vol: 2	Nbr:	Abs:	Pg: 44-56

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Genetic variants of the human obesity (OB) gene: association with body mass index in young women, psychiatric disorders, & interaction with the dopamine D2 receptor (DRD2) gene
Periodical: Molecular Psychiatry			Index Medicus:
Authors: Comings DE, et al				ART
Yr: 1996	Vol: 1	Nbr:	Abs:	Pg: 325-335

---

Polygenic inheritance and micro/minisatellites
Periodical: Molecular Psychiatry			Index Medicus:
Authors: Comings DE				ART
Yr: 0	Vol:	Nbr:	Abs:	Pg:

---

Dopamine D2 receptor gene variants: association and linkage studies in impulsive-addictive-compulsive behaviors
Periodical: Pharmacogenetics			Index Medicus:
Authors: Blum K, Sheridan PJ, Wood RC, Braverman ER, Chen TJH, Comings DE				ART
Yr: 1995	Vol: 5	Nbr: 3	Abs:	Pg: 121-141

---

The Dopamine D2 receptor (DRD2) gene: a genetic risk factor in smoking
Periodical: Pharmacogenetics			Index Medicus:
Authors: Comings DE, Ferry L, Bradshaw-Robinson S, et al				ART
Yr: 1996	Vol: 6	Nbr: 1	Abs:	Pg: 73-79

---

Reward deficiency syndrome
Periodical: American Scientist			Index Medicus:
Authors: Blum K, Cull JG, Braverman ER, Commings DE				ART
Yr: 1996	Vol: 84	Nbr: 2	Abs:	Pg: 132-145

---

Sequence of human tryptophan 2,3-dioxygenase (TDO2): presence of a glucocorticoid response-like element composed of a GTT repeat and an intronic CCCCT repeat
Periodical: Genomics			Index Medicus:
Authors: Comings DE, Muhleman D, Dieta G, Sherman M, Forest GL				ART
Yr: 1995	Vol: 29	Nbr: 2	Abs:	Pg: 390-396

---

Tourette syndrome: a hereditary neuropsyhciatric spectrum disorder
Periodical: Annals of Clinical Psychiatry			Index Medicus:
Authors: Comings DE				ART
Yr: 1994	Vol: 6	Nbr: 4	Abs:	Pg: 235-245

---

A study of the dopamine D2 receptor gene in pathological gambling
Periodical: Pharmacogenetics			Index Medicus:
Authors: Comings DE, Rosenthal RJ, Lesieur HR, et al				ART
Yr: 1996	Vol: 6	Nbr:	Abs:	Pg: 223-234

---

Polygenic inheritance of Tourette syndrome, stuttering, attention deficit hyperactivity, conduct, and oppositional defiant disorder
Periodical: American Journal of Medical Genetics			Index Medicus:
Authors: Comings DE, Wu S, Chiu C, et al				ART
Yr: 1996	Vol: 67	Nbr: 3	Abs:	Pg: 264-288

---

Exon and intron variants in the human trypophan 2,2-dioxygenase gene: potential association with Tourette syndrome, substance abuse and other disorders
Periodical: Pharmacogenetics			Index Medicus:
Authors: Comings DE				ART
Yr: 1996	Vol:	Nbr: 6	Abs:	Pg:

---

The molecular genetics of pathological gambing
Periodical: CNS Spectrums			Index Medicus:
Authors: Coming, DE				ART
Yr: 1998	Vol:	Nbr:	Abs:	Pg:

---

Exon & intron variants in the human tryptophan 2.3-dioxygenase gene: potential association with Tourette Syndrome, substance abuse & other disorders
Periodical: Pharmacogenetics			Index Medicus:
Authors: Comings DE, et al				ART
Yr: 1996	Vol:	Nbr:	Abs:	Pg: 6,307-6318

---

Correlation of length of VNTR alleles at the X-linked MAOA gene & phenotypic effect in Tourette Syndrome & drug abuse
Periodical: Molecular Psychiatry			Index Medicus:
Authors: Gade R, Muhleman D, Blake H, MacMurray J, et al				ART
Yr: 1997	Vol:	Nbr:	Abs:	Pg:

---

Studies of the potential role of the dopamine D1 receptor gene in addictive behaviors
Periodical: Molecular Psychiatry			Index Medicus:
Authors: Comings DE, et al				ART
Yr: 1997	Vol: 2	Nbr:	Abs:	Pg: 44-56

---

Genetic variants of the human obesity (OB) gene: association with body mass index in young women, psychiatric disorders, & interaction with the dopamine D2 receptor (DRD2) gene
Periodical: Molecular Psychiatry			Index Medicus:
Authors: Comings DE, et al				ART
Yr: 1996	Vol: 1	Nbr:	Abs:	Pg: 325-335

---

Polygenic inheritance and micro/minisatellites
Periodical: Molecular Psychiatry			Index Medicus:
Authors: Comings DE				ART
Yr: 0	Vol:	Nbr:	Abs:	Pg:

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