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Identification on Tumors of Molecular Targets for NK Cells

Institution: University of California, San Francisco
Investigator(s): William Seaman, M.D.
Award Cycle: 1995 (Cycle 4) Grant #: 4RT-0184 Award: $314,006
Subject Area: Cancer
Award Type: Research Project Awards
Abstracts
Publications

NKR-P1A is a target-specific receptor that activates natural killer cell cytotoxicity
Periodical: Journal of Experimental Medicine Index Medicus:
Authors: Ryan JC, Niemi EC, Nakamura MC, Seaman WE ART
Yr: 1995 Vol: 181 Nbr: 5 Abs: Pg: 1911-1915

An autosomal dominant locus, NKa, mapping to the Ly-49 region of a rat natural killer (NK) gene complex, controls NK cell lysis of allogeneic lymphocytes
Periodical: Journal of Experimental Medicine Index Medicus:
Authors: Dissen E, Ryan JC, Seaman WE, Fossum S ART
Yr: 1996 Vol: 183 Nbr: Abs: Pg: 2197-2208

Recognition and signalling by mouse Ly-49 receptors
Periodical: Chemical Immunology Index Medicus:
Authors: Seaman WE, Daniels B, Ryan J, etal ART
Yr: 1996 Vol: 64 Nbr: Abs: Pg: 1996

Mouse Ly-49A interrupts early signaling events in NK cell cytotoxicity and functionally associates with the SHP-1 tyrosine phosphatase
Periodical: Journal of Experimental Medicine Index Medicus:
Authors: Nakamura MC, Niemi EC, Fisher MJ, et al ART
Yr: 1997 Vol: 185 Nbr: Abs: Pg: 673

Divergent functions of lectin-like receptors on NK cells
Periodical: Immunological Reviews Index Medicus:
Authors: Ryan JC, Seaman WE ART
Yr: 1997 Vol: 155 Nbr: Abs: Pg: 79

The alpha2 domain of H-2D restricts the allele specificity of the murine NK cell inhibitory receptorLy-49A
Periodical: Journal of Immunology Index Medicus:
Authors: Sundback J, Nakamura MC, Waldenstrom M, et al ART
Yr: 1998 Vol: 160 Nbr: 12 Abs: Pg: 5971-5978

Identification of an inhibitory MHC receptor on alloreactive rat NK cells
Periodical: Journal of Immunology Index Medicus:
Authors: Naper C, Ryan JC, Nakamura NC, et al ART
Yr: 1998 Vol: 160 Nbr: 1 Abs: Pg: 219-224

Natural killer cells and recognition of MHC class I molecules: new perspectives and challenges in immunology
Periodical: Scandinavian Journal of Immunology Index Medicus:
Authors: Rolstad B, Seaman WE ART
Yr: 1998 Vol: 47 Nbr: 5 Abs: Pg: 412-425