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SAR Studies of Novel antitumor Agents for Lung Carcinomas

Institution:	University of California, San Diego
Investigator(s):	Michael Kelner, M.D., M.S.
Award Cycle:	1995 (Cycle 4)	Grant #: 4RT-0226	Award: $403,338
Subject Area:	Cancer
Award Type:	Research Project Awards

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Characterization of illudin S sensitivity in DNA repair-deficient Chinese hamster cells: unusually high sensitivity of ERCC2 and ERCC3 DNA helicase deficient mutants in comparison to other chemotherapeutic agents
Periodical: Biochemical Pharmacology			Index Medicus:
Authors: Kelner MJ, McMorris L, Estes M, et al				ART
Yr: 1994	Vol: 48	Nbr: 2	Abs:	Pg: 403-409

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Nonresponsiveness of the metastatic human lung carcinoma MV522 xenograft to conventional anticancer agents
Periodical: Anticancer Research			Index Medicus:
Authors: Kelner MJ, McMorris TC, Estes L, et al				ART
Yr: 1995	Vol: 15	Nbr: 3	Abs:	Pg: 867-872

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In vitro and in vivo studies on the anticancer activity of dehydroilludin M
Periodical: Anticancer Research			Index Medicus:
Authors: Kelner MJ, McMorris TC, Taetle R				ART
Yr: 1995	Vol: 15	Nbr: 3	Abs:	Pg: 873-878

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Efficacy of Acylfulvene Illudin analogs against a metastatic lung carcinoma MV522 xenograft nonresponsive to traditional anticancer agents retention of activity against various phenotypes.
Periodical: Cancer Research			Index Medicus:
Authors: Kelner MJ, McMorris TC, Estes L, et al				ART
Yr: 1995	Vol: 55	Nbr: 21	Abs:	Pg: 4936-4940

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Acylfulvenes, a new class of potent antitumor agents
Periodical: Experientia			Index Medicus:
Authors: McMorris TC, Kelner MJ, Wang W, Diaz MA, Estes LA, Taetle R				ART
Yr: 1996	Vol: 52	Nbr: (1)	Abs:	Pg: 75-80

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Efficacy of HMAF (MGI-114-02) in the MV522 metastatic lung carcinoma xenograft model nonresponsive to traditional anticancer agents
Periodical: Investigational New Drugs			Index Medicus:
Authors: Kelner MJ, McMorris TC, Estes L, et al				ART
Yr: 1996	Vol: 14	Nbr:	Abs:	Pg: 161-167

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Hydroxymethylacylfulvene: an Illudin derivative with superior antitumor properties
Periodical: Journal of Natural Products			Index Medicus:
Authors: McMorris TC, Kelner MJ, Wang W, et al				ART
Yr: 1996	Vol: 59	Nbr:	Abs:	Pg: 896-899

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Characterization of cellular accululation and toxicity of Illudin S in sensitive and non-sensitive tumor cells
Periodical: Cancer Chemotherapy and Pharmacology			Index Medicus:
Authors: Kelner MJ, McMorris TC, Montoya MA, et al				ART
Yr: 1997	Vol: 40	Nbr:	Abs:	Pg: 65-71

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Characterization of Acylfulvene histiospecific toxicity in human tumor cell lines
Periodical: Cancer Chemotherapy and Pharmacology			Index Medicus:
Authors: Kelner MJ, McMorris TC, Montoya MA, et al				ART
Yr: 1998	Vol: 41	Nbr:	Abs:	Pg: 237-242

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Reaction of antitumor hydroxymethylacylfulvene (HMAF) with thiols
Periodical: Tetrahedron Letters			Index Medicus:
Authors: McMorris TC, Yu J, Estes LA, Kelner MJ				ART
Yr: 1997	Vol: 53	Nbr:	Abs:	Pg: 14579-14590

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Efficacy of MGI 114 (6-hydroxymethylfulvene, HMAF)against the mdrI/gp170 Metastatic MV522 lung carcinoma xenograft
Periodical: European Journal of Cancer			Index Medicus:
Authors: Kelner MJ, McMorris TC, Estes L, et al				ART
Yr: 1998	Vol: 34	Nbr:	Abs:	Pg: 908-913

---

Characterization of illudin S sensitivity in DNA repair-deficient Chinese hamster cells: unusually high sensitivity of ERCC2 and ERCC3 DNA helicase deficient mutants in comparison to other chemotherapeutic agents
Periodical: Biochemical Pharmacology			Index Medicus:
Authors: Kelner MJ, McMorris L, Estes M, et al				ART
Yr: 1994	Vol: 48	Nbr: 2	Abs:	Pg: 403-409

---

Nonresponsiveness of the metastatic human lung carcinoma MV522 xenograft to conventional anticancer agents
Periodical: Anticancer Research			Index Medicus:
Authors: Kelner MJ, McMorris TC, Estes L, et al				ART
Yr: 1995	Vol: 15	Nbr: 3	Abs:	Pg: 867-872

---

In vitro and in vivo studies on the anticancer activity of dehydroilludin M
Periodical: Anticancer Research			Index Medicus:
Authors: Kelner MJ, McMorris TC, Taetle R				ART
Yr: 1995	Vol: 15	Nbr: 3	Abs:	Pg: 873-878

---

Efficacy of Acylfulvene Illudin analogs against a metastatic lung carcinoma MV522 xenograft nonresponsive to traditional anticancer agents retention of activity against various phenotypes.
Periodical: Cancer Research			Index Medicus:
Authors: Kelner MJ, McMorris TC, Estes L, et al				ART
Yr: 1995	Vol: 55	Nbr: 21	Abs:	Pg: 4936-4940

---

Acylfulvenes, a new class of potent antitumor agents
Periodical: Experientia			Index Medicus:
Authors: McMorris TC, Kelner MJ, Wang W, Diaz MA, Estes LA, Taetle R				ART
Yr: 1996	Vol: 52	Nbr: (1)	Abs:	Pg: 75-80

---

Efficacy of HMAF (MGI-114-02) in the MV522 metastatic lung carcinoma xenograft model nonresponsive to traditional anticancer agents
Periodical: Investigational New Drugs			Index Medicus:
Authors: Kelner MJ, McMorris TC, Estes L, et al				ART
Yr: 1996	Vol: 14	Nbr:	Abs:	Pg: 161-167

---

Hydroxymethylacylfulvene: an Illudin derivative with superior antitumor properties
Periodical: Journal of Natural Products			Index Medicus:
Authors: McMorris TC, Kelner MJ, Wang W, et al				ART
Yr: 1996	Vol: 59	Nbr:	Abs:	Pg: 896-899

---

Characterization of cellular accululation and toxicity of Illudin S in sensitive and non-sensitive tumor cells
Periodical: Cancer Chemotherapy and Pharmacology			Index Medicus:
Authors: Kelner MJ, McMorris TC, Montoya MA, et al				ART
Yr: 1997	Vol: 40	Nbr:	Abs:	Pg: 65-71

---

Characterization of Acylfulvene histiospecific toxicity in human tumor cell lines
Periodical: Cancer Chemotherapy and Pharmacology			Index Medicus:
Authors: Kelner MJ, McMorris TC, Montoya MA, et al				ART
Yr: 1998	Vol: 41	Nbr:	Abs:	Pg: 237-242

---

Reaction of antitumor hydroxymethylacylfulvene (HMAF) with thiols
Periodical: Tetrahedron Letters			Index Medicus:
Authors: McMorris TC, Yu J, Estes LA, Kelner MJ				ART
Yr: 1997	Vol: 53	Nbr:	Abs:	Pg: 14579-14590

---

Efficacy of MGI 114 (6-hydroxymethylfulvene, HMAF)against the mdrI/gp170 Metastatic MV522 lung carcinoma xenograft
Periodical: European Journal of Cancer			Index Medicus:
Authors: Kelner MJ, McMorris TC, Estes L, et al				ART
Yr: 1998	Vol: 34	Nbr:	Abs:	Pg: 908-913

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