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-Heterologous Expression of Brain Nicotinic Acetylcholine Re

Institution: California Institute of Technology
Investigator(s): Henry Lester, Ph.D.
Award Cycle: 1995 (Cycle 4) Grant #: 4RT-0286 Award: $598,774
Subject Area: Nicotine Dependence
Award Type: Research Project Awards
Abstracts
Publications

Regions of beta-2 and beta-4 responsible for differences between the equilibrium dose-response relationships of the alpha3beta2 and alpha3beta4 neuronal nicotinic receptors
Periodical: Journal of General Physiology Index Medicus:
Authors: Cohen BN, Figl A, Quick M, Labarca C, Davidson N, Lester HA ART
Yr: 0 Vol: Nbr: Abs: Pg:

Nicotinic receptor binding site probed with unnatural amino-acid incorporation in intact cells
Periodical: Science Index Medicus:
Authors: Nowak MW, Kearney PC, Sampson JR, et al ART
Yr: 1995 Vol: 268 Nbr: 5209 Abs: Pg: 439-442

The apparent affinity of substance P for the neuronal nAChR is not determined by a single domain of the beta-subunit
Periodical: Biophysical Journal Index Medicus:
Authors: Stafford GA, Oswald RE, Figl A, Cohen BN, Lester HA, Weiland GA ABS
Yr: 1994 Vol: 66 Nbr: Abs: Pg: A432

Examination of the nicotinic acetylcholine binding site using unnatural amino acid mutagenesis
Periodical: Biophysical Journal Index Medicus:
Authors: Nowak MW, Kearney PC, Saks ME, et al ABS
Yr: 1995 Vol: 2 Nbr: Abs: Pg: A233

Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic recptors
Periodical: Nature Index Medicus:
Authors: Labarca C, Nowak M, Zhang H, Tang L, Deshpande P, Lester HA ART
Yr: 1995 Vol: 376 Nbr: 6540 Abs: Pg: 514-516

Voltage-jump relaxation kinetics for wild type and chimeric beta subunits of neuronal nicotinic receptors
Periodical: Journal of General Physiology Index Medicus:
Authors: Figl A, Labarca C, Davidson N, Lester HA, Cohen BN ART
Yr: 1996 Vol: 107 Nbr: 3 Abs: Pg: 369-379

Interactions of leucine residues at the 9' position of the M2 domain of AChR probed using unnatural mino acid mutagenesis
Periodical: Biophysics Journal Index Medicus:
Authors: Kearney P, Zhong C, Nowak W, et al ABS
Yr: 1996 Vol: 2 Nbr: Abs: Pg: A251

Regions of beta2 and beta4 responsible for differences between the equilibrium dose-response relatioships of the alpha3beta2 and alpha3beta4 neuronal nicotinic receptors
Periodical: Journal of General Physiology Index Medicus:
Authors: Cohen BN, Figl A, Quick MW, Labarca C, Davidson N, Lester HA ART
Yr: 0 Vol: Article in Nbr: Press Abs: Pg:

Site-specific, photochemical proteolysis applied to ion channels In Vivo
Periodical: Proceedings of the National Academy of Sciences of the United States of America Index Medicus:
Authors: England P, Lester HA, Davidson N, Dougherty DA ART
Yr: 1997 Vol: 94 Nbr: Abs: Pg: 11025-11030

Expression and circular dichroism studies of the extracellular domain of the alpha subunit of the nicotinic acetylcholine receptor
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: West AP, Bjorkman PJ, Dougherty DA, Lester HA ART
Yr: 1997 Vol: 272 Nbr: Abs: Pg: 25468-25473

From ab initio quantum mechanics to molecular neurobiology: a cation-pi binding site in the nicotinic receptor
Periodical: Proceedings of the National Academy of Sciences of the United States of America Index Medicus:
Authors: Zhong W, Gallivan JP, Zhang Y, Li L, Lester HA, Dougherty DA ART
Yr: 1998 Vol: Nbr: Abs: Pg: