Controlled Thirdhand Smoke Exposure Core

Institution:	University of California, San Francisco
Investigator(s):	Suzaynn Schick, Ph.D.
Award Cycle:	2015 (Cycle 24)	Grant #: 24RT-0039	Award: $304,957
Subject Area:	Environmental Exposure/Toxicology
Award Type:	Research Project Awards

Abstracts

Initial Award Abstract

We believe that THS exposure is likely to have significant health effects because: 1. The majority of the semivolatile organic compounds in SHS (the tar) sorbs and deposits on indoor surfaces before it can be removed by ventilation. These semi-volatile organic compounds (SVOCs) include nicotine, and carcinogens like polycyclic aromatic hydrocarbons (PAHs) and tobacco-specific nitrosamines (TSNAs). 2. THS on indoor surfaces reacts with ambient oxidant compounds to form new chemicals, some of which are also toxic or carcinogenic (including NNK, NNA, formaldehyde and ultrafine particles). 3. THS chemicals build up on room surfaces when smoking is chronic and can be re-emitted back into the air, inhaled and absorbed through the skin. THS sorbed to dust can also be eaten, particularly by young children who put everything into their mouths. This means that people who live with THS are exposed to smoke compounds constantly, even when no one is actively smoking. It is possible that exposure to carcinogens in THS may contribute to the cancer that is attributed to SHS exposure. We propose to study the health effects of controlled dermal exposure to THS-contaminated clothing in human subjects and to continue to function as a core laboratory for the Thirdhand Smoke Consortium. Dermal exposure is an important exposure route because most THS is bound to indoor surfaces, including clothing, furniture and bedding. Controlled exposures minimize the influences of confounding variables that affect observational studies and can identify causal relationships and biological mechanisms. Our research bridges the gap between animal exposure studies and field research, providing unequivocal information on the uptake and health effects of THS to inform public policy. Supplying chronically exposed THS samples to the California THS Consortium provides a vital experimental bridge between field samples, that are usually exposed to smoke for long periods of time, and laboratory THS samples, that are usually generated in hours or days. In recognition of the public demand for effective methods to remediate THS contamination of housing, we will also test how paint and sealants affect absorption and emission of THS by gypsum wallboard. These three aims are profoundly innovative and will help improve the public health.

Publications

Thirdhand cigarette smoke causes stress-induced mitochondrial hyperfusion and alters the transcriptional profile of stem cells
Periodical: Toxicological Sciences			Index Medicus:
Authors: Bahl V, Johnson, K, Phandthong, R, Zahedi A, Schick SF, Talbot P				ART
Yr: 2016	Vol: 15	Nbr: 1	Abs:	Pg: 55-69

Thirdhand Smoke: new evidence, challenges and future directions
Periodical: Chemical Research in Toxicology			Index Medicus:
Authors: Jacob P, Benowitz NL, Destaillats H, et al.				ART
Yr: 2017	Vol: 30	Nbr: 1	Abs:	Pg: 270-294

Short-term early exposure to thirdhand cigarette smoke increases lung cancer incidence in mice
Periodical: Clinical Science			Index Medicus:
Authors: Hang B, Wang Y, Huang Y, Wang P, Langley SA, Bi L, Sarker AH, Schick SF, Havel C, Jacob P				ART
Yr: 2018	Vol: 132	Nbr: 4	Abs:	Pg: 475-488

Thirdhand Smoke at Philip Morris
Periodical: Nicotine and Tobacco Research			Index Medicus:
Authors: Whitlatch A and Schick SF				ART
Yr:	Vol:	Nbr:	Abs:	Pg:

Thirdhand cigarette smoke causes stress-induced mitochondrial hyperfusion and alters the transcriptional profile of stem cells
Periodical: Toxicological Sciences			Index Medicus:
Authors: Bahl V, Johnson, K, Phandthong, R, Zahedi A, Schick SF, Talbot P				ART
Yr: 2016	Vol: 15	Nbr: 1	Abs:	Pg: 55-69

Thirdhand Smoke: new evidence, challenges and future directions
Periodical: Chemical Research in Toxicology			Index Medicus:
Authors: Jacob P, Benowitz NL, Destaillats H, et al.				ART
Yr: 2017	Vol: 30	Nbr: 1	Abs:	Pg: 270-294

Short-term early exposure to thirdhand cigarette smoke increases lung cancer incidence in mice
Periodical: Clinical Science			Index Medicus:
Authors: Hang B, Wang Y, Huang Y, Wang P, Langley SA, Bi L, Sarker AH, Schick SF, Havel C, Jacob P				ART
Yr: 2018	Vol: 132	Nbr: 4	Abs:	Pg: 475-488

Thirdhand Smoke at Philip Morris
Periodical: Nicotine and Tobacco Research			Index Medicus:
Authors: Whitlatch A and Schick SF				ART
Yr:	Vol:	Nbr:	Abs:	Pg: