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Genomics & transcriptome of oral precncr prgrssion in smkers

Institution: University of California, Los Angeles
Investigator(s): Xiaofeng Zhou, Ph.D.
Award Cycle: 2004 (Cycle 13) Grant #: 13KT-0028 Award: $189,541
Subject Area: Epidemiology
Award Type: New Investigator Awards
Abstracts

Initial Award Abstract
Oral cancer is the sixth most common cancer worldwide. In the United States there are over 38,000 new cases of oral cancer each year. This is a cancer which occurs twice as often in the black population as in whites, and survival statistics for blacks over five years are also poorer at 33%, versus 55% for whites. The 5-year survival rates for oral cancer are among the worst of all cancer death rates, which is partly due to the inability for early detection. The major risk factor for oral cancer is tobacco. According to the American Cancer Society, DNA-damaging chemicals in tobacco are directly linked to the increased risk of oral cancer. The death rate associated with this cancer is particularly high due to the cancer being routinely discovered late in its development. Oral cancers are preceded by pre-cancer lesions. Approximately 18% of these lesions will transform into cancer. However, with the existing technology, it is impossible to predict which lesion will transform into cancer. The aim of this proposed research is to generate a genetic based diagnostic tool for the early detection of oral lesion with potential to transform into cancer. The proposed research will examine archived pre-cancer lesion tissue sample and determine the genetic features unique to the lesions that have the potential to transform into cancer. These unique genetic features will provide us with molecular diagnostic tools for early detection. In addition, the outcome of this project will also set the stage for an improved understanding of the pathogenesis of the progression of this disease, which in turn may eventually lead to the development of new therapeutic strategies.
Publications

Current progress in concurrent analysis of loss of heterozgosity and comparative genomic hybridization utilizing high density single nucleotide polymorphism arrays.
Periodical: Cancer Genet Cytogen Index Medicus:
Authors: X. Zhou, S.C. Mok, N.P. Rao, Z.Cheng, S.W. Cole, D.T. Wong ART
Yr: 2005 Vol: 159 Nbr: 1 Abs: Pg: 53 - 57

Identification of discrete chromosomal deletion by binary recursive partitioning of microarray differential expression data.
Periodical: Journal Medical Genet Index Medicus:
Authors: X. Zhou, S.W. Cole, N.P. Rao, Z. Chen, Y. Li, J. Mc Bride, and D.T. Wong ART
Yr: 2005 Vol: 42 Nbr: 5 Abs: Pg: 416 - 419

(appected for publication) Frequent allelic imbalance at 8pm and 11q22 in oral cavity and oropharyngeal epithelial dyplastic lessions.
Periodical: Cancer Genet Cytogen Index Medicus:
Authors: X. Zhou, R.C.K. Jordan, Y.Li, B.L. Huang and D.T. Wong ART
Yr: 0 Vol: Nbr: Abs: Pg:

Frequent allelic imbalance at 8p and 11q22 in oral cavity and oropharyngeal epithelial dysplastic lesions.
Periodical: Cancer Genet Cytogen Index Medicus:
Authors: Zhou X, Jordan RCK, Li Y, Huang BL, Wong DT ART
Yr: 0 Vol: Nbr: Abs: Pg: