Novel Drugs for Lung Cancer
Initial Award Abstract
PTHrP is the abbreviation for parathyroid hormone related protein, a substance that is abnormally expressed in a substantial majority of lung cancers, especially non-small cell lung cancers. PTHrP regulates growth and differentiation in virtually every cell and tissue studied. Our plan is to apply the power of modern combinatorial chemistry to identify novel molecules that can regulate PTHrP and act to inhibit tumor progression. These molecules can become novel drugs for the therapy of lung cancer. Thus, our proposal directly addresses a high priority goal of TDRP, namely the treatment of lung cancer.
Our proposal directly addresses a high priority goal of TDRP, namely the treatment of lung cancer. We shall undertake the discovery of novel PTHrP-inhibitory compounds that can inhibit the progression of lung cancer. This hall be accomplished by the use of modern combinatorial chemistry that can enable hundreds to thousands-fold more compounds to be synthesized and screened compared to traditional approaches, and offers tremendous enhancement toward the identification of new therapeutic candidates. This work can lead to new treatments for lung cancer. |