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Novel treatments for COPD with Statins

Institution: University of California, Davis
Investigator(s): Benjamin Davis, Ph.D.
Award Cycle: 2009 (Cycle 18) Grant #: 18KT-0037 Award: $269,523
Subject Area: Pulmonary Disease
Award Type: New Investigator Awards
Abstracts

Initial Award Abstract
Chronic Obstructive Pulmonary Disease is the fourth leading cause of death in the United States and currently there are no effective treatments. Approximately 80-90% of COPD cases can be attributed to smoking. COPD is an inflammatory pulmonary disease characterized by airflow limitation and presents as either chronic bronchitis, emphysema or both. The repeated exposure of the spontaneously hypertensive to tobacco smoke mimics the chronic lung inflammation representative of human COPD better than other rodent models. Specifically spontaneously hypertensive rats have a robust inflammatory response following tobacco smoke exposure, a sustained inflammatory response with continued exposure to tobacco smoke and progression in cellular changes symptomatic for COPD. The proposed work will use this SH rat model to better understand the progression of COPD, its correlation to anatomical changes in the lung and test Statins as a promising new treatment for COPD with the potential to prevent and reverse the smoke induced chronic inflammatory changes of the disease.
Publications

Anti-inflammatory effects of soluble epoxide hydrolase inhibition are independent of luekicyte recruitment.
Periodical: Biochemical and Biophysical Research Communications Index Medicus:
Authors: Davis, B; Lui, JY; Tancredi, DJ; Wang, L; Simon,S; Hammock, B; Pinkerton, KE ART
Yr: 2011 Vol: Nbr: Abs: Pg:

A Potent Soluble Epoxide Hydrolase Inhibitor t-AUCB Modulates the Function of Endothelial Progenitor Cells from Patients with Acute Myocardial Infarction_x000d_ through PPARy.
Periodical: International Journal of Cardiology Index Medicus:
Authors: Xu DY, Davis BB, Zhao SP, Wang ZH, Wasti B, Liu ZL, Li N, Morisseau C, Chiamvimonvat N. ART
Yr: 2012 Vol: Nbr: Abs: Pg:

Leukocytes are recruited through the Bronchial Circulation to the Lung in a Spontaneously Hypertensive Rat Model of COPD.
Periodical: PLOS One Index Medicus:
Authors: Davis BB, Shen YH, Tancredi DJ, Flores V, Davis RP, Pinkerton KE. ART
Yr: 2012 Vol: Epub 2012 Nbr: Abs: Pg:

Soluble epoxide hydrolase inhibitors and cardiovascular diseases.
Periodical: Currrent Vascular Pharmacology Index Medicus:
Authors: Wang ZH, Davis BB, Ulu A, Jiang DJ, Zhao TT, Xu DY. ART
Yr: 2012 Vol: Nbr: Abs: Pg: