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Mechanistic studies of secondhand-smoke carcinogenicity

Institution: Beckman Research Institute of the City of Hope
Investigator(s): Ahmad Besaratinia, Ph.D., M.P.H.
Award Cycle: 2009 (Cycle 18) Grant #: 18KT-0040 Award: $278,795
Subject Area: Cancer
Award Type: New Investigator Awards
Abstracts

Initial Award Abstract
Exposure to second-hand smoke (SHS) has been linked to lung cancer development. However, the extent to which lung cancer incidence depends upon SHS exposure remains elusive. This is mainly due to a lack of accurate exposure assessment for SHS, which is essential for estimating lung cancer risk. To develop biological markers, which can be used for assessing lung cancer risk in relation to SHS exposure, we will investigate the mechanisms of action of SHS of relevance for lung cancer. Generally, cancer-causing agents exert their effects through damaging DNA and/or changing gene regulation (collectively referred to as the ‘genotoxic’ and ‘epigenetic’ effects, respectively). We will investigate both the genotoxic and epigenetic effects of SHS in a validated mouse model system using state-of-the-art techniques that have been recently developed in our laboratory. By establishing the mechanisms involved in cancer-causing effects of SHS, these investigations will enable us to identify biological markers that can be used for assessing human lung cancer risk in relation to SHS exposure.
Publications

New experimental data linking secondhand smoke exposure to lung_x000D_ cancer in nonsmokers
Periodical: FASEB Journal Index Medicus:
Authors: Kim, S.L, Yoon, J.I., Tommasi, S., Besaratinia. A. ART
Yr: 2012 Vol: Nbr: 26 Abs: Pg: 1845-1854

Whole body exposure of mice to secondhand smoke induces dose-dependent and persistent promutagenic DNA adducts in the lung
Periodical: Mutation Research Index Medicus:
Authors: Kim, S.I., Arlt, V.M., Yoon, J.I., Cole, K.J., Pfeifer, G.P., Phillips, D.H., Besaratinia. ART
Yr: 2011 Vol: Nbr: 716 Abs: Pg: 92-98

A high-throughput next-generation sequencingbased_x000D_ method for detecting the mutational fingerprint of carcinogens
Periodical: Nucleic Acids Research Index Medicus:
Authors: Besaratinia, A., Li, H., Yoon, J.I., Zheng, A., Gao, H, Tornmasi, S. ART
Yr: 2012 Vol: Nbr: Abs: Pg: