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Characterization of innate immunity in pollution-induced exacerbation in Chronic Obstructive Pulmonary Disease (COPD)

Institution: University of California, San Francisco
Investigator(s): Mehrdad Arjomandi,
Award Cycle: 2019 (Cycle 29) Grant #: T29IR0715 Award: $933,635
Subject Area: Pulmonary Disease
Award Type: High Impact Research Project Award

Initial Award Abstract
Chronic obstructive pulmonary disease (COPD) is a smoking-related lung disease, which is the third leading cause of death worldwide. Patients with COPD are routinely exposed to indoor and outdoor air pollution, which appears to cause escalation of their respiratory symptoms, a process called exacerbation, with resulting need to seek medical attention. This research plan proposes to evaluate the role of lung immune cells (macrophages) in susceptibility to develop exacerbation through an experimental model of inhalational exposure to ambient levels of a component of air pollution (ozone) in patients with COPD.