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Replication Studies of Minor-Groove DNA Adducts

Institution: University of California, Riverside
Investigator(s): Nisana Andersen, M.S. Chemistry
Award Cycle: 2010 (Cycle 19) Grant #: 19DT-0009 Award: $60,000
Subject Area: Cancer
Award Type: Dissertation Awards

Initial Award Abstract
Tobacco smoke contains many components that are harmful to humans, which are capable of binding to the genetic material, or DNA, in the body. This binding can potentially impede the process in which DNA is copied or introduce mistakes during replication. These difficulties may result in cell death or mutations that can lead to diseases. In fact, over 30% of all cancers in developed countries are attributed to tobacco and its smoke. In this study, I will examine the biological effects of three components present in tobacco smoke, which are considered carcinogenic to animals and humans. By investigating how these modified DNA lesions are copied and what mistakes, if any, are generated during replication, important insights into the carcinogenic effects of these components present in tobacco smoke will be uncovered.

The Roles of DNA Polymerases K and 1 in the Error-free Bypass of N2-carboxyalkyl-dG Lesions in Mammalian Cells
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Yuan B, You C, Andersen N et. al. ART
Yr: 2011 Vol: 286 Nbr: 20 Abs: Pg: 17503-17511