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Effects of Resistance Training on Tobacco-Related CVD Risk

Institution: University of California, Los Angeles
Investigator(s): Christian Roberts, Ph.D.
Award Cycle: 2010 (Cycle 19) Grant #: 19KT-0028 Award: $270,000
Subject Area: Cardiovascular Disease
Award Type: New Investigator Awards
Abstracts

Initial Award Abstract
Poor vascular function and future risk of cardiovascular disease all hallmarks of tobacco smoking, and many young adults who smoke cigarettes already have poor vascular function. Finding therapies to facilitate smoking cessation and to modify tobacco related risk factors for future cardiovascular disease in imperative. This project will determine the role of a weight training program in isolation or conjunction with standard smoking cessation therapy via nicotine replacement plus counseling on the function of blood vessels, how much oxidation is in the body, inflammation in the body and how well the body handles glucose young men and women smokers. The main objectives of this study are to determine the effects of a weight training program either by itself or together with nicotine replacement therapy and counseling on the function of blood vessels, oxidation in the body, inflammation in the body and the action of insulin. Blood vessel function, oxidative “free radicals”, inflammation in the body, insulin function, body composition will be measured. This project will be the first one to determine the effects of weight training by itself or together with conventional smoking cessation interventions on these risk factors for cardiovascular disease. If the hypotheses are supported, greater emphasis can be placed on the pivotal role of weight training as therapeutic intervention to improve the blood vessel function and/or facilitate smoking cessation in young adult men and women smokers.
Publications

Fitness levels in smokers and healthy controls: predictability by carbon monoxide and Fagerström Test
Periodical: Medicine and Science in Sports and Exercise Index Medicus:
Authors: Oh, C.S., Chronley, M.K., Le, B.K., and Roberts, C.K. ART
Yr: Vol: Nbr: Abs: Pg:

Cross-sectional analysis of arterial stiffness in chronic smokers compared with physically-active young adults
Periodical: Medicine and Science in Sports and Exercise Index Medicus:
Authors: LaFranchi, M.L., Moon, S., and Roberts, C.K. ART
Yr: Vol: Nbr: Abs: Pg:

Endothelial progenitor cell quantifications in young adult non-smokers and smokers by a novel gating strategy.
Periodical: Medicine and Science in Sports and Exercise Index Medicus:
Authors: Katiraie, M., Feairheller, D.L., Schmid, I., and Roberts, C.K. ART
Yr: Vol: Nbr: Abs: Pg: