Research Portfolio

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Daniel Broek, Ph.D.

University of Southern California # of Grants: 1

Grants

Structure-function studies of RAS nucleotide-exchange-factor 1993 (Cycle 2) $593,460
Cancer Research Project Awards
Publications

Functional cloning of BUD5, a CDC25-related gene from S. cerevisiae that can suppress a dominant-negative RAS2 mutant
Periodical: Cell Index Medicus:
Authors: Powers S, Gonzales E, Christenson T, Cubert J, Broek D ART
Yr: 1991 Vol: 65 Nbr: 7 Abs: Pg: 1225-1231

Identification and analysis of a DNA fragment from Saccaromyces Kluyver then can complement the loss of CDC25 function in Saccharomyces cerevisiae
Periodical: Gene Index Medicus:
Authors: Prigozy T, Gonzales E, Broek D ART
Yr: 0 Vol: Nbr: Abs: Pg:

Involvement of p34cdc2 in establishing the dependency of S-phase on mitosis
Periodical: Nature Index Medicus:
Authors: Broek D, Bartlett R, Crawford K, Nurse P ART
Yr: 1991 Vol: 349 Nbr: 6308 Abs: Pg: 388-393

Identification of a mammalian gene structurally and functionally related to the CDC25 gene of Saccharomyces cerevisiae
Periodical: Proceedings of the National Academy of Sciences of the United States of America Index Medicus:
Authors: Wei W, Mosteller RD, Sangal P, et al ART
Yr: 1992 Vol: 89 Nbr: 15 Abs: Pg: 7100-7104

Influence of guanine-nucleotides on complex formation between Ras and cdc25 proteins
Periodical: Molecular and Cellular Biology Index Medicus:
Authors: Lai C-C, Broek D, Powers S ART
Yr: 1993 Vol: 13 Nbr: 3 Abs: Pg: 1345-1352

Yeast cells can center a quiescent state through G1-,S-,G2-, or M-phase of the cell cycle
Periodical: Cancer Research Index Medicus:
Authors: Wei W, Nurse P, Broek D ART
Yr: 1993 Vol: 53 Nbr: 8 Abs: Pg: 1867-1870

Localization of the cellular expression pattern of CDC25 and ras in neonatal rat brain
Periodical: Brain Research. Molecular Brain Research Index Medicus:
Authors: Wei W, Schreiber SS, Baudry M, Tocco G, Broek D ART
Yr: 1993 Vol: 19 Nbr: 4 Abs: Pg: 339-344

The catalytic domain of the mouse SOS1 gene product activates Ras proteins in vivo and in vitro
Periodical: Oncogene Index Medicus:
Authors: Liu BX, Wei W, Broek D ART
Yr: 1993 Vol: 8 Nbr: 11 Abs: Pg: 3081-3084

Identification of residues of the H-ras protein critical for functional interaction with nucleotide-exchange factors
Periodical: Molecular and Cellular Biology Index Medicus:
Authors: Mosteller R, Han J, Broek D ART
Yr: 1994 Vol: 14 Nbr: 2 Abs: Pg: 1104-1112

Genetic and biochemical characterization of a novel dominant negative mutant that interferes with alternate activators of ras in schizosaccharomyces pombe and saccharomyces cerevisiae
Periodical: Molecular and Cellular Biology Index Medicus:
Authors: Jung V, Wei W, Camonis J, et al ART
Yr: 1994 Vol: 14 Nbr: 6 Abs: Pg: 3707-3718

Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity
Periodical: Proceedings of the National Academy of Sciences of the United States of America Index Medicus:
Authors: Quilliam LA, Huff SY, Rubin KM, et al ART
Yr: 1994 Vol: 91 Nbr: 18 Abs: Pg: 8512-8516

Amino acid residues in the CDC25 guanine nucleotide exchange factor critical for interaction with Ras
Periodical: Molecular and Cellular Biology Index Medicus:
Authors: Park W, Mosteller R, Broek D ART
Yr: 1994 Vol: 14 Nbr: 12 Abs: Pg: 8117-8122

Identification and characterization of alternately spliced cdc25 cDNAs from human brain
Periodical: Gene Index Medicus:
Authors: Wei W, Das B, Park W, Broek D ART
Yr: 1994 Vol: 151 Nbr: 1-2 Abs: Pg: 279-284

Analysis of the interaction between Ras and CDC25 guanine nucleotide exchange factor using the yeast GAL4 two-hybrid system
Periodical: Methods in Enzymology Index Medicus:
Authors: Mosteller RD, Park W, Broek D ART
Yr: 1995 Vol: 255 Nbr: Abs: Pg: 135-148