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Daniel Broek, Ph.D.

University of Southern California

# of Grants: 1

Structure-function studies of RAS nucleotide-exchange-factor	1993 (Cycle 2)	$593,460
Cancer	Research Project Awards

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Functional cloning of BUD5, a CDC25-related gene from S. cerevisiae that can suppress a dominant-negative RAS2 mutant
Periodical: Cell			Index Medicus:
Authors: Powers S, Gonzales E, Christenson T, Cubert J, Broek D				ART
Yr: 1991	Vol: 65	Nbr: 7	Abs:	Pg: 1225-1231

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Identification and analysis of a DNA fragment from Saccaromyces Kluyver then can complement the loss of CDC25 function in Saccharomyces cerevisiae
Periodical: Gene			Index Medicus:
Authors: Prigozy T, Gonzales E, Broek D				ART
Yr: 0	Vol:	Nbr:	Abs:	Pg:

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Involvement of p34cdc2 in establishing the dependency of S-phase on mitosis
Periodical: Nature			Index Medicus:
Authors: Broek D, Bartlett R, Crawford K, Nurse P				ART
Yr: 1991	Vol: 349	Nbr: 6308	Abs:	Pg: 388-393

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Identification of a mammalian gene structurally and functionally related to the CDC25 gene of Saccharomyces cerevisiae
Periodical: Proceedings of the National Academy of Sciences of the United States of America			Index Medicus:
Authors: Wei W, Mosteller RD, Sangal P, et al				ART
Yr: 1992	Vol: 89	Nbr: 15	Abs:	Pg: 7100-7104

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Influence of guanine-nucleotides on complex formation between Ras and cdc25 proteins
Periodical: Molecular and Cellular Biology			Index Medicus:
Authors: Lai C-C, Broek D, Powers S				ART
Yr: 1993	Vol: 13	Nbr: 3	Abs:	Pg: 1345-1352

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Yeast cells can center a quiescent state through G1-,S-,G2-, or M-phase of the cell cycle
Periodical: Cancer Research			Index Medicus:
Authors: Wei W, Nurse P, Broek D				ART
Yr: 1993	Vol: 53	Nbr: 8	Abs:	Pg: 1867-1870

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Localization of the cellular expression pattern of CDC25 and ras in neonatal rat brain
Periodical: Brain Research. Molecular Brain Research			Index Medicus:
Authors: Wei W, Schreiber SS, Baudry M, Tocco G, Broek D				ART
Yr: 1993	Vol: 19	Nbr: 4	Abs:	Pg: 339-344

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The catalytic domain of the mouse SOS1 gene product activates Ras proteins in vivo and in vitro
Periodical: Oncogene			Index Medicus:
Authors: Liu BX, Wei W, Broek D				ART
Yr: 1993	Vol: 8	Nbr: 11	Abs:	Pg: 3081-3084

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Identification of residues of the H-ras protein critical for functional interaction with nucleotide-exchange factors
Periodical: Molecular and Cellular Biology			Index Medicus:
Authors: Mosteller R, Han J, Broek D				ART
Yr: 1994	Vol: 14	Nbr: 2	Abs:	Pg: 1104-1112

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Genetic and biochemical characterization of a novel dominant negative mutant that interferes with alternate activators of ras in schizosaccharomyces pombe and saccharomyces cerevisiae
Periodical: Molecular and Cellular Biology			Index Medicus:
Authors: Jung V, Wei W, Camonis J, et al				ART
Yr: 1994	Vol: 14	Nbr: 6	Abs:	Pg: 3707-3718

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Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity
Periodical: Proceedings of the National Academy of Sciences of the United States of America			Index Medicus:
Authors: Quilliam LA, Huff SY, Rubin KM, et al				ART
Yr: 1994	Vol: 91	Nbr: 18	Abs:	Pg: 8512-8516

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Amino acid residues in the CDC25 guanine nucleotide exchange factor critical for interaction with Ras
Periodical: Molecular and Cellular Biology			Index Medicus:
Authors: Park W, Mosteller R, Broek D				ART
Yr: 1994	Vol: 14	Nbr: 12	Abs:	Pg: 8117-8122

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Identification and characterization of alternately spliced cdc25 cDNAs from human brain
Periodical: Gene			Index Medicus:
Authors: Wei W, Das B, Park W, Broek D				ART
Yr: 1994	Vol: 151	Nbr: 1-2	Abs:	Pg: 279-284

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Analysis of the interaction between Ras and CDC25 guanine nucleotide exchange factor using the yeast GAL4 two-hybrid system
Periodical: Methods in Enzymology			Index Medicus:
Authors: Mosteller RD, Park W, Broek D				ART
Yr: 1995	Vol: 255	Nbr:	Abs:	Pg: 135-148

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Functional cloning of BUD5, a CDC25-related gene from S. cerevisiae that can suppress a dominant-negative RAS2 mutant
Periodical: Cell			Index Medicus:
Authors: Powers S, Gonzales E, Christenson T, Cubert J, Broek D				ART
Yr: 1991	Vol: 65	Nbr: 7	Abs:	Pg: 1225-1231

---

Identification and analysis of a DNA fragment from Saccaromyces Kluyver then can complement the loss of CDC25 function in Saccharomyces cerevisiae
Periodical: Gene			Index Medicus:
Authors: Prigozy T, Gonzales E, Broek D				ART
Yr: 0	Vol:	Nbr:	Abs:	Pg:

---

Involvement of p34cdc2 in establishing the dependency of S-phase on mitosis
Periodical: Nature			Index Medicus:
Authors: Broek D, Bartlett R, Crawford K, Nurse P				ART
Yr: 1991	Vol: 349	Nbr: 6308	Abs:	Pg: 388-393

---

Identification of a mammalian gene structurally and functionally related to the CDC25 gene of Saccharomyces cerevisiae
Periodical: Proceedings of the National Academy of Sciences of the United States of America			Index Medicus:
Authors: Wei W, Mosteller RD, Sangal P, et al				ART
Yr: 1992	Vol: 89	Nbr: 15	Abs:	Pg: 7100-7104

---

Influence of guanine-nucleotides on complex formation between Ras and cdc25 proteins
Periodical: Molecular and Cellular Biology			Index Medicus:
Authors: Lai C-C, Broek D, Powers S				ART
Yr: 1993	Vol: 13	Nbr: 3	Abs:	Pg: 1345-1352

---

Yeast cells can center a quiescent state through G1-,S-,G2-, or M-phase of the cell cycle
Periodical: Cancer Research			Index Medicus:
Authors: Wei W, Nurse P, Broek D				ART
Yr: 1993	Vol: 53	Nbr: 8	Abs:	Pg: 1867-1870

---

Localization of the cellular expression pattern of CDC25 and ras in neonatal rat brain
Periodical: Brain Research. Molecular Brain Research			Index Medicus:
Authors: Wei W, Schreiber SS, Baudry M, Tocco G, Broek D				ART
Yr: 1993	Vol: 19	Nbr: 4	Abs:	Pg: 339-344

---

The catalytic domain of the mouse SOS1 gene product activates Ras proteins in vivo and in vitro
Periodical: Oncogene			Index Medicus:
Authors: Liu BX, Wei W, Broek D				ART
Yr: 1993	Vol: 8	Nbr: 11	Abs:	Pg: 3081-3084

---

Identification of residues of the H-ras protein critical for functional interaction with nucleotide-exchange factors
Periodical: Molecular and Cellular Biology			Index Medicus:
Authors: Mosteller R, Han J, Broek D				ART
Yr: 1994	Vol: 14	Nbr: 2	Abs:	Pg: 1104-1112

---

Genetic and biochemical characterization of a novel dominant negative mutant that interferes with alternate activators of ras in schizosaccharomyces pombe and saccharomyces cerevisiae
Periodical: Molecular and Cellular Biology			Index Medicus:
Authors: Jung V, Wei W, Camonis J, et al				ART
Yr: 1994	Vol: 14	Nbr: 6	Abs:	Pg: 3707-3718

---

Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity
Periodical: Proceedings of the National Academy of Sciences of the United States of America			Index Medicus:
Authors: Quilliam LA, Huff SY, Rubin KM, et al				ART
Yr: 1994	Vol: 91	Nbr: 18	Abs:	Pg: 8512-8516

---

Amino acid residues in the CDC25 guanine nucleotide exchange factor critical for interaction with Ras
Periodical: Molecular and Cellular Biology			Index Medicus:
Authors: Park W, Mosteller R, Broek D				ART
Yr: 1994	Vol: 14	Nbr: 12	Abs:	Pg: 8117-8122

---

Identification and characterization of alternately spliced cdc25 cDNAs from human brain
Periodical: Gene			Index Medicus:
Authors: Wei W, Das B, Park W, Broek D				ART
Yr: 1994	Vol: 151	Nbr: 1-2	Abs:	Pg: 279-284

---

Analysis of the interaction between Ras and CDC25 guanine nucleotide exchange factor using the yeast GAL4 two-hybrid system
Periodical: Methods in Enzymology			Index Medicus:
Authors: Mosteller RD, Park W, Broek D				ART
Yr: 1995	Vol: 255	Nbr:	Abs:	Pg: 135-148

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