Research Portfolio

Funding Opportunities

Join our Mailing List
Join our mailing list to be notified of new funding opportunities.

Your Email

To receive information about funding opportunities, events, and program updates.



John Cooke, M.D., Ph.D.

Stanford University # of Grants: 5

Grants

Mechanisms by which tobacco accelerates atherosclerosis 1998 (Cycle 7) $675,731
Cardiovascular Disease Research Project Awards

Nicotine-pathological angiogenesis and genetic determinants 2002 (Cycle 11) $608,420
Cardiovascular Disease Research Project Awards

SHS Exacerbates cerebral ischemia: endothelial mechanisms 2005 (Cycle 14) $654,849
Cardiovascular Disease Research Project Awards

Mechanisms of Tobacco-Induced Retinal Neovascularization 2006 (Cycle 15) $155,211
Cardiovascular Disease Inno Dev & Exp Awards (IDEAS)

An atypical nicotine receptor: target for anti-angiogenics? 2009 (Cycle 18) $385,707
Cardiovascular Disease Exploratory/Developmental Award
Publications

Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis
Periodical: Nature Medicine Index Medicus:
Authors: Cooke JP ART
Yr: 2001 Vol: 7 Nbr: 7 Abs: Pg: 833-839

Nicotine stimulates wound healing in diabetic mice.
Periodical: American Journal of Pathology Index Medicus:
Authors: Jacobi J, Jang JJ, Sundram U, Fajardo L, and Cooke JP ART
Yr: 2002 Vol: 161 Nbr: 1 Abs: Pg: 97 - 104

Nitric oxide and angiogenesis.
Periodical: Circulation Index Medicus:
Authors: Cooke JP, and Losordo DW ART
Yr: 2002 Vol: 105 Nbr: 18 Abs: Pg: 2133 - 2135

A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors.
Periodical: Journal of Clinical Investigation Index Medicus:
Authors: Heeschen C, Weis M, and Cooke JP ART
Yr: 0 Vol: Nbr: Abs: Pg:

Nicotine promotes arteriogenesis.
Periodical: Index Medicus:
Authors: Heeschen C, Weis M, and Cooke JP ART
Yr: Vol: Nbr: Abs: Pg:

Nicotine is a potent activator of adaptive immunity.
Periodical: Index Medicus:
Authors: Aicher A, Heeschen C, Mohaupt M, Cooke JP, Zeiher AM, and Dimmeler S ART
Yr: Vol: Nbr: Abs: Pg:

Nicotine stimulates wound healing in diabetic mice.
Periodical: American Journal of Pathology Index Medicus:
Authors: Jacobi J, Jang JJ, Sundram U, Fajardo L, Cooke JP ART
Yr: 2002 Vol: 161 Nbr: 1 Abs: Pg: 97-104

Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase.
Periodical: Circulation Index Medicus:
Authors: Lin KY, Ito A, Asagami T, Tsao PS, Adimoolam S, Kimoto M, Tsuji H, Reaven G, Cooke JP ART
Yr: 2002 Vol: 106 Nbr: 8 Abs: Pg: 987-92

A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors.
Periodical: Journal of Clinical Investigation Index Medicus:
Authors: Heeschen C, Weis M, Cooke JP ART
Yr: 2002 Vol: 110 Nbr: 4 Abs: Pg: 527-536

Homocysteine impairs coronary microvasular dilator function in humans.
Periodical: Journal of American College Cardiology Index Medicus:
Authors: Tawakol A, Forgione MA, Stuehlinger M, Alpert NM, Cooke JP, et al. ART
Yr: 2002 Vol: 40 Nbr: 6 Abs: Pg: 1051-1058

Short polymers of arginine rapidly translocate into vascular cells: effects on nitric oxide synthesis.
Periodical: Circulation Index Medicus:
Authors: Uemura S, Rothbard J, Matsushita H, Tsao PS, Fathman CG, Cooke JP ART
Yr: 2002 Vol: 66 Nbr: 12 Abs: Pg: 1155-1160

Nicotine promotes arteriogenesis.
Periodical: Journal of American College Cardiology Index Medicus:
Authors: Heeschen C, Weis M, Cooke JP ART
Yr: 2003 Vol: 41 Nbr: 3 Abs: Pg: 489-496

NO and angiogenesis.
Periodical: Cardiovascular Research Index Medicus:
Authors: Cooke JP ART
Yr: 0 Vol: 4 Nbr: 4 Abs: Pg: 53-60

Nicotine strongly activates dendritic cell-mediated adaptive immunity - potential role for progression of atherosclerotic lesions.
Periodical: Circulation Index Medicus:
Authors: Aicher A, Heeschen C, Mohaupt M, Cooke JP, Zeiher AM, Dimmeler S ART
Yr: 2003 Vol: 107 Nbr: 4 Abs: Pg: 604-11

Second hand smoke stimulates tumor angiogernesis and growth.
Periodical: Cancer Cell Index Medicus:
Authors: Zhu B, Heeschen C, Sievers RE, Karliner JS, Parmley WW, Glantz SA, Cooke JP ART
Yr: 2003 Vol: 4 Nbr: 3 Abs: Pg: 191-6

Nicotine and angiogenesis: a new paradigm for tobacco-related diseases.
Periodical: Annals of Medicine Index Medicus:
Authors: Cooke JP, Bitterman H ART
Yr: 2004 Vol: 36 Nbr: 1 Abs: Pg: 33-40

NOS inhibition accelerates atherogenesis: Reversal by exercise.
Periodical: American Journal of Physiology, Heart and Circulatory Physiology Index Medicus:
Authors: Niebauer J, Maxwell AJ, Lin PS, Heidari S, Tsao P, Cooke JP ART
Yr: 2003 Vol: Nbr: Abs: Pg:

Flow-responsive remodeling after angioplasty is enhanced by high cholesterol diet. Prevention with pyrrolidine dithiocarbamate.
Periodical: Atherosclerosis Index Medicus:
Authors: Ward MR, Tsao PS, Herity NA, Cooke JP, Yeung AC ART
Yr: 2003 Vol: 168 Nbr: 2 Abs: Pg: 333-41

DDAH regulates NO synthesis: Genetic and physiological evidence.
Periodical: Circulation Index Medicus:
Authors: Dayoub H, Achan V, Adimoolam S, Jacobi J, Stuehlinger M, Wang B, Cooke AJ, et al ART
Yr: 2003 Vol: 108 Nbr: Abs: Pg: 1043-1048

Discordant effects of a soluble VEGF receptor on wound healing and angiogenesis.
Periodical: Gene Therapy Index Medicus:
Authors: Jacobi J, Tam BYY, Sundram U, von Degenfeld G, Blau HM, Kuo CJ, Cooke JP ART
Yr: 2004 Vol: 11 Nbr: 3 Abs: Pg: 302-9

Developmental endothelial locus-1 (Del-1): a novel angiogenic protein. Its role in ischemia circulation.
Periodical: Circulation Index Medicus:
Authors: Ho H-K V, Jang JJ, Kaji S, Spektor G, Fong A, Yang P. Hu RS, Cooke JP, et al ART
Yr: 2004 Vol: 109 Nbr: 10 Abs: Pg: 1314-9

Asymmetric dimethylarginine (ADMA): A key regulator of nitric oxide synthase.
Periodical: Atherosclerosis Supplement Index Medicus:
Authors: Boger RH, Vallance P, Cooke JP ART
Yr: 2003 Vol: 4 Nbr: 4 Abs: Pg: 1-3

Cardiac allograft vasculopathy and dysregulation of the nitric oxide synthase pathway.
Periodical: Arteriosclerosis, Thrombosis, and Vascular Biology Index Medicus:
Authors: Weis M, Cooke JP ART
Yr: 2003 Vol: 23 Nbr: 4 Abs: Pg: 567-75

Asymmetrical dimethylarginine: the uber marker?
Periodical: Circulation Index Medicus:
Authors: Cooke JP ART
Yr: 2004 Vol: 109 Nbr: 15 Abs: Pg: 1813-8

DDAH Overexpression suppresses graft coronary artery disease in murine cardiac allografts
Periodical: Circulation Index Medicus:
Authors: Tanaka M, Sydow K, Gunawan F, Jacobi J, Tsao PS, Robbins RC and Cooke JP ART
Yr: 2005 Vol: 11 Nbr: Abs: Pg: 1549-56

abnormal cardiovascular resonse to exercise in patients with peripheral arterial disease
Periodical: J Vasc Nurs Index Medicus:
Authors: Oka RK, Altman M, Giacomini JC, Szuba A, Cooke JP ART
Yr: 2005 Vol: 23 Nbr: 4 Abs: Pg: 130-136

Homocysteine-induced vascular dysregulation is mediated by the NMDA receptor
Periodical: Vascular Medicine Index Medicus:
Authors: Qureshi L, Chen H, Brown AT, Fitzgerald R, Wang Y , Breckenridge J, Kazi R, Crocker AJ ART
Yr: 2005 Vol: 10 Nbr: 3 Abs: Pg: 215-223

ADMA increase arterial stiffness and decreases cerebral blood flow in man
Periodical: Stroke Index Medicus:
Authors: Kielstein JT, Donnerstag F, Gasper S, Menne J, Kielstein A, Martens-Lobenhoffer J, Scalera ART
Yr: 2006 Vol: Nbr: Abs: Pg:

Insulin resistance potential role of the endogenous nitric oxide synthase inhibitor ADMA
Periodical: Vascular Medicine Index Medicus:
Authors: Sydow K, Mondon CE and Cooke JP ART
Yr: 0 Vol: Nbr: 10 Abs: Pg: 35-43

Its role in Vascular disease
Periodical: Vascular Medicine Index Medicus:
Authors: Cooke JP ART
Yr: 2005 Vol: 10 Nbr: Abs: Pg: S11-17

Asymmetric Dimethylarginine ADMA an endogenous inhibitor of angiogenesis
Periodical: European Journal of Clinical Pharmacol Index Medicus:
Authors: Cooke JP ART
Yr: 2006 Vol: 13 Nbr: Abs: Pg: 115-121

A Central role for nicotinic cholinergic regulation of growth factor- induced endothelial cell migration -Novel insights into angiogenesis.
Periodical: Arteriosclerosis, Thrombosis, and Vascular Biology Index Medicus:
Authors: Cooke JP ART
Yr: 2007 Vol: 1 Nbr: 27 Abs: Pg: 106-12

Non-bone marrowderived circulating cells contribute to postnatal neovascularization followinf tissue ischemia.
Periodical: Circulation Research Index Medicus:
Authors: Cooke JP ART
Yr: 2007 Vol: 4 Nbr: Abs: Pg: 581-589

Dimethylarginine dimethylaminohydrolase promotes endothelial repair after vascular injury.
Periodical: Journal American Coll Cardiol Index Medicus:
Authors: Cooke JP ART
Yr: 2007 Vol: 49 Nbr: 10 Abs: Pg: 1099-105

A novel bioluminescent tumor model of human renal cancer cell lines ; an in vitro and in vivo characterization.
Periodical: Journal of Urology Index Medicus:
Authors: Cooke JP ART
Yr: 2007 Vol: 6 Nbr: 117 Abs: Pg: 2342-6

Alterations in No and ADMA with with acute cerebral ischemia. amelioration with the chaperonin GroEI.
Periodical: Neuroscience Letters Index Medicus:
Authors: Cooke JP ART
Yr: 2007 Vol: 2 Nbr: 17 Abs: Pg: 201-4

Asymmetric dimethyl L-arginine (ADMA) is a critical regulator of myocardial reperfusion injury.
Periodical: Cardiovascular Research Index Medicus:
Authors: Cooke, JP ART
Yr: 2007 Vol: 2 Nbr: Abs: Pg: 417-425

Overexpression of Dimethylarginine Dimethylaminohdrolase Inibits ADMA-Induced Endothelial Dysfunction in Cerebral Circulation.
Periodical: Stroke Index Medicus:
Authors: Cooke JP ART
Yr: 2007 Vol: Nbr: Abs: Pg:

Mecamylamine suppresses basal and nicotine-stimulated choroidal neovascularization.
Periodical: Investigative Ophthalmology and Visual Science Index Medicus:
Authors: Kiuchi, Matsuoka, Wu, Lima, Silver, Kengatharan, Verghese, Yokoi, Khu, Cooke, Campochiar ART
Yr: 2008 Vol: 49 Nbr: 4 Abs: Pg: 1705-1711

Dimethylarginine dimethylaminohydrolase enhances insulin sensitivity.
Periodical: Arteriosclerosis, Thrombosis, and Vascular Biology Index Medicus:
Authors: Sydow K, Nondon CE, Schrader J, Konishi H, Cooke JP ART
Yr: 2008 Vol: 28 Nbr: 4 Abs: Pg: 692-697

Overexpression of dimethylarginine dimethylaminohydrolase inhibits ADMA-induced endothelial dysfunction in cerebral circulation.
Periodical: Stroke Index Medicus:
Authors: Sayoub H, Rodionov R, Lynch C, Cooke JP, arning E, Bottiglierie T, Lentz SR, Faraci FM ART
Yr: 2008 Vol: 39 Nbr: Abs: Pg: 180-184

Endothelial nicotinic acetylcholine receptors and angiogenesis.
Periodical: Trends in Cardiovascular Medicine Index Medicus:
Authors: Cooke JP, Ghebremariam YT ART
Yr: 2008 Vol: 18 Nbr: 7 Abs: Pg: 247-253

Murine moderlof hindimb ischemia.
Periodical: Journal of Visualized Experiments Index Medicus:
Authors: Niiyama H, Huang NF, Rollons M, Cooke JP ART
Yr: 2009 Vol: 21 Nbr: 23 Abs: Pg: pii:1035

Embryonic stem cell-derived endothelial cells for treatment of hindlimb ischemi.
Periodical: Journal of Visualized Experiments Index Medicus:
Authors: Huang NF, Niiyama H, De A, Gambhir SS, Cooke JP ART
Yr: 2009 Vol: 23 Nbr: 23 Abs: Pg: pii 1034

Cholinergic modulation of angiogenesis: Role of the a7 nicotinic acetylcholine receptor. [Epub ahead of print]
Periodical: Journal of Cellular Biochemistry Index Medicus:
Authors: Wu J, Chruscinski A, deJesus Perez V, Singh H, Pitsiouni M, Rabinovitch M, Utz P, Cooke JP ART
Yr: 2009 Vol: Nbr: Abs: Pg:

Chronic exposure to nicotine impairs cholinergic angiogenesis.
Periodical: Vascular Medicine Index Medicus:
Authors: Konshi H, Wu J. Cooke JP ART
Yr: 2009 Vol: Nbr: Abs: Pg:

Cholinergic modulation of angiogenesis: Role of the a7 nicotinic acetylcholine receptor.
Periodical: Journal of Cellular Biochemistry Index Medicus:
Authors: Chruscinski A, de Jesus Perez V, Singh H, Pitsiouni M, Rabinovitch M, Utz PJ, Cooke JP ART
Yr: 2009 Vol: Nbr: Abs: Pg:

Chronic exposure to nicotine impairs cholinergic angiogenesis.
Periodical: Vascular Medicine Index Medicus:
Authors: Konoshi H, Wu J, Cooke JP ART
Yr: 2010 Vol: PMID Nbr: Abs: Pg:

Topical mecamylamine for diabetic macular edema
Periodical: American Journal Opthalmology Index Medicus:
Authors: Campochiaro, Shah, Hafiz, Heier, Lit, Zimmer-Galler, Channa, Nguyen, Syed, Do, Lu, Monk, ART
Yr: 2010 Vol: 149 Nbr: 5 Abs: Pg: 839-851

Cholinergic activation of hematopoiesis: A new paradigm for tovacco-induced leukocytosis?
Periodical: Vascular Medicine Index Medicus:
Authors: Chang E, Forsberg C, Wang B, Wu J, Prohaska S, Allsopp R, Weissman IL, Cooke, JP ART
Yr: 2010 Vol: 15 Nbr: 5 Abs: Pg: 375-385

The role of nicotine in the pathogenesis of atherosclerosis
Periodical: Atherosclerosis Index Medicus:
Authors: Lee J, Cooke JP ART
Yr: 2011 Vol: 215 Nbr: 2 Abs: Pg: 281-283

Dietary nitrate, nitric oxide, and restenosis.
Periodical: Journal of Clinical Investigation Index Medicus:
Authors: Cooke JP, Ghebremariam YT. ART
Yr: 2011 Vol: 121 Nbr: 4 Abs: Pg: 1258-60

DDAH says NO to ADMA.
Periodical: Arteriosclerosis, Thrombosis, and Vascular Biology Index Medicus:
Authors: Cooke JP, Ghebremariam YT. ART
Yr: 2011 Vol: 31 Nbr: 7 Abs: Pg: 1462-4

Endothelial cells derived from human iPSCS increase capillary density and improve perfusion in a mouse model of peripheral arterial disease.
Periodical: Arteriosclerosis, Thrombosis, and Vascular Biology Index Medicus:
Authors: Rufaihah AJ, Huang NF, Jamé S, Lee JC, Nguyen HN, Byers B, De A, Okogbaa J, Rollins M, Rei ART
Yr: 2011 Vol: 31 Nbr: 11 Abs: Pg: e72-9

Nicotine and pathological angiogenesis.
Periodical: Life Sciences_x000D_ Index Medicus:
Authors: Lee J, Cooke JP. ART
Yr: 2012 Vol: Nbr: Abs: Pg: epub

Activation of innate immunity is required for efficient nuclear reprogramming
Periodical: Cell Index Medicus:
Authors: Lee J, Sayed N, Hunter A, Au KF, Wong WH, Mocarski E, Reijo Pera R, Cooke JP. ART
Yr: 2012 Vol: Nbr: Abs: Pg: