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Sherven Sharma, Ph.D.

University of California, Los Angeles

# of Grants: 2

Grants


Chemokine-based therapy for lung cancer	2001 (Cycle 10)	$416,940
Cancer	Research Project Awards

Immune Targeted Therapy for Lung Cancer	2006 (Cycle 15)	$419,500
Cancer	Research Project Awards

Publications

SLC reduces pulmonary tumor burden in spontaneous murine bronchoalveolar cell carcinoma.
Periodical: Cancer Research			Index Medicus:
Authors: Sharma S, Stolina M, Zhu L, Lin Y, Batra RK, Huang M, Strieter R, and Dubinett SM				ART
Yr: 2991	Vol: 61	Nbr: 17	Abs:	Pg: 6406-12

Non-small cell lung cancer cyclooxygenase-2-dependent invasion is mediated by CD44.
Periodical: Journal of Biological Chemistry			Index Medicus:
Authors: Dohadwala M, Luo J, Lin Y Dougherty GJ, Sharma S, Huang M, Pold M, Batra RK, Dubinett SM				ART
Yr: 2001	Vol: 276	Nbr: 24	Abs:	Pg: 20809-12

Ectopic expression of the thyroperoxidase gene augments radiolodide uptake and retention mediated by the socium iodide symporter in non-small cell lung cancer.
Periodical: Proceedings of the National Academy of Sciences of the United States of America			Index Medicus:
Authors: Hunag M, Batra RK, Kogai T, Lin YQ, Hershman JM, Lichtenstein A, Sharma S, et al				ART
Yr: 2000	Vol: 97	Nbr: 15	Abs:	Pg: 8519-24

SLC/CCL21-mediated anti-tumor responses require IFNy, MIG/CXCL9 and IP-10/CXCL10.
Periodical: Molecular Cancer Research			Index Medicus:
Authors: Sharma S, Yang SC, Hillinger S, Zhu L, Huang M, Batra RK, Lin JF, Burdick MD, et al				ART
Yr: 2003	Vol: 2	Nbr: 1	Abs:	Pg: 22

Tumor COX-2 dependent regulation of murine dendritic cell function.
Periodical: Clinical Cancer Research			Index Medicus:
Authors: Sharma S, Stolina M, Baratelli F, Lin JF, Atianzar K, Zhu L, Lin Y, et al				ART
Yr: 2003	Vol: 9	Nbr:	Abs:	Pg: 961-968

Non-small cell lung cancer-derived soluble mediators enhance apoptosis in T lymphocytes through an I kappa B kinase-dependent mechanism.
Periodical: Cancer Research			Index Medicus:
Authors: Batra R, Lin Y, Gardner B, Luo J, Dohadwala M, Sharma S, Dubinett SM				ART
Yr: 2003	Vol: 63	Nbr:	Abs:	Pg: 642-646

Abnormal IL-10Ralpha expression contributes to the maintenance of elevated COX-2 in non-small cell lung cancer cells.
Periodical: Cancer Research			Index Medicus:
Authors: Heuze-Vourc'h N, Krysan K, Batra RK, Sharma S, Dubinett SM				ART
Yr: 2003	Vol: 63	Nbr:	Abs:	Pg: 766-770

IL-10 mediates the sigma receptor-dependent suppression of antitumor immunity.
Periodical: Journal of Immunology			Index Medicus:
Authors: Zhu LX, Sharma S, Gardner B, Escuadro B, Atianzar K, Tashkin D, Dubinett SM				ART
Yr: 2003	Vol: 170	Nbr:	Abs:	Pg: 3585-3591

Secondary lymphoid tissue chemokine mediates T cell-dependent antitumor responses in vivo.
Periodical: Journal of Immunology			Index Medicus:
Authors: Sharma S, Stolina M, Luo J, Strieter RM, Burdick M, Zhu LI, Batra RK, Dubinett SM				ART
Yr: 2000	Vol: 164	Nbr:	Abs:	Pg: 4558 - 4563

Secondary lymphoid organ chemokine reduces pulmonary tumor burden in spontaneous murine bronchoalveolar cell carcinoma.
Periodical: Cancer Research			Index Medicus:
Authors: Sharma S, Stolina M, Zhu L, Lin Y, Batra R, Huang M Strieter R, Dubinett SM				ART
Yr: 2001	Vol: 1;61	Nbr: 17	Abs:	Pg: 6406 - 6412

Over expression of CCL-21/Secondary lymphoid tissue chemokine in human dendritic cells augments patacrine chemotactic activities for lymphocytes and antigen presenting cells.
Periodical: Molecular Cancer Research			Index Medicus:
Authors: Sharma S, Riedl K, Baratelli F, Batra RK, Yang SC, Luo J, Escuadro B, Figlin R, et al.				ART
Yr: 2003	Vol: 2	Nbr:	Abs:	Pg: 35

Cyclooxygenase 2-dependent regulation of antitumor immunity in lung cancer.
Periodical: Methods in Molecular Medicine			Index Medicus:
Authors: Sharma S, Huang M, Dohadwala M, Pold M, Batra RK, Dubinett SM, et al.				ART
Yr: 2003	Vol: 75	Nbr:	Abs:	Pg: 723 - 736

Intratumoral therapy with cytokine gene-modified dentritic cells in murine lung cancer models.
Periodical: Methods in Molecular Medicine			Index Medicus:
Authors: Sharma S, Yang SC, Batra RK, Dubinett SM				ART
Yr: 2003	Vol: 75	Nbr:	Abs:	Pg: 711 - 722

EBV-induced molecule 1 ligand chemokine (ELC/CCL19) promotes IFN-gamma-dependent antitumor responses in a lung cancer model.
Periodical: Journal of Immunology			Index Medicus:
Authors: Sharma S, Hillinger S, Yang SC, Zhu L, Huang M Duckett R, Atianzar K, Batra RK, et al.				ART
Yr: 2003	Vol: 171	Nbr: 12	Abs:	Pg: 6457 - 6465

Interleukin-7 gene-modified dendritic cells reduce pulmonary tumor burden in spontaneous murine bronchoalveolar cell carcinoma.
Periodical: Human Gene Therapy			Index Medicus:
Authors: Sharma S, Batra RK, Yang SC, Hillinger S, Zhu L, Atianzar K, Strieter RM, et al				ART
Yr: 2003	Vol: 14	Nbr: 16	Abs:	Pg: 1511 - 1524

Tumor cyclooxygenase 2-dependent suppression of dendritic cell function.
Periodical: Clinical Cancer Research			Index Medicus:
Authors: Sharma S, Stolina M, Yang SC, Baratelli F, Lin JF, Atianzar K, Luo J, Zhu L, Lin Y, et al.				ART
Yr: 2003	Vol: 9	Nbr: 3	Abs:	Pg: 961 - 968

Intratumoral administration of dendritic cells overexpressing CCL21 generates systemic antitumor responses and confers tumor immunity.
Periodical: Clinical Cancer Research			Index Medicus:
Authors: Sharma S, Yang SC, Hillinger S, Riedl K, Zhang L, Zhu L, Huang M, Atianzar K, et al.				ART
Yr: 2004	Vol: 10	Nbr: 8	Abs:	Pg: 2891 - 2901

Tumor COX-2/PGE2 dependent promotion of FOXP3 expression and CD4+CD25+ T regulatory cell activities in lung cancer.
Periodical: Cancer Research			Index Medicus:
Authors: Sharma S, Yang SC, Zhu L, Reckamp K, Gardner B, Baratelli F, Zhang L, Huang M, et al.				ART
Yr: 2005	Vol: 65	Nbr: 14	Abs:	Pg: 6275 - 6281

COX-2 inhibition promotes IFNy-dependent enhancement of anti-tumor immunity.
Periodical: Journal of Immunology			Index Medicus:
Authors: Sharma S, Zhu L, Hillinger S, Yang SC, Gardner B, Kuo B, Reckamp K. Strieter RM, et al.				ART
Yr: 2005	Vol: 175	Nbr: 2	Abs:	Pg: 813 - 819

PGE2 induces FOXP3 gene expression and T regulatory function in human CD4+ T cells.
Periodical: Journal of Immunology			Index Medicus:
Authors: Sharma S, Baratelli F, Lin Y, Zhu L, Yang SC, Heuze-Voure'h N, Zeng G, et al.				ART
Yr: 2005	Vol: 175	Nbr: 3	Abs:	Pg: 1483 - 1490

CXC chemokines: angiogenesis, immunoangiostasis, and metastases in lung cancer.
Periodical: Annals of the New York Academy of Sciences			Index Medicus:
Authors: Sharma S, Strieter RM, Belperio JA, Burdick MD, Dubinett SM Keane MP				ART
Yr: 2004	Vol: 1028	Nbr:	Abs:	Pg: 351 - 360

SLC reduces pulmonary tumor burden in spontaneous murine bronchoalveolar cell carcinoma.
Periodical: Cancer Research			Index Medicus:
Authors: Sharma S, Stolina M, Zhu L, Lin Y, Batra RK, Huang M, Strieter R, and Dubinett SM				ART
Yr: 2991	Vol: 61	Nbr: 17	Abs:	Pg: 6406-12

Non-small cell lung cancer cyclooxygenase-2-dependent invasion is mediated by CD44.
Periodical: Journal of Biological Chemistry			Index Medicus:
Authors: Dohadwala M, Luo J, Lin Y Dougherty GJ, Sharma S, Huang M, Pold M, Batra RK, Dubinett SM				ART
Yr: 2001	Vol: 276	Nbr: 24	Abs:	Pg: 20809-12

Ectopic expression of the thyroperoxidase gene augments radiolodide uptake and retention mediated by the socium iodide symporter in non-small cell lung cancer.
Periodical: Proceedings of the National Academy of Sciences of the United States of America			Index Medicus:
Authors: Hunag M, Batra RK, Kogai T, Lin YQ, Hershman JM, Lichtenstein A, Sharma S, et al				ART
Yr: 2000	Vol: 97	Nbr: 15	Abs:	Pg: 8519-24

SLC/CCL21-mediated anti-tumor responses require IFNy, MIG/CXCL9 and IP-10/CXCL10.
Periodical: Molecular Cancer Research			Index Medicus:
Authors: Sharma S, Yang SC, Hillinger S, Zhu L, Huang M, Batra RK, Lin JF, Burdick MD, et al				ART
Yr: 2003	Vol: 2	Nbr: 1	Abs:	Pg: 22

Tumor COX-2 dependent regulation of murine dendritic cell function.
Periodical: Clinical Cancer Research			Index Medicus:
Authors: Sharma S, Stolina M, Baratelli F, Lin JF, Atianzar K, Zhu L, Lin Y, et al				ART
Yr: 2003	Vol: 9	Nbr:	Abs:	Pg: 961-968

Non-small cell lung cancer-derived soluble mediators enhance apoptosis in T lymphocytes through an I kappa B kinase-dependent mechanism.
Periodical: Cancer Research			Index Medicus:
Authors: Batra R, Lin Y, Gardner B, Luo J, Dohadwala M, Sharma S, Dubinett SM				ART
Yr: 2003	Vol: 63	Nbr:	Abs:	Pg: 642-646

Abnormal IL-10Ralpha expression contributes to the maintenance of elevated COX-2 in non-small cell lung cancer cells.
Periodical: Cancer Research			Index Medicus:
Authors: Heuze-Vourc'h N, Krysan K, Batra RK, Sharma S, Dubinett SM				ART
Yr: 2003	Vol: 63	Nbr:	Abs:	Pg: 766-770

IL-10 mediates the sigma receptor-dependent suppression of antitumor immunity.
Periodical: Journal of Immunology			Index Medicus:
Authors: Zhu LX, Sharma S, Gardner B, Escuadro B, Atianzar K, Tashkin D, Dubinett SM				ART
Yr: 2003	Vol: 170	Nbr:	Abs:	Pg: 3585-3591

Secondary lymphoid tissue chemokine mediates T cell-dependent antitumor responses in vivo.
Periodical: Journal of Immunology			Index Medicus:
Authors: Sharma S, Stolina M, Luo J, Strieter RM, Burdick M, Zhu LI, Batra RK, Dubinett SM				ART
Yr: 2000	Vol: 164	Nbr:	Abs:	Pg: 4558 - 4563

Secondary lymphoid organ chemokine reduces pulmonary tumor burden in spontaneous murine bronchoalveolar cell carcinoma.
Periodical: Cancer Research			Index Medicus:
Authors: Sharma S, Stolina M, Zhu L, Lin Y, Batra R, Huang M Strieter R, Dubinett SM				ART
Yr: 2001	Vol: 1;61	Nbr: 17	Abs:	Pg: 6406 - 6412

Over expression of CCL-21/Secondary lymphoid tissue chemokine in human dendritic cells augments patacrine chemotactic activities for lymphocytes and antigen presenting cells.
Periodical: Molecular Cancer Research			Index Medicus:
Authors: Sharma S, Riedl K, Baratelli F, Batra RK, Yang SC, Luo J, Escuadro B, Figlin R, et al.				ART
Yr: 2003	Vol: 2	Nbr:	Abs:	Pg: 35

Cyclooxygenase 2-dependent regulation of antitumor immunity in lung cancer.
Periodical: Methods in Molecular Medicine			Index Medicus:
Authors: Sharma S, Huang M, Dohadwala M, Pold M, Batra RK, Dubinett SM, et al.				ART
Yr: 2003	Vol: 75	Nbr:	Abs:	Pg: 723 - 736

Intratumoral therapy with cytokine gene-modified dentritic cells in murine lung cancer models.
Periodical: Methods in Molecular Medicine			Index Medicus:
Authors: Sharma S, Yang SC, Batra RK, Dubinett SM				ART
Yr: 2003	Vol: 75	Nbr:	Abs:	Pg: 711 - 722

EBV-induced molecule 1 ligand chemokine (ELC/CCL19) promotes IFN-gamma-dependent antitumor responses in a lung cancer model.
Periodical: Journal of Immunology			Index Medicus:
Authors: Sharma S, Hillinger S, Yang SC, Zhu L, Huang M Duckett R, Atianzar K, Batra RK, et al.				ART
Yr: 2003	Vol: 171	Nbr: 12	Abs:	Pg: 6457 - 6465

Interleukin-7 gene-modified dendritic cells reduce pulmonary tumor burden in spontaneous murine bronchoalveolar cell carcinoma.
Periodical: Human Gene Therapy			Index Medicus:
Authors: Sharma S, Batra RK, Yang SC, Hillinger S, Zhu L, Atianzar K, Strieter RM, et al				ART
Yr: 2003	Vol: 14	Nbr: 16	Abs:	Pg: 1511 - 1524

Tumor cyclooxygenase 2-dependent suppression of dendritic cell function.
Periodical: Clinical Cancer Research			Index Medicus:
Authors: Sharma S, Stolina M, Yang SC, Baratelli F, Lin JF, Atianzar K, Luo J, Zhu L, Lin Y, et al.				ART
Yr: 2003	Vol: 9	Nbr: 3	Abs:	Pg: 961 - 968

Intratumoral administration of dendritic cells overexpressing CCL21 generates systemic antitumor responses and confers tumor immunity.
Periodical: Clinical Cancer Research			Index Medicus:
Authors: Sharma S, Yang SC, Hillinger S, Riedl K, Zhang L, Zhu L, Huang M, Atianzar K, et al.				ART
Yr: 2004	Vol: 10	Nbr: 8	Abs:	Pg: 2891 - 2901

Tumor COX-2/PGE2 dependent promotion of FOXP3 expression and CD4+CD25+ T regulatory cell activities in lung cancer.
Periodical: Cancer Research			Index Medicus:
Authors: Sharma S, Yang SC, Zhu L, Reckamp K, Gardner B, Baratelli F, Zhang L, Huang M, et al.				ART
Yr: 2005	Vol: 65	Nbr: 14	Abs:	Pg: 6275 - 6281

COX-2 inhibition promotes IFNy-dependent enhancement of anti-tumor immunity.
Periodical: Journal of Immunology			Index Medicus:
Authors: Sharma S, Zhu L, Hillinger S, Yang SC, Gardner B, Kuo B, Reckamp K. Strieter RM, et al.				ART
Yr: 2005	Vol: 175	Nbr: 2	Abs:	Pg: 813 - 819

PGE2 induces FOXP3 gene expression and T regulatory function in human CD4+ T cells.
Periodical: Journal of Immunology			Index Medicus:
Authors: Sharma S, Baratelli F, Lin Y, Zhu L, Yang SC, Heuze-Voure'h N, Zeng G, et al.				ART
Yr: 2005	Vol: 175	Nbr: 3	Abs:	Pg: 1483 - 1490

CXC chemokines: angiogenesis, immunoangiostasis, and metastases in lung cancer.
Periodical: Annals of the New York Academy of Sciences			Index Medicus:
Authors: Sharma S, Strieter RM, Belperio JA, Burdick MD, Dubinett SM Keane MP				ART
Yr: 2004	Vol: 1028	Nbr:	Abs:	Pg: 351 - 360

Intrapulomonary administration of CCL21 gene-modified dendritic cells reduces tumor burden in spontaneous murine bronchoalveolar cell carcinoma
Periodical: Cancer Research			Index Medicus:
Authors: Yang, S.C., Batra, R.K., Hillinger, S., Rekamp, K.L., Strieter, R.M., Dubinett, S., Sharma				ART
Yr: 2006	Vol: 66	Nbr: 6	Abs:	Pg: 3205-13

CCl19 reduces tumour burden in a model of advanced lung cancer
Periodical: British Journal of Cancer			Index Medicus:
Authors: Hillinger, S., Yang, S.C., Btra, R.K., Strieter, R.M., Weder, W., Dubinett, S.M, Sharma, S				ART
Yr: 2006	Vol: 94	Nbr: 7	Abs:	Pg: 1029-34

Inflammation in lung carcinogenesis: new targets for lung cancer chemoprevention and treatment
Periodical: Critical Reviews in Oncology/Hematolgy			Index Medicus:
Authors: Lee, J.M., Yanagawa, J., Peebles, K.A., Sharma, S., Mao, J.T., Dubinett, S.M.				ART
Yr: 2008	Vol: 66	Nbr: 3	Abs:	Pg: 208-17

Tumor response to combination celecoxib and erlotinib therapy in no-smal cell lung cancer is assocated with a low baseline matrix mettalloproteinase-9 and a decline in serum-soluable E-caderherin
Periodical: Journal of Thoracic Oncology			Index Medicus:
Authors: Reckamp, K.L, Gardner, B.K., Figlin, R.A., Elashoff, D., Kryasan, K., Dohadwala, M., Mao,				ART
Yr: 2008	Vol: 2	Nbr:	Abs:	Pg: 117-24

Immunolgic Approaches to Lung Cancer Therapy
Periodical: Lung Cancer			Index Medicus:
Authors: Lee, J.M., Dubinett, S.M., Sharma, S.				ART
Yr: 2007	Vol: 3 Edition	Nbr:	Abs:	Pg:

Inflammation and lung carcinogenesis: applying new findings in prevention and treatment
Periodical: Expert Review of Anticancer Therapy			Index Medicus:
Authors: Peebles, K.A., Lee, J.M., Mao, J.T., Harza, S., Reckamp, K.L., Krysa, K., Dohadwala, M.,				ART
Yr: 2007	Vol: 7	Nbr: 10	Abs:	Pg: 1405-21

IL-7 promotes CXCR3 ligand-dependent T cell antitumor reactivity in lung cancer.
Periodical: Journal of Immunology			Index Medicus:
Authors: Anderson A,Yang S, Huang M, Zhu L, Kar U, Batra R, Elashoff D;StrieterR;Dubinett S SharmaS				ART
Yr: 2009	Vol: 182	Nbr: 11	Abs:	Pg: 6951-6958

Intrapulomonary administration of CCL21 gene-modified dendritic cells reduces tumor burden in spontaneous murine bronchoalveolar cell carcinoma
Periodical: Cancer Research			Index Medicus:
Authors: Yang, S.C., Batra, R.K., Hillinger, S., Rekamp, K.L., Strieter, R.M., Dubinett, S., Sharma				ART
Yr: 2006	Vol: 66	Nbr: 6	Abs:	Pg: 3205-13

CCl19 reduces tumour burden in a model of advanced lung cancer
Periodical: British Journal of Cancer			Index Medicus:
Authors: Hillinger, S., Yang, S.C., Btra, R.K., Strieter, R.M., Weder, W., Dubinett, S.M, Sharma, S				ART
Yr: 2006	Vol: 94	Nbr: 7	Abs:	Pg: 1029-34

Inflammation in lung carcinogenesis: new targets for lung cancer chemoprevention and treatment
Periodical: Critical Reviews in Oncology/Hematolgy			Index Medicus:
Authors: Lee, J.M., Yanagawa, J., Peebles, K.A., Sharma, S., Mao, J.T., Dubinett, S.M.				ART
Yr: 2008	Vol: 66	Nbr: 3	Abs:	Pg: 208-17

Tumor response to combination celecoxib and erlotinib therapy in no-smal cell lung cancer is assocated with a low baseline matrix mettalloproteinase-9 and a decline in serum-soluable E-caderherin
Periodical: Journal of Thoracic Oncology			Index Medicus:
Authors: Reckamp, K.L, Gardner, B.K., Figlin, R.A., Elashoff, D., Kryasan, K., Dohadwala, M., Mao,				ART
Yr: 2008	Vol: 2	Nbr:	Abs:	Pg: 117-24

Immunolgic Approaches to Lung Cancer Therapy
Periodical: Lung Cancer			Index Medicus:
Authors: Lee, J.M., Dubinett, S.M., Sharma, S.				ART
Yr: 2007	Vol: 3 Edition	Nbr:	Abs:	Pg:

Inflammation and lung carcinogenesis: applying new findings in prevention and treatment
Periodical: Expert Review of Anticancer Therapy			Index Medicus:
Authors: Peebles, K.A., Lee, J.M., Mao, J.T., Harza, S., Reckamp, K.L., Krysa, K., Dohadwala, M.,				ART
Yr: 2007	Vol: 7	Nbr: 10	Abs:	Pg: 1405-21

IL-7 promotes CXCR3 ligand-dependent T cell antitumor reactivity in lung cancer.
Periodical: Journal of Immunology			Index Medicus:
Authors: Anderson A,Yang S, Huang M, Zhu L, Kar U, Batra R, Elashoff D;StrieterR;Dubinett S SharmaS				ART
Yr: 2009	Vol: 182	Nbr: 11	Abs:	Pg: 6951-6958