Research Portfolio

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Francis Szoka, Ph.D.

University of California, San Francisco # of Grants: 3

Grants

Gene therapy for emphysema 1997 (Cycle 6) $443,179
Pulmonary Disease Research Project Awards

Gene Therapy for Emphysema 1994 (Cycle 3) $74,844
Pulmonary Disease Inno Dev & Exp Awards (IDEAS)

Liposome targeted chemotherapy to treat lung cancer 1999 (Cycle 8) $75,000
Pulmonary Disease Inno Dev & Exp Awards (IDEAS)
Publications

Effects of complement on the pharmacokinetics and gene delivery mediated by cationic lipid-DNA complexes
Periodical: Human Gene Therapy Index Medicus:
Authors: Barron LG, Meyer KB, Szoka FC Jr ART
Yr: 1998 Vol: 9 Nbr: Abs: Pg: 315-323

Synthesis and characterization of long chain alkyl acyl carnitine esters. Potentially biodegradable cationic lipids for use in gene delivery
Periodical: Journal of Medicinal Chemistry Index Medicus:
Authors: Wang J, Guo X, Xu Y, Barron L, Szoka FC Jr ART
Yr: 1998 Vol: 41 Nbr: Abs: Pg: 2207-2215

Biochemical, morphological and functional analysis of a cyclic peptide, phospholipid and DNA tenary complex used for gene therapy
Periodical: Journal of Liposome Research Index Medicus:
Authors: Legendre JY, Huang S-K, Szoka FC Jr ART
Yr: 1998 Vol: 8 Nbr: Abs: Pg: 347-366

Branched cationic peptides for gene delivery: role of type and number of cationic residues in formation and in vitro activity of DNA polyplexes
Periodical: Human Gene Therapy Index Medicus:
Authors: Plank C, Tang MX, Wolfe AR, Szoka FC Jr. ART
Yr: 1999 Vol: 10 Nbr: Abs: Pg: 319-332

Cationic lipids are essential for gene delivery mediated by intravenous administration of lipoplexes
Periodical: Human Gene Therapy Index Medicus:
Authors: Barron LG, Uyechi LS, Szoka FC Jr. ART
Yr: 1999 Vol: 6 Nbr: Abs: Pg: 1179-1183

Lipoplex-mediated gene delivery to the lung occurs within 60 minutes of intravenous administration
Periodical: Human Gene Therapy Index Medicus:
Authors: Barron LG, Gagne L, Szoka FC Jr. ART
Yr: 1999 Vol: 10 Nbr: Abs: Pg: 1683-1894

Physicochemical characterization and purification of cationic lipoplexes
Periodical: Biophysical Journal Index Medicus:
Authors: Xu Y,Hui S-W, Frederik P, Szoka FC ART
Yr: 1999 Vol: 77 Nbr: Abs: Pg: 341-353

Controlled template-assisted assembly of plasmid DNA into nanometric particles with high DNA concentration
Periodical: Bioconjugate Chemistry Index Medicus:
Authors: Ouyang M, Remy J-S, Szoka FC ART
Yr: 2000 Vol: 11 Nbr: 1 Abs: Pg: 104-112

Liposome encapsulated doxorubicin targeted to CD44: A strategy to kill CD44 overexpressing tumor cells
Periodical: Cancer Research Index Medicus:
Authors: Eliaz RE, Szoka Jr FC ART
Yr: 2001 Vol: 61 Nbr: Abs: Pg: 2592-2601

Mechanism of lipoplex gene delivery in mouse lung: binding and internalization of fluorescent lipid and DNA components
Periodical: Human Gene Therapy Index Medicus:
Authors: Uyechi LS, Thurston G, Gagne L, Szoka Jr FC ART
Yr: 2001 Vol: 8 Nbr: Abs: Pg: 828-836