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Athina Markou, Ph.D.

University of California, San Diego # of Grants: 4

Grants

Neurobiological substrates of nicotine addiction 1998 (Cycle 7) $742,393
Nicotine Dependence Research Project Awards

Neurobiological substrates of nicotine addiction 2001 (Cycle 10) $402,852
Nicotine Dependence Research Project Awards

Neurobiological substrates of nicotine addiction 2003 (Cycle 12) $723,613
Nicotine Dependence Research Project Awards

Neurobiological substrates of nicotine addiction 2006 (Cycle 15) $419,503
Nicotine Dependence Research Project Awards
Publications

Blockade of nicotine self-administration with nicotinic antagonists in rats
Periodical: Pharmacology Biochemistry and Behavior Index Medicus:
Authors: Watkins SS, Epping-Jordan MP, Koob GF, Markou A ART
Yr: 1999 Vol: 62 Nbr: 4 Abs: Pg: 743-751

Reward and somatic changes during precipitated nicotine withdrawal in rats: centrally and peripherally mediated effects
Periodical: Journal of Pharmacology and Experimental Therapeutics Index Medicus:
Authors: Watkins SS, Stinus L, Koob GF, Markou A ART
Yr: 2000 Vol: 292 Nbr: 3 Abs: Pg: 1053-1064

Neural mechanisms underlying nicotine addiction: acute positive reinforcement and withdrawal
Periodical: Nicotine and Tobacco Research Index Medicus:
Authors: Watkins SS, Koob GF, Markou A ART
Yr: 2000 Vol: Nbr: Abs: Pg:

Nicotine potentiation of brain stimulation reward reversed by DH E and SCH 23390, but not by eticlopride, LY 314582 or MPE in rats.
Periodical: Psychopharmacology Index Medicus:
Authors: Harrison, AA, Gasparini F, and Markou A ART
Yr: 2002 Vol: 160 Nbr: Abs: Pg: 56-66

Neuroadaptations to chronic exposure to drugs of abuse: Relevance to depressive symptomatology seen across phychiatric diagnostic categories.
Periodical: Neurotoxicity Research Index Medicus:
Authors: Markou A, and Kenny JP ART
Yr: 2002 Vol: 4 Nbr: 4 Abs: Pg: 297-313

Increased GABA neurotransmission via administration of gamma-vinyl GABA decreased nicotine self-administration in the rat.
Periodical: Synapse Index Medicus:
Authors: Paterson NE, and Markou A ART
Yr: 2002 Vol: 44 Nbr: Abs: Pg: 252 - 253

Effects of repeated withdrawal episodes, nicotine dose, and duration of nicotine exposure on the severity and duration of nicotine withdrawal in rats.
Periodical: Psychopharmacology Index Medicus:
Authors: Skjei KL, Markou A ART
Yr: 2003 Vol: 168 Nbr: Abs: Pg: 280-292

Cocaine-seeking behavior after extended cocaine abstinence in rats: role of conditioned stimuli.
Periodical: Psychopharmacology Index Medicus:
Authors: Semenova S, Markou A ART
Yr: 168 Vol: Nbr: 192-200 Abs: Pg:

Decreased prepulse inhibition during nicotine withdrawal in DBA/2J mice is reversed by nicotine self-administration.
Periodical: European Journal of Pharmacology Index Medicus:
Authors: Semenova S, Bespalov A, Markou A ART
Yr: 2003 Vol: 472 Nbr: Abs: Pg: 99-110

The antismoking and antidepressant agent bupropion enhances brain reward function and reverses the affective and somatic aspects of nicotine withdrawal.
Periodical: Psychopharmacology Index Medicus:
Authors: Cryan JF, Bruijnzeel AW, Skjei KL, Markou A ART
Yr: 168 Vol: Nbr: 347-358 Abs: Pg:

Effects of bupropion on responding for nicotine and food under fixed-ratio and progressive ratio schedules of reinforcement in rats.
Periodical: Synapse Index Medicus:
Authors: Bruijnzeel AW, Markou A ART
Yr: 2003 Vol: 50 Nbr: Abs: Pg: 20-28

The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice
Periodical: Psychopharmacology Index Medicus:
Authors: Paterson NE, Semenova S, Casparini F, Markou A ART
Yr: 2003 Vol: 167 Nbr: Abs: Pg: 257-264

Clozapine treatmnet attenuated somatic and affective signs of nicotine and amphetamine withdrawal in subsets of rats that exhibited hyposensitivity to the initial effects of clozapine.
Periodical: Biological Psychiatry Index Medicus:
Authors: Semenova S, Markou A ART
Yr: 0 Vol: Nbr: Abs: Pg:

THe GABAb receptor agonists baclofen and CGP44532 decrease nicotine self-administration in the rat.
Periodical: Psychopharmacology Index Medicus:
Authors: Paterson NE, FroestlW, Markou A ART
Yr: 0 Vol: Nbr: Abs: Pg:

Effects of repeated withdrawal episodes, nicotine dose, and duration of nicotine exposure on the severity and duartion of nicotine withdrawal in rats.
Periodical: Psychopharmacology Index Medicus:
Authors: Skjei KL, Markou A ART
Yr: 2003 Vol: 168 Nbr: Abs: Pg: 280-292

Cocaine-seeking behavior after extended cocaine-free periods in rats: role of conditioned stimuli.
Periodical: Psychopharmacology Index Medicus:
Authors: Semenova S, Markou A ART
Yr: 2003 Vol: 168 Nbr: Abs: Pg: 192-200

Clozapine treatment attenuated somatic and affective signs of nicotine and amphetamine withdrawal in subsets of rats that exhibited hyposensitivity to the initial effects of clozapine.
Periodical: Biological Psychiatry Index Medicus:
Authors: Semenova S, Markou A ART
Yr: 2003 Vol: 54 Nbr: 11 Abs: Pg: 1249-1264

Bupropion enhances brain reward function and reverses the affective and somatic aspects of nicotine withdrawal in the rat.
Periodical: Psychopharmacology Index Medicus:
Authors: Cryan JF, Bruijnzeel AW, Skjei KL, Markou A ART
Yr: 2003 Vol: 168 Nbr: Abs: Pg: 347-358

Characterization of the effects of bupropion on the reinforcing properties of nicotine and food in rats.
Periodical: Synapse Index Medicus:
Authors: Bruijnzeel AW, Markou A ART
Yr: 2003 Vol: 50 Nbr: Abs: Pg: 20-28

Decreased prepulse inhibition durin gnicotine withdrawal in DBA/2J is reversed by nicotine self-administration.
Periodical: European Journal of Pharmacology Index Medicus:
Authors: Semenova S, Bespalov A, Markou A ART
Yr: 2003 Vol: 472 Nbr: Abs: Pg: 99-110

Neuroadaptations to chronic exposure to drugs of abuse: relevance to depressive sympomatology seen across psychiatric diagnostic categories.
Periodical: Neurotoxicity Research Index Medicus:
Authors: Markou A, Kenny PJ ART
Yr: 2002 Vol: 4 Nbr: 4 Abs: Pg: 297-313

Non-nicotinic neuropharmacological strategies for nicotine dependence: beyond bupropion.
Periodical: Drug Discovery Today Index Medicus:
Authors: Cryan JF, Gasparini F, van Heeke G, Markou A ART
Yr: 2003 Vol: 8 Nbr: 22 Abs: Pg: 1025-1034

The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice.
Periodical: Psychopharmacology Index Medicus:
Authors: Paterson NE, Semenova S, Gasparini F, Markou A ART
Yr: 2003 Vol: 167 Nbr: Abs: Pg: 257-264

The GABA-B receptor agonists baclofen and CGP44532 decreased nicotine self-administration in the rat.
Periodical: Psychopharmacology Index Medicus:
Authors: Paterson NE< Froestl W, Markou A ART
Yr: 2004 Vol: 172 Nbr: Abs: Pg: 179-186

Adaptations in cholinergic transmission in the ventral tegmental area associated with the affective signs of nicotine withdrawal in rats.
Periodical: Neuropharmacology Index Medicus:
Authors: Bruijnzeel AW, Markou A ART
Yr: 2004 Vol: 47 Nbr: Abs: Pg: 572 - 579

Repeated administration of the GABA B receptor agonist CGP44532 decreased nicotine self-administration, and acute administration decreased cue-reinstatement of nicotine seeking-rats in rats.
Periodical: Neuropsychopharmacology Index Medicus:
Authors: Paterson N, Froestl W, Markou A ART
Yr: 2005 Vol: 30 Nbr: Abs: Pg: 119 - 128

Conditioned nicotine withdrawal profoundly decreases the activity of brain reward systems.
Periodical: Journal of Neuroscience Index Medicus:
Authors: Kenny PJ, Markou A ART
Yr: 0 Vol: Nbr: Abs: Pg:

Adaptations in cholinergic transmission in the ventral tegmental area associated with the affective signs of nicotine withdrawal in rats.
Periodical: Index Medicus:
Authors: Bruijnzeel AW, Markou A ART
Yr: Vol: Nbr: Abs: Pg:

Active immunisation against nicotine blocks the reward facilitating effects of nicotine and partially prevents nicotine withdrawal in the rat as measured by dopamine output in the nucleus accumbens, brain reward thresholds and somatic signs.
Periodical: Naunyn-Schmiedeberg's Archives of Pharmacology Index Medicus:
Authors: Lindblom N, de Villiers S, Semenova S, Kalayanov G, Gordon S, Schilstrom B, Johansson A ART
Yr: 2005 Vol: 372 Nbr: 2 Abs: Pg: 182-194

Chronic bupropion partially attenuated the reinforcement-enhancing, but not reinforcing, effects of self-administered nicotine and enhanced motivational properties of a nicotine-associated conditioned stimulus in rats.
Periodical: Nicotine and Tobacco Research Index Medicus:
Authors: Paterson, N.E., Balfour, D.J., and Markou, A. ART
Yr: 2008 Vol: Nbr: Abs: Pg:

Role of the glutamatergic system in nicotine dependence: Implications for the discovery and development of new pharmacological smoking cessation therapies.
Periodical: CNS Drug Discovery Index Medicus:
Authors: Liechti, M.E. and Markou, A. ART
Yr: 2008 Vol: Nbr: Abs: Pg:

Spontaneous nicotine withdrawal potentiates the effects of stress in rats.
Periodical: Neuropsychopharmacology Index Medicus:
Authors: Jonkman, S., Risbrough, V.B., Geyer, M.A. and Markou, A. ART
Yr: 2008 Vol: Nbr: Abs: Pg: