Research Portfolio

Funding Opportunities

Join our Mailing List
Join our mailing list to be notified of new funding opportunities.

Your Email

To receive information about funding opportunities, events, and program updates.



Stephen Young, M.D.

J. David Gladstone Institutes # of Grants: 2

Grants

Lipoprotein classes and susceptibility to atherosclerosis 1998 (Cycle 7) $702,940
Cardiovascular Disease Research Project Awards

Post-isoprenylation processing steps as anticancer targets 2000 (Cycle 9) $1,017,450
Cancer Research Project Awards
Publications

Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100
Periodical: Journal of Clinical Investigation Index Medicus:
Authors: Veniant MM, Sullivan Ma, Kim SK, et al ART
Yr: 2000 Vol: 106 Nbr: Abs: Pg: 1501-1510

Atheroslerosis susceptibility in Chow-fed apoe-1- and Ldlr-1- mice matched for total plasma cholesterol levels
Periodical: Arteriosclerosis, Thrombosis, and Vascular Biology Index Medicus:
Authors: Veniant MM, Withycombe S, Young SG ART
Yr: 0 Vol: Nbr: Abs: Pg:

Targeted inactivation of the isoprenylcysteine carboxyl methyltranferase gene causes mislocalization of a green fluorrescent protein-K-Ras4B fusion in mammalian cells
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Bergo MO, Leung GK, Otto JC, Casey PC, Young SG ART
Yr: 2000 Vol: 275 Nbr: Abs: Pg: 17605-17610

Isoprenylcysteine carboxyl methyltransferase deficiency in mice
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Bergo MO, Leung GK, Ambroziak P, Gomes AR, Seabra MC, Young SG ART
Yr: 2000 Vol: 276 Nbr: Abs: Pg: 5841-5845

The c-terminal polylysine domain and methylation of K-Ras are critical for the interaction between K-Ras and microtubules
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Chen Z, Otto JC, Bergo MO, Young SG, Casey PJ ART
Yr: 2000 Vol: 275 Nbr: Abs: Pg: 41251-41257

Biochemical studies of zmpste24-deficient mice.
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Leung GK, Schmidt WK, Bergo MO, Gavino B, Wong DH, Tam A, Ashby MN, Michaelis S, Young SG ART
Yr: 2001 Vol: 276 Nbr: Abs: Pg: 29051-29058

Absence of the CAAX endoprotease Rce1: Effects on cell growth and transformation.
Periodical: Molecular Biology of the Cell Index Medicus:
Authors: Bergo MO, Ambroziak P, Gregory C, George A, Otto JC, Kim E, Nagase H, Casey PJ, et al ART
Yr: 2002 Vol: 22 Nbr: Abs: Pg: 171-181

Lipoprotein size and atherosclerosis susceptibility in Apoe-/- and Ldlr-/- mice.
Periodical: Arteriosclerosis, Thrombosis, and Vascular Biology Index Medicus:
Authors: Veniant MM, Withycombe S, and Young SG ART
Yr: 2001 Vol: 21 Nbr: Abs: Pg: 1567 - 1570

Membrane trafficking of heterotrimeric G proteins via the endoplasmic reticulum and golgi.
Periodical: Molecular Biology of the Cell Index Medicus:
Authors: Michaelson D, HAhearn I, Bergo M, Young S, Philips M ART
Yr: 2002 Vol: 13 Nbr: Abs: Pg: 3294-3302

Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate.
Periodical: Proceedings of the National Academy of Sciences of the United States of America Index Medicus:
Authors: Winter-Vann AM, Kamen BA, Bergo MO, Young SG, Melnyk S, James SJ, Casey PJ ART
Yr: 2003 Vol: 100 Nbr: Abs: Pg: 6529-6534

Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.
Periodical: Journal of Clinical Investigation Index Medicus:
Authors: Bergo MO, Gavion BJ, Hong C, Beigneux AP, McMahon M, Casey PJ, Young SG ART
Yr: 2004 Vol: 113 Nbr: Abs: Pg: 539-550

On the physiological importance of endoproteolysis of CAAX proteins: heart-specific Rce1 knockout mice develop a lethal cardiomyopathy.
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Bergo MO, Lieu HD, Gavino BJ, Ambroziak P, Otto JC, Casey PJ, Walker QM, Young SG ART
Yr: 2004 Vol: 279 Nbr: Abs: Pg: 4729-4736