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Stephen Young, M.D.

J. David Gladstone Institutes

# of Grants: 2

Lipoprotein classes and susceptibility to atherosclerosis	1998 (Cycle 7)	$702,940
Cardiovascular Disease	Research Project Awards
Post-isoprenylation processing steps as anticancer targets	2000 (Cycle 9)	$1,017,450
Cancer	Research Project Awards

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Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100
Periodical: Journal of Clinical Investigation			Index Medicus:
Authors: Veniant MM, Sullivan Ma, Kim SK, et al				ART
Yr: 2000	Vol: 106	Nbr:	Abs:	Pg: 1501-1510

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Atheroslerosis susceptibility in Chow-fed apoe-1- and Ldlr-1- mice matched for total plasma cholesterol levels
Periodical: Arteriosclerosis, Thrombosis, and Vascular Biology			Index Medicus:
Authors: Veniant MM, Withycombe S, Young SG				ART
Yr: 0	Vol:	Nbr:	Abs:	Pg:

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Lipoprotein size and atherosclerosis susceptibility in Apoe-/- and Ldlr-/- mice.
Periodical: Arteriosclerosis, Thrombosis, and Vascular Biology			Index Medicus:
Authors: Veniant MM, Withycombe S, and Young SG				ART
Yr: 2001	Vol: 21	Nbr:	Abs:	Pg: 1567 - 1570

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Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100
Periodical: Journal of Clinical Investigation			Index Medicus:
Authors: Veniant MM, Sullivan Ma, Kim SK, et al				ART
Yr: 2000	Vol: 106	Nbr:	Abs:	Pg: 1501-1510

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Atheroslerosis susceptibility in Chow-fed apoe-1- and Ldlr-1- mice matched for total plasma cholesterol levels
Periodical: Arteriosclerosis, Thrombosis, and Vascular Biology			Index Medicus:
Authors: Veniant MM, Withycombe S, Young SG				ART
Yr: 0	Vol:	Nbr:	Abs:	Pg:

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Lipoprotein size and atherosclerosis susceptibility in Apoe-/- and Ldlr-/- mice.
Periodical: Arteriosclerosis, Thrombosis, and Vascular Biology			Index Medicus:
Authors: Veniant MM, Withycombe S, and Young SG				ART
Yr: 2001	Vol: 21	Nbr:	Abs:	Pg: 1567 - 1570

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Targeted inactivation of the isoprenylcysteine carboxyl methyltranferase gene causes mislocalization of a green fluorrescent protein-K-Ras4B fusion in mammalian cells
Periodical: Journal of Biological Chemistry			Index Medicus:
Authors: Bergo MO, Leung GK, Otto JC, Casey PC, Young SG				ART
Yr: 2000	Vol: 275	Nbr:	Abs:	Pg: 17605-17610

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Isoprenylcysteine carboxyl methyltransferase deficiency in mice
Periodical: Journal of Biological Chemistry			Index Medicus:
Authors: Bergo MO, Leung GK, Ambroziak P, Gomes AR, Seabra MC, Young SG				ART
Yr: 2000	Vol: 276	Nbr:	Abs:	Pg: 5841-5845

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The c-terminal polylysine domain and methylation of K-Ras are critical for the interaction between K-Ras and microtubules
Periodical: Journal of Biological Chemistry			Index Medicus:
Authors: Chen Z, Otto JC, Bergo MO, Young SG, Casey PJ				ART
Yr: 2000	Vol: 275	Nbr:	Abs:	Pg: 41251-41257

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Biochemical studies of zmpste24-deficient mice.
Periodical: Journal of Biological Chemistry			Index Medicus:
Authors: Leung GK, Schmidt WK, Bergo MO, Gavino B, Wong DH, Tam A, Ashby MN, Michaelis S, Young SG				ART
Yr: 2001	Vol: 276	Nbr:	Abs:	Pg: 29051-29058

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Absence of the CAAX endoprotease Rce1: Effects on cell growth and transformation.
Periodical: Molecular Biology of the Cell			Index Medicus:
Authors: Bergo MO, Ambroziak P, Gregory C, George A, Otto JC, Kim E, Nagase H, Casey PJ, et al				ART
Yr: 2002	Vol: 22	Nbr:	Abs:	Pg: 171-181

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Membrane trafficking of heterotrimeric G proteins via the endoplasmic reticulum and golgi.
Periodical: Molecular Biology of the Cell			Index Medicus:
Authors: Michaelson D, HAhearn I, Bergo M, Young S, Philips M				ART
Yr: 2002	Vol: 13	Nbr:	Abs:	Pg: 3294-3302

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Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate.
Periodical: Proceedings of the National Academy of Sciences of the United States of America			Index Medicus:
Authors: Winter-Vann AM, Kamen BA, Bergo MO, Young SG, Melnyk S, James SJ, Casey PJ				ART
Yr: 2003	Vol: 100	Nbr:	Abs:	Pg: 6529-6534

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Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.
Periodical: Journal of Clinical Investigation			Index Medicus:
Authors: Bergo MO, Gavion BJ, Hong C, Beigneux AP, McMahon M, Casey PJ, Young SG				ART
Yr: 2004	Vol: 113	Nbr:	Abs:	Pg: 539-550

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On the physiological importance of endoproteolysis of CAAX proteins: heart-specific Rce1 knockout mice develop a lethal cardiomyopathy.
Periodical: Journal of Biological Chemistry			Index Medicus:
Authors: Bergo MO, Lieu HD, Gavino BJ, Ambroziak P, Otto JC, Casey PJ, Walker QM, Young SG				ART
Yr: 2004	Vol: 279	Nbr:	Abs:	Pg: 4729-4736

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Targeted inactivation of the isoprenylcysteine carboxyl methyltranferase gene causes mislocalization of a green fluorrescent protein-K-Ras4B fusion in mammalian cells
Periodical: Journal of Biological Chemistry			Index Medicus:
Authors: Bergo MO, Leung GK, Otto JC, Casey PC, Young SG				ART
Yr: 2000	Vol: 275	Nbr:	Abs:	Pg: 17605-17610

---

Isoprenylcysteine carboxyl methyltransferase deficiency in mice
Periodical: Journal of Biological Chemistry			Index Medicus:
Authors: Bergo MO, Leung GK, Ambroziak P, Gomes AR, Seabra MC, Young SG				ART
Yr: 2000	Vol: 276	Nbr:	Abs:	Pg: 5841-5845

---

The c-terminal polylysine domain and methylation of K-Ras are critical for the interaction between K-Ras and microtubules
Periodical: Journal of Biological Chemistry			Index Medicus:
Authors: Chen Z, Otto JC, Bergo MO, Young SG, Casey PJ				ART
Yr: 2000	Vol: 275	Nbr:	Abs:	Pg: 41251-41257

---

Biochemical studies of zmpste24-deficient mice.
Periodical: Journal of Biological Chemistry			Index Medicus:
Authors: Leung GK, Schmidt WK, Bergo MO, Gavino B, Wong DH, Tam A, Ashby MN, Michaelis S, Young SG				ART
Yr: 2001	Vol: 276	Nbr:	Abs:	Pg: 29051-29058

---

Absence of the CAAX endoprotease Rce1: Effects on cell growth and transformation.
Periodical: Molecular Biology of the Cell			Index Medicus:
Authors: Bergo MO, Ambroziak P, Gregory C, George A, Otto JC, Kim E, Nagase H, Casey PJ, et al				ART
Yr: 2002	Vol: 22	Nbr:	Abs:	Pg: 171-181

---

Membrane trafficking of heterotrimeric G proteins via the endoplasmic reticulum and golgi.
Periodical: Molecular Biology of the Cell			Index Medicus:
Authors: Michaelson D, HAhearn I, Bergo M, Young S, Philips M				ART
Yr: 2002	Vol: 13	Nbr:	Abs:	Pg: 3294-3302

---

Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate.
Periodical: Proceedings of the National Academy of Sciences of the United States of America			Index Medicus:
Authors: Winter-Vann AM, Kamen BA, Bergo MO, Young SG, Melnyk S, James SJ, Casey PJ				ART
Yr: 2003	Vol: 100	Nbr:	Abs:	Pg: 6529-6534

---

Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.
Periodical: Journal of Clinical Investigation			Index Medicus:
Authors: Bergo MO, Gavion BJ, Hong C, Beigneux AP, McMahon M, Casey PJ, Young SG				ART
Yr: 2004	Vol: 113	Nbr:	Abs:	Pg: 539-550

---

On the physiological importance of endoproteolysis of CAAX proteins: heart-specific Rce1 knockout mice develop a lethal cardiomyopathy.
Periodical: Journal of Biological Chemistry			Index Medicus:
Authors: Bergo MO, Lieu HD, Gavino BJ, Ambroziak P, Otto JC, Casey PJ, Walker QM, Young SG				ART
Yr: 2004	Vol: 279	Nbr:	Abs:	Pg: 4729-4736

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