Research Portfolio

Search by: Title Institution Investigator Cycle Award Type Research Priority

Funding Opportunities

Call for Applications

Join our Mailing List

Join our mailing list to be notified of new funding opportunities. Your Email To receive information about funding opportunities, events, and program updates.

Martin Bergo, M.D., Ph.D.

J. David Gladstone Institutes

# of Grants: 2

Importance of Rce1 and Ras in tobacco-induced cancers	1999 (Cycle 8)	$75,209
Cancer	Postdoctoral Fellowship Awards
Enzymatic targets for anticancer therapy	2002 (Cycle 11)	$267,304
Cancer	New Investigator Awards

---

Targeted inactivation of the isoprenylcysstein carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells
Periodical: Journal of Biological Chemistry			Index Medicus:
Authors: Bergo MO, Leung GK, Ambroziak P, Otto JC, Casey PJ, Young SG				ART
Yr: 2000	Vol: 275	Nbr:	Abs:	Pg: 17605-17610

---

Domain and methylation of K-Ras are critical for the interaction between K-Ras and microtubules
Periodical: Journal of Biological Chemistry			Index Medicus:
Authors: Chen Z, Otto JC, Bergo MO, Young SG, Casey PJ				ART
Yr: 2000	Vol: 275	Nbr:	Abs:	Pg: 41251-41257

---

Isoprenylcysteine carboxyl methyltransferase deficiency in mice
Periodical: Journal of Biological Chemistry			Index Medicus:
Authors: Bergo MO, Leung GK, Ambroziak P, Gomes AR, Seabra MC, Young SG				ART
Yr: 2000	Vol: 276	Nbr:	Abs:	Pg: 5841-5845

---

Biochemical studies of Zmpste24-deficient mice
Periodical: Journal of Biological Chemistry			Index Medicus:
Authors: Leung GK, Schmidt WK, Bergo MO, et al				ART
Yr: 0	Vol:	Nbr:	Abs:	Pg:

---

Targeted inactivation of the isoprenylcysstein carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells
Periodical: Journal of Biological Chemistry			Index Medicus:
Authors: Bergo MO, Leung GK, Ambroziak P, Otto JC, Casey PJ, Young SG				ART
Yr: 2000	Vol: 275	Nbr:	Abs:	Pg: 17605-17610

---

Domain and methylation of K-Ras are critical for the interaction between K-Ras and microtubules
Periodical: Journal of Biological Chemistry			Index Medicus:
Authors: Chen Z, Otto JC, Bergo MO, Young SG, Casey PJ				ART
Yr: 2000	Vol: 275	Nbr:	Abs:	Pg: 41251-41257

---

Isoprenylcysteine carboxyl methyltransferase deficiency in mice
Periodical: Journal of Biological Chemistry			Index Medicus:
Authors: Bergo MO, Leung GK, Ambroziak P, Gomes AR, Seabra MC, Young SG				ART
Yr: 2000	Vol: 276	Nbr:	Abs:	Pg: 5841-5845

---

Biochemical studies of Zmpste24-deficient mice
Periodical: Journal of Biological Chemistry			Index Medicus:
Authors: Leung GK, Schmidt WK, Bergo MO, et al				ART
Yr: 0	Vol:	Nbr:	Abs:	Pg:

---

Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate.
Periodical: Proceedings of the National Academy of Sciences of the United States of America			Index Medicus:
Authors: Winter-Vann AM, Kamen BA, Bergo MO, Young SG, Melnyk S, James SJ, Casey PJ				ART
Yr: 0	Vol:	Nbr:	Abs:	Pg:

---

Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.
Periodical: Journal of Clinical Investigation			Index Medicus:
Authors: Bergo MO, Gavino BJ, Hong C, Beigneux AP, McMahon M, Casey PJ, Young SG				ART
Yr: 2004	Vol: 113	Nbr:	Abs:	Pg: 539-550

---

On the physiologic importance of endoproteolysis of CAAX proteins: heart-specific Rcel knockout mice develop a lethal cardiomyopathy.
Periodical: Journal of Biological Chemistry			Index Medicus:
Authors: Bergo MO, Lieu HD, Otto JC, Casey PJ, Walker Q, Young SG				ART
Yr: 2004	Vol: 279	Nbr:	Abs:	Pg: 4729-4736

---

Carboxyl-terminal interactions of lamin B1 are dependent on Rcel-mediated endoproteolysis and subsequent methylation.
Periodical: Journal of Cell Biology			Index Medicus:
Authors: Maske C, Hollinshead M, Higbee NC, Bergo MO, Young SG, Vaux DJ				ART
Yr: 2003	Vol: 162	Nbr:	Abs:	Pg: 1223-1232

---

Methotrexate targets Ras signaling through inhibition of carboxyl methylation.
Periodical: Proceedings of the National Academy of Sciences of the United States of America			Index Medicus:
Authors: Winter-Vann AM, Kamen BA, Bergo MO, Young SG, Melnyk S, James SJ, Casey PJ				ART
Yr: 2003	Vol: 100	Nbr:	Abs:	Pg: 6529-6534

---

Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liver.
Periodical: Journal of Biological Chemistry			Index Medicus:
Authors: Beigneux A, Withycombe SK, Digits JA, Tschantz WR, Weinbaum CA, Griffey SM, Bergo M, et al				ART
Yr: 2002	Vol: 277	Nbr:	Abs:	Pg: 38358-38363

---

Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect.
Periodical: Proceedings of the National Academy of Sciences of the United States of America			Index Medicus:
Authors: Bergo MO, Gavino B, Ross J, Schmidt WK, Hong C, Kendal LV, Mohr A, Meta M, Genant H				ART
Yr: 2002	Vol: 99	Nbr:	Abs:	Pg: 13049-13054

---

Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate.
Periodical: Proceedings of the National Academy of Sciences of the United States of America			Index Medicus:
Authors: Winter-Vann AM, Kamen BA, Bergo MO, Young SG, Melnyk S, James SJ, Casey PJ				ART
Yr: 0	Vol:	Nbr:	Abs:	Pg:

---

Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.
Periodical: Journal of Clinical Investigation			Index Medicus:
Authors: Bergo MO, Gavino BJ, Hong C, Beigneux AP, McMahon M, Casey PJ, Young SG				ART
Yr: 2004	Vol: 113	Nbr:	Abs:	Pg: 539-550

---

On the physiologic importance of endoproteolysis of CAAX proteins: heart-specific Rcel knockout mice develop a lethal cardiomyopathy.
Periodical: Journal of Biological Chemistry			Index Medicus:
Authors: Bergo MO, Lieu HD, Otto JC, Casey PJ, Walker Q, Young SG				ART
Yr: 2004	Vol: 279	Nbr:	Abs:	Pg: 4729-4736

---

Carboxyl-terminal interactions of lamin B1 are dependent on Rcel-mediated endoproteolysis and subsequent methylation.
Periodical: Journal of Cell Biology			Index Medicus:
Authors: Maske C, Hollinshead M, Higbee NC, Bergo MO, Young SG, Vaux DJ				ART
Yr: 2003	Vol: 162	Nbr:	Abs:	Pg: 1223-1232

---

Methotrexate targets Ras signaling through inhibition of carboxyl methylation.
Periodical: Proceedings of the National Academy of Sciences of the United States of America			Index Medicus:
Authors: Winter-Vann AM, Kamen BA, Bergo MO, Young SG, Melnyk S, James SJ, Casey PJ				ART
Yr: 2003	Vol: 100	Nbr:	Abs:	Pg: 6529-6534

---

Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liver.
Periodical: Journal of Biological Chemistry			Index Medicus:
Authors: Beigneux A, Withycombe SK, Digits JA, Tschantz WR, Weinbaum CA, Griffey SM, Bergo M, et al				ART
Yr: 2002	Vol: 277	Nbr:	Abs:	Pg: 38358-38363

---

Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect.
Periodical: Proceedings of the National Academy of Sciences of the United States of America			Index Medicus:
Authors: Bergo MO, Gavino B, Ross J, Schmidt WK, Hong C, Kendal LV, Mohr A, Meta M, Genant H				ART
Yr: 2002	Vol: 99	Nbr:	Abs:	Pg: 13049-13054

---