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Martin Bergo, M.D., Ph.D.

J. David Gladstone Institutes # of Grants: 2

Grants

Importance of Rce1 and Ras in tobacco-induced cancers 1999 (Cycle 8) $75,209
Cancer Postdoctoral Fellowship Awards

Enzymatic targets for anticancer therapy 2002 (Cycle 11) $267,304
Cancer New Investigator Awards
Publications

Targeted inactivation of the isoprenylcysstein carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Bergo MO, Leung GK, Ambroziak P, Otto JC, Casey PJ, Young SG ART
Yr: 2000 Vol: 275 Nbr: Abs: Pg: 17605-17610

Domain and methylation of K-Ras are critical for the interaction between K-Ras and microtubules
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Chen Z, Otto JC, Bergo MO, Young SG, Casey PJ ART
Yr: 2000 Vol: 275 Nbr: Abs: Pg: 41251-41257

Isoprenylcysteine carboxyl methyltransferase deficiency in mice
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Bergo MO, Leung GK, Ambroziak P, Gomes AR, Seabra MC, Young SG ART
Yr: 2000 Vol: 276 Nbr: Abs: Pg: 5841-5845

Biochemical studies of Zmpste24-deficient mice
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Leung GK, Schmidt WK, Bergo MO, et al ART
Yr: 0 Vol: Nbr: Abs: Pg:

Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate.
Periodical: Proceedings of the National Academy of Sciences of the United States of America Index Medicus:
Authors: Winter-Vann AM, Kamen BA, Bergo MO, Young SG, Melnyk S, James SJ, Casey PJ ART
Yr: 0 Vol: Nbr: Abs: Pg:

Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.
Periodical: Journal of Clinical Investigation Index Medicus:
Authors: Bergo MO, Gavino BJ, Hong C, Beigneux AP, McMahon M, Casey PJ, Young SG ART
Yr: 2004 Vol: 113 Nbr: Abs: Pg: 539-550

On the physiologic importance of endoproteolysis of CAAX proteins: heart-specific Rcel knockout mice develop a lethal cardiomyopathy.
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Bergo MO, Lieu HD, Otto JC, Casey PJ, Walker Q, Young SG ART
Yr: 2004 Vol: 279 Nbr: Abs: Pg: 4729-4736

Carboxyl-terminal interactions of lamin B1 are dependent on Rcel-mediated endoproteolysis and subsequent methylation.
Periodical: Journal of Cell Biology Index Medicus:
Authors: Maske C, Hollinshead M, Higbee NC, Bergo MO, Young SG, Vaux DJ ART
Yr: 2003 Vol: 162 Nbr: Abs: Pg: 1223-1232

Methotrexate targets Ras signaling through inhibition of carboxyl methylation.
Periodical: Proceedings of the National Academy of Sciences of the United States of America Index Medicus:
Authors: Winter-Vann AM, Kamen BA, Bergo MO, Young SG, Melnyk S, James SJ, Casey PJ ART
Yr: 2003 Vol: 100 Nbr: Abs: Pg: 6529-6534

Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liver.
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Beigneux A, Withycombe SK, Digits JA, Tschantz WR, Weinbaum CA, Griffey SM, Bergo M, et al ART
Yr: 2002 Vol: 277 Nbr: Abs: Pg: 38358-38363

Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect.
Periodical: Proceedings of the National Academy of Sciences of the United States of America Index Medicus:
Authors: Bergo MO, Gavino B, Ross J, Schmidt WK, Hong C, Kendal LV, Mohr A, Meta M, Genant H ART
Yr: 2002 Vol: 99 Nbr: Abs: Pg: 13049-13054