Research Portfolio

Funding Opportunities

Join our Mailing List
Join our mailing list to be notified of new funding opportunities.

Your Email

To receive information about funding opportunities, events, and program updates.



Timothy O'Toole, Ph.D.

Scripps Research Institute # of Grants: 1

Grants

Integrin Cytoplasmic Domains and Ligand Affinity Modulation 1994 (Cycle 3) $522,649
Cardiovascular Disease Research Project Awards
Publications

Distinct functions of integrin alpha and beta subunit cytoplasmic domains in cell spreading and formation of focal adhesions
Periodical: Journal of Cell Biology Index Medicus:
Authors: Ylanne J, Chen Y, O'Toole TE, Loftus JC, Takada Y, Ginsberg MH ART
Yr: 1993 Vol: 122 Nbr: 1 Abs: Pg: 223-233

Integrin cytoplasmic domains mediate inside-out signal transduction
Periodical: Journal of Cell Biology Index Medicus:
Authors: O'Toole TE, Katagiri Y, Faull R, et al ART
Yr: 1994 Vol: 124 Nbr: 6 Abs: Pg: 1047-1059

"Inside-out" signal transduction inhibited by isolated integrin cytoplasmic domains
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Chen Y-P, O'Toole TE, Shipley T, et al ART
Yr: 1994 Vol: 269 Nbr: 28 Abs: Pg: 18307-18310

Regulation of integrin function and cellular adhesion
Periodical: Stem Cells Index Medicus:
Authors: Stuiver I, O'Toole TE ART
Yr: 1995 Vol: 13 Nbr: 3 Abs: Pg: 250-262

Regulation of integrin affinity states through an NPXY motif in the beta subunit cytoplasmic domain
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: O'Toole TE, Ylanne J, Culley BC ART
Yr: 1995 Vol: 270 Nbr: 15 Abs: Pg: 8553-8558

A conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding afinity
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Hughes PE, O'Toole TE, Ylanne J, Shattil SJ, Ginsberg MH ART
Yr: 1995 Vol: 270 Nbr: 21 Abs: Pg: 12411-12417

A point mutation in the integrin beta 3 cytoplasmic domain (S752P) impairs bidirectional signaling through alpha II beta 3 (platelet glycoprotein II-b-IIIa).
Periodical: Blood Index Medicus:
Authors: Chen YP, O'Toole TE, Rosa JP, Ginsberg MH ART
Yr: 1994 Vol: 84 Nbr: Abs: Pg: 1857-1865

Modulation of cell adhesion by changes in alpha L beta 2 (LFA-1,CD11a/CD18) cytoplasmic domain/cytoskeletal interaction
Periodical: Journal of Experimental Medicine Index Medicus:
Authors: Peter K, O'Toole TE ART
Yr: 1995 Vol: 181 Nbr: Abs: Pg: 315-326

Mutation of the cytoplasmic domain of the integrinbeta 3 subunit: differential effects on cell spreading, recruitment to adhesion plaques, endocytosis and phagocytosis
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Ylanne J, Huuskonen J, O'Toole TE, Ginsberg MH, Virtanen I, Gahmberg CG ART
Yr: 1995 Vol: 270 Nbr: Abs: Pg: 9550-9557

Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmictail of the integrin beta 3 subunit
Periodical: Journal of Cell Biology Index Medicus:
Authors: Shattil SJ, O'Toole TE, Eigenthaler M, Thon V, Williams M, Babior BM, Ginsberg MH ART
Yr: 1995 Vol: 131 Nbr: Abs: Pg: 807-816