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Timothy O'Toole, Ph.D.

Scripps Research Institute # of Grants: 1

Grants

Integrin Cytoplasmic Domains and Ligand Affinity Modulation 1994 (Cycle 3) $522,649
Cardiovascular Disease Research Project Awards
Publications

Distinct functions of integrin alpha and beta subunit cytoplasmic domains in cell spreading and formation of focal adhesions
Periodical: Journal of Cell Biology Index Medicus:
Authors: Ylanne J, Chen Y, O'Toole TE, Loftus JC, Takada Y, Ginsberg MH ART
Yr: 1993 Vol: 122 Nbr: 1 Abs: Pg: 223-233

Integrin cytoplasmic domains mediate inside-out signal transduction
Periodical: Journal of Cell Biology Index Medicus:
Authors: O'Toole TE, Katagiri Y, Faull R, et al ART
Yr: 1994 Vol: 124 Nbr: 6 Abs: Pg: 1047-1059

"Inside-out" signal transduction inhibited by isolated integrin cytoplasmic domains
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Chen Y-P, O'Toole TE, Shipley T, et al ART
Yr: 1994 Vol: 269 Nbr: 28 Abs: Pg: 18307-18310

Regulation of integrin function and cellular adhesion
Periodical: Stem Cells Index Medicus:
Authors: Stuiver I, O'Toole TE ART
Yr: 1995 Vol: 13 Nbr: 3 Abs: Pg: 250-262

Regulation of integrin affinity states through an NPXY motif in the beta subunit cytoplasmic domain
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: O'Toole TE, Ylanne J, Culley BC ART
Yr: 1995 Vol: 270 Nbr: 15 Abs: Pg: 8553-8558

A conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding afinity
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Hughes PE, O'Toole TE, Ylanne J, Shattil SJ, Ginsberg MH ART
Yr: 1995 Vol: 270 Nbr: 21 Abs: Pg: 12411-12417

A point mutation in the integrin beta 3 cytoplasmic domain (S752P) impairs bidirectional signaling through alpha II beta 3 (platelet glycoprotein II-b-IIIa).
Periodical: Blood Index Medicus:
Authors: Chen YP, O'Toole TE, Rosa JP, Ginsberg MH ART
Yr: 1994 Vol: 84 Nbr: Abs: Pg: 1857-1865

Modulation of cell adhesion by changes in alpha L beta 2 (LFA-1,CD11a/CD18) cytoplasmic domain/cytoskeletal interaction
Periodical: Journal of Experimental Medicine Index Medicus:
Authors: Peter K, O'Toole TE ART
Yr: 1995 Vol: 181 Nbr: Abs: Pg: 315-326

Mutation of the cytoplasmic domain of the integrinbeta 3 subunit: differential effects on cell spreading, recruitment to adhesion plaques, endocytosis and phagocytosis
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Ylanne J, Huuskonen J, O'Toole TE, Ginsberg MH, Virtanen I, Gahmberg CG ART
Yr: 1995 Vol: 270 Nbr: Abs: Pg: 9550-9557

Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmictail of the integrin beta 3 subunit
Periodical: Journal of Cell Biology Index Medicus:
Authors: Shattil SJ, O'Toole TE, Eigenthaler M, Thon V, Williams M, Babior BM, Ginsberg MH ART
Yr: 1995 Vol: 131 Nbr: Abs: Pg: 807-816

Distinct functions of integrin alpha and beta subunit cytoplasmic domains in cell spreading and formation of focal adhesions
Periodical: Journal of Cell Biology Index Medicus:
Authors: Ylanne J, Chen Y, O'Toole TE, Loftus JC, Takada Y, Ginsberg MH ART
Yr: 1993 Vol: 122 Nbr: 1 Abs: Pg: 223-233

Integrin cytoplasmic domains mediate inside-out signal transduction
Periodical: Journal of Cell Biology Index Medicus:
Authors: O'Toole TE, Katagiri Y, Faull R, et al ART
Yr: 1994 Vol: 124 Nbr: 6 Abs: Pg: 1047-1059

"Inside-out" signal transduction inhibited by isolated integrin cytoplasmic domains
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Chen Y-P, O'Toole TE, Shipley T, et al ART
Yr: 1994 Vol: 269 Nbr: 28 Abs: Pg: 18307-18310

Regulation of integrin function and cellular adhesion
Periodical: Stem Cells Index Medicus:
Authors: Stuiver I, O'Toole TE ART
Yr: 1995 Vol: 13 Nbr: 3 Abs: Pg: 250-262

Regulation of integrin affinity states through an NPXY motif in the beta subunit cytoplasmic domain
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: O'Toole TE, Ylanne J, Culley BC ART
Yr: 1995 Vol: 270 Nbr: 15 Abs: Pg: 8553-8558

A conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding afinity
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Hughes PE, O'Toole TE, Ylanne J, Shattil SJ, Ginsberg MH ART
Yr: 1995 Vol: 270 Nbr: 21 Abs: Pg: 12411-12417

A point mutation in the integrin beta 3 cytoplasmic domain (S752P) impairs bidirectional signaling through alpha II beta 3 (platelet glycoprotein II-b-IIIa).
Periodical: Blood Index Medicus:
Authors: Chen YP, O'Toole TE, Rosa JP, Ginsberg MH ART
Yr: 1994 Vol: 84 Nbr: Abs: Pg: 1857-1865

Modulation of cell adhesion by changes in alpha L beta 2 (LFA-1,CD11a/CD18) cytoplasmic domain/cytoskeletal interaction
Periodical: Journal of Experimental Medicine Index Medicus:
Authors: Peter K, O'Toole TE ART
Yr: 1995 Vol: 181 Nbr: Abs: Pg: 315-326

Mutation of the cytoplasmic domain of the integrinbeta 3 subunit: differential effects on cell spreading, recruitment to adhesion plaques, endocytosis and phagocytosis
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Ylanne J, Huuskonen J, O'Toole TE, Ginsberg MH, Virtanen I, Gahmberg CG ART
Yr: 1995 Vol: 270 Nbr: Abs: Pg: 9550-9557

Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmictail of the integrin beta 3 subunit
Periodical: Journal of Cell Biology Index Medicus:
Authors: Shattil SJ, O'Toole TE, Eigenthaler M, Thon V, Williams M, Babior BM, Ginsberg MH ART
Yr: 1995 Vol: 131 Nbr: Abs: Pg: 807-816