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Hrayr Karagueuzian, Ph.D.

University of California, Los Angeles

# of Grants: 4

Nicotine and cardiac vulnerability to fibrillation	1997 (Cycle 6)	$370,057
Cardiovascular Disease	Research Project Awards
Nicotine & cardiac vulnerability to fibrillation	2000 (Cycle 9)	$120,000
Cardiovascular Disease	Research Project Awards
Nicotine and cardiac vulnerability to fibrillation	2002 (Cycle 11)	$641,821
Cardiovascular Disease	Research Project Awards
Tobacco radioactivity & public health policy	2005 (Cycle 14)	$154,367
Public Health, Public Policy, and Economics	Inno Dev & Exp Awards (IDEAS)

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Transmembrane potential properties of atrial cells at different sites of a spiral wave reentry. Cellular _x000D_ evidence for an excitable but non-excited core.
Periodical: Pacing and Clinical Electrophysiology			Index Medicus:
Authors: Karagueuzian HS, Athill CA, Yashima M, et al				ART
Yr: 1998	Vol:	Nbr:	Abs:	Pg: 2360-2365

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Mechanism of acceleration of functional reentry in the ventricle
Periodical: Circulation			Index Medicus:
Authors: Uchida T, Yashima M, Gotoh M, et al				ART
Yr: 1999	Vol: 99	Nbr:	Abs:	Pg: 704-712

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Nicotine increases spatiotemporal complexity of ventricular fibrillation wave fronts on the epicardial border zone of healed canine infarcts
Periodical: Journal of Cardiovascular Pharmacology			Index Medicus:
Authors: Ohara T, Yashima M, Hamzei A, et al				ART
Yr: 1999	Vol: 4	Nbr:	Abs:	Pg: 121-127

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Idiopathic paroxysmal atrial fibrillation induced by a focal discharge mechanism in the left superior pulmonary vein. Possible role of the ligament of Marshall
Periodical: Journal of Cardiovascular Electrophysiology			Index Medicus:
Authors: Hwang C, Karagueuzian HS, Chen P-S				ART
Yr: 1999	Vol: 10	Nbr:	Abs:	Pg: 636-648

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Role of papillary muscle in the generation and maintenance of reentry during ventricular tachycardia and fibrillation in isolated swine right ventricle
Periodical: Circulation			Index Medicus:
Authors: Kim Y-H, Xie F, Yashima M, et al				ART
Yr: 1999	Vol:	Nbr:	Abs:	Pg:

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Mechanism of procainamide-induced prevention of spontaneous wave break during ventricular fibrillation. Insight into the fibrillation wave fronts
Periodical: Circulation			Index Medicus:
Authors: Kim Y-H, Yashima M, Wu T-J, Chen P-S, Karagueuzian HS				ART
Yr: 1999	Vol:	Nbr:	Abs:	Pg:

---

Current concept of ventricular defibrillation
Periodical: Journal of Cardiovascular Electrophysiology			Index Medicus:
Authors: Chen P-S, Swerldow CD, Hwang C, Karagueuzian HS				ART
Yr: 1998	Vol: 9	Nbr:	Abs:	Pg: 553-562

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Focal source hypothesis of atrial fibrillation
Periodical: Journal of Electrocardiology			Index Medicus:
Authors: Chen P-S, Wu T-J, Ikeda T, et al				ART
Yr: 1999	Vol: 31	Nbr: Suppl	Abs:	Pg: 32-34

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Chaos and the transition to ventricular fibrillation: A new approach to antiarrhythmic drug evaluation
Periodical: Circulation			Index Medicus:
Authors: Weiss JN, Garfinkel A, Karagueuzian HS, Qu Z, Chen P-S				ART
Yr: 1999	Vol:	Nbr:	Abs:	Pg:

---

Cardiac action potential recorded with pure iridium metal microelectrode
Periodical: American Journal of Physiology			Index Medicus:
Authors: Omichi C, Lee M-H, Ohara T, Naik AM, Karagueuzian HS, Chen P-S				ART
Yr: 2000	Vol: 279	Nbr:	Abs:	Pg: H3113-H3117

---

Obstacle-induced transition from ventricular fibrillation to ventricular tachycardia in isolated swine right ventricles
Periodical:			Index Medicus:
Authors: Vladerrabano M, Kim Y-H, Yashima M, Wu T-J, Karagueuzian HS, Chen P-S				ART
Yr:	Vol:	Nbr:	Abs:	Pg:

---

Co-localization of tenascin and sympathetic nerves in a canine model of nerve sprouting and sudden cardiac death
Periodical: Journal of Cardiovascular Electrophysiology			Index Medicus:
Authors: Lai AC, Wallner K, Cao J-M, et al				ART
Yr: 2000	Vol: 11	Nbr:	Abs:	Pg: 1345-1351

---

Nerve sprouting and sympathetic hyperinnervation in a canine model of atrial fibrillation produced by prolonged right atrial pacing
Periodical: Circulation			Index Medicus:
Authors: Chang C-M, Wu T-J, Zhou S-M, et al				ART
Yr: 2001	Vol: 103	Nbr:	Abs:	Pg: 22-25

---

Pulmonary veins and ligament of Marshall as sources of rapid activations in a canine model of sustained atrial fibrillation
Periodical: Circulation			Index Medicus:
Authors: Wu T-J, Ong J-JC, Chang C-M, et al				ART
Yr: 2001	Vol: 103	Nbr:	Abs:	Pg: 1157-1163

---

Increased wavebreak during ventricular fibrillation in the epicardial border zone of hearts with healed myocardial infarction
Periodical: Circulation			Index Medicus:
Authors: Ohara T, Cao J-M, Fishbein MC, Mandel WJ, Chen P-S, Karagueuzian HS				ART
Yr: 2001	Vol: 103	Nbr:	Abs:	Pg: 1465-1472

---

Transmembrane potential properties of atrial cells at different sites of a spiral wave reentry. Cellular _x000D_ evidence for an excitable but non-excited core.
Periodical: Pacing and Clinical Electrophysiology			Index Medicus:
Authors: Karagueuzian HS, Athill CA, Yashima M, et al				ART
Yr: 1998	Vol:	Nbr:	Abs:	Pg: 2360-2365

---

Mechanism of acceleration of functional reentry in the ventricle
Periodical: Circulation			Index Medicus:
Authors: Uchida T, Yashima M, Gotoh M, et al				ART
Yr: 1999	Vol: 99	Nbr:	Abs:	Pg: 704-712

---

Nicotine increases spatiotemporal complexity of ventricular fibrillation wave fronts on the epicardial border zone of healed canine infarcts
Periodical: Journal of Cardiovascular Pharmacology			Index Medicus:
Authors: Ohara T, Yashima M, Hamzei A, et al				ART
Yr: 1999	Vol: 4	Nbr:	Abs:	Pg: 121-127

---

Idiopathic paroxysmal atrial fibrillation induced by a focal discharge mechanism in the left superior pulmonary vein. Possible role of the ligament of Marshall
Periodical: Journal of Cardiovascular Electrophysiology			Index Medicus:
Authors: Hwang C, Karagueuzian HS, Chen P-S				ART
Yr: 1999	Vol: 10	Nbr:	Abs:	Pg: 636-648

---

Role of papillary muscle in the generation and maintenance of reentry during ventricular tachycardia and fibrillation in isolated swine right ventricle
Periodical: Circulation			Index Medicus:
Authors: Kim Y-H, Xie F, Yashima M, et al				ART
Yr: 1999	Vol:	Nbr:	Abs:	Pg:

---

Mechanism of procainamide-induced prevention of spontaneous wave break during ventricular fibrillation. Insight into the fibrillation wave fronts
Periodical: Circulation			Index Medicus:
Authors: Kim Y-H, Yashima M, Wu T-J, Chen P-S, Karagueuzian HS				ART
Yr: 1999	Vol:	Nbr:	Abs:	Pg:

---

Current concept of ventricular defibrillation
Periodical: Journal of Cardiovascular Electrophysiology			Index Medicus:
Authors: Chen P-S, Swerldow CD, Hwang C, Karagueuzian HS				ART
Yr: 1998	Vol: 9	Nbr:	Abs:	Pg: 553-562

---

Focal source hypothesis of atrial fibrillation
Periodical: Journal of Electrocardiology			Index Medicus:
Authors: Chen P-S, Wu T-J, Ikeda T, et al				ART
Yr: 1999	Vol: 31	Nbr: Suppl	Abs:	Pg: 32-34

---

Chaos and the transition to ventricular fibrillation: A new approach to antiarrhythmic drug evaluation
Periodical: Circulation			Index Medicus:
Authors: Weiss JN, Garfinkel A, Karagueuzian HS, Qu Z, Chen P-S				ART
Yr: 1999	Vol:	Nbr:	Abs:	Pg:

---

Cardiac action potential recorded with pure iridium metal microelectrode
Periodical: American Journal of Physiology			Index Medicus:
Authors: Omichi C, Lee M-H, Ohara T, Naik AM, Karagueuzian HS, Chen P-S				ART
Yr: 2000	Vol: 279	Nbr:	Abs:	Pg: H3113-H3117

---

Obstacle-induced transition from ventricular fibrillation to ventricular tachycardia in isolated swine right ventricles
Periodical:			Index Medicus:
Authors: Vladerrabano M, Kim Y-H, Yashima M, Wu T-J, Karagueuzian HS, Chen P-S				ART
Yr:	Vol:	Nbr:	Abs:	Pg:

---

Co-localization of tenascin and sympathetic nerves in a canine model of nerve sprouting and sudden cardiac death
Periodical: Journal of Cardiovascular Electrophysiology			Index Medicus:
Authors: Lai AC, Wallner K, Cao J-M, et al				ART
Yr: 2000	Vol: 11	Nbr:	Abs:	Pg: 1345-1351

---

Nerve sprouting and sympathetic hyperinnervation in a canine model of atrial fibrillation produced by prolonged right atrial pacing
Periodical: Circulation			Index Medicus:
Authors: Chang C-M, Wu T-J, Zhou S-M, et al				ART
Yr: 2001	Vol: 103	Nbr:	Abs:	Pg: 22-25

---

Pulmonary veins and ligament of Marshall as sources of rapid activations in a canine model of sustained atrial fibrillation
Periodical: Circulation			Index Medicus:
Authors: Wu T-J, Ong J-JC, Chang C-M, et al				ART
Yr: 2001	Vol: 103	Nbr:	Abs:	Pg: 1157-1163

---

Increased wavebreak during ventricular fibrillation in the epicardial border zone of hearts with healed myocardial infarction
Periodical: Circulation			Index Medicus:
Authors: Ohara T, Cao J-M, Fishbein MC, Mandel WJ, Chen P-S, Karagueuzian HS				ART
Yr: 2001	Vol: 103	Nbr:	Abs:	Pg: 1465-1472

---

Cardiac action potential recorded with pure iridium metal microelectrode: a comparative study with glass microelectrode studies
Periodical: American Journal of Physiology			Index Medicus:
Authors: Omichi C, Lee M-H, Ohara T, Naik AM, Karagueuzian HS, Chen P-S				ART
Yr: 2000	Vol: 279	Nbr:	Abs:	Pg: H3113-H3117

---

Obstacle-induced transition from ventricular fibrillation to ventricular tachycardia in isolated swine right ventricles
Periodical: Journal of the American College of Cardiology			Index Medicus:
Authors: Vladerrabano M, Kim Y-H, Yashima M, Wu T-J, Karagueuzian HS, Chen P-S				ART
Yr: 2000	Vol: 36	Nbr:	Abs:	Pg: 2000-2008

---

Co-localization of tenascin and sympathetic nerves in a canine model of nerve sprouting and sudden cardiac death
Periodical: Journal of Cardiovascular Electrophysiology			Index Medicus:
Authors: Lai AC, Wallner K, Cao J-M, et al				ART
Yr: 2000	Vol: 11	Nbr:	Abs:	Pg: 1345-1351

---

Nerve sprouting and sympathetic hyperinnervation in a canine model of atrial fibrillation produced by prolonged right atrial pacing
Periodical: Circulation			Index Medicus:
Authors: Chang C-M, Wu T-J, Zhou S-M, et al				ART
Yr: 2001	Vol: 103	Nbr:	Abs:	Pg: 22-25

---

Pulmonary veins and ligament of Marshall as sources of rapid activations in a canine model of sustained atrial fibrillation
Periodical: Circulation			Index Medicus:
Authors: Wu TJ, Ong JJC, Chang C-M, et al				ART
Yr: 2001	Vol: 103	Nbr:	Abs:	Pg: 1157-1163

---

Increased wavebreak during ventricular fibrillation in the epicardial border zone of hearts with healed myocardial infarction
Periodical: Circulation			Index Medicus:
Authors: Ohara T, Cao J-M, Fishbeine MC, Mandel WJ, Chen P-S, Karagueuzian HS				ART
Yr: 2001	Vol: 103	Nbr:	Abs:	Pg: 1465-1472

---

The effects of diacetyl monoxime and cytochalasin D on action potential duration restitution and the dynamics of ventricular fibrillation in isolated swine right ventricles
Periodical: American Journal of Physiology			Index Medicus:
Authors: Lee M-H, Lin S-F, Ohara T, et al				ART
Yr: 2001	Vol:	Nbr:	Abs:	Pg: H253-H265

---

Dynamics of intramural and transmural reentry during ventricular fibrillation in isolated swine ventricles
Periodical: Circulation Research			Index Medicus:
Authors: Valderrabano M, Lee M-H, Ohara T, et al				ART
Yr: 2001	Vol: 88	Nbr:	Abs:	Pg: 839-848

---

Mechanisms of ventricular defibrillation in isolated swine right ventricles
Periodical: Circulation			Index Medicus:
Authors: Wang NC, Lee M-H, Ohara, Voroshilovski, Karagueuzian HS				ART
Yr: 2001	Vol: 104	Nbr:	Abs:	Pg: 227-233

---

Modulation of QT interval by cardiac sympathetic nerve sprouting and the mechanisms of ventricular arrhythmia in a canine model of sudden cardiac death
Periodical: Journal of Cardiovascular Electrophysiology			Index Medicus:
Authors: Zhou S, Cao J-M, Tebb ZD, et al				ART
Yr: 2001	Vol:	Nbr:	Abs:	Pg:

---

Cardiac action potential recorded with pure iridium metal microelectrode: a comparative study with glass microelectrode studies
Periodical: American Journal of Physiology			Index Medicus:
Authors: Omichi C, Lee M-H, Ohara T, Naik AM, Karagueuzian HS, Chen P-S				ART
Yr: 2000	Vol: 279	Nbr:	Abs:	Pg: H3113-H3117

---

Obstacle-induced transition from ventricular fibrillation to ventricular tachycardia in isolated swine right ventricles
Periodical: Journal of the American College of Cardiology			Index Medicus:
Authors: Vladerrabano M, Kim Y-H, Yashima M, Wu T-J, Karagueuzian HS, Chen P-S				ART
Yr: 2000	Vol: 36	Nbr:	Abs:	Pg: 2000-2008

---

Co-localization of tenascin and sympathetic nerves in a canine model of nerve sprouting and sudden cardiac death
Periodical: Journal of Cardiovascular Electrophysiology			Index Medicus:
Authors: Lai AC, Wallner K, Cao J-M, et al				ART
Yr: 2000	Vol: 11	Nbr:	Abs:	Pg: 1345-1351

---

Nerve sprouting and sympathetic hyperinnervation in a canine model of atrial fibrillation produced by prolonged right atrial pacing
Periodical: Circulation			Index Medicus:
Authors: Chang C-M, Wu T-J, Zhou S-M, et al				ART
Yr: 2001	Vol: 103	Nbr:	Abs:	Pg: 22-25

---

Pulmonary veins and ligament of Marshall as sources of rapid activations in a canine model of sustained atrial fibrillation
Periodical: Circulation			Index Medicus:
Authors: Wu TJ, Ong JJC, Chang C-M, et al				ART
Yr: 2001	Vol: 103	Nbr:	Abs:	Pg: 1157-1163

---

Increased wavebreak during ventricular fibrillation in the epicardial border zone of hearts with healed myocardial infarction
Periodical: Circulation			Index Medicus:
Authors: Ohara T, Cao J-M, Fishbeine MC, Mandel WJ, Chen P-S, Karagueuzian HS				ART
Yr: 2001	Vol: 103	Nbr:	Abs:	Pg: 1465-1472

---

The effects of diacetyl monoxime and cytochalasin D on action potential duration restitution and the dynamics of ventricular fibrillation in isolated swine right ventricles
Periodical: American Journal of Physiology			Index Medicus:
Authors: Lee M-H, Lin S-F, Ohara T, et al				ART
Yr: 2001	Vol:	Nbr:	Abs:	Pg: H253-H265

---

Dynamics of intramural and transmural reentry during ventricular fibrillation in isolated swine ventricles
Periodical: Circulation Research			Index Medicus:
Authors: Valderrabano M, Lee M-H, Ohara T, et al				ART
Yr: 2001	Vol: 88	Nbr:	Abs:	Pg: 839-848

---

Mechanisms of ventricular defibrillation in isolated swine right ventricles
Periodical: Circulation			Index Medicus:
Authors: Wang NC, Lee M-H, Ohara, Voroshilovski, Karagueuzian HS				ART
Yr: 2001	Vol: 104	Nbr:	Abs:	Pg: 227-233

---

Modulation of QT interval by cardiac sympathetic nerve sprouting and the mechanisms of ventricular arrhythmia in a canine model of sudden cardiac death
Periodical: Journal of Cardiovascular Electrophysiology			Index Medicus:
Authors: Zhou S, Cao J-M, Tebb ZD, et al				ART
Yr: 2001	Vol:	Nbr:	Abs:	Pg:

---

Altered atrial electrical restitution and sympathetic hyperinnervation in hearts with chronic left ventricular myocardial infarction. Implications for atrial fibrillation.
Periodical: Circulation			Index Medicus:
Authors: Miyauchi Y, Ohara K, Ohara T, Fishbein MC, Zhou S, Lee MH, Mandel WJ, Chen P-S, Karaguezia				ART
Yr: 2003	Vol: 108	Nbr:	Abs:	Pg: 360-366

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Age-related sensitivity to nicotine for inducible atrial tachycardia and atrial fibrillation.
Periodical: American Journal of Physiology, Heart and Circulatory Physiology			Index Medicus:
Authors: Hayashi H, Omichi C, Miyauchi Y, Mandel WJ, Lin S-F, Chen P-S, Karagueuzian HS				ART
Yr: 2003	Vol: 284	Nbr:	Abs:	Pg: H249-255

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The mechanism of the probabilistic nature of ventricular defibrillation threshold.
Periodical: American Journal of Physiology			Index Medicus:
Authors: Yashima M, Miyauchi Y, Cao J-M, Kim Y-H, Mandel WJ, Chen P-S, Karagueuzian HS				ART
Yr: 2003	Vol: 284	Nbr:	Abs:	Pg: H249-255

---

Electrical current-induced atrial and pulmonary vein action potential duration shortening and repetitive activity.
Periodical: American Journal of Physiology, Heart and Circulatory Physiology			Index Medicus:
Authors: Miyauchi Y, Fishbein MC, Karagueuzian HS				ART
Yr: 0	Vol:	Nbr:	Abs:	Pg:

---

Thoracic vein ablation terminates chronic atrial fibrillation in dogs.
Periodical: American Journal of Physiology, Heart and Circulatory Physiology			Index Medicus:
Authors: Park A, Chou CC, Drury PC, Okuyama Y, Peter A, Hamabe A, Miyauchi Y, Karagueuzian HS et al				ART
Yr: 0	Vol:	Nbr:	Abs:	Pg:

---

Intracellular calcium dynamics in ventricular fibrillation.
Periodical: American Journal of Physiology			Index Medicus:
Authors: Omichi C, Lamp ST, Lin S-F, Yang J, Baher A, Zhou SM, Attin M, Karagueuzian HS, et al.				ART
Yr: 0	Vol:	Nbr:	Abs:	Pg:

---

Altered atrial electrical restitution and sympathetic hyperinnervation in hearts with chronic left ventricular myocardial infarction. Implications for atrial fibrillation.
Periodical: Circulation			Index Medicus:
Authors: Miyauchi Y, Ohara K, Ohara T, Fishbein MC, Zhou S, Lee MH, Mandel WJ, Chen P-S, Karaguezia				ART
Yr: 2003	Vol: 108	Nbr:	Abs:	Pg: 360-366

---

Age-related sensitivity to nicotine for inducible atrial tachycardia and atrial fibrillation.
Periodical: American Journal of Physiology, Heart and Circulatory Physiology			Index Medicus:
Authors: Hayashi H, Omichi C, Miyauchi Y, Mandel WJ, Lin S-F, Chen P-S, Karagueuzian HS				ART
Yr: 2003	Vol: 284	Nbr:	Abs:	Pg: H249-255

---

The mechanism of the probabilistic nature of ventricular defibrillation threshold.
Periodical: American Journal of Physiology			Index Medicus:
Authors: Yashima M, Miyauchi Y, Cao J-M, Kim Y-H, Mandel WJ, Chen P-S, Karagueuzian HS				ART
Yr: 2003	Vol: 284	Nbr:	Abs:	Pg: H249-255

---

Electrical current-induced atrial and pulmonary vein action potential duration shortening and repetitive activity.
Periodical: American Journal of Physiology, Heart and Circulatory Physiology			Index Medicus:
Authors: Miyauchi Y, Fishbein MC, Karagueuzian HS				ART
Yr: 0	Vol:	Nbr:	Abs:	Pg:

---

Thoracic vein ablation terminates chronic atrial fibrillation in dogs.
Periodical: American Journal of Physiology, Heart and Circulatory Physiology			Index Medicus:
Authors: Park A, Chou CC, Drury PC, Okuyama Y, Peter A, Hamabe A, Miyauchi Y, Karagueuzian HS et al				ART
Yr: 0	Vol:	Nbr:	Abs:	Pg:

---

Intracellular calcium dynamics in ventricular fibrillation.
Periodical: American Journal of Physiology			Index Medicus:
Authors: Omichi C, Lamp ST, Lin S-F, Yang J, Baher A, Zhou SM, Attin M, Karagueuzian HS, et al.				ART
Yr: 0	Vol:	Nbr:	Abs:	Pg:

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