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Earl Carstens, Ph.D.

University of California, Davis # of Grants: 3

Grants

Irritant & Analgesic Effects of Nicotine 1995 (Cycle 4) $75,000
General Biomedical Science Inno Dev & Exp Awards (IDEAS)

Irritant and pain-reducing effects of nicotine 1997 (Cycle 6) $415,704
Nicotine Dependence Research Project Awards

Irritant and analgesic effects of nicotine 2002 (Cycle 11) $226,650
Nicotine Dependence Research Project Awards
Publications

Brain stem neurons expressing c-fos immunoreactivity following irritant chemical stimulation of the rat's tongue
Periodical: Neuroscience Index Medicus:
Authors: Carstens E, Saxe I, Ralph R ART
Yr: 1995 Vol: 69 Nbr: (3) Abs: Pg: 939-953

Oral irritant effects of nicotine: psychophysical evidence for decreased sensation following repeated application and lack of cross-desensitization with capsaicin
Periodical: Chemical Senses Index Medicus:
Authors: Dessirier JM, O'Mahony M, Carstens E ART
Yr: 1997 Vol: 22 Nbr: Abs: Pg: 483-492

No withdrawal from reflexes to assess pain
Periodical: Pain Forum Index Medicus:
Authors: Carstens E ART
Yr: 1997 Vol: 6 Nbr: Abs: Pg: 119-123

Force of limb withdrawals elicited by graded noxious heat compared with other behavioral measures of carrageenen-induced hyperalgesia and allodynia
Periodical: Journal of Neuroscience Methods Index Medicus:
Authors: Tabo E, Eisele JH Jr, Carstens E ART
Yr: 1998 Vol: Nbr: Abs: Pg:

Mecamylamine inhibits nicotine but not capsaicin irritation on the tongue: psychophysical evidence that nicotine and sapsaicin activate separate molecular receptors
Periodical: Neuroscience Letters Index Medicus:
Authors: Dessirier JM, O'Mahoney M, Sieffermann JM, Carstens E ART
Yr: 1998 Vol: 240 Nbr: Abs: Pg: 65-68

Activation of neurons in rat trigenimal subnucleus caudalis by application of different classes of irritant chemicals to the oral or ocular mucosa
Periodical: Journal of Neurophysiology Index Medicus:
Authors: Carstens E, Kuenzler N, Handwerker HO ART
Yr: 1998 Vol: Nbr: Abs: Pg:

Modulation of nociceptive thresholds by dopamine in the rostral agranular insular cortex of the rat
Periodical: Journal of Neuroscience Index Medicus:
Authors: Burkey AR, Carstens E, Jasmin L ART
Yr: 1999 Vol: 19 Nbr: Abs: Pg: 4169-4179

Oral irritant effects of nicotine
Periodical: Annals of the New York Academy of Sciences Index Medicus:
Authors: Dessirier J-M, O'Mahony M, Carstens E ART
Yr: 1998 Vol: 855 Nbr: Abs: Pg: 828-830

Skin cooling attenuates rat dorsal horn neuronal responses to intracutaneous histamine
Periodical: NeuroReport Index Medicus:
Authors: Jinks SL, Carstens E ART
Yr: 1998 Vol: 9 Nbr: Abs: Pg: 4145-4149

Behavioral manifestations of neuropathic pain and mechanical allodynia, and changes in spinal dorsal horn neurons, following L4-L6 dorsal root contriction
Periodical: Pain Forum Index Medicus:
Authors: Tabo E, Jinks SL, Eisele JH Jr, Carstens E ART
Yr: 1999 Vol: 80 Nbr: Abs: Pg: 503-520

Recognizing pain and distress in laboratory animals
Periodical: Institute of Laboratory Animal Resources Journal Index Medicus:
Authors: Carstens E, Moberg GP ART
Yr: 2000 Vol: 41 Nbr: 2 Abs: Pg: 62-71

Deopamine reuptake inhibition in the rostral agranular insular cortex produces antinociception
Periodical: Journal of Neuroscience Index Medicus:
Authors: Burkey AR, Carstens E, Jasmin L ART
Yr: 1999 Vol: 19 Nbr: N10 Abs: Pg: 4169-4179

Analgesia induced by chronic nicotine infusion in rats: differences by gender and pain test
Periodical: Psychopharmacology Index Medicus:
Authors: Carstens E, Anderson KA, Simons CT, Iodi-Carstens M, Jinks SL ART
Yr: 0 Vol: Nbr: Abs: Pg:

Role of neuronal nicotinic acetylcholine receptors in the activation of neurons in trigeminal subnucleus caudalis by nicotine delivered to the oral mucosa
Periodical: Experimental Brain Research Index Medicus:
Authors: Carstens E, Simond Ct, Dessirier J-M, Iodi-Carstens M, Jinks SL ART
Yr: 2000 Vol: 132 Nbr: Abs: Pg: 375-383

Cross-desensitization of capsaicin-evoked oral irritation by high but not low concentrations of nicotine in human subjects
Periodical: Neuroscience Letters Index Medicus:
Authors: Dessirier J-M, Chang H-K, O'Mahony M, Carstens E ART
Yr: 2000 Vol: 290 Nbr: Abs: Pg: 133-136

Sensory properties of citric acid: Psychophysical evidence for sensitization, self-desensitization, corss-desensitization and corss-stimulus-induced recovery following capsaicin
Periodical: Chemical Senses Index Medicus:
Authors: Dessirier J-M, O'Mahony M, Iodi-Carstens M, Carstens E ART
Yr: 2000 Vol: 25 Nbr: Abs: Pg: 769-780

Oral irritation by sodium chloride: sensitization, self-desensitization and cross-sensitization to capsaicin
Periodical: Physiology & Behavior Index Medicus:
Authors: Dessirier J-M, O'Mahony M, Iodi-Carstens M, Yao E, Carstens E ART
Yr: 2001 Vol: 72 Nbr: Abs: Pg: 317-324

Oral irritant properties of menthol: sensitizing and desensitizing effects of repeated application and corss-desensitization to nicotine
Periodical: Physiology & Behavior Index Medicus:
Authors: Dessirier J-M, O'Mahony M, Carstens E ART
Yr: 2001 Vol: 73 Nbr: 1-2 Abs: Pg: 25-36

Psychophysical and neurobiological evidence that oral irritation from carbonated water is of chemogenic origin
Periodical: Chemical Senses Index Medicus:
Authors: Dessirier J-M, Simons CT, O'Mahony, Carstens E ART
Yr: 2000 Vol: 25 Nbr: Abs: Pg: 277-284

The oral sensation of carbonated water: cross-desensitization by capsaicin and potentiation by amiloride
Periodical: Chemical Senses Index Medicus:
Authors: Dessirier J-M, Simons CT, O'Mahony M, Carstens E ART
Yr: 0 Vol: Nbr: Abs: Pg:

Sensitization, desensitization and stimulus-induced recovery (SIR) of responses of rat trigeminal caudalis neurons to repeated oral application of capsaicin and nicotine
Periodical: Journal of Neurophysiology Index Medicus:
Authors: Dessirier J-M, Simons CT, Sudo M, Sudo S, Carstens E ART
Yr: 2000 Vol: 84 Nbr: Abs: Pg: 1851-1862

Superficial dorsal horn neurons identified using intracutanious histamine as a search stimulus: chemonociceptive responses and modulation by morphone
Periodical: Journal of Neurophysiology Index Medicus:
Authors: Jinks SL, Carstens E ART
Yr: 2000 Vol: 84 Nbr: Abs: Pg: 616-627

Animal model to assess aversion to intraoral capsaicin: increased threshold in mice lacking substance P
Periodical: Chemical Senses Index Medicus:
Authors: Simons CT, Dessirier J-M, Jinks SL, Carstens E ART
Yr: 2001 Vol: Nbr: Abs: Pg:

It hurts so good: oral irritation by spices and carbonated drinkds and the underlying neural mechanisms.
Periodical: Food Quality Preferences Index Medicus:
Authors: Carstens E, Iodi Carstens M, Dessirier JM, O'Mahony M, Simons CT, Sudo M, Sudo S ART
Yr: 2002 Vol: 13 Nbr: 7-8 Abs: Pg: 431-443

Intracutaneous application of pruritic and algesic chemicals elicits similar distributions of c-Fos0immunopositive neurons in rat superficial dorsal horn.
Periodical: Experimental Brain Research Index Medicus:
Authors: Jinks SL, Simons CT, Dessirier J-M, Iodi Carstens M, Antognini JF, Carstens E ART
Yr: 2002 Vol: 145 Nbr: 2 Abs: Pg: 261-269

Reduced aversion to oral capsaicin following neurotoxic destruction of superficial medullary neurons expressing NK-1 receptors.
Periodical: Brain Research Index Medicus:
Authors: Simons CT, Gogineni A, Iodi Carstens M, Carstens E ART
Yr: 2002 Vol: 945 Nbr: 1 Abs: Pg: 139-143

Sensitization of trigeminal caudalis neuronal responses to intraoral acid and salt stimuli and desensitization by nicotine.
Periodical: Pain Index Medicus:
Authors: Sudo S, Sudo M, Simons CT, Dessirier JM, Carstens E ART
Yr: 2002 Vol: 98 Nbr: 3 Abs: Pg: 277-286

Taste suppression following lingual capsaicin pretreatment in humans.
Periodical: Chemical Senses Index Medicus:
Authors: Simons CT, O'Mahony M, Carstens E ART
Yr: 2002 Vol: 27 Nbr: Abs: Pg: 353-365

Activation of brain stem neurons by irritant chemical stimulation of the throat assessed by c-fos immunohistochemistry.
Periodical: Experimental Brain Research Index Medicus:
Authors: Boucher Y, Simons CT, Cuellar JM, Jung SW, Iodi Carstns M, Carstens E ART
Yr: 2003 Vol: 148 Nbr: 2 Abs: Pg: 211-218

Suppression of central taste transmission by oral capsaicin.
Periodical: Journal of Neuroscience Index Medicus:
Authors: Simons CT, Boucher Y, Carstens E ART
Yr: 2003 Vol: 23 Nbr: 3 Abs: Pg: 978-985

Activation neurons in trigeminal caudalis by noxious oral acidic or salt stimuli is not reduced by amiloride.
Periodical: Brain Research Index Medicus:
Authors: Sudo S, Sudo M, Simons CT, Dessirier JM, Iodi Carstens M, Carstens E ART
Yr: 2003 Vol: 969 Nbr: Abs: Pg: 237-243

Trigeminal modulation of gustatory neurons in the nucleus of the solitary tract.
Periodical: Brain Research Index Medicus:
Authors: Boucher Y, Simons CT, Faurion F, Azerad J, Carstens E ART
Yr: 2003 Vol: 973 Nbr: Abs: Pg: 265-274

Lack of quinine-evoked activity in rat trigeminal subnucleus caudalis.
Periodical: Chemical Senses Index Medicus:
Authors: Simons CT, Boucher Y, Iodi Carstens M, Carstens E ART
Yr: 2003 Vol: 28 Nbr: 3 Abs: Pg: 253-259

Oral irritation by mustard oil: self-desensitization and cross-desensitization with capaicin.
Periodical: Chemical Senses Index Medicus:
Authors: Simons CT, Iodi-Carstens M, Carstens E ART
Yr: 2003 Vol: 28 Nbr: Abs: Pg: 459-465

Mecamylamine reduces nicotine cross-desensitization of trigeminal caudalis neuronal responses to oral chemical irritation.
Periodical: Brain Research Index Medicus:
Authors: Simons CT, Sudo S, Sudo M, Carstens E ART
Yr: 2003 Vol: 991 Nbr: Abs: Pg: 249-253

Mustard oil has differential effects on the response of trigeminal caudalis neurons to heat and acidity.
Periodical: Pain Index Medicus:
Authors: Simons CT, Sudo S, Sudo M, Carstens E ART
Yr: 2004 Vol: Nbr: Abs: Pg:

Antinociception induced by chronic exposure of rats to cigarette smoke.
Periodical: Neuroscience Letters Index Medicus:
Authors: Anderson KL, Pinkerton KE, Uyeminami D, Simons CT, Iodi Carstens M, Carstens E ART
Yr: 2004 Vol: Nbr: Abs: Pg:

Scratching behavior in mice with a deletion of the preprotachykinin A gene.
Periodical: Neuroscience Letters Index Medicus:
Authors: Cuellar JM, Jinks SL, Simons CT, Carstens E ART
Yr: 2003 Vol: 339 Nbr: 1 Abs: Pg: 72-76

Quantitative assessment of directed hind limb scratching behavior as a rodent itch model.
Periodical: Neuroscience Methods Index Medicus:
Authors: Nojima H, Carstens E ART
Yr: 2003 Vol: 126 Nbr: 2 Abs: Pg: 137-143

Serotonin 5-HT2 receptor involvement in acute 5-HT-evoked scratching but not in allergic pruritus induced by dinitrofluorobenzene in rats.
Periodical: Journal of Pharmacology and Experimental Therapeutics Index Medicus:
Authors: Nojima H, Carstens E ART
Yr: 2003 Vol: 306 Nbr: 1 Abs: Pg: 245-252

c-fos expression in superficial dorsal horn of cervical spinal cord associated with spontaneous scratching in rats with dry skin.
Periodical: Neuroscience Letters Index Medicus:
Authors: Nojima H, Iodi Carstens M, Carstens E ART
Yr: 2003 Vol: 347 Nbr: Abs: Pg: 62-64

Opioid modulation of scratching and spinal c-fos expression evoked by intradermal serotonin.
Periodical: Journal of Neuroscience Index Medicus:
Authors: Nojima H, Simons CT, Cuellar JM, Iodi Carstens M, Carstens E ART
Yr: 2003 Vol: 23 Nbr: Abs: Pg: 10784-10790

Spinal c-fos expression associated with spontaneous biting in a mouse model of dry skin pruritus.
Periodical: Neuroscience Letters Index Medicus:
Authors: Nojima H, Cuellar JM, Simons CT, Iodi Carstens M, Carstens E ART
Yr: 2004 Vol: 361 Nbr: Abs: Pg: 79-82

It hurts so good: oral irritation by spices and carbonated drinks and the underlying neural mefhanisms (2002)
Periodical: Food Quality Preferences Index Medicus:
Authors: Carstens, E., Iodi Carstens, M., Dessirier, J. M, O'Mahony, M., Simons ART
Yr: 2002 Vol: 13 Nbr: 7-8 Abs: Pg: 431-443

Responses of superficial dorsal horn neurons to intradermal serotonin and other irritants comparison with scratching behavior (2002)
Periodical: Journal of Neurophysiology Index Medicus:
Authors: Jinks, S.L and Carstens E, ART
Yr: 2002 Vol: 87 Nbr: Abs: Pg: 1280-1289

Intracutaneous application of pruritic and algesic chemicals elicits simiar distribution of c-Fos immunopostive neurons in rat superficial dorsal horn (2002)
Periodical: Experimental Brain Research Index Medicus:
Authors: Jinks, S.L., Simons, C.T., Dessirier, J-M., Iodi Carstens, M., Antognini, J.F. and Carsten ART
Yr: 2002 Vol: 145 Nbr: 4 Abs: Pg: 261-269

Reduced aversion to oral capsaicin following neurotoxic destruction of superficial medullary neurons expressing NK receptors (2002)
Periodical: Brain Research Index Medicus:
Authors: Simons, C.T., Gogineri, A., Iodi Carsterns, M., Carstens, E. ART
Yr: 2002 Vol: 945 Nbr: 1 Abs: Pg: 139-143