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Thrombin Function/Inhibition in Tobacco-Related Diseases

Institution: SRI International
Investigator(s): Paul Johnson, Ph.D.
Award Cycle: 1992 (Cycle 1) Grant #: 1RT-0391 Award: $578,441
Subject Area: Cardiovascular Disease
Award Type: Research Project Awards
Abstracts
Publications

Hirudin: amino-terminal residues play a major role in the interaction with thrombin
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Lazar JB, Winant R, Johnson PH ART
Yr: 1991 Vol: 266 Nbr: 2 Abs: Pg: 685-688

Chemical modifications and amino acid substitutions in recombinant hirudin that increase hirudin-thrombin affinity
Periodical: Biochemistry Index Medicus:
Authors: Winant R, Lazar JB, Johnson PH ART
Yr: 1991 Vol: 30 Nbr: 5 Abs: Pg: 1271-1277

The structure of a complex of bovine alpha-thrombin and recombinant hirudin at 2.8 angstroms resolution
Periodical: Journal of Biological Chemistry Index Medicus:
Authors: Vitali J, Martin PD, Malkowski MG, et al ART
Yr: 1992 Vol: 267 Nbr: 25 Abs: Pg: 17670-17678

Expression of synthetic genes encoding fused proteins under tight control of modified regulatory regions of the colicin E1 operon
Periodical: Gene Index Medicus:
Authors: Waleh N, Sohel I, Hudson D, et al ART
Yr: 1992 Vol: 117 Nbr: 1 Abs: Pg: 7-14

Determination of the structure of a complex of bovine thrombin with a peptide consisting of residues 51 through 65 of hirudin
Periodical: Index Medicus:
Authors: Vitali J, Martin PD, Malkowski MG, Olsen CM, Johnson PH, Edwards BFP ABS
Yr: 1993 Vol: Nbr: Abs: Pg: