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Regulation of Tranformation by the Fos Gene

Institution: Salk Institute for Biological Studies
Investigator(s): Ronald Wisdom, M.D.
Award Cycle: 1993 (Cycle 2) Grant #: 2FT-0011 Award: $61,384
Subject Area: General Biomedical Science
Award Type: Postdoctoral Fellowship Awards

An alternative spliced form of FosB is anegative regulator of transcriptional activation and transformation by Fos proteins
Periodical: Proceedings of the National Academy of Sciences of the United States of America Index Medicus:
Authors: Yen J, Wisdom R, Tratner I, Verma IM ART
Yr: 1991 Vol: 88 Nbr: 12 Abs: Pg: 5077-5081

Transformation by FosB requires a transactivation domain missing in FosB2 that can be substituted by heterologous activation domains
Periodical: Genes and Development Index Medicus:
Authors: Wisdom R, Yen J, Rashid D, Verma IM ART
Yr: 1992 Vol: 6 Nbr: 4 Abs: Pg: 667-675

Proto-oncogene FosB: The amino terminus encodes a regulatory function required for transformation
Periodical: Molecular and Cellular Biology Index Medicus:
Authors: Wisdom R, Verma IM ART
Yr: 13 Vol: 13 Nbr: 5 Abs: Pg: 2635-2643