Segregation Analysis of Tobacco Use in Families

Institution:	SRI International
Investigator(s):	Gary Swan, Ph.D.
Award Cycle:	1998 (Cycle 7)	Grant #: 7PT-2002	Award: $863,966
Subject Area:	Epidemiology
Award Type:	Integrated Research Project

Abstracts

Initial Award Abstract

The proposed study will examine the extent to which hereditary factors operate alone or in combination with environmental factors to determine whether adolescents are likely to experiment with tobacco or become regular smokers. The data to be used in this study derive from 763 adolescents, their parents, and their siblings. As part of the “SMOFAM” study being conducted by the Oregon Research Institute (ORI), these study participants have provided information about their substance use, including tobacco, at 12 assessments over the past 14 years. In addition, they provided information about the many psychological and environmental factors that are known or hypothesized to be related to smoking.

In Study 1 of this Integrated Research Proposal, we will combine existing data from ORI with in-depth measures of nicotine dependence (collected by the Statistical Core), cotinine clearance data (Study 3), and genetic data (Study 2) to (1) determine and combine descriptions of nicotine addiction in young smokers and their families; (2) analyze family data to determine whether nicotine addiction as defined in 1 above have parent-offspring patterns suggestive of genetic influence; (3) use the Transmission Disequilibrium Test (a recent approach to determining genetic associations) to determine the presence of genotype-nicotine addiction associations in ever-smoking children; (4) use a variation of the TDT to examine the data for evidence of gene-environment interactions in determining susceptibility to tobacco use; 5) identify independent and joint genetic and environmental factors that predict the speed with which young people transition from experimentation with tobacco to regular use; 6) identify subgroups of young people based on unique combinations of genetic and environmental risk factor profiles and who differ with respect to the age at which they experimented with tobacco and then began to smoke on a regular basis. The successful completion of this analysis will provide evidence on: 1) both the limits and extent of genetic involvement in the susceptibility to become a regular smoker in young adults, and 2) the extent to which genetic and environmental risk factors operate independently or jointly to determine the susceptibility to becoming a regular smoker, the speed with which young people become regular smokers, and the age at which they become regular smokers.

Publications

Multiple risk factors for the initiation of smoking: the public health imperative for multidisciplinary genetic epidemiological investigation of nicotine addiction
Periodical: Nicotine and Tobacco Research			Index Medicus:
Authors: Swan GE				ART
Yr: 1999	Vol:	Nbr: Suppl 2	Abs:	Pg: S71-S73

A genetic analysis of smoking behavior in family members of older adult males
Periodical: Addiction			Index Medicus:
Authors: Cheng L S-C, Swan GE, Carmelli D				ART
Yr: 2000	Vol: 95	Nbr:	Abs:	Pg: 427-435

A multidimensional model for characterizing tobacco dependence.
Periodical: Nicotine and Tobacco Research			Index Medicus:
Authors: Hudmon KS, Marks JL, Pomerleau CS, Bolt DM, Brigham J, Swan GE				ART
Yr: 2003	Vol: 5	Nbr:	Abs:	Pg: 655-664

Genetics and prevention of drug abuse: implications for transdisciplinary research and practice.
Periodical: Substance Use and Misuse			Index Medicus:
Authors: Lessov CN, Swan GE, Ring HZ, Khroyan TV, Lerman C				ART
Yr: 0	Vol:	Nbr:	Abs:	Pg:

Agreement between proband and parental self-report of smoking behavior and nicotine dependence.
Periodical: Nicotine and Tobacco Research			Index Medicus:
Authors: Marks JL, Swan GE, Pomerleau CS, Pomerleau OF				ART
Yr: 2003	Vol: 5	Nbr:	Abs:	Pg: 527-533

Intergenerational transmission of tobacco use and dependence: a transdisciplinary perspective.
Periodical: Nicotine and Tobacco Research			Index Medicus:
Authors: Shenassa ED, McCaffery JM, Swan GE, et al.				ART
Yr: 2003	Vol: 5	Nbr: suppl 1	Abs:	Pg: S55-69

Environmental and genetic determinants of tobacco use: methodology for a multidisciplinary, longitudinal family-based intervention.
Periodical: Cancer Epidemiology Biomarkers and Prevention			Index Medicus:
Authors: Swan GE, Hudmon K, Cheng L S-C, et al.				ART
Yr: 2003	Vol: 12	Nbr:	Abs:	Pg: 994-1005

A genome-wide search for quantitative trait loci associated with tobacco use phenotypes.
Periodical: TRDRP Annual Report to the State of California Legislature			Index Medicus:
Authors: Swan GE< Wilhelmsen K, Feiler H, et al.				ABS
Yr: 2003	Vol:	Nbr:	Abs:	Pg:

Gene-environment interaction in nicotine addiction: the need for a large-scale, collaborative effort.
Periodical: Substance Use and Misuse			Index Medicus:
Authors: Swan GE, Lessov CN				ART
Yr: 2004	Vol: 39	Nbr: 10-12	Abs:	Pg: 2083-2085

Genetics and drug use as a complex phenotype.
Periodical: Substance Use and Misuse			Index Medicus:
Authors: Lessov CN, Swan GE, Ring HZ, Khroyan TV, Lerman C				ART
Yr: 2004	Vol: 39	Nbr: 10-12	Abs:	Pg: 1515-1569

Nicotine addiction through a neurogenomic prism: Ethics, public health, and smoking.
Periodical: Nicotine and Tobacco Research			Index Medicus:
Authors: Caron L, Karkazis K, Raffin TA, Swan GE, Koenig BA				ART
Yr: 0	Vol: 7	Nbr: 2	Abs:	Pg:

Multiple risk factors for the initiation of smoking: the public health imperative for multidisciplinary genetic epidemiological investigation of nicotine addiction
Periodical: Nicotine and Tobacco Research			Index Medicus:
Authors: Swan GE				ART
Yr: 1999	Vol:	Nbr: Suppl 2	Abs:	Pg: S71-S73

A genetic analysis of smoking behavior in family members of older adult males
Periodical: Addiction			Index Medicus:
Authors: Cheng L S-C, Swan GE, Carmelli D				ART
Yr: 2000	Vol: 95	Nbr:	Abs:	Pg: 427-435

A multidimensional model for characterizing tobacco dependence.
Periodical: Nicotine and Tobacco Research			Index Medicus:
Authors: Hudmon KS, Marks JL, Pomerleau CS, Bolt DM, Brigham J, Swan GE				ART
Yr: 2003	Vol: 5	Nbr:	Abs:	Pg: 655-664

Genetics and prevention of drug abuse: implications for transdisciplinary research and practice.
Periodical: Substance Use and Misuse			Index Medicus:
Authors: Lessov CN, Swan GE, Ring HZ, Khroyan TV, Lerman C				ART
Yr: 0	Vol:	Nbr:	Abs:	Pg:

Agreement between proband and parental self-report of smoking behavior and nicotine dependence.
Periodical: Nicotine and Tobacco Research			Index Medicus:
Authors: Marks JL, Swan GE, Pomerleau CS, Pomerleau OF				ART
Yr: 2003	Vol: 5	Nbr:	Abs:	Pg: 527-533

Intergenerational transmission of tobacco use and dependence: a transdisciplinary perspective.
Periodical: Nicotine and Tobacco Research			Index Medicus:
Authors: Shenassa ED, McCaffery JM, Swan GE, et al.				ART
Yr: 2003	Vol: 5	Nbr: suppl 1	Abs:	Pg: S55-69

Environmental and genetic determinants of tobacco use: methodology for a multidisciplinary, longitudinal family-based intervention.
Periodical: Cancer Epidemiology Biomarkers and Prevention			Index Medicus:
Authors: Swan GE, Hudmon K, Cheng L S-C, et al.				ART
Yr: 2003	Vol: 12	Nbr:	Abs:	Pg: 994-1005

A genome-wide search for quantitative trait loci associated with tobacco use phenotypes.
Periodical: TRDRP Annual Report to the State of California Legislature			Index Medicus:
Authors: Swan GE< Wilhelmsen K, Feiler H, et al.				ABS
Yr: 2003	Vol:	Nbr:	Abs:	Pg:

Gene-environment interaction in nicotine addiction: the need for a large-scale, collaborative effort.
Periodical: Substance Use and Misuse			Index Medicus:
Authors: Swan GE, Lessov CN				ART
Yr: 2004	Vol: 39	Nbr: 10-12	Abs:	Pg: 2083-2085

Genetics and drug use as a complex phenotype.
Periodical: Substance Use and Misuse			Index Medicus:
Authors: Lessov CN, Swan GE, Ring HZ, Khroyan TV, Lerman C				ART
Yr: 2004	Vol: 39	Nbr: 10-12	Abs:	Pg: 1515-1569

Nicotine addiction through a neurogenomic prism: Ethics, public health, and smoking.
Periodical: Nicotine and Tobacco Research			Index Medicus:
Authors: Caron L, Karkazis K, Raffin TA, Swan GE, Koenig BA				ART
Yr: 0	Vol: 7	Nbr: 2	Abs:	Pg: