Anabolic therapies for muscle dysfunction in women with COPD
Abstracts
Initial Award Abstract |
|
This project aims to improve the effectiveness of medical treatment for women with lung disease produced by cigarette smoking. Chronic obstructive pulmonary disease (COPD, also called emphysema or bronchitis) is a disorder affecting approximately 14 million people in the United States. It is a disabling disorder and inability to exercise is usually the foremost problem. It is becoming clear that these patients suffer not only from poorly functioning lungs but also because the muscles of ambulation perform poorly. We have recently shown that muscle function can be improved in men with COPD both by strength training and by giving supplemental testosterone, a drug known to build muscles. Until now, most research into methods to improve muscle function has involved only men. However, the number of women suffering from COPD is accelerating and is nearly equal to that of men. The body chemicals that stimulate muscle growth operate differently in women than they do in men. We will focus on two specific strategies intended to improve the muscle's ability to tolerate exercise. First, there is a growing realization that testosterone is not only a “male hormone”. Though levels in women are much lower than in men, studies in healthy women suggest that testosterone supplementation increases muscle size. We have found that women with COPD have low levels of this chemical. However, the amount of testosterone that best balances the benefits of testosterone without creating troubling side effects has yet to be determined. We will determine whether administering testosterone to women with COPD will increase muscle mass and exercise tolerance. Second, we have found that women with COPD usually have a low level of activity; we will determine whether a strength conditioning program consisting of a varied group of exercises improves exercise tolerance.
We will assign by chance 72 women with COPD to one of six groups. Four of the groups will receive no training, but will apply a gel to their skin daily that will contain no testosterone or one of three doses of testosterone. Two of the groups will receive strength training (for one hour a day three times per week) plus either a gel with no testosterone or with the highest of the three doses of testosterone. A number of state-of-the art measurements will be made before and after the 10 week study period including: 1) precise measurement of the muscle and fat mass in the body, 2) muscle strength by weight lifting and by measuring the electrical activity of the muscle, 3) exercise capacity measured on a stationary bicycle, 4) strength of the breathing muscles and 5) the overall quality of life, assessed by well-designed questionnaires. In this study, a number of safeguards will be in place to assure the participants' safety.
Programs are already in place to help rehabilitate patients with COPD. This study should be directly applicable to these programs and will help to decrease the suffering of patients with this smoking-related disease. |
Publications
| Skeletal muscle dysfunction in chronic obstructive pulmonary disease. |
| Periodical: Medicine and Science in Sports and Exercise |
Index Medicus: |
| Authors: Casaburi R |
ART |
| Yr: 2001 |
Vol: 33 |
Nbr: 7 |
Abs: |
Pg: S662 - S670 |
| Effect of oxygen on hyperinflation and exercise endurance in non-hypoxemic COPD patients. |
| Periodical: European Respiratory Journal |
Index Medicus: |
| Authors: Somfay A, Porszasz J, Lee SM, and Casaburi R |
ART |
| Yr: 2001 |
Vol: 18 |
Nbr: |
Abs: |
Pg: 77 - 84 |
| Testosterone dose-response relationships in healthy young men. |
| Periodical: American Journal of Physiology Endocrinology and Metabolism |
Index Medicus: |
| Authors: Bhasin S, Woodhouse L, Casaburi R, Singh AB, Bhasin D, Berman N, Magliano L, et al |
ART |
| Yr: 2001 |
Vol: 281 |
Nbr: |
Abs: |
Pg: E1172 - E1181 |
| 21st century perspective on chronic obstructive pulmonary disease. |
| Periodical: Respiration |
Index Medicus: |
| Authors: Ward SA, and Casaburi R |
ART |
| Yr: 2001 |
Vol: 68 |
Nbr: |
Abs: |
Pg: 557 - 561 |
| Megesterol acetate stimulates weight gain and ventilation in underweight COPD patients. |
| Periodical: Chest |
Index Medicus: |
| Authors: Weisberg J, Wanger J, Olson J, Streit B, Fogarty C, Martin T, and Casaburi R |
ART |
| Yr: 2002 |
Vol: 121 |
Nbr: |
Abs: |
Pg: 1070 - 1078 |
| A long-term evaluation of once-daily tiotropium in chronic obstructive pulmonary disease. |
| Periodical: European Respiratory Journal |
Index Medicus: |
| Authors: Casaburi R, Mahler DA, Jones PW, Wanner A, San Pedro G, ZuWallack RL, et al |
ART |
| Yr: 2002 |
Vol: 19 |
Nbr: |
Abs: |
Pg: 217 - 224 |
| Effect of hyperoxia on gas exchange and lactate kinetics following exercise onset in non-hypoxemic COPD patients. |
| Periodical: Chest |
Index Medicus: |
| Authors: Somfay A, Porszasz J, Lee S-M, and Casaburi R |
ART |
| Yr: 2002 |
Vol: 121 |
Nbr: |
Abs: |
Pg: 393 - 400 |
| Adjunctive pharmacologic treatment in chronic obstructive pulmonary disease. |
| Periodical: European Respiration Rev |
Index Medicus: |
| Authors: Casaburi R |
ART |
| Yr: 0 |
Vol: |
Nbr: |
Abs: |
Pg: |
| A new anticholinergic bronchodilator for chronic obstructive pulmonary disease. |
| Periodical: European Respiration Rev |
Index Medicus: |
| Authors: Casaburi R, van Noord JA, and Witek TJ |
ART |
| Yr: 0 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Testosterone-induced increase inmuscle size in healthy, young men is associated with muscle fiber hypertrophy. |
| Periodical: American Journal of Physiology Endocrinology and Metabolism |
Index Medicus: |
| Authors: Sinha-Hikim I, Artaza J, Gonzalez-Cadivid N, Singh AB, Casaburi R, Woodhouse L, et al |
ART |
| Yr: 2002 |
Vol: 283 |
Nbr: |
Abs: |
Pg: E154 - E164 |
| Testosterone dose response relationships in health young men. |
| Periodical: Journal of Investigative Medicine |
Index Medicus: |
| Authors: Storer TW, Casaburi R, Singh AB, Magliano L, Bhasin D, Dzekov C, Dzekov J, et al |
ABS |
| Yr: 2001 |
Vol: 49 |
Nbr: 1 |
Abs: |
Pg: 16A |
| Megestrol acetate induces weight gain and stimulates ventilation in underweight COPD patients. A randomized, double-blind, placebo-controlled, multi-center trial. |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Weisberg J, Casaburi R, Olson J, and Wanger J |
ABS |
| Yr: 2001 |
Vol: 163 |
Nbr: 5 |
Abs: |
Pg: A503 |
| Comparison of a new linearized treadmill ramp protocol with a cycle ergometer ramp protocol in cardiopulmonary exercise testing (CPX). |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Porszasz J, Woodhouse L, Somfay A, Yu A, DeBellis E, and Casaburi R |
ABS |
| Yr: 2001 |
Vol: 163 |
Nbr: 5 |
Abs: |
Pg: A267 |
| Effect of supplemental oxygen on hyperinflation and exercise endurance in non-hypoxemic COPD patients. |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Somfay A, Porszasz J, Lee SM, and Casaburi R |
ABS |
| Yr: 2001 |
Vol: 163 |
Nbr: 5 |
Abs: |
Pg: A267 |
| A randomized trial of strength training and testosterone supplementation in men with chronic obstructive pulmonary disease. |
| Periodical: European Respiratory Journal |
Index Medicus: |
| Authors: Casaburi R, Consentino G, Bhasin S, Fournier M, Lewis M, Porszasz J, and Storer T |
ABS |
| Yr: 2001 |
Vol: 18 |
Nbr: Suppl 33 |
Abs: |
Pg: 173S |
| Effect of hyperoxia on gas exchange and lactate kinetics following exercise onset in non-hypoxemic COPD patients. |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Porszasz J, Somfay A, Lee SM, and Casaburi R |
ABS |
| Yr: 2002 |
Vol: 165 |
Nbr: 8 |
Abs: |
Pg: A503 |
| Hormonal and safety profile resulting from physiologic testosterone supplementation in men with COPD. |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Casaburi R, Cosentino L, Porszasz J, Bhasin S, and Storer T |
ABS |
| Yr: 2002 |
Vol: 165 |
Nbr: 8 |
Abs: |
Pg: A506 |
| Spiriva(R) (Tiotropium) reduces lung hyperinflation in COPD. |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Magnussen H, O'Donnel DE, Casaburi R, Kesten S, Gerken F, and Fluge T |
ABS |
| Yr: 2002 |
Vol: 165 |
Nbr: 8 |
Abs: |
Pg: A227 |
| Testosterone replacement and resistance training improve muscle and physical function in men with COPD. |
| Periodical: Medicine and Science in Sports and Exercise |
Index Medicus: |
| Authors: Storer T, Magliano L, Cosentino G, Walsh D, Bhasin S and Casaburi R |
ABS |
| Yr: 2002 |
Vol: 34 |
Nbr: 5, Suppl |
Abs: |
Pg: |
| Dysfonction musculaire peripherique dans la bronchopneumopathie chronique obstructive. |
| Periodical: Rev. Mal. Respir. |
Index Medicus: |
| Authors: Maltais F, Le Blanc P, Jobin J, Casaburi |
ART |
| Yr: 2002 |
Vol: 19 |
Nbr: |
Abs: |
Pg: 444-453 |
| The range of outcome measures used to evaluate treatment in chronic obstructive pulmonary disease. |
| Periodical: European Respiration Rev |
Index Medicus: |
| Authors: Casaburi R |
ART |
| Yr: 2003 |
Vol: 12 |
Nbr: 83 |
Abs: |
Pg: 58-60 |
| Long-term effects of a maintenance program after supervised or self-monitored training programmes in patients with COPD. |
| Periodical: Lung |
Index Medicus: |
| Authors: Puente-Maestu L, Luisa M, Pilar S, Jose S, Casaburi R, et al. |
ART |
| Yr: 2003 |
Vol: 181 |
Nbr: |
Abs: |
Pg: 67-78 |
| Benefits of supplemental oxygen in exercise training in non-hypoxemic COPD patients. |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Emtner M, Porszasz J, Burns M, Somfay A, Casaburi R |
ART |
| Yr: 2003 |
Vol: 168 |
Nbr: |
Abs: |
Pg: 1034-1042 |
| A linear treadmill ramp protocol using simultaneous changes in walking speed and grade. |
| Periodical: Medicine and Science in Sports and Exercise |
Index Medicus: |
| Authors: Porszasz J, Casaburi R, Somfay A et al |
ART |
| Yr: 2003 |
Vol: 35 |
Nbr: |
Abs: |
Pg: 1596-1603 |
| Limitation to exercise tolerance in COPD: look to the muscles of ambulation. |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Casaburi R |
ART |
| Yr: 2003 |
Vol: 168 |
Nbr: |
Abs: |
Pg: 409-410 |
| Testosterone-induced muscle fiber hypertrophy is associated with an increase in muscle satellite cell number in healthy young men. |
| Periodical: Journal of Investigative Medicine |
Index Medicus: |
| Authors: Sinha-Hikim I, Woodhouse LJ, Singh AB, Casaburi R, Storer TW, Bhasin S |
ABS |
| Yr: 2002 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Low intensity endurance training improves muscle function, physical performance, and FFM in hemodialysis. |
| Periodical: Medicine and Science in Sports and Exercise |
Index Medicus: |
| Authors: Storer TW, Casaburi R, Gottron C, Walsh D, Kopple JD |
ABS |
| Yr: 2003 |
Vol: 35 |
Nbr: 5 |
Abs: s231 |
Pg: |
| Endurance training decreases exercise-induced dynamic hyperinflation in patients with COPD. |
| Periodical: European Respiratory Journal |
Index Medicus: |
| Authors: Porszasz J, Emtner M, Whipp BJ, Goto S, Somfay A, Casaburi R |
ABS |
| Yr: 2003 |
Vol: 22 |
Nbr: 45 |
Abs: |
Pg: 205s |
| A linear incremental work rate protocol for treadmill ergometry by means of continuous grade and velocity increases. |
| Periodical: European Society for Respiratory Disease |
Index Medicus: |
| Authors: Casaburi R, Porszasz J, Woodhouse L, Somfay A, Whipp BJ |
ABS |
| Yr: 2003 |
Vol: 22 |
Nbr: 45 |
Abs: |
Pg: 89s |
| Endocrinological disturbances in COPD |
| Periodical: European Respiratory Journal |
Index Medicus: |
| Authors: Creutzberg EC, Casaburi R |
ART |
| Yr: 2003 |
Vol: 22 |
Nbr: Suppl. 46 |
Abs: |
Pg: 76s-80s |
| Anabolic hormone supplementation as an adjunct to pulmonary rehabilitation. |
| Periodical: American Journal of Medicine and Sports |
Index Medicus: |
| Authors: Casaburi R |
ART |
| Yr: 2004 |
Vol: 6 |
Nbr: |
Abs: |
Pg: 28-31 |
| Lung function improvements with once-daily tiotropium in COPD. |
| Periodical: American Journal of Medicine |
Index Medicus: |
| Authors: Casaburi R, Conscenti CS |
ART |
| Yr: 0 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Effect of helium breathing on dynamic hyperinflation, minute ventilation and exercise tolerance in severe COPD patients. |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Goto S, Porszasz J, Sakurai S, Whipp BJ, Casaburi R |
ABS |
| Yr: 2004 |
Vol: 169 |
Nbr: 7 |
Abs: |
Pg: A467 |
| Tiotropium augments improvements in dyspnea and health-related quality of life following pulmonary rehabilitation in COPD. |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Cooper CB, Kukafka D, Casaburi R, Kesten S |
ABS |
| Yr: 2004 |
Vol: 169 |
Nbr: 7 |
Abs: |
Pg: A518 |
| Improvement in endurance time with the combination of tiotropium and rehabilitative exercise training in COPD patients. |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Casaburi R, Kakafka D, Cooper C, Wang S, Kesten S |
ABS |
| Yr: 2004 |
Vol: 169 |
Nbr: 7 |
Abs: |
Pg: A756 |
| Work rate selection for constant work rate exercise testing for interventional studies in COPD. |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Casaburi R, Chen C, Porszasz, Whipp BJ |
ABS |
| Yr: 2004 |
Vol: 169 |
Nbr: 7 |
Abs: |
Pg: A770 |
| Cellular and molecular adaptations in skeletal muscle to testosterone and/or resistance training in men with COPD. |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Fournier M, Casaburi R, Storer T, Porszasz J, Bhasin S, Da X, Lewis MI |
ABS |
| Yr: 2004 |
Vol: 169 |
Nbr: 7 |
Abs: |
Pg: A904 |
| Use of physiological calibration to validate gas exchange measurements during exercise. |
| Periodical: Medicine and Science in Sports and Exercise |
Index Medicus: |
| Authors: Porszasz J, Woodhouse LJ, Casaburi R, Nguyen A, Tsurugaya H, Whipp BJ |
ABS |
| Yr: 2004 |
Vol: 36 |
Nbr: 5 |
Abs: |
Pg: S27 |
| Effects of heliox breathing on R-R variability at rest and during exercise in COPD. |
| Periodical: Medicine and Science in Sports and Exercise |
Index Medicus: |
| Authors: Sakurai S, Whipp BJ, Goto S, Casaburi R |
ABS |
| Yr: 2004 |
Vol: 36 |
Nbr: 5 |
Abs: |
Pg: S210 |
| Testosterone dose-dependently increases maximal voluntary strength and leg power, but does not affect fatiguability or specific tension. |
| Periodical: Journal of Clincal Endocrinology and Metabolism |
Index Medicus: |
| Authors: Casaburi R, Storer TW, Magliano K, Woodhouse L, Lee ML, Dzekov C, et al. |
ART |
| Yr: 2003 |
Vol: 88 |
Nbr: |
Abs: |
Pg: 1478 - 1485 |
| Effects of testosterone replacement and resistance training in men with chronic obstructive pulmonary disease. |
| Periodical: American Journal of Critical Care Medicine |
Index Medicus: |
| Authors: Casaburi R, Bhasin S, Cosentino L, Porszasz J, Somfay A, Lewis MI, Fournier M, Storer TW |
ART |
| Yr: 2004 |
Vol: 170 |
Nbr: |
Abs: |
Pg: 870 - 878 |
| Older men are as responsive as young men to the anabolic effects of graded testosterone on the skeletal muscle. |
| Periodical: Journal of Clincal Endocrinology and Metabolism |
Index Medicus: |
| Authors: Casaburi R, Bhasin L, Woodhouse L, Singh AB, Phong R, Lee M, et al. |
ART |
| Yr: 2005 |
Vol: 90 |
Nbr: |
Abs: |
Pg: 678 - 688 |
| Dose-dependent effects of testosterone on sexual function, mood and visuospatial cognition in older men. |
| Periodical: Journal of Clincal Endocrinology and Metabolism |
Index Medicus: |
| Authors: asaburi R, Gray PB, Singh AB, Woodhouse LJ, Storer TW, Dzekov J, Dzekov C, et al. |
ART |
| Yr: 2005 |
Vol: 90 |
Nbr: |
Abs: |
Pg: 3838 - 3846 |
| Skeletal muscle dysfunction in chronic obstructive pulmonary disease. |
| Periodical: Medicine and Science in Sports and Exercise |
Index Medicus: |
| Authors: Casaburi R |
ART |
| Yr: 2001 |
Vol: 33 |
Nbr: 7 |
Abs: |
Pg: S662 - S670 |
| Effect of oxygen on hyperinflation and exercise endurance in non-hypoxemic COPD patients. |
| Periodical: European Respiratory Journal |
Index Medicus: |
| Authors: Somfay A, Porszasz J, Lee SM, and Casaburi R |
ART |
| Yr: 2001 |
Vol: 18 |
Nbr: |
Abs: |
Pg: 77 - 84 |
| Testosterone dose-response relationships in healthy young men. |
| Periodical: American Journal of Physiology Endocrinology and Metabolism |
Index Medicus: |
| Authors: Bhasin S, Woodhouse L, Casaburi R, Singh AB, Bhasin D, Berman N, Magliano L, et al |
ART |
| Yr: 2001 |
Vol: 281 |
Nbr: |
Abs: |
Pg: E1172 - E1181 |
| 21st century perspective on chronic obstructive pulmonary disease. |
| Periodical: Respiration |
Index Medicus: |
| Authors: Ward SA, and Casaburi R |
ART |
| Yr: 2001 |
Vol: 68 |
Nbr: |
Abs: |
Pg: 557 - 561 |
| Megesterol acetate stimulates weight gain and ventilation in underweight COPD patients. |
| Periodical: Chest |
Index Medicus: |
| Authors: Weisberg J, Wanger J, Olson J, Streit B, Fogarty C, Martin T, and Casaburi R |
ART |
| Yr: 2002 |
Vol: 121 |
Nbr: |
Abs: |
Pg: 1070 - 1078 |
| A long-term evaluation of once-daily tiotropium in chronic obstructive pulmonary disease. |
| Periodical: European Respiratory Journal |
Index Medicus: |
| Authors: Casaburi R, Mahler DA, Jones PW, Wanner A, San Pedro G, ZuWallack RL, et al |
ART |
| Yr: 2002 |
Vol: 19 |
Nbr: |
Abs: |
Pg: 217 - 224 |
| Effect of hyperoxia on gas exchange and lactate kinetics following exercise onset in non-hypoxemic COPD patients. |
| Periodical: Chest |
Index Medicus: |
| Authors: Somfay A, Porszasz J, Lee S-M, and Casaburi R |
ART |
| Yr: 2002 |
Vol: 121 |
Nbr: |
Abs: |
Pg: 393 - 400 |
| Adjunctive pharmacologic treatment in chronic obstructive pulmonary disease. |
| Periodical: European Respiration Rev |
Index Medicus: |
| Authors: Casaburi R |
ART |
| Yr: 0 |
Vol: |
Nbr: |
Abs: |
Pg: |
| A new anticholinergic bronchodilator for chronic obstructive pulmonary disease. |
| Periodical: European Respiration Rev |
Index Medicus: |
| Authors: Casaburi R, van Noord JA, and Witek TJ |
ART |
| Yr: 0 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Testosterone-induced increase inmuscle size in healthy, young men is associated with muscle fiber hypertrophy. |
| Periodical: American Journal of Physiology Endocrinology and Metabolism |
Index Medicus: |
| Authors: Sinha-Hikim I, Artaza J, Gonzalez-Cadivid N, Singh AB, Casaburi R, Woodhouse L, et al |
ART |
| Yr: 2002 |
Vol: 283 |
Nbr: |
Abs: |
Pg: E154 - E164 |
| Testosterone dose response relationships in health young men. |
| Periodical: Journal of Investigative Medicine |
Index Medicus: |
| Authors: Storer TW, Casaburi R, Singh AB, Magliano L, Bhasin D, Dzekov C, Dzekov J, et al |
ABS |
| Yr: 2001 |
Vol: 49 |
Nbr: 1 |
Abs: |
Pg: 16A |
| Megestrol acetate induces weight gain and stimulates ventilation in underweight COPD patients. A randomized, double-blind, placebo-controlled, multi-center trial. |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Weisberg J, Casaburi R, Olson J, and Wanger J |
ABS |
| Yr: 2001 |
Vol: 163 |
Nbr: 5 |
Abs: |
Pg: A503 |
| Comparison of a new linearized treadmill ramp protocol with a cycle ergometer ramp protocol in cardiopulmonary exercise testing (CPX). |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Porszasz J, Woodhouse L, Somfay A, Yu A, DeBellis E, and Casaburi R |
ABS |
| Yr: 2001 |
Vol: 163 |
Nbr: 5 |
Abs: |
Pg: A267 |
| Effect of supplemental oxygen on hyperinflation and exercise endurance in non-hypoxemic COPD patients. |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Somfay A, Porszasz J, Lee SM, and Casaburi R |
ABS |
| Yr: 2001 |
Vol: 163 |
Nbr: 5 |
Abs: |
Pg: A267 |
| A randomized trial of strength training and testosterone supplementation in men with chronic obstructive pulmonary disease. |
| Periodical: European Respiratory Journal |
Index Medicus: |
| Authors: Casaburi R, Consentino G, Bhasin S, Fournier M, Lewis M, Porszasz J, and Storer T |
ABS |
| Yr: 2001 |
Vol: 18 |
Nbr: Suppl 33 |
Abs: |
Pg: 173S |
| Effect of hyperoxia on gas exchange and lactate kinetics following exercise onset in non-hypoxemic COPD patients. |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Porszasz J, Somfay A, Lee SM, and Casaburi R |
ABS |
| Yr: 2002 |
Vol: 165 |
Nbr: 8 |
Abs: |
Pg: A503 |
| Hormonal and safety profile resulting from physiologic testosterone supplementation in men with COPD. |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Casaburi R, Cosentino L, Porszasz J, Bhasin S, and Storer T |
ABS |
| Yr: 2002 |
Vol: 165 |
Nbr: 8 |
Abs: |
Pg: A506 |
| Spiriva(R) (Tiotropium) reduces lung hyperinflation in COPD. |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Magnussen H, O'Donnel DE, Casaburi R, Kesten S, Gerken F, and Fluge T |
ABS |
| Yr: 2002 |
Vol: 165 |
Nbr: 8 |
Abs: |
Pg: A227 |
| Testosterone replacement and resistance training improve muscle and physical function in men with COPD. |
| Periodical: Medicine and Science in Sports and Exercise |
Index Medicus: |
| Authors: Storer T, Magliano L, Cosentino G, Walsh D, Bhasin S and Casaburi R |
ABS |
| Yr: 2002 |
Vol: 34 |
Nbr: 5, Suppl |
Abs: |
Pg: |
| Dysfonction musculaire peripherique dans la bronchopneumopathie chronique obstructive. |
| Periodical: Rev. Mal. Respir. |
Index Medicus: |
| Authors: Maltais F, Le Blanc P, Jobin J, Casaburi |
ART |
| Yr: 2002 |
Vol: 19 |
Nbr: |
Abs: |
Pg: 444-453 |
| The range of outcome measures used to evaluate treatment in chronic obstructive pulmonary disease. |
| Periodical: European Respiration Rev |
Index Medicus: |
| Authors: Casaburi R |
ART |
| Yr: 2003 |
Vol: 12 |
Nbr: 83 |
Abs: |
Pg: 58-60 |
| Long-term effects of a maintenance program after supervised or self-monitored training programmes in patients with COPD. |
| Periodical: Lung |
Index Medicus: |
| Authors: Puente-Maestu L, Luisa M, Pilar S, Jose S, Casaburi R, et al. |
ART |
| Yr: 2003 |
Vol: 181 |
Nbr: |
Abs: |
Pg: 67-78 |
| Benefits of supplemental oxygen in exercise training in non-hypoxemic COPD patients. |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Emtner M, Porszasz J, Burns M, Somfay A, Casaburi R |
ART |
| Yr: 2003 |
Vol: 168 |
Nbr: |
Abs: |
Pg: 1034-1042 |
| A linear treadmill ramp protocol using simultaneous changes in walking speed and grade. |
| Periodical: Medicine and Science in Sports and Exercise |
Index Medicus: |
| Authors: Porszasz J, Casaburi R, Somfay A et al |
ART |
| Yr: 2003 |
Vol: 35 |
Nbr: |
Abs: |
Pg: 1596-1603 |
| Limitation to exercise tolerance in COPD: look to the muscles of ambulation. |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Casaburi R |
ART |
| Yr: 2003 |
Vol: 168 |
Nbr: |
Abs: |
Pg: 409-410 |
| Testosterone-induced muscle fiber hypertrophy is associated with an increase in muscle satellite cell number in healthy young men. |
| Periodical: Journal of Investigative Medicine |
Index Medicus: |
| Authors: Sinha-Hikim I, Woodhouse LJ, Singh AB, Casaburi R, Storer TW, Bhasin S |
ABS |
| Yr: 2002 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Low intensity endurance training improves muscle function, physical performance, and FFM in hemodialysis. |
| Periodical: Medicine and Science in Sports and Exercise |
Index Medicus: |
| Authors: Storer TW, Casaburi R, Gottron C, Walsh D, Kopple JD |
ABS |
| Yr: 2003 |
Vol: 35 |
Nbr: 5 |
Abs: s231 |
Pg: |
| Endurance training decreases exercise-induced dynamic hyperinflation in patients with COPD. |
| Periodical: European Respiratory Journal |
Index Medicus: |
| Authors: Porszasz J, Emtner M, Whipp BJ, Goto S, Somfay A, Casaburi R |
ABS |
| Yr: 2003 |
Vol: 22 |
Nbr: 45 |
Abs: |
Pg: 205s |
| A linear incremental work rate protocol for treadmill ergometry by means of continuous grade and velocity increases. |
| Periodical: European Society for Respiratory Disease |
Index Medicus: |
| Authors: Casaburi R, Porszasz J, Woodhouse L, Somfay A, Whipp BJ |
ABS |
| Yr: 2003 |
Vol: 22 |
Nbr: 45 |
Abs: |
Pg: 89s |
| Endocrinological disturbances in COPD |
| Periodical: European Respiratory Journal |
Index Medicus: |
| Authors: Creutzberg EC, Casaburi R |
ART |
| Yr: 2003 |
Vol: 22 |
Nbr: Suppl. 46 |
Abs: |
Pg: 76s-80s |
| Anabolic hormone supplementation as an adjunct to pulmonary rehabilitation. |
| Periodical: American Journal of Medicine and Sports |
Index Medicus: |
| Authors: Casaburi R |
ART |
| Yr: 2004 |
Vol: 6 |
Nbr: |
Abs: |
Pg: 28-31 |
| Lung function improvements with once-daily tiotropium in COPD. |
| Periodical: American Journal of Medicine |
Index Medicus: |
| Authors: Casaburi R, Conscenti CS |
ART |
| Yr: 0 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Effect of helium breathing on dynamic hyperinflation, minute ventilation and exercise tolerance in severe COPD patients. |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Goto S, Porszasz J, Sakurai S, Whipp BJ, Casaburi R |
ABS |
| Yr: 2004 |
Vol: 169 |
Nbr: 7 |
Abs: |
Pg: A467 |
| Tiotropium augments improvements in dyspnea and health-related quality of life following pulmonary rehabilitation in COPD. |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Cooper CB, Kukafka D, Casaburi R, Kesten S |
ABS |
| Yr: 2004 |
Vol: 169 |
Nbr: 7 |
Abs: |
Pg: A518 |
| Improvement in endurance time with the combination of tiotropium and rehabilitative exercise training in COPD patients. |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Casaburi R, Kakafka D, Cooper C, Wang S, Kesten S |
ABS |
| Yr: 2004 |
Vol: 169 |
Nbr: 7 |
Abs: |
Pg: A756 |
| Work rate selection for constant work rate exercise testing for interventional studies in COPD. |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Casaburi R, Chen C, Porszasz, Whipp BJ |
ABS |
| Yr: 2004 |
Vol: 169 |
Nbr: 7 |
Abs: |
Pg: A770 |
| Cellular and molecular adaptations in skeletal muscle to testosterone and/or resistance training in men with COPD. |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Fournier M, Casaburi R, Storer T, Porszasz J, Bhasin S, Da X, Lewis MI |
ABS |
| Yr: 2004 |
Vol: 169 |
Nbr: 7 |
Abs: |
Pg: A904 |
| Use of physiological calibration to validate gas exchange measurements during exercise. |
| Periodical: Medicine and Science in Sports and Exercise |
Index Medicus: |
| Authors: Porszasz J, Woodhouse LJ, Casaburi R, Nguyen A, Tsurugaya H, Whipp BJ |
ABS |
| Yr: 2004 |
Vol: 36 |
Nbr: 5 |
Abs: |
Pg: S27 |
| Effects of heliox breathing on R-R variability at rest and during exercise in COPD. |
| Periodical: Medicine and Science in Sports and Exercise |
Index Medicus: |
| Authors: Sakurai S, Whipp BJ, Goto S, Casaburi R |
ABS |
| Yr: 2004 |
Vol: 36 |
Nbr: 5 |
Abs: |
Pg: S210 |
| Testosterone dose-dependently increases maximal voluntary strength and leg power, but does not affect fatiguability or specific tension. |
| Periodical: Journal of Clincal Endocrinology and Metabolism |
Index Medicus: |
| Authors: Casaburi R, Storer TW, Magliano K, Woodhouse L, Lee ML, Dzekov C, et al. |
ART |
| Yr: 2003 |
Vol: 88 |
Nbr: |
Abs: |
Pg: 1478 - 1485 |
| Effects of testosterone replacement and resistance training in men with chronic obstructive pulmonary disease. |
| Periodical: American Journal of Critical Care Medicine |
Index Medicus: |
| Authors: Casaburi R, Bhasin S, Cosentino L, Porszasz J, Somfay A, Lewis MI, Fournier M, Storer TW |
ART |
| Yr: 2004 |
Vol: 170 |
Nbr: |
Abs: |
Pg: 870 - 878 |
| Older men are as responsive as young men to the anabolic effects of graded testosterone on the skeletal muscle. |
| Periodical: Journal of Clincal Endocrinology and Metabolism |
Index Medicus: |
| Authors: Casaburi R, Bhasin L, Woodhouse L, Singh AB, Phong R, Lee M, et al. |
ART |
| Yr: 2005 |
Vol: 90 |
Nbr: |
Abs: |
Pg: 678 - 688 |
| Dose-dependent effects of testosterone on sexual function, mood and visuospatial cognition in older men. |
| Periodical: Journal of Clincal Endocrinology and Metabolism |
Index Medicus: |
| Authors: asaburi R, Gray PB, Singh AB, Woodhouse LJ, Storer TW, Dzekov J, Dzekov C, et al. |
ART |
| Yr: 2005 |
Vol: 90 |
Nbr: |
Abs: |
Pg: 3838 - 3846 |
