Therapies of muscle dysfunction in obstructive lung disease
Abstracts
Initial Award Abstract |
|
This project aims to improve the effectiveness of medical treatment for people with lung disease produced by cigarette smoking. Chronic obstructive pulmonary disease (COPD, which includes emphysema and bronchitis) is a disorder affecting approximately 14 million people in the United States. It is a disabling disease and inability to exercise is usually the foremost problem. It is becoming clear that these patients suffer not only from poorly functioning lungs but from poorly functioning muscles as well. We will focus on strategies that can be predicted to improve the muscle's ability to tolerate exercise. Two specific strategies will be explored. First, in men, the naturally occurring body chemical, testosterone, is important in maintaining muscle mass. We have found that men with COPD have low levels of this chemical. We will determine whether administering testosterone to male COPD patients will increase muscle mass (and exercise tolerance) as we have demonstrated in healthy elderly men. Second, we have found that patients with COPD usually have a low level of physical activity; we will determine whether a conditioning program consisting of a varied group of weight lifting exercises improves exercise tolerance.
We will randomly assign 48 men with COPD to one of four groups that will receive one of the following treatments: no exercise training and no testosterone, exercise training (for one hour a day three times per week) but no testosterone, testosterone but no exercise training, or both exercise training and testosterone. A number of state-of-the art measurements will be made before and after the 10 week study period including: 1 ) precise measurement of the muscle and fat mass of the body, 2) muscle strength by weight lifting and by measuring the electrical activity of the muscle, 3) exercise capacity measured on a stationary bicycle, 4) strength of the breathing muscles and 5) the overall quality of life, assessed by well-designed questionnaires. Also a sophisticated x-ray procedure will be used to measure the mass of the heart and the strength of the heart muscle both at rest and during exercise. In this way, we will determine whether heart muscle function (which is often a problem in these patients) is improved. In this study, a number of safeguards will be in place to assure the participants' safety. Programs are already in place to help rehabilitate patients with COPD. This study should be directly applicable to these programs and help to decrease the suffering of patients with this smoking-related disease. |
Final Report |
|
It was the aim of this project to improve the effectiveness of treatment for people with lung disease produced by cigarette smoking. Chronic obstructive pulmonary disease (COPD, also called emphysema or bronchitis) afflicts approximately 14 million people in the United States. It is a disabling disorder and inability to exercise is usually the foremost problem. It is now clear that these patients suffer not only from poor lung function but from poor muscle function as well. We focused on strategies intended to improve the muscle's ability to tolerate exercise. Two strategies were explored. First, in men the naturally occurring body chemical, testosterone, is important in maintaining muscle mass. Many men with COPD have low testosterone levels. We determined whether administering testosterone to COPD patients increases muscle mass and strength as we have demonstrated in healthy young men. Second, we determined whether a conditioning program consisting of a group of weight lifting exercises improves muscle strength.
We recruited a total of 52 men with COPD; 47 completed the protocol. They were assigned by chance to one of four groups that received: no strength training and no testosterone, strength training (for one hour a day three times per week) but no testosterone, testosterone (100mg of testosterone enanthate intramuscularly) but no strength training, or both strength training and testosterone. A large number of state-of-the art measurements were made before and after the 10 week study period. On average, subjects had severe COPD (FEV1=40% predicted); measures of pulmonary function did not change in any group. Testosterone levels on entry were low; subjects receiving testosterone doubled nadir blood levels to the middle of the normal range for young men. In the groups receiving testosterone, muscle mass (assessed by DEXA scan) increased; in the group receiving strength training alone muscle mass of the legs increased. The group receiving the combined intervention had a 3.3kg (6.3%) increase in muscle mass and an average decrease in fat mass of 1.5kg (6%). Strength of the thigh muscles (measured by 1 repetition maximum of the leg press exercise) increased both in the groups receiving testosterone alone and strength training alone; the group receiving the combined intervention experienced an average 23.3% increase in strength. As expected, measures of exercise endurance did not improve. We employed an x-ray procedure capable of measuring cardiac dimensions and contractility and found that the groups receiving testosterone supplementation increased left ventricular wall mass (by an average of approximately 5%). There were no adverse effects of these interventions; specifically no hepatic or prostatic side-effects were observed. A companion study funded by TRDRP is studying the changes in muscle tissue structure (determined by muscle biopsy) produced by these interventions.
These findings suggest that both strength training and testosterone supplementation will be beneficial additions to programs of pulmonary rehabilitation for patients with COPD and, thereby, help decrease the suffering of patients with this smoking-related disease. |
Publications
| Physiologic benefits of exercise training in rehabilitation of severe COPD patients |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Casaburi RJ, Porszasz MR, Burns ER, Carithers RSY,Chang, Cooper CB |
ART |
| Yr: 1997 |
Vol: 155 |
Nbr: |
Abs: |
Pg: 1541-1551 |
| Replacement doses of testosterone increase fat-free mass and muscle size in hypogonadal men |
| Periodical: Journal of Clincal Endocrinology and Metabolism |
Index Medicus: |
| Authors: Bhasin S, Storer TW, Berman N, et al |
ART |
| Yr: 1997 |
Vol: 82 |
Nbr: |
Abs: |
Pg: 407-413 |
| Effect of acute bicarbonate administration on the responses to incremental exercise responses of COPD patients |
| Periodical: Medicine and Science in Sports and Exercise |
Index Medicus: |
| Authors: Coppoolse R, Barstow TJ, Stringer WW, Carithers E, Casaburi R |
ART |
| Yr: 1997 |
Vol: 29 |
Nbr: |
Abs: |
Pg: 725-732 |
| The effect of exercise training on aerobic fitness, immune function, and quality of life in HIV+ patients |
| Periodical: Medicine and Science in Sports and Exercise |
Index Medicus: |
| Authors: Stringer WW, Berezovskaya M, O'Brien WA, Beck CK, Casaburi R |
ART |
| Yr: 1998 |
Vol: 30 |
Nbr: |
Abs: |
Pg: 11-16 |
| Clinical exercise testing with reference to lung disease: indications, standardization and interpretation strategies |
| Periodical: European Respiratory Journal |
Index Medicus: |
| Authors: Roca J, Whipp BJ, Austi AGN, et al |
ART |
| Yr: 1997 |
Vol: 10 |
Nbr: |
Abs: |
Pg: 2662-2689 |
| Equipment, measurements and quality control in clinical exercise testing |
| Periodical: European Respiratory Monthly |
Index Medicus: |
| Authors: Casaburi R, Cotes JE, Prefaut C |
ART |
| Yr: 1997 |
Vol: 6 |
Nbr: |
Abs: |
Pg: 72-87 |
| Exercise training in chronic lung disease: exercise prescription |
| Periodical: European Respiratory Monthly |
Index Medicus: |
| Authors: Patessio A, Casaburi R, Prefaut C, Folgering H |
ART |
| Yr: 1997 |
Vol: 6 |
Nbr: |
Abs: |
Pg: 129-146 |
| Pulmonary rehabilitation: evidence based guidelines |
| Periodical: Chest |
Index Medicus: |
| Authors: Ries AL, Carlin V, Carrieri-Kohlman R, et al |
ART |
| Yr: 1997 |
Vol: 112 |
Nbr: |
Abs: |
Pg: 1363-1396 |
| Anabolic therapies in chronic obstructive pulmonary disease |
| Periodical: Monaldi Archives of Chest Disease |
Index Medicus: |
| Authors: Casaburi R |
ART |
| Yr: 1998 |
Vol: 53 |
Nbr: |
Abs: |
Pg: 454-459 |
| Rationale for anabolic therapy to facilitate rehabilitation in chronic obstructive pulmonary disease |
| Periodical: Bailliere's Clinical Endocrinology and Metabolism |
Index Medicus: |
| Authors: Casaburi R |
ART |
| Yr: 1998 |
Vol: 12 |
Nbr: 3 |
Abs: |
Pg: 407-418 |
| Emerging issues in androgen replacement therapy |
| Periodical: Journal of Clincal Endocrinology and Metabolism |
Index Medicus: |
| Authors: Bhasin S, Bremner WJ |
ART |
| Yr: 1997 |
Vol: 82 |
Nbr: 1 |
Abs: |
Pg: 3-7 |
| The use of a sensitive equilibrium dialysis assay for measurements of free testosterone levels during the normal menstrual cycle and in HIV-infected women |
| Periodical: Journal of Clincal Endocrinology and Metabolism |
Index Medicus: |
| Authors: Sinha-Hikim I, Arver S, Beall G, et al |
ART |
| Yr: 1998 |
Vol: 83 |
Nbr: |
Abs: |
Pg: 1101-1117 |
| Effects of testosterone replacement with a non-genital system, Androderm, in HIV-infected men with low testosterone levels |
| Periodical: Journal of Clincal Endocrinology and Metabolism |
Index Medicus: |
| Authors: Bhasin S, Storer TW, Asbel-Sethi N, et al |
ART |
| Yr: 0 |
Vol: 83 |
Nbr: |
Abs: |
Pg: 3155-3162 |
| Age-associated sarcopenia: Issies in testosterone replacement of older men |
| Periodical: Journal of Clincal Endocrinology and Metabolism |
Index Medicus: |
| Authors: Bhasin S, Tenover JS |
ART |
| Yr: 1997 |
Vol: 82 |
Nbr: |
Abs: |
Pg: 1659-1661 |
| Electron beam tomography of the coronary arteries:Relationship of coronary calcium score to arteriographic findings in asymptomatic and symptomatic adults |
| Periodical: American Journal of Cardiology |
Index Medicus: |
| Authors: Buerci AD, Spadaro LA, Popma JJ, et al |
ART |
| Yr: 1997 |
Vol: 79 |
Nbr: |
Abs: |
Pg: 128-133 |
| Coronary calcium and standard risk factors in symptomatic patients referred for coronary angiography |
| Periodical: American Heart Journal |
Index Medicus: |
| Authors: Kennedy JM, Shavelle RM, Wong SM, Budoff MJ, Detrano RC |
ART |
| Yr: 1998 |
Vol: 135 |
Nbr: |
Abs: |
Pg: 696-702 |
| Comparison of ultra fast computed tomography and sestamibi in the evaluation of coronary artery disease |
| Periodical: American Journal of Cardiology |
Index Medicus: |
| Authors: Budoff MJ, Georgiou D, Narahara KA, French WJ, Mena, I, Brundage BH |
ART |
| Yr: 1998 |
Vol: 81 |
Nbr: |
Abs: |
Pg: 682-687 |
| Clinical utility of electron beam computed tomography |
| Periodical: Medical Progress |
Index Medicus: |
| Authors: Budoff MJ |
ART |
| Yr: 1998 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Randomized placebo controlled study of growth hormone in severe COPD patients undergoing endurance exercising training. |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Casaburi R, Carithers E, Tosolini J, Phillips J, Bhasin, S |
ABS |
| Yr: 1997 |
Vol: 155 |
Nbr: 4 |
Abs: |
Pg: A498 |
| Effects of physiologic testosterone replacement by Androderm, a non-genital transdermal testosterone system, in HIV-infected men with low testosterone levels |
| Periodical: Proceedings of the Endocrine Society Meeting |
Index Medicus: |
| Authors: Bhasin S, Storer TW, Berman N, et al |
ABS |
| Yr: 1998 |
Vol: |
Nbr: |
Abs: |
Pg: |
| cDNA cloning, chromosomal mapping, mRNA expression, and secretion of myostatin, a muscle growth inhibitor |
| Periodical: Proceedings of the Endocrine Society Meeting |
Index Medicus: |
| Authors: Gonzalez-Cadavid N, Taylor WE, Ma K, et al |
ABS |
| Yr: 1998 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Exercise testing and electron beam computed tomography in the evaluation of coronary artery disease |
| Periodical: Circulation |
Index Medicus: |
| Authors: Shavelle DM, Budoff MJ, Lamont DH, Shavelle RM, Kennedy JM, Brundage BH |
ABS |
| Yr: 1997 |
Vol: 96 |
Nbr: 8 |
Abs: |
Pg: 1-306 |
| Intravenous three dimensional coronary angiography using contrast enhanced electron beam computed tomography |
| Periodical: Journal of the American College of Cardiology |
Index Medicus: |
| Authors: Budoff MJ, Oudiz RJ, Zalace CP, et al |
ABS |
| Yr: 1997 |
Vol: 29 |
Nbr: 2 |
Abs: |
Pg: 393-A |
| Coronary calcium scanning identifies patients with false positive stress tests |
| Periodical: Circulation |
Index Medicus: |
| Authors: Lamont DH, Budoff MJ, Shavelle DM, Brundage BH, Hagar JM |
ABS |
| Yr: 1997 |
Vol: 96 |
Nbr: 8 |
Abs: |
Pg: 1-306 |
| Effects of cigarette-smoking levels of carbon monoxide on carboxyhemoglobin, exercise gas exchange and hemodynamics |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Lewis DA, Otsuka T, Hansen JE, Wasserman K |
ABS |
| Yr: 1998 |
Vol: 157 |
Nbr: 4, part 2 |
Abs: |
Pg: A94 |
| Changes in arterial blood gases during obstructive sleep apnea |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Abe J, Kawaoka J, Lewis DA |
ABS |
| Yr: 1998 |
Vol: 157 |
Nbr: 4, part 2 |
Abs: |
Pg: A58 |
| Mechanism of the acute ventilatory increase to pulse inhalation of carbon monoxide during exercise |
| Periodical: FASEB Journal |
Index Medicus: |
| Authors: Lewis DA, Otsuka T, Hansen JE, Wasserman K |
ABS |
| Yr: 1998 |
Vol: 12 |
Nbr: 4, part 1 |
Abs: |
Pg: A498 |
| Pharmacologic modulators of respiratory control |
| Periodical: Monaldi Archives of Chest Disease |
Index Medicus: |
| Authors: Casaburi R |
ART |
| Yr: 1198 |
Vol: 53 |
Nbr: |
Abs: |
Pg: 287-293 |
| The human myostatin gene: genomic organization, chromosomal mapping, cDNA expression, and secretion in healthy and HIV-infected men |
| Periodical: Proceedings of the National Academy of Sciences of the United States of America |
Index Medicus: |
| Authors: |
ART |
| Yr: 1998 |
Vol: 95 |
Nbr: |
Abs: |
Pg: 14938-14943 |
| Effect of muscle fibre type and cardiorespiratory fitness on the oxygen uptake/work rate slope during incremental exercise |
| Periodical: Journal of Physiology |
Index Medicus: |
| Authors: Jones AM, Barstow TJ, Nguyen PH, Casaburi R |
ABS |
| Yr: 1998 |
Vol: |
Nbr: |
Abs: 9P |
Pg: 511 |
| The spirometric efficacy of once daily dosing with tiotropium in stable COPD |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Casaburi R, Serby CW, Menjoge SS, Witek TJ |
ABS |
| Yr: 1999 |
Vol: 159 |
Nbr: 3 |
Abs: A524 |
Pg: |
| Skeletal muscle dysfunction in obstructive pulmonary disease |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Casaburi R, Gosselink M, Decramer PNR, et al |
ART |
| Yr: 1999 |
Vol: 159 |
Nbr: 4 part 2 |
Abs: |
Pg: S1-S40 |
| Skeletal muscle function in COPD |
| Periodical: Chest |
Index Medicus: |
| Authors: Casaburi R |
ART |
| Yr: 2000 |
Vol: 117 |
Nbr: |
Abs: |
Pg: 267S-271S |
| Comparison of effects of supervised versus self-monitored training programmes in patients with chronic obstructive pulmonary disease |
| Periodical: European Respiratory Journal |
Index Medicus: |
| Authors: Puente-Maestu L, Sanz ML, Sanz P, Cubillo JM, Mayol J, Casaburi R |
ART |
| Yr: 2000 |
Vol: 15 |
Nbr: |
Abs: |
Pg: 517-526 |
| Influence of muscle fibre type and fitness on the oxygen uptake/power slope during incremental exercise in humans |
| Periodical: Experimental Physiology_x000D_ |
Index Medicus: |
| Authors: Barstow TJ, Jones AM, Nguyen PH, Casaburi R |
ART |
| Yr: 2000 |
Vol: 85 |
Nbr: |
Abs: |
Pg: 109-116 |
| The spirometric efficacy of once daily dosing with tiotropium in stable COPD |
| Periodical: Chest |
Index Medicus: |
| Authors: Casaburi R, Briggs DD, Donohue JF, Serby CW, Menjoge SS, Witek TJ |
ART |
| Yr: 0 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Effects of the workrate incremental rate on the response to exercise in patients with COPD |
| Periodical: Medicine and Science in Sports and Exercise |
Index Medicus: |
| Authors: Debigare R, Maltais F, Mallet M, Casaburi R |
ART |
| Yr: 2000 |
Vol: 32 |
Nbr: |
Abs: |
Pg: 1365-1368 |
| New advances in anticholinergic therapy - clinical effectiveness of a very long-acting anticholinergic, tiotropium promide, for inhalation once-daily in COPD |
| Periodical: Lungeforum |
Index Medicus: |
| Authors: Casaburi R, Serby CW, Menjoge SS, Witek T |
ABS |
| Yr: 1999 |
Vol: 9 |
Nbr: 11 |
Abs: 12 |
Pg: |
| Comparison of two pulse 02 delivery modes vs continuous flow 02 during exe5rcise in hypoxemic COPD patients |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Porszasz J, Ditch J, Bradley R, Casaburi R |
ABS |
| Yr: 2000 |
Vol: 161 |
Nbr: 3 |
Abs: A227 |
Pg: |
| Androgen effects on body composition and muscle function: implications for the use of androgens as anabolic agents in sarcopenic states |
| Periodical: Bailliere's Clinical Endocrinology and Metabolism |
Index Medicus: |
| Authors: Bross R, Casaburi R, Storer TW, Bhasin S |
ART |
| Yr: 1998 |
Vol: 12 |
Nbr: 3 |
Abs: |
Pg: 365-378 |
| Peripheral muscle dysfunction in chronic obstructive pulmonary disease |
| Periodical: Clinics in Chest Medicine |
Index Medicus: |
| Authors: Maltais F, LeBlanc P, Jobin J, Casaburi R |
ART |
| Yr: 2000 |
Vol: 21 |
Nbr: 4 |
Abs: |
Pg: 665-677 |
| Exercise limitation in COPD: Role of skeletal muscle dysfunction |
| Periodical: Medicine and Science in Sports and Exercise |
Index Medicus: |
| Authors: Casaburi R |
ART |
| Yr: 2001 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Effect of oxygen on hyperinflation and exercise endurance in non-hypoxemic COPD patients |
| Periodical: European Respiratory Journal |
Index Medicus: |
| Authors: Somfay A, Porszasz J, Lee SM, Casaburi R |
ART |
| Yr: 0 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Testosterone dose-response relationships in healthy young men |
| Periodical: American Journal of Physiology |
Index Medicus: |
| Authors: Bhasin S, Woodhouse L, Casaburi R, et al |
ART |
| Yr: 0 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Resistance training, but not testosterone supplementation, increases thigh muscle specific tension in men |
| Periodical: Proceedings of the Western American Federation of Medical Research |
Index Medicus: |
| Authors: Storer TW, Casaburi R, Singh AB, et al |
ABS |
| Yr: 0 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Testosterone dose response relationships in healthy young men |
| Periodical: Proceedings of the Western American Federation of Medical Research |
Index Medicus: |
| Authors: Storer TW, Casaburi R, Singh AB, et al |
ABS |
| Yr: 0 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Megestrol acetate induces weight gain and stimulates ventilation in underweight COPD patients: a randomized, double-blind, placebo-controlled, multi-center trial |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Weisberg J, Casaburi R, Olson J, Wanger J |
ABS |
| Yr: 2001 |
Vol: 163 |
Nbr: 5 |
Abs: A503 |
Pg: |
| Comparison of a new linearized treadmill ramp protocol with a cycle ergometer ramp protocol in cardiopulmonary exercise testing (CPX) |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Porszasz J, Woodhouse L, Somfay A, Yu A, DeBellis E, Casaburi R |
ABS |
| Yr: 2001 |
Vol: 163 |
Nbr: 5 |
Abs: A267 |
Pg: |
| Effect of supplemental oxygen on hyperinflation and exercise endurance in non-hypoxemic COPD patients |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Somfay A, Porszasz J, Lee SM, Casaburi R |
ABS |
| Yr: 2001 |
Vol: 163 |
Nbr: 5 |
Abs: |
Pg: |
| Testosterone dose-dependently increases muscle strength, power and endurance, but not measures of aerobic capacity in healthy young men |
| Periodical: Proceedings of the American College of Sports Medicine |
Index Medicus: |
| Authors: Storer TW, Magliano L, Woodhouse J, Dzekov J, Casaburi R, Bhasin S |
ABS |
| Yr: 0 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Testosterone dose-response relationships differ among androgen-dependent biochemical and physiological processes in healthy young men |
| Periodical: Proceedings of the Endocrine Society Meeting |
Index Medicus: |
| Authors: Woodhouse L, Storer TW, Casaburi R, et al |
ABS |
| Yr: 2001 |
Vol: |
Nbr: |
Abs: |
Pg: P2-476 |
| Dose-dependent effects of testosterone on muscle strength, power and fatigability in healthy young men |
| Periodical: Proceedings of the Endocrine Society Meeting |
Index Medicus: |
| Authors: Storer TW, Woodhouse LJ, Casaburi R, et al |
ABS |
| Yr: 2001 |
Vol: |
Nbr: |
Abs: OR11-1 |
Pg: |
| Testosterone-induced increase in muscle size in healthy men is associated with muscle fiber hypertrophy, but not fiber hyperplasia |
| Periodical: Proceedings of the Endocrine Society Meeting |
Index Medicus: |
| Authors: Sinha-Hikim I, Woodhouse LJ, Shen R, et al |
ABS |
| Yr: 2001 |
Vol: |
Nbr: |
Abs: OR11-2 |
Pg: |
| Physiologic benefits of exercise training in rehabilitation of severe COPD patients |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Casaburi RJ, Porszasz MR, Burns ER, Carithers RSY,Chang, Cooper CB |
ART |
| Yr: 1997 |
Vol: 155 |
Nbr: |
Abs: |
Pg: 1541-1551 |
| Replacement doses of testosterone increase fat-free mass and muscle size in hypogonadal men |
| Periodical: Journal of Clincal Endocrinology and Metabolism |
Index Medicus: |
| Authors: Bhasin S, Storer TW, Berman N, et al |
ART |
| Yr: 1997 |
Vol: 82 |
Nbr: |
Abs: |
Pg: 407-413 |
| Effect of acute bicarbonate administration on the responses to incremental exercise responses of COPD patients |
| Periodical: Medicine and Science in Sports and Exercise |
Index Medicus: |
| Authors: Coppoolse R, Barstow TJ, Stringer WW, Carithers E, Casaburi R |
ART |
| Yr: 1997 |
Vol: 29 |
Nbr: |
Abs: |
Pg: 725-732 |
| The effect of exercise training on aerobic fitness, immune function, and quality of life in HIV+ patients |
| Periodical: Medicine and Science in Sports and Exercise |
Index Medicus: |
| Authors: Stringer WW, Berezovskaya M, O'Brien WA, Beck CK, Casaburi R |
ART |
| Yr: 1998 |
Vol: 30 |
Nbr: |
Abs: |
Pg: 11-16 |
| Clinical exercise testing with reference to lung disease: indications, standardization and interpretation strategies |
| Periodical: European Respiratory Journal |
Index Medicus: |
| Authors: Roca J, Whipp BJ, Austi AGN, et al |
ART |
| Yr: 1997 |
Vol: 10 |
Nbr: |
Abs: |
Pg: 2662-2689 |
| Equipment, measurements and quality control in clinical exercise testing |
| Periodical: European Respiratory Monthly |
Index Medicus: |
| Authors: Casaburi R, Cotes JE, Prefaut C |
ART |
| Yr: 1997 |
Vol: 6 |
Nbr: |
Abs: |
Pg: 72-87 |
| Exercise training in chronic lung disease: exercise prescription |
| Periodical: European Respiratory Monthly |
Index Medicus: |
| Authors: Patessio A, Casaburi R, Prefaut C, Folgering H |
ART |
| Yr: 1997 |
Vol: 6 |
Nbr: |
Abs: |
Pg: 129-146 |
| Pulmonary rehabilitation: evidence based guidelines |
| Periodical: Chest |
Index Medicus: |
| Authors: Ries AL, Carlin V, Carrieri-Kohlman R, et al |
ART |
| Yr: 1997 |
Vol: 112 |
Nbr: |
Abs: |
Pg: 1363-1396 |
| Anabolic therapies in chronic obstructive pulmonary disease |
| Periodical: Monaldi Archives of Chest Disease |
Index Medicus: |
| Authors: Casaburi R |
ART |
| Yr: 1998 |
Vol: 53 |
Nbr: |
Abs: |
Pg: 454-459 |
| Rationale for anabolic therapy to facilitate rehabilitation in chronic obstructive pulmonary disease |
| Periodical: Bailliere's Clinical Endocrinology and Metabolism |
Index Medicus: |
| Authors: Casaburi R |
ART |
| Yr: 1998 |
Vol: 12 |
Nbr: 3 |
Abs: |
Pg: 407-418 |
| Emerging issues in androgen replacement therapy |
| Periodical: Journal of Clincal Endocrinology and Metabolism |
Index Medicus: |
| Authors: Bhasin S, Bremner WJ |
ART |
| Yr: 1997 |
Vol: 82 |
Nbr: 1 |
Abs: |
Pg: 3-7 |
| The use of a sensitive equilibrium dialysis assay for measurements of free testosterone levels during the normal menstrual cycle and in HIV-infected women |
| Periodical: Journal of Clincal Endocrinology and Metabolism |
Index Medicus: |
| Authors: Sinha-Hikim I, Arver S, Beall G, et al |
ART |
| Yr: 1998 |
Vol: 83 |
Nbr: |
Abs: |
Pg: 1101-1117 |
| Effects of testosterone replacement with a non-genital system, Androderm, in HIV-infected men with low testosterone levels |
| Periodical: Journal of Clincal Endocrinology and Metabolism |
Index Medicus: |
| Authors: Bhasin S, Storer TW, Asbel-Sethi N, et al |
ART |
| Yr: 0 |
Vol: 83 |
Nbr: |
Abs: |
Pg: 3155-3162 |
| Age-associated sarcopenia: Issies in testosterone replacement of older men |
| Periodical: Journal of Clincal Endocrinology and Metabolism |
Index Medicus: |
| Authors: Bhasin S, Tenover JS |
ART |
| Yr: 1997 |
Vol: 82 |
Nbr: |
Abs: |
Pg: 1659-1661 |
| Electron beam tomography of the coronary arteries:Relationship of coronary calcium score to arteriographic findings in asymptomatic and symptomatic adults |
| Periodical: American Journal of Cardiology |
Index Medicus: |
| Authors: Buerci AD, Spadaro LA, Popma JJ, et al |
ART |
| Yr: 1997 |
Vol: 79 |
Nbr: |
Abs: |
Pg: 128-133 |
| Coronary calcium and standard risk factors in symptomatic patients referred for coronary angiography |
| Periodical: American Heart Journal |
Index Medicus: |
| Authors: Kennedy JM, Shavelle RM, Wong SM, Budoff MJ, Detrano RC |
ART |
| Yr: 1998 |
Vol: 135 |
Nbr: |
Abs: |
Pg: 696-702 |
| Comparison of ultra fast computed tomography and sestamibi in the evaluation of coronary artery disease |
| Periodical: American Journal of Cardiology |
Index Medicus: |
| Authors: Budoff MJ, Georgiou D, Narahara KA, French WJ, Mena, I, Brundage BH |
ART |
| Yr: 1998 |
Vol: 81 |
Nbr: |
Abs: |
Pg: 682-687 |
| Clinical utility of electron beam computed tomography |
| Periodical: Medical Progress |
Index Medicus: |
| Authors: Budoff MJ |
ART |
| Yr: 1998 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Randomized placebo controlled study of growth hormone in severe COPD patients undergoing endurance exercising training. |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Casaburi R, Carithers E, Tosolini J, Phillips J, Bhasin, S |
ABS |
| Yr: 1997 |
Vol: 155 |
Nbr: 4 |
Abs: |
Pg: A498 |
| Effects of physiologic testosterone replacement by Androderm, a non-genital transdermal testosterone system, in HIV-infected men with low testosterone levels |
| Periodical: Proceedings of the Endocrine Society Meeting |
Index Medicus: |
| Authors: Bhasin S, Storer TW, Berman N, et al |
ABS |
| Yr: 1998 |
Vol: |
Nbr: |
Abs: |
Pg: |
| cDNA cloning, chromosomal mapping, mRNA expression, and secretion of myostatin, a muscle growth inhibitor |
| Periodical: Proceedings of the Endocrine Society Meeting |
Index Medicus: |
| Authors: Gonzalez-Cadavid N, Taylor WE, Ma K, et al |
ABS |
| Yr: 1998 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Exercise testing and electron beam computed tomography in the evaluation of coronary artery disease |
| Periodical: Circulation |
Index Medicus: |
| Authors: Shavelle DM, Budoff MJ, Lamont DH, Shavelle RM, Kennedy JM, Brundage BH |
ABS |
| Yr: 1997 |
Vol: 96 |
Nbr: 8 |
Abs: |
Pg: 1-306 |
| Intravenous three dimensional coronary angiography using contrast enhanced electron beam computed tomography |
| Periodical: Journal of the American College of Cardiology |
Index Medicus: |
| Authors: Budoff MJ, Oudiz RJ, Zalace CP, et al |
ABS |
| Yr: 1997 |
Vol: 29 |
Nbr: 2 |
Abs: |
Pg: 393-A |
| Coronary calcium scanning identifies patients with false positive stress tests |
| Periodical: Circulation |
Index Medicus: |
| Authors: Lamont DH, Budoff MJ, Shavelle DM, Brundage BH, Hagar JM |
ABS |
| Yr: 1997 |
Vol: 96 |
Nbr: 8 |
Abs: |
Pg: 1-306 |
| Effects of cigarette-smoking levels of carbon monoxide on carboxyhemoglobin, exercise gas exchange and hemodynamics |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Lewis DA, Otsuka T, Hansen JE, Wasserman K |
ABS |
| Yr: 1998 |
Vol: 157 |
Nbr: 4, part 2 |
Abs: |
Pg: A94 |
| Changes in arterial blood gases during obstructive sleep apnea |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Abe J, Kawaoka J, Lewis DA |
ABS |
| Yr: 1998 |
Vol: 157 |
Nbr: 4, part 2 |
Abs: |
Pg: A58 |
| Mechanism of the acute ventilatory increase to pulse inhalation of carbon monoxide during exercise |
| Periodical: FASEB Journal |
Index Medicus: |
| Authors: Lewis DA, Otsuka T, Hansen JE, Wasserman K |
ABS |
| Yr: 1998 |
Vol: 12 |
Nbr: 4, part 1 |
Abs: |
Pg: A498 |
| Pharmacologic modulators of respiratory control |
| Periodical: Monaldi Archives of Chest Disease |
Index Medicus: |
| Authors: Casaburi R |
ART |
| Yr: 1198 |
Vol: 53 |
Nbr: |
Abs: |
Pg: 287-293 |
| The human myostatin gene: genomic organization, chromosomal mapping, cDNA expression, and secretion in healthy and HIV-infected men |
| Periodical: Proceedings of the National Academy of Sciences of the United States of America |
Index Medicus: |
| Authors: |
ART |
| Yr: 1998 |
Vol: 95 |
Nbr: |
Abs: |
Pg: 14938-14943 |
| Effect of muscle fibre type and cardiorespiratory fitness on the oxygen uptake/work rate slope during incremental exercise |
| Periodical: Journal of Physiology |
Index Medicus: |
| Authors: Jones AM, Barstow TJ, Nguyen PH, Casaburi R |
ABS |
| Yr: 1998 |
Vol: |
Nbr: |
Abs: 9P |
Pg: 511 |
| The spirometric efficacy of once daily dosing with tiotropium in stable COPD |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Casaburi R, Serby CW, Menjoge SS, Witek TJ |
ABS |
| Yr: 1999 |
Vol: 159 |
Nbr: 3 |
Abs: A524 |
Pg: |
| Skeletal muscle dysfunction in obstructive pulmonary disease |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Casaburi R, Gosselink M, Decramer PNR, et al |
ART |
| Yr: 1999 |
Vol: 159 |
Nbr: 4 part 2 |
Abs: |
Pg: S1-S40 |
| Skeletal muscle function in COPD |
| Periodical: Chest |
Index Medicus: |
| Authors: Casaburi R |
ART |
| Yr: 2000 |
Vol: 117 |
Nbr: |
Abs: |
Pg: 267S-271S |
| Comparison of effects of supervised versus self-monitored training programmes in patients with chronic obstructive pulmonary disease |
| Periodical: European Respiratory Journal |
Index Medicus: |
| Authors: Puente-Maestu L, Sanz ML, Sanz P, Cubillo JM, Mayol J, Casaburi R |
ART |
| Yr: 2000 |
Vol: 15 |
Nbr: |
Abs: |
Pg: 517-526 |
| Influence of muscle fibre type and fitness on the oxygen uptake/power slope during incremental exercise in humans |
| Periodical: Experimental Physiology_x000D_ |
Index Medicus: |
| Authors: Barstow TJ, Jones AM, Nguyen PH, Casaburi R |
ART |
| Yr: 2000 |
Vol: 85 |
Nbr: |
Abs: |
Pg: 109-116 |
| The spirometric efficacy of once daily dosing with tiotropium in stable COPD |
| Periodical: Chest |
Index Medicus: |
| Authors: Casaburi R, Briggs DD, Donohue JF, Serby CW, Menjoge SS, Witek TJ |
ART |
| Yr: 0 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Effects of the workrate incremental rate on the response to exercise in patients with COPD |
| Periodical: Medicine and Science in Sports and Exercise |
Index Medicus: |
| Authors: Debigare R, Maltais F, Mallet M, Casaburi R |
ART |
| Yr: 2000 |
Vol: 32 |
Nbr: |
Abs: |
Pg: 1365-1368 |
| New advances in anticholinergic therapy - clinical effectiveness of a very long-acting anticholinergic, tiotropium promide, for inhalation once-daily in COPD |
| Periodical: Lungeforum |
Index Medicus: |
| Authors: Casaburi R, Serby CW, Menjoge SS, Witek T |
ABS |
| Yr: 1999 |
Vol: 9 |
Nbr: 11 |
Abs: 12 |
Pg: |
| Comparison of two pulse 02 delivery modes vs continuous flow 02 during exe5rcise in hypoxemic COPD patients |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Porszasz J, Ditch J, Bradley R, Casaburi R |
ABS |
| Yr: 2000 |
Vol: 161 |
Nbr: 3 |
Abs: A227 |
Pg: |
| Androgen effects on body composition and muscle function: implications for the use of androgens as anabolic agents in sarcopenic states |
| Periodical: Bailliere's Clinical Endocrinology and Metabolism |
Index Medicus: |
| Authors: Bross R, Casaburi R, Storer TW, Bhasin S |
ART |
| Yr: 1998 |
Vol: 12 |
Nbr: 3 |
Abs: |
Pg: 365-378 |
| Peripheral muscle dysfunction in chronic obstructive pulmonary disease |
| Periodical: Clinics in Chest Medicine |
Index Medicus: |
| Authors: Maltais F, LeBlanc P, Jobin J, Casaburi R |
ART |
| Yr: 2000 |
Vol: 21 |
Nbr: 4 |
Abs: |
Pg: 665-677 |
| Exercise limitation in COPD: Role of skeletal muscle dysfunction |
| Periodical: Medicine and Science in Sports and Exercise |
Index Medicus: |
| Authors: Casaburi R |
ART |
| Yr: 2001 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Effect of oxygen on hyperinflation and exercise endurance in non-hypoxemic COPD patients |
| Periodical: European Respiratory Journal |
Index Medicus: |
| Authors: Somfay A, Porszasz J, Lee SM, Casaburi R |
ART |
| Yr: 0 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Testosterone dose-response relationships in healthy young men |
| Periodical: American Journal of Physiology |
Index Medicus: |
| Authors: Bhasin S, Woodhouse L, Casaburi R, et al |
ART |
| Yr: 0 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Resistance training, but not testosterone supplementation, increases thigh muscle specific tension in men |
| Periodical: Proceedings of the Western American Federation of Medical Research |
Index Medicus: |
| Authors: Storer TW, Casaburi R, Singh AB, et al |
ABS |
| Yr: 0 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Testosterone dose response relationships in healthy young men |
| Periodical: Proceedings of the Western American Federation of Medical Research |
Index Medicus: |
| Authors: Storer TW, Casaburi R, Singh AB, et al |
ABS |
| Yr: 0 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Megestrol acetate induces weight gain and stimulates ventilation in underweight COPD patients: a randomized, double-blind, placebo-controlled, multi-center trial |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Weisberg J, Casaburi R, Olson J, Wanger J |
ABS |
| Yr: 2001 |
Vol: 163 |
Nbr: 5 |
Abs: A503 |
Pg: |
| Comparison of a new linearized treadmill ramp protocol with a cycle ergometer ramp protocol in cardiopulmonary exercise testing (CPX) |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Porszasz J, Woodhouse L, Somfay A, Yu A, DeBellis E, Casaburi R |
ABS |
| Yr: 2001 |
Vol: 163 |
Nbr: 5 |
Abs: A267 |
Pg: |
| Effect of supplemental oxygen on hyperinflation and exercise endurance in non-hypoxemic COPD patients |
| Periodical: American Journal of Respiratory and Critical Care Medicine |
Index Medicus: |
| Authors: Somfay A, Porszasz J, Lee SM, Casaburi R |
ABS |
| Yr: 2001 |
Vol: 163 |
Nbr: 5 |
Abs: |
Pg: |
| Testosterone dose-dependently increases muscle strength, power and endurance, but not measures of aerobic capacity in healthy young men |
| Periodical: Proceedings of the American College of Sports Medicine |
Index Medicus: |
| Authors: Storer TW, Magliano L, Woodhouse J, Dzekov J, Casaburi R, Bhasin S |
ABS |
| Yr: 0 |
Vol: |
Nbr: |
Abs: |
Pg: |
| Testosterone dose-response relationships differ among androgen-dependent biochemical and physiological processes in healthy young men |
| Periodical: Proceedings of the Endocrine Society Meeting |
Index Medicus: |
| Authors: Woodhouse L, Storer TW, Casaburi R, et al |
ABS |
| Yr: 2001 |
Vol: |
Nbr: |
Abs: |
Pg: P2-476 |
| Dose-dependent effects of testosterone on muscle strength, power and fatigability in healthy young men |
| Periodical: Proceedings of the Endocrine Society Meeting |
Index Medicus: |
| Authors: Storer TW, Woodhouse LJ, Casaburi R, et al |
ABS |
| Yr: 2001 |
Vol: |
Nbr: |
Abs: OR11-1 |
Pg: |
| Testosterone-induced increase in muscle size in healthy men is associated with muscle fiber hypertrophy, but not fiber hyperplasia |
| Periodical: Proceedings of the Endocrine Society Meeting |
Index Medicus: |
| Authors: Sinha-Hikim I, Woodhouse LJ, Shen R, et al |
ABS |
| Yr: 2001 |
Vol: |
Nbr: |
Abs: OR11-2 |
Pg: |
