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George Koob, Ph.D.

Scripps Research Institute # of Grants: 2

Grants

Nicotine self-administration in an animal model 2003 (Cycle 12) $660,156
Nicotine Dependence Research Project Awards

Nicotine Self-Administration in an Animal Model 2008 (Cycle 17) $720,434
Nicotine Dependence Research Project Awards
Publications

Neurobiological mechanisms in the transition from drug use to drug dependence.
Periodical: Neuroscience Biobehavior Index Medicus:
Authors: Koob GF, Ahmed SH, Boutrel B, Chen SA, Kenny PJ, Markou A, O'Dell LE, et al. ART
Yr: 2004 Vol: 27 Nbr: Abs: Pg: 739-749

Nicotine withdrawal in adolescent and adult rats.
Periodical: Annals of the New York Academy of Sciences Index Medicus:
Authors: O'Dell LE, Bruijnzeel AW, Ghozland S, Markou A, Koob GF ART
Yr: 0 Vol: Nbr: Abs: Pg:

Nicotine withrawal in adolescent and adult rats
Periodical: Index Medicus:
Authors: Koob, GF ART
Yr: Vol: Nbr: Abs: Pg:

Metabotropic Glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self -administration but not nicotine and cocaine-induced facilitation of brain reward function in rats
Periodical: Annals of the New York Academy of Sciences Index Medicus:
Authors: Kenny, P.J., Paterson N.E., Boutrel B, Semenova S., Harrison A.A., Gasparini, F. , Koob G. ART
Yr: 2003 Vol: Nbr: Abs: Pg: 415-418

Nicotine withdrawal in adolescent and adult rats
Periodical: Annals of the New York Academy of Sciences Index Medicus:
Authors: O'dell, L.E. Bruijnzee;, AW., Ghozland ,S. Markou, A and Koob, G.F. ART
Yr: 2004 Vol: Nbr: Abs: Pg: 167-174

Investigations using immunization to attenuate the psychoactive effects of nicotine
Periodical: Bioorganic Medical Chemistry Index Medicus:
Authors: Carrera, M.R.A. , Ashley, J. A., Hoffman , T. Z., Isomura S., Wirsching, P. Koob, G.F. ART
Yr: 2004 Vol: Nbr: Abs: Pg: 563-570

Monoamine Oxidase inhibition dramatically increases the motivation to self-administer nicotine in rats
Periodical: Journal of Neuroscience Index Medicus:
Authors: Guillem K, Vouillac C., Azar, MR., Parsons., L.H., Koob, G.F. Cador , M. and Stinus ART
Yr: 2005 Vol: Nbr: Abs: Pg: 8593-8600

Diminished nicotine withdrawal in adolescent rats implications for vulnerability to addicition
Periodical: Psychopharmacology Index Medicus:
Authors: O'Dell, L.E., Bruijnzeel, A.W., Smith R.T., Parsons, L.H. Merves, M.L., Koob G.F. ART
Yr: 2006 Vol: 186 Nbr: Abs: Pg: 612-619

MAO-A and MAO-B inhibition on nicotine self -administration in rats
Periodical: European Journal of Neuroscience Index Medicus:
Authors: Guillem, K., Vouillac, C., Azar, M.R. , Parsons , L.H., Koob, G.F., ART
Yr: 0 Vol: Nbr: Abs: Pg:

Addiction and the brain antireward system.
Periodical: Annual Review of Psychology Index Medicus:
Authors: Koob GF; Le Moal M ART
Yr: 2008 Vol: Nbr: 59 Abs: Pg: 29-53

A role for brain stress systems in addiction.
Periodical: Neuron Index Medicus:
Authors: Koob GF ART
Yr: 2008 Vol: Nbr: 59 Abs: Pg: 11-34

Neurobiological mechanisms for opponent motivational processes in addiction.
Periodical: Philosophical Transactions of the Royal Society of London Series B: Biological Sciences Index Medicus:
Authors: Koob GF; Le Moal M ART
Yr: 2008 Vol: Nbr: 363 Abs: Pg: 3113-3123

Neurobiological substrates for the dark sid eof compulsivity in addiction.
Periodical: Neuropharmacology Index Medicus:
Authors: Koob GF ART
Yr: 2009 Vol: Nbr: 56 Abs: Pg: 18-31

Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal.
Periodical: Proceedings of the National Academy of Sciences of the United States of America Index Medicus:
Authors: Grieder TE, George 0, Tan H, George SR, Le Foll B, Laviolette SR, van der Kooy D ART
Yr: 2012 Vol: 109 Nbr: Abs: PMCID:PMC3 Pg: 3101-3106

Effects of the combination of metyrapone and oxazepam on intravenous nicotine self-administration in rats.
Periodical: Psychopharmacology Index Medicus:
Authors: Goeders NE, Cohen A, Fox BS, Azar MR, George 0, Koob GF ART
Yr: Vol: Nbr: Abs: I Pg:

Effects of the_x000d_ specific a4~2 nAChR antagonist, 2-fluoro-3-(4-nitrophenyl) deschloroepibatidine, on nicotine reward-related behaviors in rats and mice.
Periodical: Psychopharmacology Index Medicus:
Authors: Tobey KM, Walentiny DM, Wiley JL, Carroll FI, Damaj MI, Azar MR, Koob GF, George 0, Harris ART
Yr: Vol: Nbr: Abs: Pg:

Robust escalation of nicotine intake with extended access to nicotine self-administration and_x000d_ intermittent periods of abstinence.
Periodical: Neuropsychopharmacology Index Medicus:
Authors: Cohen A, Koob GF, George 0. ART
Yr: Vol: Nbr: Abs: Pg: